PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30182051-2 2018 Hephaestin (HEPH), the only MCF known to be expressed in enterocytes, aids in the basolateral transfer of dietary iron to the blood. Iron 114-118 hephaestin Mus musculus 0-10 30060949-3 2018 Compared with wild-type (WT) mice, Heph/Cp mice at both ages presented with severe anemia and significantly lower iron level in the serum and spleen, but with significantly higher iron level in the liver, heart, kidney, and duodenal enterocytes. Iron 114-118 hephaestin Mus musculus 35-39 30060949-3 2018 Compared with wild-type (WT) mice, Heph/Cp mice at both ages presented with severe anemia and significantly lower iron level in the serum and spleen, but with significantly higher iron level in the liver, heart, kidney, and duodenal enterocytes. Iron 180-184 hephaestin Mus musculus 35-39 30060949-6 2018 Together, our results suggest that ablation of HEPH and CP could lead to severe systemic iron deficiency and local tissue iron overload, which disrupt the whole body iron homeostasis and impact on tissue functions. Iron 89-93 hephaestin Mus musculus 47-51 30060949-6 2018 Together, our results suggest that ablation of HEPH and CP could lead to severe systemic iron deficiency and local tissue iron overload, which disrupt the whole body iron homeostasis and impact on tissue functions. Iron 122-126 hephaestin Mus musculus 47-51 31263155-2 2019 Our previous work has shown that hephaestin (Heph) and ceruloplasmin (Cp) double knockout (KO) mice induced iron accumulation in multiple brain regions and that this was paralleled by increased oxidative damage and deficits in cognition and memory. Iron 108-112 hephaestin Mus musculus 33-43 31263155-2 2019 Our previous work has shown that hephaestin (Heph) and ceruloplasmin (Cp) double knockout (KO) mice induced iron accumulation in multiple brain regions and that this was paralleled by increased oxidative damage and deficits in cognition and memory. Iron 108-112 hephaestin Mus musculus 45-49 31263155-6 2019 The expression of Heph, Cp, and other iron-related genes was examined in astrocytes and oligodendrocytes both with and without iron treatment. Iron 127-131 hephaestin Mus musculus 18-22 31263155-8 2019 Our findings collectively demonstrate that HEPH and CP are important for the prevention of glial iron accumulation and thus may be protective against oxidative damage. Iron 97-101 hephaestin Mus musculus 43-47 29883959-0 2018 Ceruloplasmin and hephaestin jointly protect the exocrine pancreas against oxidative damage by facilitating iron efflux. Iron 108-112 hephaestin Mus musculus 18-28 29883959-7 2018 These data indicate that HEPH and CP play mutually compensatory roles in facilitating iron efflux from the exocrine pancreas, and show that MCFs are able to protect the pancreas against iron-induced oxidative damage. Iron 86-90 hephaestin Mus musculus 25-29 29883959-7 2018 These data indicate that HEPH and CP play mutually compensatory roles in facilitating iron efflux from the exocrine pancreas, and show that MCFs are able to protect the pancreas against iron-induced oxidative damage. Iron 186-190 hephaestin Mus musculus 25-29 29355933-0 2018 Ablation of hephaestin and ceruloplasmin results in iron accumulation in adipocytes and type 2 diabetes. Iron 52-56 hephaestin Mus musculus 12-22 29659961-8 2018 Results: Iron concentration was significantly higher in Heph/Cp KO mice than in WT control mice at 4 wk of age in the cortex (50%), hippocampus (120%), brainstem (35%), and cerebellum (220%) and at 6 mo of age in the cortex (140%), hippocampus (420%), brainstem (560%), and cerebellum (340%). Iron 9-13 hephaestin Mus musculus 56-60 29355933-7 2018 Together, these results demonstrate the protective roles of HEPH and CP in preventing iron overload in adipocytes. Iron 86-90 hephaestin Mus musculus 60-64 29296776-0 2017 Intestinal hephaestin potentiates iron absorption in weanling, adult, and pregnant mice under