PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10497330-4 1999 1]) describes the phenotype of a gene knockout for an enzyme, retinaldehyde dehydrogenase 2 (RALDH-2), that synthesizes retinoic acid (RA) in the early embryo. Tretinoin 120-133 aldehyde dehydrogenase 1 family member A2 Homo sapiens 62-91 10497330-4 1999 1]) describes the phenotype of a gene knockout for an enzyme, retinaldehyde dehydrogenase 2 (RALDH-2), that synthesizes retinoic acid (RA) in the early embryo. Tretinoin 120-133 aldehyde dehydrogenase 1 family member A2 Homo sapiens 93-100 10497330-4 1999 1]) describes the phenotype of a gene knockout for an enzyme, retinaldehyde dehydrogenase 2 (RALDH-2), that synthesizes retinoic acid (RA) in the early embryo. Tretinoin 93-95 aldehyde dehydrogenase 1 family member A2 Homo sapiens 62-91 30790278-25 2019 AUTHORS" CONCLUSIONS: The included studies provide low certainty evidence that IV iron compared with oral iron increases haemoglobin, ferritin and transferrin levels in CKD participants, increases the number of participants who achieve target haemoglobin and reduces ESA requirements. Iron 106-110 transferrin Homo sapiens 147-158 30760082-4 2019 Impaired iron status was defined as ferritin <100 mug/L or transferrin saturation <20%. Iron 9-13 transferrin Homo sapiens 62-73 30760082-6 2019 In multivariate models, greater norepinephrine levels were associated with impaired iron transport (transferrin saturation <20%, odds ratio=2.28; 95% CI [1.19-4.35]; P=0.013), but not with impaired iron storage (ferritin <100 mug/L, odds ratio=1.25; 95% CI [0.73-2.16]; P=0.415). Iron 84-88 transferrin Homo sapiens 100-111 30760082-7 2019 Norepinephrine was a significant predictor of increased iron demand (soluble transferrin receptor, standardized beta-coefficient=0.12; P=0.006) and low transferrin saturation (standardized beta-coefficient=-0.12; P=0.003). Iron 56-60 transferrin Homo sapiens 77-88 30728365-8 2019 We hypothesize that decreased expression of miR-148a in HCC may elevate transferrin-bound iron uptake, increasing cellular iron levels and cell proliferation. Iron 90-94 transferrin Homo sapiens 72-83 30717475-2 2019 Our aim was to assess serum non-transferrin bound iron (NTBI), a toxic biochemical that accumulates in blood when too much iron is absorbed, in Cambodian women who received daily iron supplements in accordance with the 2016 global World Health Organization (WHO) guidelines. Iron 50-54 transferrin Homo sapiens 32-43 30312834-0 2019 Association of SNPs in transferrin and transferrin receptor genes with blood iron levels in human. Iron 77-81 transferrin Homo sapiens 23-34 30312834-0 2019 Association of SNPs in transferrin and transferrin receptor genes with blood iron levels in human. Iron 77-81 transferrin Homo sapiens 39-50 30312834-1 2019 Iron is bound to mobile transferrin (TF) and ferritin in blood. Iron 0-4 transferrin Homo sapiens 24-35 30312834-1 2019 Iron is bound to mobile transferrin (TF) and ferritin in blood. Iron 0-4 transferrin Homo sapiens 37-39 30312834-2 2019 TF receptors (TFRC and TFR2) regulate intracellular iron by delivering iron from TF into the cytoplasm. Iron 52-56 transferrin Homo sapiens 0-2 30312834-2 2019 TF receptors (TFRC and TFR2) regulate intracellular iron by delivering iron from TF into the cytoplasm. Iron 71-75 transferrin Homo sapiens 0-2 30312834-3 2019 In this study, we examined the effects of 10 single nucleotide polymorphisms (SNPs) in each of the genes for TF and TF receptors on blood iron concentrations in Japanese subjects. Iron 138-142 transferrin Homo sapiens 109-111 30312834-3 2019 In this study, we examined the effects of 10 single nucleotide polymorphisms (SNPs) in each of the genes for TF and TF receptors on blood iron concentrations in Japanese subjects. Iron 138-142 transferrin Homo sapiens 116-118 30312834-8 2019 Among