PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19824072-0 2009 Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload. Iron 106-110 homeostatic iron regulator Mus musculus 21-24 19824072-2 2009 HFE and transferrin receptor 2 (TFR2) are mutated in adult-onset forms of hereditary hemochromatosis and regulate the expression of hepcidin in response to iron. Iron 156-160 homeostatic iron regulator Mus musculus 0-3 19809161-9 2009 Furthermore, by mimicking the altered iron metabolism associated with Hfe deficiency, we found that 3 different inhibitors of hepcidin attenuated Salmonella-induced and noninfectious enterocolitis. Iron 38-42 homeostatic iron regulator Mus musculus 70-73 19348938-0 2009 Iron speciation study in Hfe knockout mice tissues: magnetic and ultrastructural characterisation. Iron 0-4 homeostatic iron regulator Mus musculus 25-28 19591830-11 2009 CONCLUSIONS: HFE is not involved in regulation of BMP6 by iron, but does regulate the downstream signals of BMP6 that are triggered by iron. Iron 135-139 homeostatic iron regulator Mus musculus 13-16 19700664-3 2009 This increased resistance is paralleled by an enhanced production of the enterochelin-binding peptide lipocalin-2 (Lcn2), which reduces the availability of iron for Salmonella within Hfe-deficient macrophages. Iron 156-160 homeostatic iron regulator Mus musculus 183-186 19787063-2 2009 HFE-related hereditary hemochromatosis (HH) is characterized by abnormally low expression of the iron-regulatory hormone, hepcidin, which results in increased iron absorption. Iron 97-101 homeostatic iron regulator Mus musculus 0-3 17264297-2 2007 Identification of a direct interaction between Hfe and transferrin receptor 1 in duodenal cells led to the hypothesis that the lack of functional Hfe in the duodenum affects TfR1-mediated serosal uptake of iron and misprogramming of the iron absorptive cells. Iron 237-241 homeostatic iron regulator Mus musculus 47-50 18684963-4 2008 The macrophage iron exporter ferroportin (FPN) was up-regulated in the Hfe(-/-) mice, and correspondingly, intramacrophage iron levels were lowered. Iron 15-19 homeostatic iron regulator Mus musculus 71-74 18393371-0 2008 The role of Hfe in transferrin-bound iron uptake by hepatocytes. Iron 37-41 homeostatic iron regulator Mus musculus 12-15 18393371-1 2008 UNLABELLED: HFE-related hereditary hemochromatosis results in hepatic iron overload. Iron 70-74 homeostatic iron regulator Mus musculus 12-15 18393371-3 2008 In this study, the role of Hfe in the regulation of hepatic transferrin-bound iron uptake by these pathways was investigated using Hfe knockout mice. Iron 78-82 homeostatic iron regulator Mus musculus 27-30 18393371-6 2008 Tfr1-mediated iron and transferrin uptake by Hfe knockout hepatocytes were increased by 40% to 70% compared with iron-loaded wild-type hepatocytes with similar iron levels and Tfr1 expression. Iron 14-18 homeostatic iron regulator Mus musculus 45-48 18393371-6 2008 Tfr1-mediated iron and transferrin uptake by Hfe knockout hepatocytes were increased by 40% to 70% compared with iron-loaded wild-type hepatocytes with similar iron levels and Tfr1 expression. Iron 113-117 homeostatic iron regulator Mus musculus 45-48 18393371-6 2008 Tfr1-mediated iron and transferrin uptake by Hfe knockout hepatocytes were increased by 40% to 70% compared with iron-loaded wild-type hepatocytes with similar iron levels and Tfr1 expression. Iron 113-117 homeostatic iron regulator Mus musculus 45-48 18393371-9 2008 CONCLUSION: Tfr1-mediated iron uptake is regulated by Hfe in hepatocytes. Iron 26-30 homeostatic iron regulator Mus musculus 54-57 18317567-3 2008 Although the cytosol contained excess iron, Hfe(-/-) mitochondria contained normal iron but decreased copper, manganese, and zinc, associated with reduced activities of copper-dependent cytochrome c oxidase and manganese-dependent superoxide dismutase (MnSOD). Iron 83-87 homeostatic iron regulator Mus musculus 44-47 17719830-4 2008 Our objective was to evaluate the effect of bone marrow transplantation from wild type mice on the status of iron overload in Hfe knockout hemochromatotic mice (Hfe(-/-)). Iron 109-113 homeostatic iron regulator Mus musculus 126-129 17719830-7 2008 The iron content in the Hfe(-/-) mice descended 2.9-fold in the liver and 2.4-fold in the duodenum 6 months after transplantation. Iron 4-8 homeostatic iron regulator Mus musculus 24-27 17719830-8 2008 Non-significant changes of relative mRNA abundance of genes of iron metabolism were observed in the liver and duodenum of Hfe(-/-) transplanted mice. Iron 63-67 homeostatic iron regulator Mus musculus 122-125 17299088-5 2007 Our study reveals that the degree of IE dictates tissue iron distribution and that IE and iron content regulate hepcidin (Hamp1) and other iron-regulatory genes such as Hfe and Cebpa. Iron 90-94 homeostatic iron regulator Mus musculus 169-172 19191760-1 2009 Haemochromatosis is a genetic disorder of iron overload resulting from loss-of-function mutations in genes coding for the iron-regulatory proteins HFE [HLA-like protein involved in iron (Fe) homoeostasis], transferrin receptor 2, ferroportin, hepcidin and HJV (haemojuvelin). Iron 42-46 homeostatic iron regulator Mus musculus 147-150 19191760-1 2009 Haemochromatosis is a genetic disorder of iron overload resulting from loss-of-function mutations in genes coding for the iron-regulatory proteins HFE [HLA-like protein involved in iron (Fe) homoeostasis], transferrin receptor 2, ferroportin, hepcidin and HJV (haemojuvelin). Iron 122-126 homeostatic iron regulator Mus musculus 147-150 19191760-1 2009 Haemochromatosis is a genetic disorder of iron overload resulting from loss-of-function mutations in genes coding for the iron-regulatory proteins HFE [HLA-like protein involved in iron (Fe) homoeostasis], transferrin receptor 2, ferroportin, hepcidin and HJV (haemojuvelin). Iron 122-126 homeostatic iron regulator Mus musculus 147-150 18694968-6 2008 This pathology is characterized by increased serum transferrin saturation with iron deposition in parenchymal cells, mainly in the liver, and is most often associated with mutations in the gene encoding the molecule HFE. Iron 79-83 homeostatic iron regulator Mus musculus 216-219 18694968-7 2008 In this paper, we demonstrate that mice of two genetically determined primary iron overload phenotypes, Hfe(-/-) and beta2m(-/-), show an increased susceptibility to experimental infection with M. avium and that during infection these animals accumulate iron inside granuloma macrophages. Iron 78-82 homeostatic iron regulator Mus musculus 104-107 18694968-7 2008 In this paper, we demonstrate that mice of two genetically determined primary iron overload phenotypes, Hfe(-/-) and beta2m(-/-), show an increased susceptibility to experimental infection with M. avium and that during infection these animals accumulate iron inside granuloma macrophages. Iron 254-258 homeostatic iron regulator Mus musculus 104-107 18316026-2 2008 We developed mutant mouse strains to gain insight into the role of the Hfe/Tfr1 complex in regulating iron homeostasis. Iron 102-106 homeostatic iron regulator Mus musculus 71-74 18316026-4 2008 Under conditions favoring a constitutive Hfe/Tfr1 interaction, mice developed iron overload attributable to inappropriately low expression of the hormone hepcidin. Iron 78-82 homeostatic iron regulator Mus musculus 41-44 18249176-4 2008 This work demonstrates that local Hfe expression in hepatocytes serves to maintain physiological iron homeostasis, answering a long-standing question in medicine and explaining earlier clinical observations. Iron 97-101 homeostatic iron regulator Mus musculus 34-37 17299088-5 2007 Our study reveals that the degree of IE dictates tissue iron distribution and that IE and iron content regulate hepcidin (Hamp1) and other iron-regulatory genes such as Hfe and Cebpa. Iron 90-94 homeostatic iron regulator Mus musculus 169-172 17264297-0 2007 Physiologic systemic iron metabolism in mice deficient for duodenal Hfe. Iron 21-25 homeostatic iron regulator Mus musculus 68-71 17264297-1 2007 Mutations in the Hfe gene result in hereditary hemochromatosis (HH), a disorder characterized by increased duodenal iron absorption and tissue iron overload. Iron 116-120 homeostatic iron regulator Mus musculus 17-20 17264297-1 2007 Mutations in the Hfe gene result in hereditary hemochromatosis (HH), a disorder characterized by increased duodenal iron absorption and tissue iron overload. Iron 143-147 homeostatic iron regulator Mus musculus 17-20 17264297-2 2007 Identification of a direct interaction between Hfe and transferrin receptor 1 in duodenal cells led to the hypothesis that the lack of functional Hfe in the duodenum affects TfR1-mediated serosal uptake of iron and misprogramming of the iron absorptive cells. Iron 206-210 homeostatic iron regulator Mus musculus 47-50 17264297-5 2007 Mice with efficient deletion of Hfe in crypt- and villi-enterocytes maintain physiologic iron metabolism with wild-type unsaturated iron binding capacity, hepatic iron levels, and hepcidin mRNA expression. Iron 89-93 homeostatic iron regulator Mus musculus 32-35 17264297-8 2007 These findings exclude a primary role for duodenal Hfe in the pathogenesis of HH and support the model according to which Hfe is required for appropriate expression of the "iron hormone" hepcidin which then controls intestinal iron absorption. Iron 173-177 homeostatic iron regulator Mus musculus 122-125 17264297-8 2007 These findings exclude a primary role for duodenal Hfe in the pathogenesis of HH and support the model according to which Hfe is required for appropriate expression of the "iron hormone" hepcidin which then controls intestinal iron absorption. Iron 227-231 homeostatic iron regulator Mus musculus 122-125 17258727-9 2007 In contrast, Hfe(-/-) x Cp(R435/R435X) or Cp(R435X/R435X) x Hfe(+/-) showed 30% decrease in liver iron when compared with single mutant mice. Iron 98-102 homeostatic iron regulator Mus musculus 13-16 17255318-1 2007 Genetic iron overload, or hemochromatosis, can be caused by mutations in HFE, hemojuvelin, and hepcidin genes. Iron 8-12 homeostatic iron regulator Mus musculus 73-76 17258727-9 2007 In contrast, Hfe(-/-) x Cp(R435/R435X) or Cp(R435X/R435X) x Hfe(+/-) showed 30% decrease in liver iron when compared with single mutant mice. Iron 98-102 homeostatic iron regulator Mus musculus 60-63 17258727-10 2007 CONCLUSIONS: This study highlights the existence of complex interactions between Cp and HFE and represents the first example of a modifier gene with a protective effect, in which heterozygosity reduces the iron load in the context of HFE deficiency. Iron 206-210 homeostatic iron regulator Mus musculus 88-91 17207112-12 2007 In an alcohol-susceptible strain, mutation of the Hfe gene diminished the response of the measured iron indices to alcohol treatment. Iron 99-103 homeostatic iron regulator Mus musculus 50-53 17207112-13 2007 This indicates that either maximal suppression of hepcidin levels had already occurred as a result of the Hfe mutation or that Hfe was a component of the pathway utilized by EtOH in suppressing hepcidin production and increasing iron absorption. Iron 229-233 homeostatic iron regulator Mus musculus 127-130 17945001-4 2007 In liver, Hfe disruption upregulated genes involved in antioxidant defense, reflecting mechanisms of hepatoprotection activated by iron overload. Iron 131-135 homeostatic iron regulator Mus musculus 10-13 16565419-0 2006 Distinct requirements for Hfe in basal and induced hepcidin levels in iron overload and inflammation. Iron 70-74 homeostatic iron regulator Mus musculus 26-29 17945001-5 2007 Hfe disruption also downregulated the expression of genes involved in fatty acid beta-oxidation and cholesterol catabolism, and of genes participating in mitochondrial iron traffic, suggesting a link between Hfe and the mitochondrion in regulation of iron homeostasis. Iron 168-172 homeostatic iron regulator Mus musculus 0-3 17945001-5 2007 Hfe disruption also downregulated the expression of genes involved in fatty acid beta-oxidation and cholesterol catabolism, and of genes participating in mitochondrial iron traffic, suggesting a link between Hfe and the mitochondrion in regulation of iron homeostasis. Iron 168-172 homeostatic iron regulator Mus musculus 208-211 17945001-5 2007 Hfe disruption also downregulated the expression of genes involved in fatty acid beta-oxidation and cholesterol catabolism, and of genes participating in mitochondrial iron traffic, suggesting a link between Hfe and the mitochondrion in regulation of iron homeostasis. Iron 251-255 homeostatic iron regulator Mus musculus 0-3 17945001-5 2007 Hfe disruption also downregulated the expression of genes involved in fatty acid beta-oxidation and cholesterol catabolism, and of genes participating in mitochondrial iron traffic, suggesting a link between Hfe and the mitochondrion in regulation of iron homeostasis. Iron 251-255 homeostatic iron regulator Mus musculus 208-211 17945001-8 2007 CONCLUSION: The expression patterns identified in this study contribute novel insights into the mechanisms of Hfe action and potential candidate genes for iron loading severity. Iron 155-159 homeostatic iron regulator Mus musculus 110-113 17376729-4 2007 However, despite significant effort, the role of the HFE protein in iron metabolism is still unknown. Iron 68-72 homeostatic iron regulator Mus musculus 53-56 17116709-1 2006 HFE, a major histocompatibility complex class I-related protein, is implicated in the iron overload disease, hereditary hemochromatosis. Iron 86-90 homeostatic iron regulator Mus musculus 0-3 16565419-4 2006 We found that whereas basal hepcidin levels were manifestly dependent on the presence of Hfe and on the mouse background, all Hfe-deficient mice were still able to regulate hepcidin in situations of altered iron homeostasis. Iron 207-211 homeostatic iron regulator Mus musculus 126-129 16339398-6 2006 We demonstrate that induction of chronic hepcidin expression in 2-month-old Hfe-/- mice alters their pattern of cellular iron accumulation, leading to increased iron in tissue macrophages and duodenal cells but less iron in hepatocytes. Iron 121-125 homeostatic iron regulator Mus musculus 76-79 