physiological conditions. Iron 34-38 hephaestin Mus musculus 11-21 28880952-2 2017 Newly absorbed dietary iron is exported across the enterocyte basolateral membrane by the ferrous iron transporter ferroportin, but hephaestin increases the efficiency of this process by oxidizing the transported iron to its ferric form and promoting its release from ferroportin. Iron 98-102 hephaestin Mus musculus 132-142 28880952-3 2017 Deletion or mutation of the hephaestin gene leads to systemic anemia with iron accumulation in the intestinal epithelium. Iron 74-78 hephaestin Mus musculus 28-38 29296776-3 2017 The process of iron uptake into duodenal enterocytes is relatively well understood, but less is known about the functional coupling between the iron exporter ferroportin 1 and the basolateral membrane iron oxidase hephaestin (Heph). Iron 144-148 hephaestin Mus musculus 214-224 25788583-0 2015 Hephaestin and ceruloplasmin play distinct but interrelated roles in iron homeostasis in mouse brain. Iron 69-73 hephaestin Mus musculus 0-10 27991585-0 2016 Hephaestin and ceruloplasmin facilitate iron metabolism in the mouse kidney. Iron 40-44 hephaestin Mus musculus 0-10 27991585-5 2016 The non-heme iron content both in the renal cortex and medulla of Heph/Cp KO mice was significantly increased. Iron 13-17 hephaestin Mus musculus 66-70 27991585-6 2016 Perls" Prussian blue staining showed iron accumulation on the apical side of renal tubular cells in Heph/Cp KO mice. Iron 37-41 hephaestin Mus musculus 100-104 27991585-10 2016 These results suggest that KO of both the HEPH and CP genes leads to kidney iron deposition and toxicity, MCFs could protect kidney against a damage from iron excess. Iron 76-80 hephaestin Mus musculus 42-46 29296776-5 2017 Furthermore, because ferroportin 1-mediated iron export from some tissues (eg, liver) is impaired in the absence of the Heph homolog, ceruloplasmin, we hypothesized that Heph is rate limiting for intestinal iron absorption, especially when iron demands increase. Iron 44-48 hephaestin Mus musculus 170-174 29296776-5 2017 Furthermore, because ferroportin 1-mediated iron export from some tissues (eg, liver) is impaired in the absence of the Heph homolog, ceruloplasmin, we hypothesized that Heph is rate limiting for intestinal iron absorption, especially when iron demands increase. Iron 207-211 hephaestin Mus musculus 170-174 29296776-5 2017 Furthermore, because ferroportin 1-mediated iron export from some tissues (eg, liver) is impaired in the absence of the Heph homolog, ceruloplasmin, we hypothesized that Heph is rate limiting for intestinal iron absorption, especially when iron demands increase. Iron 207-211 hephaestin Mus musculus 170-174 29296776-7 2017 Results demonstrate that intestinal Heph is essential for optimal iron transport in weanlings and adults of both sexes and during pregnancy, but not in adult mice with iron-deficiency or hemolytic anemia. Iron 66-70 hephaestin Mus musculus 36-40 29296776-8 2017 Moreover, activation of unidentified, intestinal ferroxidases was noted, which may explain why intestinal Heph is not always required for optimal iron absorption. Iron 146-150 hephaestin Mus musculus 106-110 26303407-0 2015 Cp/Heph mutant mice have iron-induced neurodegeneration diminished by deferiprone. Iron 25-29 hephaestin Mus musculus 3-7 26303407-12 2015 Below: In mice with mutation of Cp and Heph, iron accumulates in glia, while neurons have low iron levels. Iron 45-49 hephaestin Mus musculus 39-43 26303407-12 2015 Below: In mice with mutation of Cp and Heph, iron accumulates in glia, while neurons have low iron levels. Iron 94-98 hephaestin Mus musculus 39-43 25788583-4 2015 OBJECTIVE: The aim was to study the role of hephaestin (HEPH) and ceruloplasmin (CP) in CNS iron metabolism and homeostasis. Iron 92-96 hephaestin Mus musculus 44-54 25788583-4 2015 OBJECTIVE: The aim was to study the role of hephaestin (HEPH) and ceruloplasmin (CP) in CNS iron metabolism and