the 10 SNPs in TF, TFRC, and TFR2 genes, significant associations were observed between TF genotypes (rs12769) and male iron concentrations. Iron 126-130 transferrin Homo sapiens 21-23 30312834-8 2019 Among the 10 SNPs in TF, TFRC, and TFR2 genes, significant associations were observed between TF genotypes (rs12769) and male iron concentrations. Iron 126-130 transferrin Homo sapiens 25-27 30763826-10 2019 However, in the patients with myocardial iron deposition, there were trends toward higher pretransplant transferrin saturation (TSAT) and more units of red blood cells transfused (uRBC). Iron 41-45 transferrin Homo sapiens 104-115 30828802-0 2019 Iron overload in congenital haemolytic anaemias: role of hepcidin and cytokines and predictive value of ferritin and transferrin saturation. Iron 0-4 transferrin Homo sapiens 117-128 30806852-2 2019 In systemic iron overload, elevated circulating levels of transferrin-bound (TBI) and non-transferrin-bound iron (NTBI) are filtered to the renal proximal tubules, where they may cause injury. Iron 12-16 transferrin Homo sapiens 58-69 30806852-2 2019 In systemic iron overload, elevated circulating levels of transferrin-bound (TBI) and non-transferrin-bound iron (NTBI) are filtered to the renal proximal tubules, where they may cause injury. Iron 12-16 transferrin Homo sapiens 90-101 30806852-2 2019 In systemic iron overload, elevated circulating levels of transferrin-bound (TBI) and non-transferrin-bound iron (NTBI) are filtered to the renal proximal tubules, where they may cause injury. Iron 108-112 transferrin Homo sapiens 90-101 30806852-9 2019 Furthermore, ZIP14 silencing decreased 55Fe uptake after 55Fe-Transferrin exposure (p < 0.05), suggesting ZIP14 could be involved in early endosomal transport of TBI-derived iron into the cytosol. Iron 177-181 transferrin Homo sapiens 62-73 30604643-3 2019 We selected the more promising candidate (H7), based on its ability to inhibit TfR1-mediated iron-loaded transferrin internalization in Raji cells (B-cell lymphoma). Iron 93-97 transferrin Homo sapiens 105-116 30917125-12 2019 PRS-080#22 dose-dependently mobilized serum iron with increases in both serum iron concentration and transferrin saturation. Iron 44-48 transferrin Homo sapiens 101-112 30963028-8 2019 Results: WES revealed gene variants involved in iron absorption and transport, in the transmembrane protease, serine 6 (TMPRSS6) and transferrin (TF) genes; multiple genetic variants in CUBN, which encodes cubilin (a receptor involved in the absorption of vitamin B12 as well as the reabsorption of transferrin-bound iron and vitamin D in the kidneys); SLC25A37 (involved in iron transport into mitochondria) and CD163 (a scavenger receptor involved in hemorrhage resolution). Iron 48-52 transferrin Homo sapiens 146-148 30963028-12 2019 Conclusion: Our findings highlight the potential value of WES to identify heritable risk factors that could affect the reabsorption of transferrin-bound iron in the kidneys causing sustained iron loss, together with inhibition of vitamin B12 absorption and vitamin D reabsorption (CUBN) and iron transport into mitochondria (SLC25A37) as the sole site of heme synthesis. Iron 153-157 transferrin Homo sapiens 135-146 30963028-12 2019 Conclusion: Our findings highlight the potential value of WES to identify heritable risk factors that could affect the reabsorption of transferrin-bound iron in the kidneys causing sustained iron loss, together with inhibition of vitamin B12 absorption and vitamin D reabsorption (CUBN) and iron transport into mitochondria (SLC25A37) as the sole site of heme synthesis. Iron 191-195 transferrin Homo sapiens 135-146 30963028-12 2019 Conclusion: Our findings highlight the potential value of WES to identify heritable risk factors that could affect the reabsorption of transferrin-bound iron in the kidneys