16875497-9 2006 The large hepatic mononuclear cell infiltrates seen in Hfe-/- stained for ferritin, may point to the iron sequestration capacity of lymphocytes and contribute to the clarification of the differences found in the progression of hepatic iron overload and steatosis in older animals from the two strains. Iron 101-105 homeostatic iron regulator Mus musculus 55-58 16875497-9 2006 The large hepatic mononuclear cell infiltrates seen in Hfe-/- stained for ferritin, may point to the iron sequestration capacity of lymphocytes and contribute to the clarification of the differences found in the progression of hepatic iron overload and steatosis in older animals from the two strains. Iron 235-239 homeostatic iron regulator Mus musculus 55-58 16688533-2 2006 HFE, the hereditary hemochromatosis gene product, is expressed in the crypts of the duodenum, but the molecular mechanism by which it contributes to the inhibition of iron absorption is still unknown. Iron 167-171 homeostatic iron regulator Mus musculus 0-3 16688533-7 2006 The functional annotation of upregulated genes highlighted that mucus production and cell maintenance may account for the influence of Hfe on epithelium integrity and luminal iron uptake. Iron 175-179 homeostatic iron regulator Mus musculus 135-138 16271796-0 2006 Limited iron export by hepatocytes contributes to hepatic iron-loading in the Hfe knockout mouse. Iron 8-12 homeostatic iron regulator Mus musculus 78-81 16271796-0 2006 Limited iron export by hepatocytes contributes to hepatic iron-loading in the Hfe knockout mouse. Iron 58-62 homeostatic iron regulator Mus musculus 78-81 16271796-3 2006 METHODS: Iron release by hepatocytes from Hfe knockout, non-iron-loaded and iron-loaded wild-type mice was measured after incubation with nontransferrin-bound iron as iron-citrate. Iron 9-13 homeostatic iron regulator Mus musculus 42-45 16271796-5 2006 When expressed as a percentage of total iron uptake, iron release was decreased in Hfe knockout hepatocytes (4.6+/-0.7 versus 13.7+/-1.2%, P<0.0001) and increased in iron-loaded wild-type hepatocytes (29.5+/-0.5 versus 13.5+/-0.7%; P<0.0001) compared with wild-type hepatocytes. Iron 40-44 homeostatic iron regulator Mus musculus 83-86 16271796-5 2006 When expressed as a percentage of total iron uptake, iron release was decreased in Hfe knockout hepatocytes (4.6+/-0.7 versus 13.7+/-1.2%, P<0.0001) and increased in iron-loaded wild-type hepatocytes (29.5+/-0.5 versus 13.5+/-0.7%; P<0.0001) compared with wild-type hepatocytes. Iron 53-57 homeostatic iron regulator Mus musculus 83-86 16271796-5 2006 When expressed as a percentage of total iron uptake, iron release was decreased in Hfe knockout hepatocytes (4.6+/-0.7 versus 13.7+/-1.2%, P<0.0001) and increased in iron-loaded wild-type hepatocytes (29.5+/-0.5 versus 13.5+/-0.7%; P<0.0001) compared with wild-type hepatocytes. Iron 53-57 homeostatic iron regulator Mus musculus 83-86 16271796-6 2006 In contrast, in vitro iron-loading increased iron release and ferroportin expression by both Hfe knockout and wild-type hepatocytes. Iron 22-26 homeostatic iron regulator Mus musculus 93-96 16271796-7 2006 CONCLUSIONS: Hfe knockout hepatocytes accumulate iron as a result of limited iron export and enhanced iron uptake. Iron 49-53 homeostatic iron regulator Mus musculus 13-16 16271796-7 2006 CONCLUSIONS: Hfe knockout hepatocytes accumulate iron as a result of limited iron export and enhanced iron uptake. Iron 77-81 homeostatic iron regulator Mus musculus 13-16 16271796-7 2006 CONCLUSIONS: Hfe knockout hepatocytes accumulate iron as a result of limited iron export and enhanced iron uptake. Iron 77-81 homeostatic iron regulator Mus musculus 13-16 16024130-6 2005 Hfe and beta2-microglobulin knockout mice have similar levels of prohepcidin protein expression as compared to wild-type mice despite increased iron stores. Iron 144-148 homeostatic iron regulator Mus musculus 0-3 16132052-5 2005 In turn, recent findings from studies of knockout mice and functional studies have confirmed that HAMP plays a central role in mobilization of iron, shown that HFE, TFR2 and HJV modulate HAMP production according to the body"s iron status, and demonstrated that HAMP negatively regulates cellular iron efflux by affecting the ferroportin cell surface availability. Iron 143-147 homeostatic iron regulator Mus musculus 160-163 16132052-5 2005 In turn, recent findings from studies of knockout mice and functional studies have confirmed that HAMP plays a central role in mobilization of iron, shown that HFE, TFR2 and HJV modulate HAMP production according to the body"s iron status, and demonstrated that HAMP negatively regulates cellular iron efflux by affecting the ferroportin cell surface availability. Iron 227-231 homeostatic iron regulator Mus musculus 160-163 16132052-5 2005 In turn, recent findings from studies of knockout mice and functional studies have confirmed that HAMP plays a central role in mobilization of iron, shown that HFE, TFR2 and HJV modulate HAMP production according to the body"s iron status, and demonstrated that HAMP negatively regulates cellular iron efflux by affecting the ferroportin cell surface availability. Iron 227-231 homeostatic iron regulator Mus musculus 160-163 16354190-4 2005 In Hfe(-/-) mice, iron content in the epidermis and dermis was unexpectedly the same as in Hfe(+/+) mice, and there were no histological abnormalities detected after 30 wk. Iron 18-22 homeostatic iron regulator Mus musculus 3-6 16123136-7 2005 T cell antigen receptor recognition of MHC molecules independently of bound ligand has potential general implications in alloreactivity and identifies in the Hfe case a cognitive link supporting the concept that the immune system could be involved in the control of iron metabolism. Iron 266-270 homeostatic iron regulator Mus musculus 158-161 15914561-0 2005 Contribution of Hfe expression in macrophages to the regulation of hepatic hepcidin levels and iron loading. Iron 95-99 homeostatic iron regulator Mus musculus 16-19 15914561-1 2005 Hereditary hemochromatosis (HH), an iron overload disease associated with mutations in the HFE gene, is characterized by increased intestinal iron absorption and consequent deposition of excess iron, primarily in the liver. Iron 36-40 homeostatic iron regulator Mus musculus 91-94 15914561-1 2005 Hereditary hemochromatosis (HH), an iron overload disease associated with mutations in the HFE gene, is characterized by increased intestinal iron absorption and consequent deposition of excess iron, primarily in the liver. Iron 142-146 homeostatic iron regulator Mus musculus 91-94 15914561-1 2005 Hereditary hemochromatosis (HH), an iron overload disease associated with mutations in the HFE gene, is characterized by increased intestinal iron absorption and consequent deposition of excess iron, primarily in the liver. Iron 142-146 homeostatic iron regulator Mus musculus 91-94 15914561-3 2005 In this study, we investigated the contribution of Hfe expression in macrophages to the regulation of liver hepcidin levels and iron loading. Iron 128-132 homeostatic iron regulator Mus musculus 51-54 15914561-7 2005 Our results suggest that macrophage Hfe participates in the regulation of splenic and liver iron concentrations and liver hepcidin expression. Iron 92-96 homeostatic iron regulator Mus musculus 36-39 15737887-0 2005 New insights into iron homeostasis through the study of non-HFE hereditary haemochromatosis. Iron 18-22 homeostatic iron regulator Mus musculus 60-63 15921699-3 2005 MATERIALS AND METHODS: Hfe-/- mice (a murine homologue of hemochromatosis) abnormally accumulate iron in their tissues. Iron 97-101 homeostatic iron regulator Mus musculus 23-26 15744772-0 2005 Regulatory networks for the control of body iron homeostasis and their dysregulation in HFE mediated hemochromatosis. Iron 44-48 homeostatic iron regulator Mus musculus 88-91 15744772-3 2005 In HFE +/+ mice dietary iron supplementation increased hepatic expression of hepcidin which was paralleled by decreased iron regulatory protein (IRP) activity, and reduced expression of divalent metal transporter-1 (DMT-1) and duodenal cytochrome b (Dcytb) in the enterocyte. Iron 24-28 homeostatic iron regulator Mus musculus 3-6 15744772-4 2005 In HFE -/- mice hepcidin formation was diminished upon iron challenge which was associated with decreased hepatic transferrin receptor (TfR)-2 levels. Iron 55-59 homeostatic iron regulator Mus musculus 3-6 15744772-5 2005 Accordingly, HFE -/- mice presented with high duodenal Dcytb and DMT-1 levels, and increased IRP and TfR expression, suggesting iron deficiency in the enterocyte and increased iron absorption. Iron 128-132 homeostatic iron regulator Mus musculus 13-16 15744772-7 2005 Our data suggest that the feed back regulation of duodenal iron absorption by hepcidin is impaired in HFE -/- mice, a model for genetic hemochromatosis. Iron 59-63 homeostatic iron regulator Mus musculus 102-105 15737887-2 2005 Four genes are responsible for the distinct types of non-HFE haemochromatosis: hepcidin and hemojuvelin are the genes involved in type 2 or juvenile haemochromatosis, transferrin receptor 2 is involved in type 3 haemochromatosis, and ferroportin 1 is mutated in type 4, the atypical dominant form of primary iron overload. Iron 308-312 homeostatic iron regulator Mus musculus 57-60 15718038-1 2005 Mutations in the Hfe gene can be associated with the iron overload disorder known as hemochromatosis. Iron 53-57 homeostatic iron regulator Mus musculus 17-20 15718038-6 2005 The labile iron pool was consistently decreased when Hfe expression increased. Iron 11-15 homeostatic iron regulator Mus musculus 53-56 15718038-8 2005 These data provide insight into the induction of Hfe in AD and indicate that Hfe expression may be a protective function to limit cellular iron exposure during cell stress. Iron 139-143 homeostatic iron regulator Mus musculus 49-52 16103673-3 2005 METHODS: Using quantitative RT-PCR, the iron-dependent hepatic expression patterns of HAMP, HJV, and TFR2 were evaluated in human and murine HFE-related hemochromatosis. Iron 40-44 homeostatic iron regulator Mus musculus 141-144 15718038-8 2005 These data provide insight into the induction of Hfe in AD and indicate that Hfe expression may be a protective function to limit cellular iron exposure during cell stress. Iron 139-143 homeostatic iron regulator Mus musculus 77-80 15613548-7 2005 Here, we show that Hfe and haptoglobin compound mutant mice accumulate significantly less hepatic iron than Hfe-null mice, thus demonstrating that haptoglobin-mediated heme-iron recovery may contribute significantly to iron loading in HH. Iron 98-102 homeostatic iron regulator Mus musculus 19-22 15613548-7 2005 Here, we show that Hfe and haptoglobin compound mutant mice accumulate significantly less hepatic iron than Hfe-null mice, thus demonstrating that haptoglobin-mediated heme-iron recovery may contribute significantly to iron loading in HH. Iron 173-177 homeostatic iron regulator Mus musculus 19-22 15613548-7 2005 Here, we show that Hfe and haptoglobin compound mutant mice accumulate significantly less hepatic iron than Hfe-null mice, thus demonstrating that haptoglobin-mediated heme-iron recovery may contribute significantly to iron loading in HH. Iron 173-177 homeostatic iron regulator Mus musculus 19-22 15866286-0 2005 Nuclear iron deposits in hepatocytes of iron-loaded HFE-knock-out mice: a morphometric and immunocytochemical analysis. Iron 8-12 homeostatic iron regulator Mus musculus 52-55 15866286-0 2005 Nuclear iron deposits in hepatocytes of iron-loaded HFE-knock-out mice: a morphometric and immunocytochemical analysis. Iron 40-44 homeostatic iron regulator Mus musculus 52-55 16103673-4 2005 RESULTS: The overall level of hepatic HAMP expression in human and murine HFE-related hemochromatosis is impaired but can still be modulated by iron stores. Iron 144-148 homeostatic iron regulator Mus musculus 74-77 15308612-3 2004 Mice with targeted deletion of the hemochromatosis gene (Hfe(-/-)) on the 129/Sv genetic background exhibited a 72% increase in iron content in the islets of Langerhans compared with wild-type controls. Iron 128-132 homeostatic iron regulator Mus musculus 57-60 15389541-0 2005 Mouse HFE inhibits Tf-uptake and iron accumulation but induces non-transferrin bound iron (NTBI)-uptake in transformed mouse fibroblasts. Iron 33-37 homeostatic iron regulator Mus musculus 6-9 15389541-0 2005 Mouse HFE inhibits Tf-uptake and iron accumulation but induces non-transferrin bound iron (NTBI)-uptake in transformed mouse fibroblasts. Iron 85-89 homeostatic iron regulator Mus musculus 6-9 15389541-2 2005 A non-classical class I MHC molecule, the hemochromatosis factor (HFE), has been shown to regulate iron metabolism, potentially via its interaction with the transferrin receptor. Iron 99-103 homeostatic iron regulator Mus musculus 66-69 15155457-3 2004 The aim of this study was to examine the importance of NTBI in the pathogenesis of hepatic iron loading in Hfe knockout mice. Iron 91-95 homeostatic iron regulator Mus musculus 107-110 15155457-9 2004 We conclude that NTBI uptake by hepatocytes from Hfe knockout mice contributed to hepatic iron loading. Iron 90-94 homeostatic iron regulator Mus musculus 49-52 15173932-0 2004 Duodenal HFE expression and hepcidin levels determine body iron homeostasis: modulation by genetic diversity and dietary iron availability. Iron 59-63 homeostatic iron regulator Mus musculus 9-12 15155457-0 2004 Nontransferrin-bound iron uptake by hepatocytes is increased in the Hfe knockout mouse model of hereditary hemochromatosis. Iron 21-25 homeostatic iron regulator Mus musculus 68-71 15173932-1 2004 HFE affects the interaction of transferrin bound iron with transferrin receptors (TfR) thereby modulating iron uptake. Iron 106-110 homeostatic iron regulator Mus musculus 0-3 15173932-5 2004 Duodenal HFE expression was positively associated with serum iron and liver HFE levels. Iron 61-65 homeostatic iron regulator Mus musculus 9-12 15257718-1 2004 The effect of HFE inactivation on iron homeostasis during an acute phase response was investigated in mice. Iron 34-38 homeostatic iron regulator Mus musculus 14-17 15192150-6 2004 Studies in humans and mice