homeostasis. Iron 92-96 hephaestin Mus musculus 56-60 16614410-3 2006 The copper requirement of the multicopper ferroxidases hephaestin and ceruloplasmin likely explains this link between copper and iron homeostasis in mammals. Iron 129-133 hephaestin Mus musculus 55-65 22342521-1 2012 Hephaestin (Heph) is a ferroxidase protein that converts ferrous to ferric iron to facilitate cellular iron export by ferroportin. Iron 75-79 hephaestin Mus musculus 0-4 22342521-3 2012 In mice, a combined systemic mutation of Heph and systemic knockout of Cp (Cp(-/-), Heph(sla/sla)) causes retinal iron accumulation and retinal degeneration, with features of human age-related macular degeneration; however, the role of Heph and Cp in the individual retinal cells is unclear. Iron 114-118 hephaestin Mus musculus 41-45 22342521-3 2012 In mice, a combined systemic mutation of Heph and systemic knockout of Cp (Cp(-/-), Heph(sla/sla)) causes retinal iron accumulation and retinal degeneration, with features of human age-related macular degeneration; however, the role of Heph and Cp in the individual retinal cells is unclear. Iron 114-118 hephaestin Mus musculus 84-88 22342521-5 2012 Loss of both Heph and Cp from RPE cells alone results in RPE cell iron accumulation and degeneration. Iron 66-70 hephaestin Mus musculus 13-17 22342521-7 2012 Photoreceptor-specific Heph knockout indicates that the additional iron in the RPE cells does not result from loss of ferroxidases in the photoreceptors, and Cp and Heph play minor roles in photoreceptors. Iron 67-71 hephaestin Mus musculus 23-27 22342521-9 2012 Cp and Heph are necessary for iron export from the retina but are not essential for iron import into the retina. Iron 30-34 hephaestin Mus musculus 7-11 21917813-7 2011 Mice with mutations in the hephaestin gene (sex-linked anemia mice) show iron accumulation in oligodendrocytes in the gray matter, but not in the white matter, and exhibit motor deficits. Iron 73-77 hephaestin Mus musculus 27-37 21917813-10 2011 This was further confirmed in ceruloplasmin/hephaestin double-mutant mice, which show iron accumulation in both gray and white matter oligodendrocytes. Iron 86-90 hephaestin Mus musculus 44-54 24896847-0 2014 The multicopper ferroxidase hephaestin enhances intestinal iron absorption in mice. Iron 59-63 hephaestin Mus musculus 28-38 24896847-1 2014 Hephaestin is a vertebrate multicopper ferroxidase important for the transfer of dietary iron from intestinal cells to the blood. Iron 89-93 hephaestin Mus musculus 0-10 24896847-9 2014 In addition, the similarities of the phenotypes of the whole body and intestine-specific hephaestin knockout mice clarify the important role of hephaestin specifically in intestinal enterocytes in maintaining whole body iron homeostasis. Iron 220-224 hephaestin Mus musculus 144-154 24896847-10 2014 These mouse models will serve as valuable tools to study the role of hephaestin and associated proteins in iron transport in the small intestine and other tissues. Iron 107-111 hephaestin Mus musculus 69-79 22331876-2 2012 However, sex-linked anemia (sla) mice harboring a 194-amino acid deletion in the Heph protein are able to absorb dietary iron despite reduced expression and mislocalization of the mutant protein. Iron 121-125 hephaestin Mus musculus 9-26 22331876-2 2012 However, sex-linked anemia (sla) mice harboring a 194-amino acid deletion in the Heph protein are able to absorb dietary iron despite reduced expression and mislocalization of the mutant protein. Iron 121-125 hephaestin Mus musculus 28-31 22331876-2 2012 However, sex-linked anemia (sla) mice harboring a 194-amino acid deletion in the Heph protein are able to absorb dietary iron despite reduced expression and mislocalization of the mutant protein. Iron 121-125 hephaestin Mus musculus 81-85 19747625-6 2009 In the cerebral cortex and caudate putamen of 80-week-old CP(-/-) mice, the expression of Heph increased significantly whilst iron levels remain