causing sustained iron loss, together with inhibition of vitamin B12 absorption and vitamin D reabsorption (CUBN) and iron transport into mitochondria (SLC25A37) as the sole site of heme synthesis. Iron 191-195 transferrin Homo sapiens 135-146 30929390-13 2019 After iron chelation therapy, the values of SF, transferrin saturation, ALT, AST, pro-BNP and LIC of 7 patients were decreased compared with values before iron chelation therapy, and the peripheral blood cell level was increased. Iron 6-10 transferrin Homo sapiens 48-59 30906244-2 2019 Serum melanotransferrin (MTf), a transferrin homolog capable of reversibly binding iron, has been proposed as a biochemical marker of AD. Iron 83-87 transferrin Homo sapiens 12-23 30850661-1 2019 Human transferrin receptor 1 (CD71) guarantees iron supply by endocytosis upon binding of iron-loaded transferrin and ferritin. Iron 47-51 transferrin Homo sapiens 6-17 30850661-1 2019 Human transferrin receptor 1 (CD71) guarantees iron supply by endocytosis upon binding of iron-loaded transferrin and ferritin. Iron 47-51 transferrin Homo sapiens 102-113 30850661-1 2019 Human transferrin receptor 1 (CD71) guarantees iron supply by endocytosis upon binding of iron-loaded transferrin and ferritin. Iron 90-94 transferrin Homo sapiens 6-17 30850661-1 2019 Human transferrin receptor 1 (CD71) guarantees iron supply by endocytosis upon binding of iron-loaded transferrin and ferritin. Iron 90-94 transferrin Homo sapiens 102-113 30623722-6 2019 In patients with systemic iron overload, increased urinary iron levels were associated with elevated circulating iron, as indicated by transferrin saturation (TSAT), and increased body iron, as suggested by plasma ferritin concentrations. Iron 59-63 transferrin Homo sapiens 135-146 30623722-6 2019 In patients with systemic iron overload, increased urinary iron levels were associated with elevated circulating iron, as indicated by transferrin saturation (TSAT), and increased body iron, as suggested by plasma ferritin concentrations. Iron 59-63 transferrin Homo sapiens 135-146 30623722-6 2019 In patients with systemic iron overload, increased urinary iron levels were associated with elevated circulating iron, as indicated by transferrin saturation (TSAT), and increased body iron, as suggested by plasma ferritin concentrations. Iron 59-63 transferrin Homo sapiens 135-146 30623722-8 2019 In systemic iron overload, elevated urinary iron and transferrin levels were associated with increased injury to proximal tubules, indicated by increased urinary kidney injury marker 1 (KIM-1) excretion. Iron 12-16 transferrin Homo sapiens 53-64 30823916-1 2019 BACKGROUND: Iron is administered intravenously (IV) to many dialysis patients at regular intervals and iron stores are evaluated through periodic measurements of ferritin and transferrin saturation (TSAT). Iron 12-16 transferrin Homo sapiens 175-186 30956962-8 2019 The mean serum ferritin and HbA2 levels were significantly lower, while the RDW, sickle Hb, and serum transferrin levels were significantly higher in patients with microcytosis and iron deficiency compared to non-iron deficient subjects (P<0.05). Iron 181-185 transferrin Homo sapiens 102-113 29969719-1 2019 In vertebrates, transferrin (Tf) safely delivers iron through circulation to cells. Iron 49-53 transferrin Homo sapiens 16-27 29969719-1 2019 In vertebrates, transferrin (Tf) safely delivers iron through circulation to cells. Iron 49-53 transferrin Homo sapiens 29-31 29969719-2 2019 Tf-bound iron is incorporated through Tf receptor (TfR) 1-mediated endocytosis. Iron 9-13 transferrin Homo sapiens 0-2 29969719-3 2019 TfR1 can mediate cellular uptake of both Tf and H-ferritin, an iron storage protein. Iron 63-67 transferrin Homo sapiens 0-2 29969719-10 2019 Administration of apo-Tf, which scavenges free iron, has been explored for various