PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28287409-0	2017	Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2.	Iron	29-33	sirtuin 2	Mus musculus	0-9	
28287409-2	2017	Since these processes require iron, we hypothesized that SIRT2 directly regulates cellular iron homeostasis.	Iron	30-34	sirtuin 2	Mus musculus	57-62	
28287409-2	2017	Since these processes require iron, we hypothesized that SIRT2 directly regulates cellular iron homeostasis.	Iron	91-95	sirtuin 2	Mus musculus	57-62	
28287409-3	2017	Here, we have demonstrated that SIRT2 depletion results in a decrease in cellular iron levels both in vitro and in vivo.	Iron	82-86	sirtuin 2	Mus musculus	32-37	
28287409-4	2017	Mechanistically, we determined that SIRT2 maintains cellular iron levels by binding to and deacetylating nuclear factor erythroid-derived 2-related factor 2 (NRF2) on lysines 506 and 508, leading to a reduction in total and nuclear NRF2 levels.	Iron	61-65	sirtuin 2	Mus musculus	36-41	
28287409-6	2017	Finally, we observed that Sirt2 deletion reduced cell viability in response to iron deficiency.	Iron	79-83	sirtuin 2	Mus musculus	26-31	
28287409-7	2017	Moreover, livers from Sirt2-/- mice had decreased iron levels, while this effect was reversed in Sirt2-/- Nrf2-/- double-KO mice.	Iron	50-54	sirtuin 2	Mus musculus	22-27