normal [Patel BN, Dunn RJ, Jeong SY, Zhu Q, Julien JP, David S. Ceruloplasmin regulates iron levels in the CNS and prevents free radical injury. Iron 233-237 hephaestin Mus musculus 90-94 16274220-2 2005 Mutations in the murine hephaestin gene (sla) produce microcytic, hypochromic anemia that is refractory to oral iron therapy. Iron 112-116 hephaestin Mus musculus 24-34 16271531-2 2005 The paralogous vertebrate ferroxidases ceruloplasmin (Cp) and hephaestin (Heph) are considered to have nonidentical functions in iron transport: plasma Cp drives iron transport from tissue stores while intestinal Heph facilitates iron absorption from the intestinal lumen. Iron 129-133 hephaestin Mus musculus 62-72 16271531-2 2005 The paralogous vertebrate ferroxidases ceruloplasmin (Cp) and hephaestin (Heph) are considered to have nonidentical functions in iron transport: plasma Cp drives iron transport from tissue stores while intestinal Heph facilitates iron absorption from the intestinal lumen. Iron 129-133 hephaestin Mus musculus 74-78 16271531-2 2005 The paralogous vertebrate ferroxidases ceruloplasmin (Cp) and hephaestin (Heph) are considered to have nonidentical functions in iron transport: plasma Cp drives iron transport from tissue stores while intestinal Heph facilitates iron absorption from the intestinal lumen. Iron 162-166 hephaestin Mus musculus 62-72 16271531-2 2005 The paralogous vertebrate ferroxidases ceruloplasmin (Cp) and hephaestin (Heph) are considered to have nonidentical functions in iron transport: plasma Cp drives iron transport from tissue stores while intestinal Heph facilitates iron absorption from the intestinal lumen. Iron 162-166 hephaestin Mus musculus 74-78 16271531-2 2005 The paralogous vertebrate ferroxidases ceruloplasmin (Cp) and hephaestin (Heph) are considered to have nonidentical functions in iron transport: plasma Cp drives iron transport from tissue stores while intestinal Heph facilitates iron absorption from the intestinal lumen. Iron 162-166 hephaestin Mus musculus 62-72 16271531-2 2005 The paralogous vertebrate ferroxidases ceruloplasmin (Cp) and hephaestin (Heph) are considered to have nonidentical functions in iron transport: plasma Cp drives iron transport from tissue stores while intestinal Heph facilitates iron absorption from the intestinal lumen. Iron 162-166 hephaestin Mus musculus 74-78 16271531-7 2005 Regulated relocalization of intestinal Cp may represent a fail-safe mechanism in which Cp shares with Heph responsibility for iron absorption under stress. Iron 126-130 hephaestin Mus musculus 102-106 12547227-2 2002 These animals have a defect in the export of iron from intestinal enterocytes into the circulation and this implicates hephaestin in the basolateral transfer step of iron absorption. Iron 45-49 hephaestin Mus musculus 119-129 14724150-0 2004 Mislocalisation of hephaestin, a multicopper ferroxidase involved in basolateral intestinal iron transport, in the sex linked anaemia mouse. Iron 92-96 hephaestin Mus musculus 19-29 14724150-1 2004 BACKGROUND: Hephaestin is a multicopper ferroxidase required for basolateral transport of iron from enterocytes. Iron 90-94 hephaestin Mus musculus 12-22 14724150-2 2004 Sex linked anaemia (sla) mice have a defect in the release of iron from intestinal enterocytes into the circulation due to an interstitial deletion in the hephaestin gene (heph). Iron 62-66 hephaestin Mus musculus 155-165 15365174-0 2004 Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration. Iron 66-70 hephaestin Mus musculus 32-42 15365174-4 2004 Mice deficient in both Cp and Heph, but not each individually, had a striking, age-dependent increase in retinal pigment epithelium and retinal iron. Iron 144-148 hephaestin Mus musculus 30-34 15365174-7 2004 This pathology indicates that Cp and Heph are critical for CNS iron homeostasis and that loss of Cp and Heph in the mouse leads to age-dependent retinal neurodegeneration, providing a model that can be