have shown that this iron-dependent pathway requires the presence of Hfe, hemojuvelin, and probably transferrin receptor 2 (tfr-2). Iron 48-52 homeostatic iron regulator Mus musculus 96-99 15173932-6 2004 Dietary iron supplementation decreased HFE in the duodenum but not in the liver. Iron 8-12 homeostatic iron regulator Mus musculus 39-42 15173932-1 2004 HFE affects the interaction of transferrin bound iron with transferrin receptors (TfR) thereby modulating iron uptake. Iron 49-53 homeostatic iron regulator Mus musculus 0-3 15173932-8 2004 Duodenal and liver HFE levels are regulated by divergent penetration of as yet unelucidated modifier genes and to a much lesser extent by dietary iron. Iron 146-150 homeostatic iron regulator Mus musculus 19-22 15173932-9 2004 These measures control duodenal iron transport and liver iron homeostasis by modulating HFE expression either directly or via stimulation of iron sensitive regulatory molecules, such as hepcidin, which then exert their effects on body iron homeostasis. Iron 32-36 homeostatic iron regulator Mus musculus 88-91 14656877-5 2004 Our studies revealed that introduction of Rag1 deficiency in Hfe knock-out mice leads to heightened iron overload, mainly in the liver, whereas the heart and pancreas are relatively spared compared with beta2mRag1(-/-) mice. Iron 100-104 homeostatic iron regulator Mus musculus 61-64 15173932-9 2004 These measures control duodenal iron transport and liver iron homeostasis by modulating HFE expression either directly or via stimulation of iron sensitive regulatory molecules, such as hepcidin, which then exert their effects on body iron homeostasis. Iron 57-61 homeostatic iron regulator Mus musculus 88-91 15173932-9 2004 These measures control duodenal iron transport and liver iron homeostasis by modulating HFE expression either directly or via stimulation of iron sensitive regulatory molecules, such as hepcidin, which then exert their effects on body iron homeostasis. Iron 57-61 homeostatic iron regulator Mus musculus 88-91 15173932-9 2004 These measures control duodenal iron transport and liver iron homeostasis by modulating HFE expression either directly or via stimulation of iron sensitive regulatory molecules, such as hepcidin, which then exert their effects on body iron homeostasis. Iron 57-61 homeostatic iron regulator Mus musculus 88-91 15131800-5 2004 To circumvent these difficulties, we used 2 strains of mice made deficient for the Hfe gene that strongly differ in their propensity to develop hepatic iron loading. Iron 152-156 homeostatic iron regulator Mus musculus 83-86 15131800-9 2004 CONCLUSIONS: Our data provide a clear demonstration of the polygenic pattern of hepatic iron loading inheritance in Hfe-deficient mice. Iron 88-92 homeostatic iron regulator Mus musculus 116-119 14618243-0 2004 Iron overload in adult Hfe-deficient mice independent of changes in the steady-state expression of the duodenal iron transporters DMT1 and Ireg1/ferroportin. Iron 0-4 homeostatic iron regulator Mus musculus 23-26 14981211-7 2004 Four genes involved in iron homeostasis were included in the 50 differentially expressed genes [hemochromatosis (Hfe), diaphorase 1, transferrin receptor (Trfr) 2, and protoporphyrinogen oxidase] and two additional iron-related genes did not quite meet the stringent criteria for differential expression (Trfr and lactotransferrin). Iron 23-27 homeostatic iron regulator Mus musculus 113-116 14656876-4 2004 In mice, deficiency of either HFE (Hfe(-/-)) or hepcidin (Usf2(-/-)) is associated with the same pattern of iron overload observed in patients with HH. Iron 108-112 homeostatic iron regulator Mus musculus 35-44 14656876-6 2004 Our results showed that, indeed, liver iron accumulation was greater in the Hfe(-/-)Usf2(+/-) mice than in mice lacking Hfe alone. Iron 39-43 homeostatic iron regulator Mus musculus 76-79 14618243-2 2004 It has been hypothesized that mutations in the HH gene HFE cause misprogramming of the duodenal enterocytes towards a paradoxical iron-deficient state, resulting in increased iron transporter expression. Iron 130-134 homeostatic iron regulator Mus musculus 55-58 12805055-6 2003 DOX-induced iron metabolism changes were intensified in Hfe-/- mice, which accumulated significantly more iron in the heart, liver, and pancreas, but less in the spleen compared with wild-type mice. Iron 12-16 homeostatic iron regulator Mus musculus 56-59 14704284-8 2004 In addition, hepcidin is decreased in HFE knockout mice, which demonstrates characteristics of iron overload as in hemochromatosis patients. Iron 95-99 homeostatic iron regulator Mus musculus 38-41 12805055-6 2003 DOX-induced iron metabolism changes were intensified in Hfe-/- mice, which accumulated significantly more iron in the heart, liver, and pancreas, but less in the spleen compared with wild-type mice. Iron 106-110 homeostatic iron regulator Mus musculus 56-59 12805055-9 2003 DOX-treated Hfe-/- mice had a higher degree of mitochondrial damage and iron deposits in the heart than did wild-type mice. Iron 72-76 homeostatic iron regulator Mus musculus 12-15 12813369-3 2003 Mice deleted in the hfe gene (hfe-/-) abnormally accumulate iron in tissue; defects in the human hfe gene are clinically expressed as hemochromatosis. Iron 60-64 homeostatic iron regulator Mus musculus 20-23 14510961-1 2003 The effect of Hfe (haemochromatosis) gene deletion on the hypoxic response of iron absorption was investigated. Iron 78-82 homeostatic iron regulator Mus musculus 14-17 14510961-2 2003 Hfe knock-out mice were exposed to 0.5 atmospheres hypoxia for 3 d before in vivo iron absorption was measured. Iron 82-86 homeostatic iron regulator Mus musculus 0-3 14510961-3 2003 Both wild-type and Hfe knock-out mice had similar (two- to threefold) increases in iron absorption in response to hypoxia. Iron 83-87 homeostatic iron regulator Mus musculus 19-22 14510961-5 2003 The data further support the hypothesis that at least two independent mechanisms for the regulation of iron absorption exist, only one of which requires Hfe. Iron 103-107 homeostatic iron regulator Mus musculus 153-156 12813369-3 2003 Mice deleted in the hfe gene (hfe-/-) abnormally accumulate iron in tissue; defects in the human hfe gene are clinically expressed as hemochromatosis. Iron 60-64 homeostatic iron regulator Mus musculus 30-33 12813369-6 2003 A preliminary (but underpowered) study suggested that iron-loaded hfe-/- mice had increased mortality as compared with hfe-/- mice fed a low-iron diet. Iron 54-58 homeostatic iron regulator Mus musculus 66-69 12813369-8 2003 A subsequent, appropriately powered study showed that iron-loaded hfe-/- mice had significantly higher mortality from intra-abdominal sepsis than hfe-/- mice fed a low-iron diet. Iron 54-58 homeostatic iron regulator Mus musculus 66-69 12813369-8 2003 A subsequent, appropriately powered study showed that iron-loaded hfe-/- mice had significantly higher mortality from intra-abdominal sepsis than hfe-/- mice fed a low-iron diet. Iron 168-172 homeostatic iron regulator Mus musculus 66-69 12706501-1 2003 The HFE mutation is common and, when homozygous, can lead to a morbid accumulation of body iron and the disease hereditary hemochromatosis. Iron 91-95 homeostatic iron regulator Mus musculus 4-7 12750309-6 2003 The hearts of the HFE knockout mice showed increased iron deposition, increased content of reactive oxygen species (ROS) as evidenced by the increased formation of malondialdehyde, and reduced antioxidant enzymes including superoxide dismutase, catalase, and glutathione peroxidase. Iron 53-57 homeostatic iron regulator Mus musculus 18-21 12750309-7 2003 The results suggest that increased amount of ROS and reduced antioxidant reserve secondary to iron overloading may be instrumental for the susceptibility of the HFE gene knockout mice to cardiac injury. Iron 94-98 homeostatic iron regulator Mus musculus 161-164 12706501-3 2003 Dietary iron content was hypothesized to interact with the HFE genotype to influence oxidative damage in mammary and colon tissue. Iron 8-12 homeostatic iron regulator Mus musculus 59-62 12706501-6 2003 These results suggest that dietary modification may affect the course of iron overload from HFE mutations. Iron 73-77 homeostatic iron regulator Mus musculus 92-95 12468424-2 2003 It has been proposed that mutations causing loss of function of HFE gene result in reduced iron incorporation into immature duodenal crypt cells. Iron 91-95 homeostatic iron regulator Mus musculus 64-67 12704388-4 2003 Mice lacking Hfe or producing a C282Y mutant Hfe protein develop hyperferremia and have high hepatic iron levels. Iron 101-105 homeostatic iron regulator Mus musculus 45-48 12704388-6 2003 It has been suggested that HFE modulates uptake of transferrin-bound iron by undifferentiated intestinal crypt cells, thereby programming the absorptive capacity of enterocytes derived from these cells; however, this model is unproven and controversial. Iron 69-73 homeostatic iron regulator Mus musculus 27-30 12704388-9 2003 We crossed Hfe-/- mice with transgenic mice overexpressing Hamp and found that Hamp inhibited the iron accumulation normally observed in the Hfe-/- mice. Iron 98-102 homeostatic iron regulator Mus musculus 11-14 12704388-9 2003 We crossed Hfe-/- mice with transgenic mice overexpressing Hamp and found that Hamp inhibited the iron accumulation normally observed in the Hfe-/- mice. Iron 98-102 homeostatic iron regulator Mus musculus 141-144 12468424-5 2003 In both normal and Hfe knock-out mice, duodenal nonheme iron content was found to correlate with liver iron stores (P <.001, r = 0.643 and 0.551, respectively), and this effect did not depend on dietary iron levels. Iron 56-60 homeostatic iron regulator Mus musculus 19-22 12468424-5 2003 In both normal and Hfe knock-out mice, duodenal nonheme iron content was found to correlate with liver iron stores (P <.001, r = 0.643 and 0.551, respectively), and this effect did not depend on dietary iron levels. Iron 103-107 homeostatic iron regulator Mus musculus 19-22 12468424-5 2003 In both normal and Hfe knock-out mice, duodenal nonheme iron content was found to correlate with liver iron stores (P <.001, r = 0.643 and 0.551, respectively), and this effect did not depend on dietary iron levels. Iron 103-107 homeostatic iron regulator Mus musculus 19-22 12631660-0 2003 Duodenal mucosal reductase in wild-type and Hfe knockout mice on iron adequate, iron deficient, and iron rich feeding. Iron 65-69 homeostatic iron regulator Mus musculus 44-47 12468424-6 2003 However, duodenal iron content was reduced in Hfe knock-out mice for any given content of liver iron stores (P <.001). Iron 18-22 homeostatic iron regulator Mus musculus 46-49 12468424-6 2003 However, duodenal iron content was reduced in Hfe knock-out mice for any given content of liver iron stores (P <.001). Iron 96-100 homeostatic iron regulator Mus musculus 46-49 12547217-0 2002 Hemochromatosis protein (HFE) and tumor necrosis factor receptor 2 (TNFR2) influence tissue iron levels: elements of a common gut pathway? Iron 92-96 homeostatic iron regulator Mus musculus 25-28 12606179-7 2003 Similarly, we noted a decrease in Hamp expression in iron-loaded Hfe-knockout mice. Iron 53-57 homeostatic iron regulator Mus musculus 65-68 12540785-7 2003 The increases in nonheme iron in Hfe(-/-) mice were associated with diffuse increases in iron staining of parenchymal cells but without evidence of significant liver injury. Iron 25-29 homeostatic iron regulator Mus musculus 33-36 12540785-7 2003 The increases in nonheme iron in Hfe(-/-) mice were associated with diffuse increases in iron staining of parenchymal cells but without evidence of significant liver injury. Iron 89-93 homeostatic iron regulator Mus musculus 33-36 12547226-8 2002 Placing 8 week-old wild type and Hfe knockout mice on a 2% carbonyl iron diet for 2 weeks led to a similar degree of hepatic iron loading in each group. Iron 125-129 homeostatic iron regulator Mus musculus 33-36 12547226-10 2002 The lack of an increase in liver hepcidin expression in these iron-loaded Hfe knockout mice was associated with sparing of iron deposition into the spleen. Iron 62-66 homeostatic iron regulator Mus musculus 74-77 12547226-11 2002 These data indicate that the normal relationship between body iron stores and liver hepcidin mRNA levels is altered in Hfe knockout mice, such that liver hepcidin expression is relatively decreased. Iron 62-66 homeostatic iron regulator Mus musculus 119-122 12547217-3 2002 This result contrasted with mice deficient in the hemochromatosis protein, HFE, which demonstrated a significant increase in normally high hepatic iron levels, but no change in splenic iron, when fed an iron-enriched chow. Iron 147-151 homeostatic iron regulator Mus musculus 75-78 12547217-6 2002 These results suggest that HFE and TNFR2 are both involved in regulating iron deposition in tissues and that the regulation occurs at the level of the intestine through IEL-orchestrated production of TNF following the binding to TNFR2. Iron 73-77 homeostatic iron regulator Mus musculus 27-30 12547217-7 2002 These data suggest that HFE and TNFR2 may contribute to a common pathway of the iron stores regulator insuring the controlled efflux of gut iron. Iron 80-84 homeostatic iron regulator Mus musculus 24-27 12547217-7 2002 These data suggest that HFE and TNFR2 may contribute to a common pathway of the iron stores regulator insuring the controlled efflux of gut iron. Iron 140-144 homeostatic iron regulator Mus musculus 24-27 12190960-10 2002 CONCLUSION: C57BL/6 x 129/O1a HFE(o/o) mice mimic HH iron distribution and the regulation of intestinal iron absorption after long-term feeding. Iron 53-57 homeostatic iron regulator Mus musculus 30-33 12149232-0 2002 Regulation of iron absorption in Hfe mutant mice. Iron 14-18 homeostatic iron regulator Mus musculus 33-36 12149232-6 2002 Similarly, the iron loading associated with age in Hfe mutant mice resulted in nearly a 4-fold reduction in iron absorption. Iron 15-19 homeostatic iron regulator Mus musculus 51-54 12149232-6 2002 Similarly, the iron loading associated with age in Hfe mutant mice resulted in nearly a 4-fold reduction in iron absorption. Iron 108-112 homeostatic iron regulator