PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33212230-0 2021 Use of 2-dimensional cell monolayers and 3-dimensional microvascular networks on microfluidic devices shows that iron increases transendothelial adiponectin flux via inducing ROS production. Iron 113-117 adiponectin, C1Q and collagen domain containing Homo sapiens 145-156 33432609-0 2021 Iron overload reduces adiponectin receptor expression via a ROS/FOXO1-dependent mechanism leading to adiponectin resistance in skeletal muscle cells. Iron 0-4 adiponectin, C1Q and collagen domain containing Homo sapiens 22-33 33212230-1 2021 BACKGROUND: Iron excess is a risk factor for cardiovascular diseases and it is important to understand the effect of iron on vascular permeability, particularly for the transport of large metabolic hormones such as adiponectin. Iron 12-16 adiponectin, C1Q and collagen domain containing Homo sapiens 215-226 33212230-1 2021 BACKGROUND: Iron excess is a risk factor for cardiovascular diseases and it is important to understand the effect of iron on vascular permeability, particularly for the transport of large metabolic hormones such as adiponectin. Iron 117-121 adiponectin, C1Q and collagen domain containing Homo sapiens 215-226 33212230-4 2021 Flux analysis indicated that under control conditions permeability of 70 kDa dextran and oligomeric forms of adiponectin were restricted in comparison with a 3 kDa dextran, however upon iron treatment permeability of the larger molecules was increased. Iron 186-190 adiponectin, C1Q and collagen domain containing Homo sapiens 109-120 27484685-9 2017 CONCLUSIONS: Increased iron storage may be associated with higher circulating concentrations of leptin and visfatin in men and with lower concentrations of adiponectin in women. Iron 23-27 adiponectin, C1Q and collagen domain containing Homo sapiens 156-167 29777745-1 2018 AIMS: Body iron inhibits the metabolism of adiponectin, an insulin sensitizing adipokine. Iron 11-15 adiponectin, C1Q and collagen domain containing Homo sapiens 43-54 32316589-0 2020 Iron Status in Elderly Women Impacts Myostatin, Adiponectin and Osteocalcin Levels Induced by Nordic Walking Training. Iron 0-4 adiponectin, C1Q and collagen domain containing Homo sapiens 48-59 31945260-9 2020 CONCLUSIONS: The positive associations between these lipid species and ferritin or the ferritin/adiponectin ratio suggest a potential cross-talk between iron and lipid metabolism in obesity and IR. Iron 153-157 adiponectin, C1Q and collagen domain containing Homo sapiens 96-107 26677772-0 2016 Indicators of iron status are correlated with adiponectin expression in adipose tissue of patients with morbid obesity. Iron 14-18 adiponectin, C1Q and collagen domain containing Homo sapiens 46-57 26677772-8 2016 CONCLUSION: Iron content appears to be increased in the SCAT and VAT of obese patients, and negatively correlated with adiponectin expression, which could be contributing to insulin resistance and the metabolic complications of obesity. Iron 12-16 adiponectin, C1Q and collagen domain containing Homo sapiens 119-130 24065958-0 2013 Ratiometric Measurements of Adiponectin by Mass Spectrometry in Bottlenose Dolphins (Tursiops truncatus) with Iron Overload Reveal an Association with Insulin Resistance and Glucagon. Iron 110-114 adiponectin, C1Q and collagen domain containing Homo sapiens 28-39 24167545-9 2013 CONCLUSIONS: We described, for the first time, an inverse association between serum ferritin and sTfR with osteocalcin and extend previous results on adiponectin, thus supporting that factors related to iron metabolism could contribute to the insulin resistance and the development of type 2 diabetes mellitus. Iron 203-207 adiponectin, C1Q and collagen domain containing Homo sapiens 150-161 22961568-6 2013 Using linear regression analyses, we investigated the difference in adipocyte IR or adiponectin (in %) according to differences in iron metabolism markers. Iron 131-135 adiponectin, C1Q and collagen domain containing Homo sapiens 78-95 22961568-0 2013 Iron metabolism is associated with adipocyte insulin resistance and plasma adiponectin: the Cohort on Diabetes and Atherosclerosis Maastricht (CODAM) study. Iron 0-4 adiponectin, C1Q and collagen domain containing Homo sapiens 75-86 22961568-10 2013 CONCLUSIONS: The observed associations of several markers of iron metabolism with adipocyte IR and adiponectin suggest that factors related to iron and iron metabolism may contribute to adipocyte IR early in the pathogenesis of T2DM. Iron 143-147 adiponectin, C1Q and collagen domain containing Homo sapiens 99-110 