clinical conditions including atransferrinemia, iron overload, and tissue ischemia. Iron 47-51 transferrin Homo sapiens 22-24 29969719-10 2019 Administration of apo-Tf, which scavenges free iron, has been explored for various clinical conditions including atransferrinemia, iron overload, and tissue ischemia. Iron 131-135 transferrin Homo sapiens 22-24 30656553-6 2019 The transferrin receptors at the BBB, which are responsible for transporting transferrin-bound iron from the blood into the brain parenchyma, can be used to shuttle therapeutic molecules across the BBB. Iron 95-99 transferrin Homo sapiens 4-15 30656553-6 2019 The transferrin receptors at the BBB, which are responsible for transporting transferrin-bound iron from the blood into the brain parenchyma, can be used to shuttle therapeutic molecules across the BBB. Iron 95-99 transferrin Homo sapiens 77-88 30804745-5 2019 We computed also the Cp:Tf ratio as an index of oxidative stress related to iron metabolism. Iron 76-80 transferrin Homo sapiens 24-26 30782036-4 2019 Iron deficiency anemia was established when ferritin <30microg/l and transferrin saturation <16%. Iron 0-4 transferrin Homo sapiens 69-80 30782036-5 2019 Iron deficiency anemia and anemia of chronic disease were established when ferritin was between 30 and 100microg/l and transferrin saturation <16%. Iron 0-4 transferrin Homo sapiens 119-130 30173950-5 2019 Iron excess develops following hypersideremia and the formation of non-transferrin-bound iron, which targets preferentially parenchymal cells (hepatocytes). Iron 0-4 transferrin Homo sapiens 71-82 30173950-5 2019 Iron excess develops following hypersideremia and the formation of non-transferrin-bound iron, which targets preferentially parenchymal cells (hepatocytes). Iron 89-93 transferrin Homo sapiens 71-82 30650364-2 2019 Mammalian serum transferrin (TF) plays a primary role in delivering iron to cells. Iron 68-72 transferrin Homo sapiens 16-27 30650364-2 2019 Mammalian serum transferrin (TF) plays a primary role in delivering iron to cells. Iron 68-72 transferrin Homo sapiens 29-31 30662950-6 2019 Since toxic iron accumulates in RD, we propose TF supplementation as an adjunctive therapy to surgery for improving the visual outcomes of patients with RD. Iron 12-16 transferrin Homo sapiens 47-49 30970349-8 2019 When iron deficiency (defined as ferritin <100 ng/mL or serum ferritin 100-299 ng/mL and transferrin saturation <20%) is present, current evidence supports treating HF patients with iron deficiency with IV iron. Iron 5-9 transferrin Homo sapiens 92-103 31456203-5 2019 Plasma transferrin (Tf) then carries iron to various tissues and cells. Iron 37-41 transferrin Homo sapiens 7-18 31456203-5 2019 Plasma transferrin (Tf) then carries iron to various tissues and cells. Iron 37-41 transferrin Homo sapiens 20-22 31456206-4 2019 Iron metabolism mainly depends on iron regulatory proteins including ferritin, transferrin and transferrin receptor, hepcidin, ferroportin, lactoferrin. Iron 0-4 transferrin Homo sapiens 79-90 31311016-1 2019 BACKGROUND: Transferrin saturation (TSAT) is an index that represents the iron-binding capacity of transferrin, which is the main transport protein for iron, and is widely used to evaluate iron status. Iron 74-78 transferrin Homo sapiens 12-23 31311016-1 2019 BACKGROUND: Transferrin saturation (TSAT) is an index that represents the iron-binding capacity of transferrin, which is the main transport protein for iron, and is widely used to evaluate iron status. Iron 74-78 transferrin Homo sapiens 99-110 31311016-1 2019 BACKGROUND: Transferrin saturation (TSAT) is an index that represents the iron-binding capacity of transferrin, which is the main transport protein for iron, and is widely used to evaluate iron status. Iron 152-156 transferrin Homo sapiens 12-23 31311016-1 2019 BACKGROUND: Transferrin saturation (TSAT) is an index that represents the iron-binding capacity of transferrin, which is the main transport protein for iron, and is widely used to evaluate iron status. Iron 152-156 transferrin Homo sapiens 99-110 31311016-1 2019 BACKGROUND: Transferrin saturation (TSAT) is an index that represents the iron-binding capacity of transferrin, which is the main transport protein for iron, and is widely used to evaluate iron status. Iron 152-156 transferrin Homo sapiens 12-23 31311016-1 2019 BACKGROUND: Transferrin saturation (TSAT) is an index that represents the iron-binding capacity of transferrin, which is the main transport protein for iron, and is widely used to evaluate iron status. Iron 152-156 transferrin Homo sapiens 99-110 30897319-2 2019 The mobilization of iron stores from macrophage to plasma as holo-transferrin (Tf) from where it is accessible to erythroid precursor cells impacts iron homeostasis. Iron 20-24 transferrin Homo sapiens 66-77 30897319-2 2019 The mobilization of iron stores from macrophage to plasma as holo-transferrin (Tf) from where it is accessible to erythroid precursor cells impacts iron homeostasis. Iron 148-152 transferrin Homo sapiens 66-77 30897319-3 2019 Despite the immediate need for enhanced iron uptake by bone marrow cells, numerous studies have shown that transferrin receptor levels do not rise until more than 24 hours after the onset of hypoxia, suggesting the existence of heretofore unknown rapid response cellular machinery for iron acquisition in the early stages of cellular hypoxia. Iron 285-289 transferrin Homo sapiens 107-118 31318328-1 2019 Transferrin is an iron binding glycoprotein actively involved in the growth and maintenance of cell cycle. Iron 18-22 transferrin Homo sapiens 0-11 30572266-7 2019 Patients with hepatic iron overload had higher mean ferritin levels (1182 ng/mL versus 185 ng/mL, p < 0.0001), transferrin saturation (76% versus 34%, p < 0.0001) and lower survival rates. Iron 22-26 transferrin Homo sapiens 114-125 30402883-7 2019 VL cases had decreased iron uptake by transferrin-dependent and transferrin-independent routes while elevated hepcidin, degraded sole iron exporter ferroportin. Iron 23-27 transferrin Homo sapiens 38-49 30402883-7 2019 VL cases had decreased iron uptake by transferrin-dependent and transferrin-independent routes while elevated hepcidin, degraded sole iron exporter ferroportin. Iron 23-27 transferrin Homo sapiens 64-75 30596656-1 2018 The bloodstream form of the parasite Trypanosoma brucei obtains iron from its mammalian host by receptor-mediated endocytosis of host transferrin through its own unique transferrin receptor (TbTfR). Iron 64-68 transferrin Homo sapiens 134-145 30055098-0 2018 Baseline hepcidin measurement in the differential diagnosis of anaemia for elderly patients and its correlation with the increment of transferrin saturation following an oral iron absorption test. Iron 175-179 transferrin Homo sapiens 134-145 30383305-4 2019 However, animals transfused with 35-day-old RBCs stored at higher temperatures developed plasma elevations in non-transferrin-bound iron and cell-free hemoglobin at 24 and 72 hours. Iron 132-136 transferrin Homo sapiens 114-125 31050989-8 2019 The ceruloplasmin activity and the transferrin saturation in blood plasma by iron were determined by G. Babenko"s method. Iron 77-81 transferrin Homo sapiens 35-46 31050989-11 2019 The saturation of blood plasma transferrin by iron was significantly reduced - for 15.27 % in patients with severe course of influenza stomatitis. Iron 46-50 transferrin Homo sapiens 31-42 20301613-5 1993 DIAGNOSIS/TESTING: The diagnosis of clinical HFE-HH in individuals with clinical findings consistent with HFE-HH and the diagnosis of biochemical HFE-HH are typically based on finding elevated transferrin-iron saturation 45% or higher