used to test the therapeutic efficacy of iron chelators and antiangiogenic agents. Iron 63-67 hephaestin Mus musculus 37-41 14751926-1 2004 Hephaestin (Hp) plays an important role in intestinal iron absorption and is predicted to be a ferroxidase based on significant sequence identity to the serum multicopper ferroxidase ceruloplasmin. Iron 54-58 hephaestin Mus musculus 0-10 14751926-6 2004 We suggest that hephaestin, by way of its ferroxidase activity, facilitates iron export from intestinal enterocytes, most likely in cooperation with the basolateral iron transporter, Ireg1. Iron 76-80 hephaestin Mus musculus 16-26 12730111-1 2003 Hephaestin is a membrane-bound multicopper ferroxidase necessary for iron egress from intestinal enterocytes into the circulation. Iron 69-73 hephaestin Mus musculus 0-10 12730111-2 2003 Mice with sex-linked anemia (sla) have a mutant form of Hephaestin and a defect in intestinal basolateral iron transport, which results in iron deficiency and anemia. Iron 106-110 hephaestin Mus musculus 29-32 12730111-4 2003 We compared iron levels and expression of genes involved in iron uptake and storage in sla mice and C57BL/6J mice fed iron-deficient, iron-overload, or control diets. Iron 60-64 hephaestin Mus musculus 87-90 12730111-4 2003 We compared iron levels and expression of genes involved in iron uptake and storage in sla mice and C57BL/6J mice fed iron-deficient, iron-overload, or control diets. Iron 60-64 hephaestin Mus musculus 87-90 12730111-4 2003 We compared iron levels and expression of genes involved in iron uptake and storage in sla mice and C57BL/6J mice fed iron-deficient, iron-overload, or control diets. Iron 60-64 hephaestin Mus musculus 87-90 12730111-5 2003 Both iron-deficient wild-type mice and sla mice showed increased expression of Heph and Ireg1 mRNA, compared to controls, whereas only iron-deficient wild-type mice had increased expression of the brush border transporter Dmt1. Iron 5-9 hephaestin Mus musculus 79-83 12730111-6 2003 Unlike iron-deficient mice, sla mouse enterocytes accumulated nonheme iron and ferritin. Iron 70-74 hephaestin Mus musculus 28-31 12547227-2 2002 These animals have a defect in the export of iron from intestinal enterocytes into the circulation and this implicates hephaestin in the basolateral transfer step of iron absorption. Iron 166-170 hephaestin Mus musculus 119-129 9988272-0 1999 Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse. Iron 63-67 hephaestin Mus musculus 0-10 10791995-5 2000 Similarly, compound mutants deficient in both Hfe and hephaestin (Heph) show less iron loading than do Hfe knockout mice, indicating that iron absorption in hemochromatosis involves the function of Heph as well. Iron 82-86 hephaestin Mus musculus 54-64 10791995-5 2000 Similarly, compound mutants deficient in both Hfe and hephaestin (Heph) show less iron loading than do Hfe knockout mice, indicating that iron absorption in hemochromatosis involves the function of Heph as well. Iron 82-86 hephaestin Mus musculus 66-70 10791995-5 2000 Similarly, compound mutants deficient in both Hfe and hephaestin (Heph) show less iron loading than do Hfe knockout mice, indicating that iron absorption in hemochromatosis involves the function of Heph as well. Iron 138-142 hephaestin Mus musculus 54-64 10791995-5 2000 Similarly, compound mutants deficient in both Hfe and hephaestin (Heph) show less iron loading than do Hfe knockout mice, indicating that iron absorption in hemochromatosis involves the function of Heph as well. Iron 138-142 hephaestin Mus musculus 66-70 10791995-5 2000 Similarly, compound mutants deficient in both Hfe and hephaestin (Heph) show less iron loading than do Hfe knockout mice, indicating that iron absorption in hemochromatosis involves the function of Heph as well. Iron 138-142 hephaestin Mus musculus 198-202 11557513-7 2001 The high sequence conservation between rat and mouse hephaestin is consistent with this protein playing a central