Mus musculus 51-54 12149232-7 2002 When mice were stimulated to absorb iron either by depleting iron stores or by inducing erythropoiesis, wild type and Hfe mutant strains increased absorption to similar levels, approximately 5-fold over control values. Iron 36-40 homeostatic iron regulator Mus musculus 118-121 12149232-8 2002 Our data indicate that Hfe mutant mice retain the ability to regulate iron absorption. Iron 70-74 homeostatic iron regulator Mus musculus 23-26 12297827-2 2002 Acute iron administration or mutations of the hemochromatosis gene (Hfe) have been used to generate hepatic siderosis, a nearly uniform finding in PCT. Iron 6-10 homeostatic iron regulator Mus musculus 68-71 12297827-6 2002 Homozygosity for an Hfe-null mutation significantly elevated hepatic iron but not to the extent seen with parenteral iron-dextran administration. Iron 69-73 homeostatic iron regulator Mus musculus 20-23 12190960-7 2002 After 3 months of iron-rich feeding duodenal 59Fe absorption decreased to approximately 15% of iron-adequate controls but remained about twice as high in HFE(o/o) as in HFE(+/+) mice. Iron 18-22 homeostatic iron regulator Mus musculus 154-157 12190960-7 2002 After 3 months of iron-rich feeding duodenal 59Fe absorption decreased to approximately 15% of iron-adequate controls but remained about twice as high in HFE(o/o) as in HFE(+/+) mice. Iron 18-22 homeostatic iron regulator Mus musculus 169-172 12190960-10 2002 CONCLUSION: C57BL/6 x 129/O1a HFE(o/o) mice mimic HH iron distribution and the regulation of intestinal iron absorption after long-term feeding. Iron 104-108 homeostatic iron regulator Mus musculus 30-33 11875007-5 2002 In DBA/2 Hfe-/- mice, increased intestinal iron absorption results from the concomitant up-regulation of the Dcytb, DMT1, and FPN1 messengers. Iron 43-47 homeostatic iron regulator Mus musculus 9-12 12367579-0 2002 Iron overload in mice expressing HFE exclusively in the intestinal villi provides evidence that HFE regulates a functional cross-talk between crypt and villi enterocytes. Iron 0-4 homeostatic iron regulator Mus musculus 33-36 12367579-0 2002 Iron overload in mice expressing HFE exclusively in the intestinal villi provides evidence that HFE regulates a functional cross-talk between crypt and villi enterocytes. Iron 0-4 homeostatic iron regulator Mus musculus 96-99 12367579-1 2002 Hereditary hemochromatosis (HH), a common autosomal recessive disorder due to a mutation in HFE, which encodes an atypical MHC class I glycoprotein, is characterized by excessive absorption of dietary iron. Iron 201-205 homeostatic iron regulator Mus musculus 92-95 12367579-2 2002 Little is known however of the apparently complex pathophysiology of HFE involvement in the process of iron influx. Iron 103-107 homeostatic iron regulator Mus musculus 69-72 11943867-0 2002 Iron uptake from plasma transferrin by the duodenum is impaired in the Hfe knockout mouse. Iron 0-4 homeostatic iron regulator Mus musculus 71-74 11943867-3 2002 The function of HFE protein is unknown, but it is hypothesized that it acts in association with beta(2)-microglobulin and transferrin receptor 1 to regulate iron uptake from plasma transferrin by the duodenum, the proposed mechanism by which body iron levels are sensed. Iron 157-161 homeostatic iron regulator Mus musculus 16-19 11943867-3 2002 The function of HFE protein is unknown, but it is hypothesized that it acts in association with beta(2)-microglobulin and transferrin receptor 1 to regulate iron uptake from plasma transferrin by the duodenum, the proposed mechanism by which body iron levels are sensed. Iron 247-251 homeostatic iron regulator Mus musculus 16-19 11943867-4 2002 The aim of this study was to test this hypothesis by comparing clearance of transferrin-bound iron in Hfe knockout (KO) mice with that observed in C57BL/6 control mice. Iron 94-98 homeostatic iron regulator Mus musculus 102-105 11943867-9 2002 In both Hfe KO and C57BL/6 mice, plasma iron turnover and iron uptake from plasma transferrin by the duodenum, liver, and kidney correlated positively with plasma iron concentration. Iron 40-44 homeostatic iron regulator Mus musculus 8-11 11943867-10 2002 However, duodenal iron uptake from plasma transferrin was decreased in the Hfe KO mice compared with the control mice. Iron 18-22 homeostatic iron regulator Mus musculus 75-78 11943867-12 2002 These data support the hypothesis that HFE regulates duodenal uptake of transferrin-bound iron from plasma, and that this mechanism of sensing body iron status, as reflected in plasma iron levels, is impaired in HH. Iron 90-94 homeostatic iron regulator Mus musculus 39-42 11943867-12 2002 These data support the hypothesis that HFE regulates duodenal uptake of transferrin-bound iron from plasma, and that this mechanism of sensing body iron status, as reflected in plasma iron levels, is impaired in HH. Iron 148-152 homeostatic iron regulator Mus musculus 39-42 11943867-12 2002 These data support the hypothesis that HFE regulates duodenal uptake of transferrin-bound iron from plasma, and that this mechanism of sensing body iron status, as reflected in plasma iron levels, is impaired in HH. Iron 148-152 homeostatic iron regulator Mus musculus 39-42 11875007-1 2002 BACKGROUND & AIMS: Hfe knockout mice, like patients with hereditary hemochromatosis, have augmented duodenal iron absorption and increased iron deposition in hepatic parenchymal cells. Iron 113-117 homeostatic iron regulator Mus musculus 23-26 11875007-1 2002 BACKGROUND & AIMS: Hfe knockout mice, like patients with hereditary hemochromatosis, have augmented duodenal iron absorption and increased iron deposition in hepatic parenchymal cells. Iron 143-147 homeostatic iron regulator Mus musculus 23-26 11313312-2 2001 We examined the role of DMT1 and the mucosal iron uptake defect in HFE-knockout mice. Iron 45-49 homeostatic iron regulator Mus musculus 67-70 11826284-3 2002 Despite the discovery of the mutation underlying most cases of HH, considerable uncertainty exists in the mechanism by which the normal gene product, HFE, regulates iron homeostasis. Iron 165-169 homeostatic iron regulator Mus musculus 150-153 11826284-5 2002 However, studies on HFE expressed in cultured cells have not yet clarified the mechanism by which HFE mutations lead to increased dietary iron absorption. Iron 138-142 homeostatic iron regulator Mus musculus 98-101 11826284-6 2002 Recent discoveries suggest other genes, including a second transferrin receptor and the circulating peptide hepcidin, participate in a shared pathway with HFE in regulation of iron absorption. Iron 176-180 homeostatic iron regulator Mus musculus 155-158 17582936-3 2001 The mechanisms by which a dysfunctional HFE molecule determines increased absorption of iron in HH are on the way to be fully clarified, due to the availability of a knockout mouse model. Iron 88-92 homeostatic iron regulator Mus musculus 40-43 11447267-8 2001 We propose that hepcidin acts as a signaling molecule that is required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. Iron 123-127 homeostatic iron regulator Mus musculus 91-94 11447267-8 2001 We propose that hepcidin acts as a signaling molecule that is required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. Iron 143-147 homeostatic iron regulator Mus musculus 91-94 11313312-5 2001 RESULTS: Ferrous iron uptake at 3.5-450 micromol/L was greatly enhanced in HFE-knockouts compared with wild-type, the apparent V(max) for Fe2+ transport being doubled (P < 0.01). Iron 9-21 homeostatic iron regulator Mus musculus 75-78 11313312-6 2001 Supplied as Fe3+, uptake was only enhanced in HFE-knockouts at < or =18 micromol/L, when the iron was almost completely converted to Fe2+ by mucosal ferrireductases. Iron 96-100 homeostatic iron regulator Mus musculus 46-49 11313312-8 2001 CONCLUSIONS: Disruption of the HFE gene up-regulates functional DMT1 transporters and enhances uptake of ferrous iron by this mechanism; DMT1 also mediates increased uptake after reduction of ferric iron presented at physiological concentrations. Iron 113-117 homeostatic iron regulator Mus musculus 31-34 11226304-0 2001 Mouse strain differences determine severity of iron accumulation in Hfe knockout model of hereditary hemochromatosis. Iron 47-51 homeostatic iron regulator Mus musculus 68-71 11226304-2 2001 Clinical studies demonstrate that the severity of iron loading is highly variable among individuals with identical HFE genotypes. Iron 50-54 homeostatic iron regulator Mus musculus 115-118 11226304-5 2001 Although the Hfe -/- mice from all three strains demonstrated increased transferrin saturations and liver iron concentrations compared with Hfe +/+ mice, strain differences in severity of iron accumulation were striking. Iron 106-110 homeostatic iron regulator Mus musculus 13-16 10923364-3 2000 Duodenal crypt cells of HFE-knockout mice show low intracellular iron concentrations which lead to an upregulation of the divalent metal transporter and enhanced iron uptake by duodenal enterocytes. Iron 65-69 homeostatic iron regulator Mus musculus 24-27 11226304-6 2001 Targeted disruption of the Hfe gene led to hepatic iron levels in Hfe -/- AKR mice that were 2.5 or 3.6 times higher than those of Hfe -/- C3H or Hfe -/- C57BL/6 mice, respectively. Iron 51-55 homeostatic iron regulator Mus musculus 27-30 11226304-8 2001 These observations demonstrate that heritable factors markedly influence iron homeostasis in response to Hfe disruption. Iron 73-77 homeostatic iron regulator Mus musculus 105-108 11172342-0 2001 Uroporphyria in Hfe mutant mice given 5-aminolevulinate: a new model of Fe-mediated porphyria cutanea tarda. Iron 72-74 homeostatic iron regulator Mus musculus 16-19 11172342-3 2001 Mice homozygous for either the null mutation in the Hfe gene or the C282Y missense mutation rapidly accumulate hepatic parenchymal iron similar to patients with hemochromatosis. Iron 131-135 homeostatic iron regulator Mus musculus 52-55 11172342-8 2001 Iron in both wild-type and Hfe (+/-) mice was mostly in Kupffer cells. Iron 0-4 homeostatic iron regulator Mus musculus 27-30 11172342-9 2001 In contrast, Hfe (-/-) mice had considerable parenchymal iron deposition as well, in a pattern similar to that observed in wild-type mice treated with iron carbonyl. Iron 57-61 homeostatic iron regulator Mus musculus 13-16 11172342-9 2001 In contrast, Hfe (-/-) mice had considerable parenchymal iron deposition as well, in a pattern similar to that observed in wild-type mice treated with iron carbonyl. Iron 151-155 homeostatic iron regulator Mus musculus 13-16 10923364-3 2000 Duodenal crypt cells of HFE-knockout mice show low intracellular iron concentrations which lead to an upregulation of the divalent metal transporter and enhanced iron uptake by duodenal enterocytes. Iron 162-166 homeostatic iron regulator Mus musculus 24-27 25403101-3 2015 The proteins transmembrane protease, serine 6 (TMPRSS6; also termed matriptase-2), HFE and transferrin receptor 2 (TFR2) play important and opposing roles in systemic iron homeostasis, by regulating expression of the iron regulatory hormone hepcidin. Iron 167-171 homeostatic iron regulator Mus musculus 83-86 10791995-3 2000 Compound mutant mice lacking both Hfe and its interacting protein, beta-2 microglobulin (B2m), deposit more tissue iron than mice lacking Hfe only, suggesting that another B2m-interacting protein may be involved in iron regulation. Iron 115-119 homeostatic iron regulator Mus musculus 34-37 10791995-3 2000 Compound mutant mice lacking both Hfe and its interacting protein, beta-2 microglobulin (B2m), deposit more tissue iron than mice lacking Hfe only, suggesting that another B2m-interacting protein may be involved in iron regulation. Iron 215-219 homeostatic iron regulator Mus musculus 34-37 10791995-4 2000 Hfe knockout mice carrying mutations in the iron transporter DMT1 fail to load iron, indicating that hemochromatosis involves iron flux through DMT1. Iron 44-48 homeostatic iron regulator Mus musculus 0-3 10791995-4 2000 Hfe knockout mice carrying mutations in the iron transporter DMT1 fail to load iron, indicating that hemochromatosis involves iron flux through DMT1. Iron 79-83 homeostatic iron regulator Mus musculus 0-3 10791995-5 2000 Similarly, compound mutants deficient in both Hfe and hephaestin (Heph) show less iron loading than do Hfe knockout mice, indicating that iron absorption in hemochromatosis involves the function of Heph as well. Iron 82-86 homeostatic iron regulator Mus musculus 46-49 10791995-5 2000 Similarly, compound mutants deficient in both Hfe and hephaestin (Heph) show less iron loading than do Hfe knockout mice, indicating that iron absorption in hemochromatosis involves the function of Heph as well. Iron 138-142 homeostatic iron regulator Mus musculus 46-49 10791995-6 2000 Finally, compound mutants lacking Hfe and the transferrin receptor accumulate more tissue iron than do mice lacking Hfe alone, consistent with the idea that interaction between these two proteins contributes to the control of normal iron absorption. Iron 90-94 homeostatic iron regulator Mus musculus 34-37 10791995-6 2000 Finally, compound mutants lacking Hfe and the transferrin receptor accumulate more tissue iron than do mice lacking Hfe alone, consistent with the idea that interaction between these two proteins contributes to the control of normal iron absorption. Iron 233-237 homeostatic iron regulator Mus musculus 34-37 10077651-2 1999 We recently reported that HFE, the protein defective in HH, was physically associated with the transferrin receptor (TfR) in duodenal crypt cells and proposed that mutations in HFE attenuate the uptake of transferrin-bound iron from plasma by duodenal crypt cells, leading to up-regulation of transporters for dietary iron. Iron 223-227 homeostatic iron regulator Mus musculus 26-29 10077651-2 1999 We recently reported that HFE, the protein defective in HH, was physically associated with the transferrin receptor (TfR) in duodenal crypt cells and proposed that mutations in HFE attenuate the uptake of transferrin-bound iron from plasma by duodenal crypt cells, leading to up-regulation of transporters for dietary iron. Iron 223-227 homeostatic iron regulator Mus musculus 177-180 10077651-2 1999 We recently