and serum ferritin concentration above the upper limit of normal (i.e., >300 ng/mL in men and >200 ng/mL in women) and two pathogenic variants on confirmatory HFE molecular genetic testing. Iron 205-209 transferrin Homo sapiens 193-204 30178146-0 2018 Response to Letter to the Editor: "Comment on "Serum Hepcidin and Soluble Transferrin Receptor in the Assessment of Iron Metabolism in Children on a Vegetarian Diet"". Iron 116-120 transferrin Homo sapiens 74-85 30311019-2 2018 These nanoparticles require processing by the reticuloendothelial system to release iron, which is subsequently picked up by the iron-binding protein transferrin and distributed throughout the body, with most of the iron supplied to the bone marrow. Iron 84-88 transferrin Homo sapiens 150-161 30311019-2 2018 These nanoparticles require processing by the reticuloendothelial system to release iron, which is subsequently picked up by the iron-binding protein transferrin and distributed throughout the body, with most of the iron supplied to the bone marrow. Iron 129-133 transferrin Homo sapiens 150-161 30311019-2 2018 These nanoparticles require processing by the reticuloendothelial system to release iron, which is subsequently picked up by the iron-binding protein transferrin and distributed throughout the body, with most of the iron supplied to the bone marrow. Iron 129-133 transferrin Homo sapiens 150-161 30311019-5 2018 In this study, we show that FPC can directly transfer iron to apo-transferrin. Iron 54-58 transferrin Homo sapiens 66-77 30311019-6 2018 Kinetic analyses reveal that FPC donates iron to apo-transferrin with fast binding kinetics. Iron 41-45 transferrin Homo sapiens 53-64 30311019-7 2018 In addition, the crystal structure of transferrin bound to FPC shows that FPC can donate iron to both iron-binding sites found within the transferrin structure. Iron 89-93 transferrin Homo sapiens 38-49 30311019-7 2018 In addition, the crystal structure of transferrin bound to FPC shows that FPC can donate iron to both iron-binding sites found within the transferrin structure. Iron 89-93 transferrin Homo sapiens 138-149 30311019-7 2018 In addition, the crystal structure of transferrin bound to FPC shows that FPC can donate iron to both iron-binding sites found within the transferrin structure. Iron 102-106 transferrin Homo sapiens 38-49 30311019-7 2018 In addition, the crystal structure of transferrin bound to FPC shows that FPC can donate iron to both iron-binding sites found within the transferrin structure. Iron 102-106 transferrin Homo sapiens 138-149 31318328-2 2019 The transferrin receptors expression is increased on growing cancer/tumor cells for absorption of iron through transferrin and participation in biological activity. Iron 98-102 transferrin Homo sapiens 4-15 31318328-6 2019 Purified transferrin was characterized by SDS-PAGE, MALDI-TOF, ELISA, Western blot, and its activity was further confirmed by iron binding assay and receptor binding assays. Iron 126-130 transferrin Homo sapiens 9-20 30381181-2 2018 The zero-field splitting (ZFS) parameters, D- and E-values, are very close to the reported values, D = 0.25 cm-1 and E/D = 0.06, for an Fe-transferrin with oxalate anion, and to D = 0.25 cm-1 and E/D = 0.04 for one with malonate anion in human sera, suggesting that the Fe3+ species are from Fe-transferrins or their homologues. Iron 140-142 transferrin Homo sapiens 143-154 30033906-7 2018 Biochemically, Fe and Zn in insects occur predominantly in non-haem forms, bound to the proteins ferritin, transferrin and other transport and storage proteins. Iron 15-17 transferrin Homo sapiens 107-118 30510932-2 2018 Malfunctions within iron homeostasis have a range of physiological consequences, and can lead to the development of pathological conditions that can result in an excess of non-transferrin bound iron (NTBI). Iron 