PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23819597-4 2013 In Lck-Bax38&1 mice, a 100 cGy dose of high-LET iron ions caused a significant dose dependent acceleration of lymphomagenesis in both males and females that was not seen with silicon ions. Iron 52-56 BCL2-associated X protein Mus musculus 3-18 25301748-8 2015 Furthermore, our findings suggest that the increased nigral iron content exacerbates the oxidative stress levels, promoting apoptosis through the Bcl-2/Bax pathway and the activated caspase-3 pathway in the brain. Iron 60-64 BCL2-associated X protein Mus musculus 152-155 27843711-11 2016 Iron contributed to the permeabilizatio of mitochondria, leading to the release of cytochrome C (cyto C), which, in turn, induced mitochondrial apoptosis in osteoblasts via activation of Caspase-3, up-regulation of Bax, and down-regulation of Bcl-2. Iron 0-4 BCL2-associated X protein Mus musculus 215-218 27342530-12 2016 CD8+ T cell apoptosis in iron overload group was significantly higher than that in control groups (P<0.01); the expression of BCL-2 at mRNA level was lower than that in control group, but the expression of BAX at mRNA level was higher than that in control group (P<0.05). Iron 25-29 BCL2-associated X protein Mus musculus 209-212 23605050-3 2013 The purpose of this study was to describe the effect of different iron and/or glucose concentrations over Mfn2, Bax, and Bcl2 expressions in a beta-pancreatic cell line (MIN6 cells). Iron 66-70 BCL2-associated X protein Mus musculus 112-115 23605050-9 2013 Our study revealed that high glucose/Fe concentrations in MIN6 cells induced an increase of the Bcl2/Bax ratio, an indicator of increased cell apoptosis. Iron 37-39 BCL2-associated X protein Mus musculus 101-104 16679553-3 2006 Iron-induced mitochondrial damage and apoptosis were characterized by reactive oxygen species production, increased metallothionein and glutathione synthesis, caspase- 3 activation, NF-kappaB induction, and decreased Bcl-2 expression, without any significant change in Bax expression. Iron 0-4 BCL2-associated X protein Mus musculus 269-272 21346313-6 2011 Moreover, we demonstrated that both iron chelators were able to decrease TDP-43 protein aggregation and the proapoptotic molecule Bax, and to enhance antiapoptotic protein Bcl-2 expression, in the ALS mice. Iron 36-40 BCL2-associated X protein Mus musculus 130-133 32373202-4 2020 Chronic exposure to excess iron induced epithelial-mesenchymal transition (EMT) in normal and cancer cell lines, loss of p53, and suppression of p53 transcriptional activity evidenced from decreased expression of p53 target genes (p21, cyclin D1, Bax, SLC7A11). Iron 27-31 BCL2-associated X protein Mus musculus 247-250 34464637-7 2021 The protective effect of MAME against iron-overload-induced apoptosis was confirmed by upregulation of protein levels of Bax, Caspase-3, and PARP. Iron 38-42 BCL2-associated X protein Mus musculus 121-124 28874056-9 2018 INNOVATION: CP alterations in iron contents were mediated through DMT1(-IRE) and changes in ROS levels, which in turn attenuated the progression of AD through the Erk/p38 and Bcl-2/Bax signaling pathways. Iron 30-34 BCL2-associated X protein Mus musculus 181-184