reported that HFE, the protein defective in HH, was physically associated with the transferrin receptor (TfR) in duodenal crypt cells and proposed that mutations in HFE attenuate the uptake of transferrin-bound iron from plasma by duodenal crypt cells, leading to up-regulation of transporters for dietary iron. Iron 318-322 homeostatic iron regulator Mus musculus 26-29 10077651-2 1999 We recently reported that HFE, the protein defective in HH, was physically associated with the transferrin receptor (TfR) in duodenal crypt cells and proposed that mutations in HFE attenuate the uptake of transferrin-bound iron from plasma by duodenal crypt cells, leading to up-regulation of transporters for dietary iron. Iron 318-322 homeostatic iron regulator Mus musculus 177-180 10077651-4 1999 By 4 weeks of age, the HFE-/- mice demonstrated iron loading when compared with HFE+/+ littermates, with elevated transferrin saturations (68.4% vs. 49.8%) and elevated liver iron concentrations (985 micrograms vs. 381 micrograms). Iron 48-52 homeostatic iron regulator Mus musculus 23-26 10077651-4 1999 By 4 weeks of age, the HFE-/- mice demonstrated iron loading when compared with HFE+/+ littermates, with elevated transferrin saturations (68.4% vs. 49.8%) and elevated liver iron concentrations (985 micrograms vs. 381 micrograms). Iron 175-179 homeostatic iron regulator Mus musculus 23-26 10077651-7 1999 HFE-/- mice also demonstrated an increase in duodenal DMT1(IRE) mRNA (average 7.7-fold), despite their elevated transferrin saturation and hepatic iron content. Iron 147-151 homeostatic iron regulator Mus musculus 0-3 10077651-9 1999 These data support the model for HH in which HFE mutations lead to inappropriately low crypt cell iron, with resultant stabilization of DMT1(IRE) mRNA, up-regulation of DMT1, and increased absorption of dietary iron. Iron 98-102 homeostatic iron regulator Mus musculus 45-48 10077651-9 1999 These data support the model for HH in which HFE mutations lead to inappropriately low crypt cell iron, with resultant stabilization of DMT1(IRE) mRNA, up-regulation of DMT1, and increased absorption of dietary iron. Iron 211-215 homeostatic iron regulator Mus musculus 45-48 9531620-2 1998 Further support for a causative role of HFE in this disease comes from the observation that beta2-microglobulin knockout (beta2m-/-) mice, that fail to express MHC class I products, develop iron overload. Iron 190-194 homeostatic iron regulator Mus musculus 40-43 9482913-4 1998 To test the hypothesis that the HFE gene is involved in regulation of iron homeostasis, we studied the effects of a targeted disruption of the murine homologue of the HFE gene. Iron 70-74 homeostatic iron regulator Mus musculus 32-35 9482913-7 1998 Stainable hepatic iron in the HFE mutant mice was predominantly in hepatocytes in a periportal distribution. Iron 18-22 homeostatic iron regulator Mus musculus 30-33 9482913-10 1998 This study shows that the HFE protein is involved in the regulation of iron homeostasis and that mutations in this gene are responsible for HH. Iron 71-75 homeostatic iron regulator Mus musculus 26-29 25403101-3 2015 The proteins transmembrane protease, serine 6 (TMPRSS6; also termed matriptase-2), HFE and transferrin receptor 2 (TFR2) play important and opposing roles in systemic iron homeostasis, by regulating expression of the iron regulatory hormone hepcidin. Iron 217-221 homeostatic iron regulator Mus musculus 83-86 34995689-0 2022 Disruption of Hfe leads to skeletal muscle iron loading and reduction of hemoproteins involved in oxidative metabolism in a mouse model of hereditary hemochromatosis. Iron 43-47 homeostatic iron regulator Mus musculus 14-17 34829689-9 2021 Hfe-/- mice on HI showed very high liver iron levels, decreased mitochondrial respiratory capacity and increased ROS production associated with reduced mitochondrial aconitase activity. Iron 41-45 homeostatic iron regulator Mus musculus 0-3 34829689-10 2021 Although Hfe-/- resulted in increased mitochondrial iron loading, the concentration of metabolically reactive cytoplasmic iron and mitochondrial density remained unchanged. Iron 52-56 homeostatic iron regulator Mus musculus 9-12 34722560-0 2021 Hfe Gene Knock-Out in a Mouse Model of Hereditary Hemochromatosis Affects Bodily Iron Isotope Compositions. Iron 81-85 homeostatic iron regulator Mus musculus 0-3 34722560-1 2021 Hereditary hemochromatosis is a genetic iron overload disease related to a mutation within the HFE gene that controls the expression of hepcidin, the master regulator of systemic iron metabolism. Iron 40-44 homeostatic iron regulator Mus musculus 95-98 34722560-1 2021 Hereditary hemochromatosis is a genetic iron overload disease related to a mutation within the HFE gene that controls the expression of hepcidin, the master regulator of systemic iron metabolism. Iron 179-183 homeostatic iron regulator Mus musculus 95-98 34722560-5 2021 Iron concentration increases in liver and red blood cells of Hfe -/- mice compared to controls. Iron 0-4 homeostatic iron regulator Mus musculus 61-64 35445828-8 2022 Next, we validated the efficacy of NBMI in Hfe H67D mutant mice, a mouse model of brain iron accumulation (BIA). Iron 88-92 homeostatic iron regulator Mus musculus 43-46 32083318-3 2020 Iron levels are significantly increased in iron overloaded transferrin receptor 2 (Tfr2) mutant mice and homeostatic iron regulator (Hfe) gene-deficient mice and this is associated with increases in airway fibrosis and reduced lung function. Iron 0-4 homeostatic iron regulator Mus musculus 133-136 33839281-3 2021 In this study we investigated whether the feeding of an iron deficient/HCD to Hfe-/- mice influenced the development of NAFLD. Iron 56-60 homeostatic iron regulator Mus musculus 78-81 32861780-2 2020 The most frequent mutation in Hfe leads to reduced hepcidin expression and thereby causes iron overload. Iron 90-94 homeostatic iron regulator Mus musculus 30-33 32861780-7 2020 HFE protein levels were increased in Alk3fl/fl;Alb-Cre mice compared to Alk3fl/fl mice, which was caused by iron overload - and not by Alk3 deficiency. Iron 108-112 homeostatic iron regulator Mus musculus 0-3 32754933-0 2020 Iron promotes the clearance of alpha-synuclein: An Editorial for "H63D variant of the homeostatic iron regulator (HFE) gene alters alpha-synuclein expression, aggregation, and toxicity" on https://doi.org/10.1111/jnc.15107. Iron 0-4 homeostatic iron regulator Mus musculus 114-117 32754933-0 2020 Iron promotes the clearance of alpha-synuclein: An Editorial for "H63D variant of the homeostatic iron regulator (HFE) gene alters alpha-synuclein expression, aggregation, and toxicity" on https://doi.org/10.1111/jnc.15107. Iron 98-102 homeostatic iron regulator Mus musculus 114-117 32754933-4 2020 have shown that the H63D variant of the homeostatic iron regulator (HFE) facilitates alpha-syn degradation via REDD1-mediated autophagy. Iron 52-56 homeostatic iron regulator Mus musculus 68-71 32766721-2 2020 Subjects with HFE (Homeostatic Iron Regulator) p.C282Y mutations and the GNPAT p.D519G variant had more iron loading compared to subjects without the GNPAT variant. Iron 104-108 homeostatic iron regulator Mus musculus 14-17 32079697-0 2021 Macrophage-HFE controls iron metabolism and immune responses in aged mice. Iron 24-28 homeostatic iron regulator Mus musculus 11-14 33148716-0 2020 ESAT-6 Protein of Mycobacterium tuberculosis Increases Holotransferrin-Mediated Iron Uptake in Macrophages by Downregulating Surface Hemochromatosis Protein HFE. Iron 80-84 homeostatic iron regulator Mus musculus 157-160 33148716-7 2020 In the current study, we report that interaction of the ESAT-6 protein with beta2M causes downregulation of surface HFE, a protein regulating iron homeostasis via interacting with transferrin receptor 1 (TFR1). Iron 142-146 homeostatic iron regulator Mus musculus 116-119 33148716-8 2020 We found that ESAT-6:beta2M interaction leads to sequestration of HFE in endoplasmic reticulum, causing poorer surface expression of HFE and HFE:TFR1 complex (nonfunctional TFR1) in peritoneal macrophages from C57BL/6 mice, resulting in increased holotransferrin-mediated iron uptake in these macrophages. Iron 272-276 homeostatic iron regulator Mus musculus 66-69 32861780-10 2020 HFE protein expression is induced by iron overload, which further emphasizes the iron sensing function of HFE. Iron 37-41 homeostatic iron regulator Mus musculus 0-3 32861780-10 2020 HFE protein expression is induced by iron overload, which further emphasizes the iron sensing function of HFE. Iron 37-41 homeostatic iron regulator Mus musculus 106-109 32861780-10 2020 HFE protein expression is induced by iron overload, which further emphasizes the iron sensing function of HFE. Iron 81-85 homeostatic iron regulator Mus musculus 0-3 32861780-10 2020 HFE protein expression is induced by iron overload, which further emphasizes the iron sensing function of HFE. Iron 81-85 homeostatic iron regulator Mus musculus 106-109 33054105-1 2021 Mutations in HFE cause hereditary hemochromatosis type I hallmarked by increased iron absorption, iron accumulation in hepatocytes and iron deficiency in myeloid cells. Iron 81-85 homeostatic iron regulator Mus musculus 13-16 33054105-1 2021 Mutations in HFE cause hereditary hemochromatosis type I hallmarked by increased iron absorption, iron accumulation in hepatocytes and iron deficiency in myeloid cells. Iron 98-102 homeostatic iron regulator Mus musculus 13-16 33054105-6 2021 By contrast, mice with hepatocyte-specific deletion of Hfe succumbed earlier to Salmonella infection because of unrestricted extracellular bacterial replication associated with high iron availability in the serum and impaired expression of essential host defense molecules such as interleukin-6, interferon-gamma and nitric oxide synthase-2. Iron 182-186 homeostatic iron regulator Mus musculus 55-58 33054105-7 2021 Wild-type mice subjected to dietary iron overload phenocopied hepatocyte-specific Hfe deficiency suggesting that increased iron availability in the serum is deleterious in Salmonella infection and underlies impaired host immune responses. Iron 36-40 homeostatic iron regulator Mus musculus 82-85 33054105-7 2021 Wild-type mice subjected to dietary iron overload phenocopied hepatocyte-specific Hfe deficiency suggesting that increased iron availability in the serum is deleterious in Salmonella infection and underlies impaired host immune responses. Iron 123-127 homeostatic iron regulator Mus musculus 82-85 33054105-8 2021 Moreover, the macrophage-specific effect is dominant over hepatocyte-specific Hfe-depletion, as Hfe knock-out mice have increased survival despite the higher parenchymal iron load associated with systemic loss of Hfe. Iron 170-174 homeostatic iron regulator Mus musculus 96-99 33054105-8 2021 Moreover, the macrophage-specific effect is dominant over hepatocyte-specific Hfe-depletion, as Hfe knock-out mice have increased survival despite the higher parenchymal iron load associated with systemic loss of Hfe. Iron 170-174 homeostatic iron regulator Mus musculus 96-99 33054105-9 2021 We conclude that cell-specific expression of Hfe in hepatocytes and macrophages differentially affects the course of infections with specific pathogens by determining bacterial iron access and the efficacy of anti-microbial immune effector pathways. Iron 177-181 homeostatic iron regulator Mus musculus 45-48 32380257-5 2020 Hfe-/- and FpnC326S mice show increased plasma iron levels and liver iron content, whereas iron overload was more pronounced in FpnC326S compared to Hfe-/- mice. Iron 47-51 homeostatic iron regulator Mus musculus 0-3 32380257-5 2020 Hfe-/- and FpnC326S mice show increased plasma iron levels and liver iron content, whereas iron overload was more pronounced in FpnC326S compared to Hfe-/- mice. Iron 69-73 homeostatic iron regulator Mus musculus 0-3 32380257-5 2020 Hfe-/- and FpnC326S mice show increased plasma iron levels and liver iron content, whereas iron overload was more pronounced in FpnC326S compared to Hfe-/- mice. Iron 69-73 homeostatic iron regulator Mus musculus 0-3 31778583-7 2020 In contrast, double Hfe/endothelial Bmp2 KO mice exhibited reduced hepcidin and increased extrahepatic iron loading compared to single Hfe or endothelial Bmp2 KO mice. Iron 103-107 homeostatic iron regulator Mus musculus 20-23 32083318-3 2020 Iron levels are significantly increased in iron overloaded transferrin receptor 2 (Tfr2) mutant mice and homeostatic iron regulator (Hfe) gene-deficient mice and this is associated with increases in airway fibrosis and reduced lung function. Iron 117-121 homeostatic iron regulator Mus musculus 133-136 32108988-1 2020 The GNPAT variant rs11558492 (p.D519G) was identified as a novel genetic factor that modifies the iron-overload phenotype in homozygous carriers of the HFE p.C282Y variant. Iron 98-102 homeostatic iron regulator Mus musculus 152-155 32239172-1 2020 Hereditary hemochromatosis (HH) is mostly caused by mutations in the iron-regulatory gene HFE. Iron 69-73 homeostatic iron regulator Mus musculus 90-93 31717526-2 2019 Therefore, we assessed iron metabolism and variants in the Homeostatic Iron Regulator gene (HFE) as the major cause of hereditary iron overload in a large cohort of Pi*ZZ subjects without liver comorbidities. Iron 130-134 homeostatic iron regulator Mus musculus 92-95 31339576-5 2020 In this study, we used a mouse model expressing a mutant form of the iron homeostatic regulator protein HFE, (Hfe H63D), the most common gene variant in Caucasians, to determine impact of the mutation on brain iron uptake. Iron 69-73 homeostatic iron regulator Mus musculus 104-107 31339576-5 2020 In this study, we used a mouse model expressing a mutant form of the iron homeostatic regulator protein HFE, (Hfe H63D), the most common gene variant in Caucasians, to determine impact of the mutation on brain iron uptake. Iron 69-73 homeostatic iron regulator Mus musculus 110-113 31339576-5 2020 In this study, we used a mouse model expressing a mutant form of the iron homeostatic regulator protein HFE, (Hfe H63D), the most common gene variant in Caucasians, to determine impact of the mutation on brain iron uptake. Iron 210-214 homeostatic iron regulator Mus musculus 104-107 31669736-9 2019 KEY FINDINGS: HFe consumption caused an equal impact on circulating iron-overload, oxidative stress, and inflammation in WT and HT mice. Iron 68-72 homeostatic iron regulator Mus musculus 14-17 31669736-10 2019 Brain iron-overload and iron-mediated neurotoxicity, such as oxidative stress, inflammation, glial activation, mitochondrial dysfunction, and Alzheimer"s like pathologies, were observed to an equal degree in HFe fed WT and HT mice. Iron 6-10 homeostatic iron regulator Mus musculus 208-211 31669736-10 2019 Brain iron-overload and iron-mediated neurotoxicity, such as oxidative stress, inflammation, glial activation, mitochondrial dysfunction, and Alzheimer"s like pathologies, were observed to an equal degree in HFe fed WT and HT mice. Iron 24-28 homeostatic iron regulator Mus musculus 208-211 31717526-8 2019 HFE knockout and DTg mice displayed similar extent of iron overload and of fibrosis. Iron 54-58 homeostatic iron regulator Mus musculus 0-3 30538134-12 2019 Our data are consistent with an inhibitory function of Tfr1 on iron signaling to hepcidin via its interaction with Hfe. Iron 63-67 homeostatic iron regulator Mus musculus 115-118 31188032-0 2019 Renal iron accelerates the progression of diabetic nephropathy in the HFE gene knockout mouse model of iron overload. Iron 6-10 homeostatic iron regulator Mus musculus 70-73 31188032-0 2019 Renal iron accelerates the progression of diabetic nephropathy in the HFE gene knockout mouse model of iron overload. Iron 103-107 homeostatic iron regulator Mus musculus 70-73 30277817-2 2019 While mutation in the hemochromatosis ( HFE) gene disrupts iron homeostasis and promotes oxidative stress that increases the risk of neurodegeneration, it is largely unknown whether HFE mutation modifies GABAergic homeostasis and emotional behavior. Iron 59-63 homeostatic iron regulator Mus musculus 40-43 30277817-9 2019 Taken together, our results suggest a putative role of HFE in regulating labile iron status in the brain, and mutation in H67D perturbs redox-methylation status, contributing to GABAergic dysfunction.