20-24 transferrin Homo sapiens 176-187 30510932-2 2018 Malfunctions within iron homeostasis have a range of physiological consequences, and can lead to the development of pathological conditions that can result in an excess of non-transferrin bound iron (NTBI). Iron 194-198 transferrin Homo sapiens 176-187 30571402-4 2018 Methods- A study of 48 972 subjects performed by the Genetics of Iron Status consortium identified genetic variants with concordant relations to 4 biomarkers of iron status (serum iron, transferrin saturation, ferritin, and transferrin) that supported their use as instruments for overall iron status. Iron 65-69 transferrin Homo sapiens 186-197 30571402-4 2018 Methods- A study of 48 972 subjects performed by the Genetics of Iron Status consortium identified genetic variants with concordant relations to 4 biomarkers of iron status (serum iron, transferrin saturation, ferritin, and transferrin) that supported their use as instruments for overall iron status. Iron 65-69 transferrin Homo sapiens 224-235 30571402-7 2018 Results- The main results, reported as odds ratio (OR) of stroke per SD unit increase in genetically determined iron status biomarker, showed a detrimental effect of increased iron status on stroke risk (serum iron OR, 1.07; 95% CI, 1.01-1.14; [log-transformed] ferritin OR, 1.18; 95% CI, 1.02-1.36; and transferrin saturation OR, 1.06; 95% CI, 1.01-1.11). Iron 112-116 transferrin Homo sapiens 304-315 30571402-7 2018 Results- The main results, reported as odds ratio (OR) of stroke per SD unit increase in genetically determined iron status biomarker, showed a detrimental effect of increased iron status on stroke risk (serum iron OR, 1.07; 95% CI, 1.01-1.14; [log-transformed] ferritin OR, 1.18; 95% CI, 1.02-1.36; and transferrin saturation OR, 1.06; 95% CI, 1.01-1.11). Iron 176-180 transferrin Homo sapiens 304-315 30571402-7 2018 Results- The main results, reported as odds ratio (OR) of stroke per SD unit increase in genetically determined iron status biomarker, showed a detrimental effect of increased iron status on stroke risk (serum iron OR, 1.07; 95% CI, 1.01-1.14; [log-transformed] ferritin OR, 1.18; 95% CI, 1.02-1.36; and transferrin saturation OR, 1.06; 95% CI, 1.01-1.11). Iron 176-180 transferrin Homo sapiens 304-315 30571402-8 2018 A higher transferrin, indicative of lower iron status, was also associated with decreased stroke risk (OR, 0.92; 95% CI, 0.86-0.99). Iron 42-46 transferrin Homo sapiens 9-20 30501713-4 2018 Transferrin saturation negatively correlated with platelet count and platelet crit(r=-0.353,P<0.01;r=-0.271, P<0.05).Serum ferritin and total iron binding capacity revealed no significant relation with any platelet parameters.Hemoglobin level , hematocrit and mean corpuscular hemoglobin concentration negatively correlated with platelet count(r=-0.239,P<0.05;r=-0.250,P<0.05;r=-0.339,P<0.01).There were differences in iron metabolism indexes and platelet parameters between mild to moderate anemia group and severe anemia group. Iron 148-152 transferrin Homo sapiens 0-11 30501713-4 2018 Transferrin saturation negatively correlated with platelet count and platelet crit(r=-0.353,P<0.01;r=-0.271, P<0.05).Serum ferritin and total iron binding capacity revealed no significant relation with any platelet parameters.Hemoglobin level , hematocrit and mean corpuscular hemoglobin concentration negatively correlated with platelet count(r=-0.239,P<0.05;r=-0.250,P<0.05;r=-0.339,P<0.01).There were differences in iron metabolism indexes and platelet parameters between mild to moderate anemia group and severe anemia group. Iron 434-438 transferrin Homo sapiens 0-11 30501713-6 2018 CONCLUSION: The important iron metabolism indexes affecting platelet count are serum iron and transferrin saturation,that is,the severer iron deficiency, the higher platelet count.Patients