role in intestinal iron absorption, although its precise function remains to be determined. Iron 133-137 hephaestin Mus musculus 53-63 9988272-9 1999 We suggest that the hephaestin protein is a multicopper ferroxidase necessary for iron egress from intestinal enterocytes into the circulation and that it is an important link between copper and iron metabolism in mammals. Iron 82-86 hephaestin Mus musculus 20-30 9988272-9 1999 We suggest that the hephaestin protein is a multicopper ferroxidase necessary for iron egress from intestinal enterocytes into the circulation and that it is an important link between copper and iron metabolism in mammals. Iron 195-199 hephaestin Mus musculus 20-30 35202704-2 2022 Retinal iron overload has been reported in several mouse disease models with systemic or neural retina-specific knockout (KO) of homologous ferroxidases ceruloplasmin (Cp) and hephaestin (Heph). Iron 8-12 hephaestin Mus musculus 176-186 35271829-4 2022 In mice, systemic knockout of the ferroxidases ceruloplasmin (Cp) and hephaestin (Heph), which oxidize iron, results in retinal iron accumulation and iron-induced degeneration. Iron 103-107 hephaestin Mus musculus 70-80 35271829-4 2022 In mice, systemic knockout of the ferroxidases ceruloplasmin (Cp) and hephaestin (Heph), which oxidize iron, results in retinal iron accumulation and iron-induced degeneration. Iron 103-107 hephaestin Mus musculus 82-86 35271829-4 2022 In mice, systemic knockout of the ferroxidases ceruloplasmin (Cp) and hephaestin (Heph), which oxidize iron, results in retinal iron accumulation and iron-induced degeneration. Iron 128-132 hephaestin Mus musculus 70-80 35202704-2 2022 Retinal iron overload has been reported in several mouse disease models with systemic or neural retina-specific knockout (KO) of homologous ferroxidases ceruloplasmin (Cp) and hephaestin (Heph). Iron 8-12 hephaestin Mus musculus 188-192 35271829-4 2022 In mice, systemic knockout of the ferroxidases ceruloplasmin (Cp) and hephaestin (Heph), which oxidize iron, results in retinal iron accumulation and iron-induced degeneration. Iron 128-132 hephaestin Mus musculus 82-86 35202704-3 2022 Cp and Heph can potentiate ferroportin (Fpn) mediated cellular iron export. Iron 63-67 hephaestin Mus musculus 7-11 35271829-4 2022 In mice, systemic knockout of the ferroxidases ceruloplasmin (Cp) and hephaestin (Heph), which oxidize iron, results in retinal iron accumulation and iron-induced degeneration. Iron 150-154 hephaestin Mus musculus 70-80 35271829-4 2022 In mice, systemic knockout of the ferroxidases ceruloplasmin (Cp) and hephaestin (Heph), which oxidize iron, results in retinal iron accumulation and iron-induced degeneration. Iron 150-154 hephaestin Mus musculus 82-86 35271829-9 2022 These findings indicate that Heph has a local role in regulating neural retina iron homeostasis, but also suggest that preserved Heph function in either the RPE or systemically mitigates the degeneration phenotype observed in the systemic Cp-/-, Heph-/- mice. Iron 79-83 hephaestin Mus musculus 29-33 35271829-9 2022 These findings indicate that Heph has a local role in regulating neural retina iron homeostasis, but also suggest that preserved Heph function in either the RPE or systemically mitigates the degeneration phenotype observed in the systemic Cp-/-, Heph-/- mice. Iron 79-83 hephaestin Mus musculus 129-133 6498623-5 1984 Iron or cobalt in a 10-fold molar excess predominantly lowered 65Zn transfer in both sla and controls, but in a study of the effect of zinc on iron transport only the uptake of 59Fe in sla mice was lowered by excess zinc in the perfusate. Iron 0-4 hephaestin Mus musculus 85-88 6498623-5 1984 Iron or cobalt in a 10-fold molar excess predominantly lowered 65Zn transfer in both sla and controls, but in a study of the effect of zinc on iron transport only the uptake of 59Fe in sla mice was lowered by excess zinc in the perfusate. Iron 0-4 hephaestin Mus musculus 185-188