-Ye, Q., Trivedi, M., Zhang, Y., Bohlke, M., Alsulimani, H., Chang, J., Maher, T., Deth, R., Kim, J. Iron 80-84 homeostatic iron regulator Mus musculus 55-58 31442254-4 2019 Hfe-/- mice, a model of moderate iron overload, were reported to develop early liver fibrosis in response to a high fat diet. Iron 33-37 homeostatic iron regulator Mus musculus 0-3 31442254-6 2019 These data raised the possibility that the Hfe gene may protect against liver injury independently of its iron regulatory function. Iron 106-110 homeostatic iron regulator Mus musculus 43-46 31188032-9 2019 Iron accumulation in the kidneys of HFE knockout mice was associated with increase in serum and intrarenal renin expression. Iron 0-4 homeostatic iron regulator Mus musculus 36-39 31188032-10 2019 Induction of diabetes in HFE knockout mice using streptozotocin caused a much higher accumulation of renal iron and accelerated the progression of nephropathy compared with diabetic wild-type mice. Iron 107-111 homeostatic iron regulator Mus musculus 25-28 31667458-3 2019 Clinical data and preclinical models have brought considerable attention to the correlation between iron overload and the development of osteoporosis in HFE/Hfe hemochromatosis. Iron 100-104 homeostatic iron regulator Mus musculus 153-156 31132316-0 2019 Intracellular iron uptake is favored in Hfe-KO mouse primary chondrocytes mimicking an osteoarthritis-related phenotype. Iron 14-18 homeostatic iron regulator Mus musculus 40-43 31132316-1 2019 HFE-hemochromatosis is a disease characterized by a systemic iron overload phenotype mainly associated with mutations in the HFE protein (HFE) gene. Iron 61-65 homeostatic iron regulator Mus musculus 0-3 31132316-1 2019 HFE-hemochromatosis is a disease characterized by a systemic iron overload phenotype mainly associated with mutations in the HFE protein (HFE) gene. Iron 61-65 homeostatic iron regulator Mus musculus 125-128 31132316-4 2019 Our data provide evidence that both wt- and Hfe-KO-derived chondrocytes, when exposed to 50 muM iron, develop characteristics of an OA-related phenotype, such as an increased expression of metalloproteases, a decreased extracellular matrix production, and a lower expression level of aggrecan. Iron 96-100 homeostatic iron regulator Mus musculus 44-47 31132316-5 2019 In addition, Hfe-KO cells also showed an increased expression of iron metabolism markers and MMP3, indicating an increased susceptibility to intracellular iron accumulation and higher levels of chondrocyte catabolism. Iron 65-69 homeostatic iron regulator Mus musculus 13-16 31132316-5 2019 In addition, Hfe-KO cells also showed an increased expression of iron metabolism markers and MMP3, indicating an increased susceptibility to intracellular iron accumulation and higher levels of chondrocyte catabolism. Iron 155-159 homeostatic iron regulator Mus musculus 13-16 31132316-7 2019 In conclusion, high iron exposure can compromise chondrocyte metabolism, which, when simultaneously affected by an Hfe loss of function, appears to be more susceptible to the establishment of an OA-related phenotype. Iron 20-24 homeostatic iron regulator Mus musculus 115-118 30271947-1 2018 Mutations in HFE, the most common cause of hereditary hemochromatosis, lead to iron overload. Iron 79-83 homeostatic iron regulator Mus musculus 13-16 30479929-4 2018 Distinct iron distribution profiles are also found throughout liver zones in wild-type mice and various mouse models with iron metabolism disorders, including hemochromatosis (Hfe-/- ), iron deficiency, and inflammation. Iron 9-13 homeostatic iron regulator Mus musculus 176-179 29927322-0 2018 Liver HFE protein content is posttranscriptionally decreased in iron-deficient mice and rats. Iron 64-68 homeostatic iron regulator Mus musculus 6-9 29927322-4 2018 Five-week-old male C57BL/6 mice fed an iron-deficient diet for 4 wk presented with a significant decrease in liver iron content and liver Hamp expression, as well as with a significant decrease in liver HFE protein content. Iron 39-43 homeostatic iron regulator Mus musculus 203-206 29927322-11 2018 NEW & NOTEWORTHY Feeding of iron-deficient diet for 4 wk decreased liver HFE protein content in both mice and rats, suggesting that decreased HFE-dependent signaling may contribute to hepcidin downregulation in iron deficiency. Iron 32-36 homeostatic iron regulator Mus musculus 77-80 28350201-0 2018 A role for sex and a common HFE gene variant in brain iron uptake. Iron 54-58 homeostatic iron regulator Mus musculus 28-31 29315562-3 2018 The HFE protein is critical for the regulation of cellular iron uptake. Iron 59-63 homeostatic iron regulator Mus musculus 4-7 29113455-7 2018 Notably, the long-term treatment with entinostat in Hfe-/- mice significantly alleviated iron overload through upregulating hepcidin transcription. Iron 89-93 homeostatic iron regulator Mus musculus 52-55 28350201-1 2018 HFE (high iron) is an essential protein for regulating iron transport into cells. Iron 10-14 homeostatic iron regulator Mus musculus 0-3 28350201-1 2018 HFE (high iron) is an essential protein for regulating iron transport into cells. Iron 55-59 homeostatic iron regulator Mus musculus 0-3 28350201-2 2018 Mutations of the HFE gene result in loss of this regulation causing accumulation of iron within the cell. Iron 84-88 homeostatic iron regulator Mus musculus 17-20 28350201-5 2018 While much has been studied regarding the role of HFE in cellular iron uptake, it has remained unclear what role the protein plays in the transport of iron into the brain. Iron 66-70 homeostatic iron regulator Mus musculus 50-53 28350201-6 2018 We investigated regulation of iron transport into the brain using a mouse model with a mutation in the HFE gene. Iron 30-34 homeostatic iron regulator Mus musculus 103-106 28558947-0 2017 Hemochromatosis Protein (HFE) Knockout Mice As a Novel Model of Hemochromatosis: Implications for Study and Management of Iron-Overload Cardiomyopathy. Iron 122-126 homeostatic iron regulator Mus musculus 25-28 29467298-5 2018 The role of iron in A. fumigatus invasive growth was further confirmed by showing that this invasive phenotype was increased in tracheal transplants from donor mice lacking the hemochromatosis gene (Hfe-/- ). Iron 12-16 homeostatic iron regulator Mus musculus 199-202 28720890-3 2017 Cardiac iron levels increased progressively with age, which was exacerbated in Hfe-deficient mice. Iron 8-12 homeostatic iron regulator Mus musculus 79-82 27936457-7 2017 The combination of iron overload (Hfe-/-) and defective antioxidant defences (Nrf2-/-) increased the number of iron-related necroinflammatory lesions (sideronecrosis), possibly due to the accumulation of toxic oxidation products such as 4-hydroxy-2-nonenal-protein adducts. Iron 19-23 homeostatic iron regulator Mus musculus 34-41 28443246-2 2017 HFE-associated hereditary hemochromatosis is characterized by overwhelming intestinal iron absorption, parenchymal iron deposition, and macrophage iron depletion. Iron 86-90 homeostatic iron regulator Mus musculus 0-3 28443246-2 2017 HFE-associated hereditary hemochromatosis is characterized by overwhelming intestinal iron absorption, parenchymal iron deposition, and macrophage iron depletion. Iron 115-119 homeostatic iron regulator Mus musculus 0-3 28443246-2 2017 HFE-associated hereditary hemochromatosis is characterized by overwhelming intestinal iron absorption, parenchymal iron deposition, and macrophage iron depletion. Iron 115-119 homeostatic iron regulator Mus musculus 0-3 28443246-6 2017 As predicted, Hfe-/- mice, a model of hereditary hemochromatosis, displayed reduced spleen iron content, which translated into improved control of Salmonella replication. Iron 91-95 homeostatic iron regulator Mus musculus 14-17 28443246-7 2017 Salmonella adapted to the iron-poor microenvironment in the spleens of Hfe-/- mice by inducing the expression of its siderophore iron-uptake machinery. Iron 26-30 homeostatic iron regulator Mus musculus 71-74 28443246-7 2017 Salmonella adapted to the iron-poor microenvironment in the spleens of Hfe-/- mice by inducing the expression of its siderophore iron-uptake machinery. Iron 44-48 homeostatic iron regulator Mus musculus 71-74 28443246-8 2017 Dietary iron loading resulted in higher bacterial numbers in both WT and Hfe-/- mice, although Hfe deficiency still resulted in better pathogen control and improved survival. Iron 8-12 homeostatic iron regulator Mus musculus 73-76 28443246-11 2017 Moreover, Hfe-associated iron overload and dietary iron excess result in different outcomes in infection, indicating that tissue and cellular iron distribution determines the susceptibility to infection with specific pathogens. Iron 25-29 homeostatic iron regulator Mus musculus 10-13 27936457-7 2017 The combination of iron overload (Hfe-/-) and defective antioxidant defences (Nrf2-/-) increased the number of iron-related necroinflammatory lesions (sideronecrosis), possibly due to the accumulation of toxic oxidation products such as 4-hydroxy-2-nonenal-protein adducts. Iron 111-115 homeostatic iron regulator Mus musculus 34-41 27354540-6 2016 Hepatic iron concentration (HIC) was increased in Hfe(+/-) mice of both dietary groups. Iron 8-12 homeostatic iron regulator Mus musculus 50-53 28202542-10 2017 HFE-/- livers were overloaded with ferritin but had low mitochondrial iron levels. Iron 70-74 homeostatic iron regulator Mus musculus 0-3 27500074-1 2016 We previously demonstrated elevated brain iron levels in myelinated structures and associated cells in a hemochromatosis Hfe (-/-) xTfr2 (mut) mouse model. Iron 42-46 homeostatic iron regulator Mus musculus 121-124 25608116-1 2015 AIMS: Hereditary hemochromatosis (HH) is an iron overload disease that is caused by mutations in HFE, HJV, and several other genes. Iron 44-48 homeostatic iron regulator Mus musculus 97-100 26403062-1 2016 OBJECTIVE: Hereditary hemochromatosis (HH) is a disease caused by mutations in the Hfe gene characterised by systemic iron overload and associated with an increased prevalence of osteoarthritis (OA) but the role of iron overload in the development of OA is still undefined. Iron 118-122 homeostatic iron regulator Mus musculus 83-86 26403062-5 2016 RESULTS: Hfe-KO mice showed a systemic iron overload and an increased iron accumulation in the knee synovial membrane following surgery. Iron 39-43 homeostatic iron regulator Mus musculus 9-12 26403062-5 2016 RESULTS: Hfe-KO mice showed a systemic iron overload and an increased iron accumulation in the knee synovial membrane following surgery. Iron 70-74 homeostatic iron regulator Mus musculus 9-12 26047483-20 2015 We propose the following two novel pathways in the lung: (i) for supplying iron in iron deficiency, mediated principally by DMT1 and TfR and regulated by the action of FPN and HFE; and (ii) for iron detoxification in order to protect the lung against iron overload, facilitated by the action of DMT1, ZIP14, FPN and ferritin. Iron 75-79 homeostatic iron regulator Mus musculus 176-179 25608116-5 2015 RESULTS: Hfe(-/-)Hjv(-/-) mice developed iron overload in multiple organs at levels comparable to Hjv(-/-) mice. Iron 41-45 homeostatic iron regulator Mus musculus 9-12 25608116-6 2015 After an acute delivery of iron, the expression of hepcidin (i.e., Hamp1 mRNA) was increased in the livers of wild-type and Hfe(-/-) mice, but not in either Hjv(-/-) or Hfe(-/-)Hjv(-/-) mice. Iron 27-31 homeostatic iron regulator Mus musculus 124-127 25608116-6 2015 After an acute delivery of iron, the expression of hepcidin (i.e., Hamp1 mRNA) was increased in the livers of wild-type and Hfe(-/-) mice, but not in either Hjv(-/-) or Hfe(-/-)Hjv(-/-) mice. Iron 27-31 homeostatic iron regulator Mus musculus 169-172 26829642-4 2016 Our aim was to analyse the impact of excess iron in Hfe-/- mice on osteoblast activity and on bone microarchitecture. Iron 44-48 homeostatic iron regulator Mus musculus 52-55 26829642-7 2016 We found that bone contains excess iron associated with increased hepatic iron concentration in Hfe-/- mice. Iron 35-39 homeostatic iron regulator Mus musculus 96-99 26829642-7 2016 We found that bone contains excess iron associated with increased