22961568-3 2013 We therefore investigated whether markers of iron metabolism were associated with adipocyte IR and plasma adiponectin. Iron 45-49 adiponectin, C1Q and collagen domain containing Homo sapiens 106-117 22961568-10 2013 CONCLUSIONS: The observed associations of several markers of iron metabolism with adipocyte IR and adiponectin suggest that factors related to iron and iron metabolism may contribute to adipocyte IR early in the pathogenesis of T2DM. Iron 143-147 adiponectin, C1Q and collagen domain containing Homo sapiens 99-110 19645734-6 2009 For example, plasminogen activator inhibitor 1 was shown to play a central role for steatosis, the anti-inflammatory adipokine, adiponectin profoundly regulates liver macrophage function and excessive hepatic deposition of iron is caused by chronic ethanol intoxication and increases the risk of hepatocellular carcinoma development. Iron 223-227 adiponectin, C1Q and collagen domain containing Homo sapiens 128-139 23615377-9 2013 CONCLUSIONS: The present study demonstrated that community-living elderly Japanese women with low serum iron levels have nontraditional risk factors for CVD, including low-grade inflammation and higher levels of serum adiponectin. Iron 104-108 adiponectin, C1Q and collagen domain containing Homo sapiens 218-229 22996660-0 2012 Adipocyte iron regulates adiponectin and insulin sensitivity. Iron 10-14 adiponectin, C1Q and collagen domain containing Homo sapiens 25-36 22996660-2 2012 We therefore investigated the effect of iron on adiponectin, an insulin-sensitizing adipokine that is decreased in diabetic patients. Iron 40-44 adiponectin, C1Q and collagen domain containing Homo sapiens 48-59 22996660-6 2012 We found that iron negatively regulated adiponectin transcription via FOXO1-mediated repression. Iron 14-18 adiponectin, C1Q and collagen domain containing Homo sapiens 40-51 22996660-8 2012 Conversely, organismal iron overload and increased adipocyte ferroportin expression because of hemochromatosis are associated with decreased adipocyte iron, increased adiponectin, improved glucose tolerance, and increased insulin sensitivity. Iron 23-27 adiponectin, C1Q and collagen domain containing Homo sapiens 167-178 22996660-10 2012 These findings demonstrate a causal role for iron as a risk factor for metabolic syndrome and a role for adipocytes in modulating metabolism through adiponectin in response to iron stores. Iron 176-180 adiponectin, C1Q and collagen domain containing Homo sapiens 149-160 20709802-0 2010 Adiponectin-mediated heme oxygenase-1 induction protects against iron-induced liver injury via a PPARalpha dependent mechanism. Iron 65-69 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 20709802-1 2010 Protective effects of adiponectin (APN; an adipocytokine) were shown against various oxidative challenges; however, its therapeutic implications and the mechanisms underlying hepatic iron overload remain unclear. Iron 183-187 adiponectin, C1Q and collagen domain containing Homo sapiens 22-33 20709802-1 2010 Protective effects of adiponectin (APN; an adipocytokine) were shown against various oxidative challenges; however, its therapeutic implications and the mechanisms underlying hepatic iron overload remain unclear. Iron 183-187 adiponectin, C1Q and collagen domain containing Homo sapiens 35-38 20709802-2 2010 Herein, we show that the deleterious effects of iron dextran on liver function and iron deposition were significantly reversed by adiponectin gene therapy, which was accompanied by AMP-activated protein kinase (AMPK) phosphorylation and heme oxygenase (HO)-1 induction. Iron 48-52 adiponectin, C1Q and collagen domain containing Homo sapiens 130-141 20709802-5 2010 Interestingly, overexpression of HO-1 in hepatocytes mimicked the protective effect of APN in attenuating iron-mediated injury, whereas it was abolished by SnPP and small interfering HO-1. Iron 106-110 adiponectin, C1Q and collagen domain containing Homo sapiens 87-90 20709802-7 2010 Herein, we demonstrate a novel functional PPRE in the promoter regions of HO-1, and APN-mediated HO-1 induction elicited an antiapoptotic effect and a decrease in iron deposition in hepatocytes subjected to iron challenge. Iron 163-167 adiponectin, C1Q and collagen domain containing Homo sapiens 84-87 20709802-7 2010 Herein, we demonstrate a novel functional PPRE in the promoter regions of HO-1, and APN-mediated HO-1 induction elicited an antiapoptotic effect and a decrease in iron deposition in hepatocytes subjected to iron challenge. Iron 207-211 adiponectin, C1Q and collagen domain containing Homo sapiens 84-87