PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22732705-7	2012	AA release diminished as the association of cyclooxygenase-2 increased in microsomes from retinas exposed to iron.	Iron	109-113	prostaglandin-endoperoxide synthase 2	Homo sapiens	44-60	
16527254-7	2006	This result suggested that the iron chelating function of DFX was important to induce the increase of COX-2 and HIF-1alpha protein.	Iron	31-35	prostaglandin-endoperoxide synthase 2	Homo sapiens	102-107	
20045320-4	2010	Molecular modeling studies showed that the N-difluoromethyl-1,2-dihydropyridin-2-one moiety present in 9a inserts into the secondary pocket present in COX-2 to confer COX-2 selectivity, and that the N-difluoromethyl-1,2-dihydropyrid-2-one group (9a) binds close to the region of the 15-LOX enzyme containing catalytic iron (His361, His366).	Iron	318-322	prostaglandin-endoperoxide synthase 2	Homo sapiens	151-156	
16527254-10	2006	Together, our findings suggest that iron metabolism may regulate stabilization of HIF-1alpha protein by modulating cyclooxygenase-2 signaling pathway.	Iron	36-40	prostaglandin-endoperoxide synthase 2	Homo sapiens	115-131	
12842821-5	2003	However, iron/ascorbate-mediated lipid peroxidation promoted inhibitor-kappaB degradation and NF-kappaB activation, as well as gave rise to IL-8, cyclooxygenase-2, and ICAM-1.	Iron	9-13	prostaglandin-endoperoxide synthase 2	Homo sapiens	146-162	
11352890-5	2001	Increased release of AA in iron-overloaded NRVMs was reduced by the diacylglycerol lipase inhibitor RHC80267 but was largely insensitive to inhibitors of phospholipases A(2) and C. Iron-overloaded cardiomyocytes also displayed increased production of eicosanoids and induction of cyclooxygenase-2 after stimulation with interleukin-1alpha.	Iron	27-31	prostaglandin-endoperoxide synthase 2	Homo sapiens	280-296