hepatic iron concentration in Hfe-/- mice. Iron 74-78 homeostatic iron regulator Mus musculus 96-99 26406355-0 2016 Differing impact of the deletion of hemochromatosis-associated molecules HFE and transferrin receptor-2 on the iron phenotype of mice lacking bone morphogenetic protein 6 or hemojuvelin. Iron 111-115 homeostatic iron regulator Mus musculus 73-76 26406355-1 2016 UNLABELLED: Hereditary hemochromatosis, which is characterized by inappropriately low levels of hepcidin, increased dietary iron uptake, and systemic iron accumulation, has been associated with mutations in the HFE, transferrin receptor-2 (TfR2), and hemojuvelin (HJV) genes. Iron 124-128 homeostatic iron regulator Mus musculus 211-214 26406355-1 2016 UNLABELLED: Hereditary hemochromatosis, which is characterized by inappropriately low levels of hepcidin, increased dietary iron uptake, and systemic iron accumulation, has been associated with mutations in the HFE, transferrin receptor-2 (TfR2), and hemojuvelin (HJV) genes. Iron 150-154 homeostatic iron regulator Mus musculus 211-214 26456104-3 2015 HFE influences iron absorption by modulating the expression of hepcidin, the main controller of iron metabolism. Iron 15-19 homeostatic iron regulator Mus musculus 0-3 26456104-3 2015 HFE influences iron absorption by modulating the expression of hepcidin, the main controller of iron metabolism. Iron 96-100 homeostatic iron regulator Mus musculus 0-3 26456104-6 2015 We describe the pertinence of HFE and HFE to mechanisms of iron homeostasis, the origin and fixation of HFE polymorphisms in European and other populations, and the genetic and biochemical basis of HFE hemochromatosis and iron overload. Iron 59-63 homeostatic iron regulator Mus musculus 30-33 26456104-6 2015 We describe the pertinence of HFE and HFE to mechanisms of iron homeostasis, the origin and fixation of HFE polymorphisms in European and other populations, and the genetic and biochemical basis of HFE hemochromatosis and iron overload. Iron 59-63 homeostatic iron regulator Mus musculus 38-41 26456104-6 2015 We describe the pertinence of HFE and HFE to mechanisms of iron homeostasis, the origin and fixation of HFE polymorphisms in European and other populations, and the genetic and biochemical basis of HFE hemochromatosis and iron overload. Iron 59-63 homeostatic iron regulator Mus musculus 38-41 25609138-12 2015 Single Hjv(-)/(-) and double Hfe(-)/(-)Hjv(-)/(-) mice exhibit comparable iron overload. Iron 74-78 homeostatic iron regulator Mus musculus 29-32 24658816-2 2014 Hepatic TFR2, together with HFE, activates the transcription of the iron-regulator hepcidin, while erythroid TFR2 is a member of the erythropoietin receptor complex. Iron 68-72 homeostatic iron regulator Mus musculus 28-31 25609138-0 2015 Hfe and Hjv exhibit overlapping functions for iron signaling to hepcidin. Iron 46-50 homeostatic iron regulator Mus musculus 0-3 25609138-7 2015 As expected, Hfe (-)/(-) and Hjv (-)/(-) mice developed relatively mild or severe iron overload, respectively, which corresponded to the degree of hepcidin inhibition. Iron 82-86 homeostatic iron regulator Mus musculus 13-16 25609138-8 2015 The double Hfe (-)/(-) Hjv (-)/(-) mice exhibited an indistinguishable phenotype to single Hjv (-)/(-) counterparts with regard to suppression of hepcidin, serum and hepatic iron overload, splenic iron deficiency, tissue iron metabolism, and Smad signaling, under both dietary regimens. Iron 174-178 homeostatic iron regulator Mus musculus 11-14 25609138-8 2015 The double Hfe (-)/(-) Hjv (-)/(-) mice exhibited an indistinguishable phenotype to single Hjv (-)/(-) counterparts with regard to suppression of hepcidin, serum and hepatic iron overload, splenic iron deficiency, tissue iron metabolism, and Smad signaling, under both dietary regimens. Iron 197-201 homeostatic iron regulator Mus musculus 11-14 25609138-10 2015 Our results provide genetic evidence that Hfe and Hjv operate in the same pathway for the regulation of hepcidin expression and iron metabolism. Iron 128-132 homeostatic iron regulator Mus musculus 42-45 25427953-3 2015 Murine hfe knockout models have demonstrated that strain background has a strong effect on the severity of iron loading. Iron 107-111 homeostatic iron regulator Mus musculus 7-10 25427953-4 2015 We noted that hepatic iron loading in hfe-/- mice occurs primarily over the first postnatal weeks (loading phase) followed by a timeframe of relatively static iron concentrations (plateau phase). Iron 22-26 homeostatic iron regulator Mus musculus 38-41 23592271-3 2013 We efficiently detected small differences in macrophage steady-state iron levels in Hfe (-/-) mice as well as inflammation-induced iron sequestration upon lipopolysaccharide instillation. Iron 69-73 homeostatic iron regulator Mus musculus 84-87 24284962-9 2014 Our results demonstrate that Hfe and Tfr2 play separate roles in the regulatory responses to iron compartmentalized in different cell types and further elucidates the regulatory mechanisms controlling iron homeostasis. Iron 93-97 homeostatic iron regulator Mus musculus 29-32 24284962-9 2014 Our results demonstrate that Hfe and Tfr2 play separate roles in the regulatory responses to iron compartmentalized in different cell types and further elucidates the regulatory mechanisms controlling iron homeostasis. Iron 201-205 homeostatic iron regulator Mus musculus 29-32 24155934-3 2013 This model of iron sensing which centers upon the requirement for an interaction between HFE and TFR2 has recently been questioned with in vivo studies in mice from our laboratory and others which suggest that Hfe and Tfr2 can regulate hepcidin independently of each other. Iron 14-18 homeostatic iron regulator Mus musculus 89-92 24155934-3 2013 This model of iron sensing which centers upon the requirement for an interaction between HFE and TFR2 has recently been questioned with in vivo studies in mice from our laboratory and others which suggest that Hfe and Tfr2 can regulate hepcidin independently of each other. Iron 14-18 homeostatic iron regulator Mus musculus 210-213 23705020-1 2013 Hereditary hemochromatosis, an iron overload disease associated with excessive intestinal iron absorption, is commonly caused by loss of HFE gene function. Iron 31-35 homeostatic iron regulator Mus musculus 137-140 23922777-8 2013 Opposite to Tmprss6 KO mice, Hfe(-/-) mice are characterized by iron overload with inappropriately low hepcidin levels. Iron 64-68 homeostatic iron regulator Mus musculus 29-32 23874600-7 2013 Inhibition of beta2-M or HFE sensitized prostate cancer cells to radiation by increasing iron and reactive oxygen species and decreasing DNA repair and stress response proteins. Iron 89-93 homeostatic iron regulator Mus musculus 25-28 23429074-0 2013 A mutation in the HFE gene is associated with altered brain iron profiles and increased oxidative stress in mice. Iron 60-64 homeostatic iron regulator Mus musculus 18-21 23705020-7 2013 Intestinal absorption of (59)Fe was increased and clearance of injected (59)Fe was also increased in Hfe(-/-) mice compared to controls. Iron 29-31 homeostatic iron regulator Mus musculus 101-104 23705020-7 2013 Intestinal absorption of (59)Fe was increased and clearance of injected (59)Fe was also increased in Hfe(-/-) mice compared to controls. Iron 76-78 homeostatic iron regulator Mus musculus 101-104 23705020-1 2013 Hereditary hemochromatosis, an iron overload disease associated with excessive intestinal iron absorption, is commonly caused by loss of HFE gene function. Iron 90-94 homeostatic iron regulator Mus musculus 137-140 23705020-3 2013 Loss of HFE function is known to alter the intestinal expression of DMT1 (divalent metal transporter-1) and Fpn (ferroportin), transporters that have been implicated in absorption of both iron and manganese. Iron 188-192 homeostatic iron regulator Mus musculus 8-11 23223430-1 2013 Mutations in HFE lead to hereditary hemochromatosis (HH) because of inappropriately high iron uptake from the diet resulting from decreased hepatic expression of the iron-regulatory hormone hepcidin. Iron 89-93 homeostatic iron regulator Mus musculus 13-16 23524968-7 2013 ASO treatment in mice affected by hemochromatosis (Hfe(-/-)) significantly decreased serum iron, transferrin saturation and liver iron accumulation. Iron 91-95 homeostatic iron regulator Mus musculus 51-54 23524968-7 2013 ASO treatment in mice affected by hemochromatosis (Hfe(-/-)) significantly decreased serum iron, transferrin saturation and liver iron accumulation. Iron 130-134 homeostatic iron regulator Mus musculus 51-54 23223430-5 2013 In the present study, we demonstrate that LNP-Tmprss6 siRNA treatment of Hfe(-/-) and Hbb(th3/+) mice induces hepcidin and diminishes tissue and serum iron levels. Iron 151-155 homeostatic iron regulator Mus musculus 73-76 23169885-1 2013 PURPOSE: Hemochromatosis is a disorder of iron overload arising mostly from mutations in HFE. Iron 42-46 homeostatic iron regulator Mus musculus 89-92 23169885-2 2013 HFE is expressed in retinal pigment epithelium (RPE), and Hfe(-/-) mice develop age-related iron accumulation and retinal degeneration associated with RPE hyperproliferation. Iron 92-96 homeostatic iron regulator Mus musculus 58-61 22858058-9 2012 Iron deposition in the pancreas and heart occurred after maximal iron loading of the liver was reached and was most marked in the Hfe(-/-)/Tfr2(-/-) mice. Iron 0-4 homeostatic iron regulator Mus musculus 130-133 22960056-4 2013 This regulatory circuitry is disconnected by iron treatment of Hfe-/- and Hfe/TfR2 mice that significantly increases hepatic iron levels as well as hepcidin, Smad6 and Smad7 mRNA expression but fails to augment pSmad1/5/8 levels. Iron 45-49 homeostatic iron regulator Mus musculus 63-66 22960056-4 2013 This regulatory circuitry is disconnected by iron treatment of Hfe-/- and Hfe/TfR2 mice that significantly increases hepatic iron levels as well as hepcidin, Smad6 and Smad7 mRNA expression but fails to augment pSmad1/5/8 levels. Iron 45-49 homeostatic iron regulator Mus musculus 74-77 22960056-4 2013 This regulatory circuitry is disconnected by iron treatment of Hfe-/- and Hfe/TfR2 mice that significantly increases hepatic iron levels as well as hepcidin, Smad6 and Smad7 mRNA expression but fails to augment pSmad1/5/8 levels. Iron 125-129 homeostatic iron regulator Mus musculus 63-66 22960056-4 2013 This regulatory circuitry is disconnected by iron treatment of Hfe-/- and Hfe/TfR2 mice that significantly increases hepatic iron levels as well as hepcidin, Smad6 and Smad7 mRNA expression but fails to augment pSmad1/5/8 levels. Iron 125-129 homeostatic iron regulator Mus musculus 74-77 22580926-3 2012 The iron regulatory protein 2 (Irp2) and one of the genes mutated in hereditary hemochromatosis Hfe , are both proteins involved in the regulation of systemic iron homeostasis. Iron 4-8 homeostatic iron regulator Mus musculus 96-99 22531912-1 2012 HFE, an MHC class Ib molecule that controls iron metabolism, can be directly targeted by cytotoxic TCR alphabeta T lymphocytes. Iron 44-48 homeostatic iron regulator Mus musculus 0-3 22383097-7 2012 Hfe(-/-) xTfr2(mut) mice had elevated hepatic iron with a periportal distribution and increased plasma iron, transferrin saturation, and non-transferrin-bound iron, compared with Hfe(-/-), Tfr2(mut), and wild-type (WT) mice. Iron 46-50 homeostatic iron regulator Mus musculus 0-3 22383097-7 2012 Hfe(-/-) xTfr2(mut) mice had elevated hepatic iron with a periportal distribution and increased plasma iron, transferrin saturation, and non-transferrin-bound iron, compared with Hfe(-/-), Tfr2(mut), and wild-type (WT) mice. Iron 103-107 homeostatic iron regulator Mus musculus 0-3 22383097-13 2012 CONCLUSION: Disruption of both Hfe and Tfr2 caused more severe hepatic iron overload with more advanced lipid peroxidation, inflammation, and portal fibrosis than was observed with the disruption of either gene alone. Iron 71-75 homeostatic iron regulator Mus musculus 31-34 22383097-14 2012 The Hfe(-/-) xTfr2(mut) mouse model of iron-induced liver injury reflects the liver injury phenotype observed in human HH. Iron 39-43 homeostatic iron regulator Mus musculus 4-7 22465035-0 2012 Quantitative magnetic analysis reveals ferritin-like iron as the most predominant iron-containing species in the murine Hfe-haemochromatosis. Iron 53-57 homeostatic iron regulator Mus musculus 120-123 22465035-0 2012 Quantitative magnetic analysis reveals ferritin-like iron as the most predominant iron-containing species in the murine Hfe-haemochromatosis. Iron 82-86 homeostatic iron regulator Mus musculus 120-123 22465035-1 2012 Quantitative analysis of the temperature dependent AC magnetic susceptibility of freeze-dried mouse tissues from an Hfe hereditary haemochromatosis disease model indicates that iron predominantly appears biomineralised, like in the ferritin cores, in the liver, the spleen and duodenum. Iron 177-181 homeostatic iron regulator Mus musculus 116-119 22370144-0 2012 Brain transcriptome perturbations in the Hfe(-/-) mouse model of genetic iron loading. Iron 73-77 homeostatic iron regulator Mus musculus 41-44 22370144-4 2012 The Hfe(-/-) mouse brain showed numerous significant changes in transcript levels (p<0.05) although few of these related to proteins directly involved in iron homeostasis. Iron 157-161 homeostatic iron regulator Mus musculus 4-7 21817060-1 2011 The HFE protein plays a crucial role in the control of cellular iron homeostasis. Iron 64-68 homeostatic iron regulator Mus musculus 4-7 21943374-1 2012 Haemochromatosis is a genetic disorder of iron overload resulting from loss-of-function mutations in genes coding for the iron-regulatory proteins HFE (human leucocyte antigen-like protein involved in iron homoeostasis), transferrin receptor 2, ferroportin, hepcidin and HJV (haemojuvelin). Iron 42-46 homeostatic iron regulator Mus musculus 147-150 21943374-1 2012 Haemochromatosis is a genetic disorder of iron overload resulting from loss-of-function mutations in genes coding for the iron-regulatory proteins HFE (human leucocyte antigen-like protein involved in iron homoeostasis), transferrin receptor 2, ferroportin, hepcidin and HJV (haemojuvelin). Iron 122-126 homeostatic iron regulator Mus musculus 147-150 22244935-1 2012 Cell surface proteins Hfe, Tfr2, hemojuvelin and Tmprss6 play key roles in iron homeostasis. Iron 75-79 homeostatic iron regulator Mus musculus 22-25 22745741-2 2012 Here we investigate how imbalanced systemic iron homeostasis in a murine disease model of hereditary hemochromatosis (Hfe(-/-) mice) affects the inflammatory responses of the lung. Iron 44-48 homeostatic iron regulator Mus musculus 118-121 21817060-2 2011 Steatosis is commonly observed in HFE-related iron-overload disorders, and current evidence suggests a causal link between iron and steatosis. Iron 46-50 homeostatic iron regulator Mus musculus 34-37 21817060-2 2011 Steatosis is commonly observed in HFE-related iron-overload disorders, and current evidence suggests a causal link between iron and steatosis. Iron 123-127 homeostatic iron regulator Mus musculus 34-37 21817060-9 2011 In conclusion, our results demonstrate that Hfe(-/-) mice show defective hepatic-intestinal iron and lipid signaling, which predispose them toward diet-induced hepatic lipotoxicity, accompanied by an accelerated progression of injury to fibrosis. Iron 92-96 homeostatic iron regulator Mus musculus 44-47 21364282-4 2011 Moreover, miR-122 inhibition increased the amount of mRNA transcribed by genes that control systemic iron levels, such as hemochromatosis (Hfe), hemojuvelin (Hjv), bone morphogenetic protein receptor type 1A (Bmpr1a), and Hamp. Iron 101-105 homeostatic iron regulator Mus musculus 139-142 21745449-1 2011 BACKGROUND & AIMS: HFE and transferrin receptor 2 (TFR2) are each necessary for the normal relationship between body iron status and liver hepcidin expression. Iron 121-125 homeostatic iron regulator Mus musculus 23-26 21745449-11 2011 CONCLUSIONS: These observations show that Tfr2 and Hfe are each required for normal signaling of iron status to hepcidin via the Bmp6/Smad1,5,8 pathway. Iron 97-101 homeostatic iron regulator Mus musculus 51-54 21745449-12 2011 Mice with combined loss of Hfe and Tfr2 up-regulate hepcidin in response to dietary iron loading without increases in liver Bmp6 messenger RNA or steady-state P-Smad1,5,8 levels. Iron 84-88 homeostatic iron regulator Mus musculus 27-30 21355094-1 2011 The hereditary hemochromatosis protein HFE promotes the expression of hepcidin, a circulating hormone produced by the liver that inhibits dietary iron absorption and macrophage iron release. Iron 146-150 homeostatic iron regulator Mus musculus 39-42 21355094-1 2011 The hereditary hemochromatosis protein HFE promotes the expression of hepcidin, a circulating hormone produced by the liver that inhibits dietary iron absorption and macrophage iron release. Iron 177-181 homeostatic iron regulator Mus musculus 39-42 21355094-4 2011 In the present study, we used genetic approaches in mice to examine the relationship between Hfe and Tmprss6 in the regulation of systemic iron homeostasis. Iron 139-143 homeostatic iron regulator Mus musculus 93-96 21427356-4 2011 beta2-M interacts with its receptor, hemochromatosis (HFE) protein, to modulate iron responsive pathways in cancer cells. Iron 80-84 homeostatic iron regulator Mus musculus 54-57 21480335-2 2011 Mutations in HFE, transferrin receptor 2 (Tfr2), hemojuvelin (HJV), or bone morphogenetic protein 6 (BMP6) prevent appropriate hepcidin response to iron, allowing increased absorption of dietary iron, and eventually iron overload. Iron 148-152 homeostatic iron regulator Mus musculus 13-16 21480335-2 2011 Mutations in HFE, transferrin receptor 2 (Tfr2), hemojuvelin (HJV), or bone morphogenetic protein 6 (BMP6) prevent appropriate hepcidin response to iron, allowing increased absorption of dietary iron, and eventually iron overload. Iron 195-199 homeostatic iron regulator Mus musculus 13-16 21480335-2 2011 Mutations in HFE, transferrin receptor 2 (Tfr2), hemojuvelin (HJV), or bone morphogenetic protein 6 (BMP6) prevent appropriate hepcidin response to iron, allowing increased absorption of dietary iron, and eventually iron overload. Iron 195-199 homeostatic iron regulator Mus musculus 13-16 21480335-4 2011 After 1-day (acute) iron challenge, Hfe(-/-) mice showed a smaller hepcidin increase than their wild-type strain-matched controls, Bmp6(-/-) mice showed nearly no increase, and Tfr2 and Hjv mutant mice showed no increase in hepcidin expression, indicating that all four proteins participate in hepcidin regulation by acute iron changes. Iron 20-24 homeostatic iron regulator Mus musculus 36-39 20976594-10 2011 RESULTS: There was a significant increase in hepatic iron concentration and bone iron content in HFE (-/-) mice. Iron 53-57 homeostatic iron regulator Mus musculus 97-100 20976594-10 2011 RESULTS: There was a significant increase in hepatic iron concentration and bone iron content in HFE (-/-) mice. Iron 81-85 homeostatic iron regulator Mus musculus 97-100 21292994-7 2011 When challenged with the high-iron diet, Bmp6 and Hfe expression was significantly increased. Iron 30-34 homeostatic iron regulator Mus musculus 50-53 21480335-5 2011 After a 21-day (chronic) iron challenge, Hfe and Tfr2 mutant mice increased hepcidin expression to nearly wild-type levels, but a blunted increase of hepcidin was seen in Bmp6(-/-) and Hjv(-/-) mice. Iron 25-29 homeostatic iron regulator Mus musculus 41-44 21480335-8 2011 CONCLUSION: TfR2, HJV, BMP6, and, to a lesser extent, HFE are required for the hepcidin response to acute iron loading, but are partially redundant for hepcidin regulation during chronic iron loading and are not involved in the regulation of BMP6 expression. Iron 106-110 homeostatic iron regulator Mus musculus 54-57 21059897-0 2011 Enhanced erythropoiesis in Hfe-KO mice indicates a role for Hfe in the modulation of erythroid iron homeostasis. Iron 95-99 homeostatic iron regulator Mus musculus 60-63 21059897-1 2011 In hereditary hemochromatosis, mutations in HFE lead to iron overload through abnormally low levels of hepcidin. Iron 56-60 homeostatic iron regulator Mus musculus 44-47 21059897-2 2011 In addition, HFE potentially modulates cellular iron uptake by interacting with transferrin receptor, a crucial protein during erythropoiesis. Iron 48-52 homeostatic iron regulator Mus musculus 13-16 21059897-4 2011 We hypothesize that HFE modulates erythropoiesis by affecting dietary iron absorption and erythroid iron intake. Iron 70-74 homeostatic iron regulator Mus musculus 20-23 21059897-4 2011 We hypothesize that HFE modulates erythropoiesis by affecting dietary iron absorption and erythroid iron intake. Iron 100-104 homeostatic iron regulator Mus musculus 20-23 21059897-5 2011 To investigate this, we used Hfe-KO mice in conditions of altered dietary iron and erythropoiesis. Iron 74-78 homeostatic iron regulator Mus musculus 29-32 21059897-6 2011 We show that Hfe-KO mice can overcome phlebotomy-induced anemia more rapidly than wild-type mice (even when iron loaded). Iron 108-112 homeostatic iron regulator Mus musculus 13-16 21059897-8 2011 Our results suggest that lack of Hfe is advantageous in conditions of increased erythropoietic activity because of augmented iron mobilization driven by deficient hepcidin response. Iron 125-129 homeostatic iron regulator Mus musculus 33-36 21059897-9 2011 Lastly, we demonstrate that Hfe is expressed in erythroid cells and impairs iron uptake, whereas its absence exclusively from the hematopoietic compartment is sufficient to accelerate recovery from phlebotomy. Iron 76-80 homeostatic iron regulator Mus musculus 28-31 21059897-10 2011 In summary, we demonstrate that Hfe influences erythropoiesis by 2 distinct mechanisms: limiting hepcidin expression under conditions of simultaneous iron overload and stress erythropoiesis, and impairing transferrin-bound iron uptake by erythroid cells. Iron 150-154 homeostatic iron regulator Mus musculus 32-35 21059897-10 2011 In summary, we demonstrate that Hfe influences erythropoiesis by 2 distinct mechanisms: limiting hepcidin expression under conditions of simultaneous iron overload and stress erythropoiesis, and impairing transferrin-bound iron uptake by erythroid cells. Iron 223-227 homeostatic iron regulator Mus musculus 32-35 20712796-0 2010 Hepcidin and Hfe in iron overload in beta-thalassemia. Iron 20-24 homeostatic iron regulator Mus musculus 13-16 20712796-4 2010 We also showed that the iron metabolism gene Hfe is down-regulated in concert with hepcidin in th3/+ mice. Iron 24-28 homeostatic iron regulator Mus musculus 45-48 20712796-6 2010 Therefore, these studies suggest that increasing hepcidin and/or Hfe expression could be a strategy to reduces iron overload in these animals. Iron 111-115 homeostatic iron regulator Mus musculus 65-68 20542038-5 2010 In mice, deletion of the iron hormone hepcidin and any of 8 genes that regulate its biology, including Hfe, transferrin receptor 2 (Tfr2), and hemojuvelin (Hjv) (which all sense the accumulation of iron that hepcidin corrects) or ferroportin (Fpn) (the cellular iron exporter down-regulated by hepcidin), cause iron overload but not organ disease. Iron 25-29 homeostatic iron regulator Mus musculus 103-106 20542038-5 2010 In mice, deletion of the iron hormone hepcidin and any of 8 genes that regulate its biology, including Hfe, transferrin receptor 2 (Tfr2), and hemojuvelin (Hjv) (which all sense the accumulation of iron that hepcidin corrects) or ferroportin (Fpn) (the cellular iron exporter down-regulated by hepcidin), cause iron overload but not organ disease. Iron 198-202 homeostatic iron regulator Mus musculus 103-106 20542038-5 2010 In mice, deletion of the iron hormone hepcidin and any of 8 genes that regulate its biology, including Hfe, transferrin receptor 2 (Tfr2), and hemojuvelin (Hjv) (which all sense the accumulation of iron that hepcidin corrects) or ferroportin (Fpn) (the cellular iron exporter down-regulated by hepcidin), cause iron overload but not organ disease. Iron 198-202 homeostatic iron regulator Mus musculus 103-106 20542038-5 2010 In mice, deletion of the iron hormone hepcidin and any of 8 genes that regulate its biology, including Hfe, transferrin receptor 2 (Tfr2), and hemojuvelin (Hjv) (which all sense the accumulation of iron that hepcidin corrects) or ferroportin (Fpn) (the cellular iron exporter down-regulated by hepcidin), cause iron overload but not organ disease. Iron 198-202 homeostatic iron regulator Mus musculus 103-106 20338170-4 2010 RESULTS: At 6-8 months after OLT, Hfe(-/-) mice that received Hfe(-/-) livers maintained the hemochromatosis phenotype: iron accumulation in hepatocytes but not Kupffer cells (KC), increased transferrin levels, and low levels of iron in the spleen. Iron 120-124 homeostatic iron regulator Mus musculus 34-37 20338170-4 2010 RESULTS: At 6-8 months after OLT, Hfe(-/-) mice that received Hfe(-/-) livers maintained the hemochromatosis phenotype: iron accumulation in hepatocytes but not Kupffer cells (KC), increased transferrin levels, and low levels of iron in the spleen. Iron 229-233 homeostatic iron regulator Mus musculus 34-37 20338170-1 2010 BACKGROUND & AIMS: Hemochromatosis is a common hereditary disease caused by mutations in HFE and characterized by increased absorption of iron in the intestine. Iron 142-146 homeostatic iron regulator Mus musculus 93-96 20338170-5 2010 Hfe(+/+) mice that received Hfe(-/-) livers had increased levels of iron in serum and liver and low levels of iron in spleen. Iron 68-72 homeostatic iron regulator Mus musculus 0-3 20338170-5 2010 Hfe(+/+) mice that received Hfe(-/-) livers had increased levels of iron in serum and liver and low levels of iron in spleen. Iron 68-72 homeostatic iron regulator Mus musculus 28-31 20338170-5 2010 Hfe(+/+) mice that received Hfe(-/-) livers had increased levels of iron in serum and liver and low levels of iron in spleen. Iron 110-114 homeostatic iron regulator Mus musculus 0-3 20338170-5 2010 Hfe(+/+) mice that received Hfe(-/-) livers had increased levels of iron in serum and liver and low levels of iron in spleen. Iron 110-114 homeostatic iron regulator Mus musculus 28-31 20338170-7 2010 Transplantation of Hfe(+/+) livers into Hfe(-/-) mice prevented hepatic iron accumulation but did not return spleen and plasma levels of iron to normal; KCs still appeared to be iron poor, despite normal hepcidin expression. Iron 72-76 homeostatic iron regulator Mus musculus 19-22 20338170-8 2010 CONCLUSIONS: In Hfe(-/-) mice, transplantation of livers from Hfe(+/+) mice reversed the iron-loading phenotype associated with hemochromatosis (regardless of Hfe expression in intestine). Iron 89-93 homeostatic iron regulator Mus musculus 62-65 20338170-8 2010 CONCLUSIONS: In Hfe(-/-) mice, transplantation of livers from Hfe(+/+) mice reversed the iron-loading phenotype associated with hemochromatosis (regardless of Hfe expression in intestine). Iron 89-93 homeostatic iron regulator Mus musculus 62-65 20338170-10 2010 These findings indicate an independent, iron-modifying effect of HFE in KCs. Iron 40-44 homeostatic iron regulator Mus musculus 65-68 20177050-5 2010 Expression of Hfe in Hfe-null mice both increased Hfe and hepcidin mRNA and lowered hepatic iron and Tf saturation. Iron 92-96 homeostatic iron regulator Mus musculus 14-17 20456487-5 2010 RESULTS: Hepcidin reverted the high plasma iron concentrations in Hfe(-/-) mice to normal values. Iron 43-47 homeostatic iron regulator Mus musculus 66-69 20177050-5 2010 Expression of Hfe in Hfe-null mice both increased Hfe and hepcidin mRNA and lowered hepatic iron and Tf saturation. Iron 92-96 homeostatic iron regulator Mus musculus 21-24 20177050-5 2010 Expression of Hfe in Hfe-null mice both increased Hfe and hepcidin mRNA and lowered hepatic iron and Tf saturation. Iron 92-96 homeostatic iron regulator Mus musculus 21-24 20177050-7 2010 Expression of Hfe in wild-type mice increased hepcidin mRNA and lowered iron levels. Iron 72-76 homeostatic iron regulator Mus musculus 14-17 20110460-0 2010 Hemochromatosis and pregnancy: iron stores in the Hfe-/- mouse are not reduced by multiple pregnancies. Iron 31-35 homeostatic iron regulator Mus musculus 50-53 20110460-5 2010 The Hfe-/- mouse model recapitulates key aspects of HH, including an iron overload phenotype similar to that observed in human patients. Iron 69-73 homeostatic iron regulator Mus musculus 4-7