with more severe and hypochronic anemia has higher platelet count. Iron 26-30 transferrin Homo sapiens 94-105 29981284-0 2018 Non-transferrin-bound iron and oxidative stress during allogeneic hemopoietic stem cell transplantation in patients with or without iron overload. Iron 22-26 transferrin Homo sapiens 4-15 30420953-12 2018 Aceruloplasminemia and atransferrinemia are further inherited disorders of iron overload caused by deficiency in ceruloplasmin or transferrin, the plasma ferroxidase and iron carrier, respectively. Iron 75-79 transferrin Homo sapiens 24-35 30340457-7 2018 As an example, oxidatively damaged transferrin released iron ion, which may mediate Fenton reactions and generate additional reactive oxygen species. Iron 56-60 transferrin Homo sapiens 35-46 30341355-10 2018 The radical changes in host-bacteria relationships and bacterial co-occurrence patterns according to the TSAT level also suggested a shift in the bacterial iron supply from transferrin to NTBI when TSAT exceeded 45%. Iron 156-160 transferrin Homo sapiens 173-184 30059941-1 2018 BACKGROUND: Because iron and cadmium share common transport mechanisms, iron-processing protein variants such as HFE C282Y, HFE H63D, and Transferrin P570S may influence cadmium metabolism. Iron 20-24 transferrin Homo sapiens 138-149 30059941-1 2018 BACKGROUND: Because iron and cadmium share common transport mechanisms, iron-processing protein variants such as HFE C282Y, HFE H63D, and Transferrin P570S may influence cadmium metabolism. Iron 72-76 transferrin Homo sapiens 138-149 30201907-2 2018 Plasma non-transferrin-bound iron (NTBI) is potentially harmful due to the generation of free radicals that cause tissue damage in vascular and other diseases. Iron 29-33 transferrin Homo sapiens 11-22 30188794-6 2018 Participants in the iron group received 250 mg of iv iron, once a month for six months, provided that their ferritin remained < 300 microg/L and their transferrin saturation remained < 45%. Iron 20-24 transferrin Homo sapiens 154-165 29982934-1 2018 Transferrin (TrF) is a very important human body glycoprotein and a clinical biomarker which controls the body"s iron ion channels and iron ion balance. Iron 113-117 transferrin Homo sapiens 0-11 29982934-1 2018 Transferrin (TrF) is a very important human body glycoprotein and a clinical biomarker which controls the body"s iron ion channels and iron ion balance. Iron 113-117 transferrin Homo sapiens 13-16 29524196-3 2018 It competes with iron for transferrin (binding site for transportation) and with lactoferrin as it is secreted in milk also. Iron 17-21 transferrin Homo sapiens 26-37 30099506-11 2018 Knockdown of TF in differentiated Simpson-Golabi-Behmel syndrome adipocytes by short hairpin RNA decreased intracellular iron, reduced maximal insulin-stimulated glucose uptake, and reduced Akt phosphorylation. Iron 121-125 transferrin Homo sapiens 13-15 30099506-13 2018 Iron chelation recapitulated key changes in the expression profile induced by TF knockdown. Iron 0-4 transferrin Homo sapiens 78-80 30003313-2 2018 Ferric pyrophosphate citrate (FPC, Triferic ) donates iron directly to transferrin, bypassing the reticuloendothelial system and avoiding iron sequestration. Iron 54-58 transferrin Homo sapiens 71-82 30029410-1 2018 Transferrin (TrF) is an important glycoprotein and disease biomarker that controls iron ion balance in the human body. Iron 83-87 transferrin Homo sapiens 0-11 30029410-1 2018 Transferrin (TrF) is an important glycoprotein and disease biomarker that controls iron ion balance in the human body. Iron 83-87 transferrin Homo sapiens 13-16 30236065-6 2018 Furthermore, serum ferritin and transferrin saturation increased in all groups (anemic [64 mug/L, 5.0%, P < 0.001] iron deficient [76 mug/L, 3.6%, P < 0.001]). Iron 118-122 transferrin Homo sapiens 32-43 29982934-1 2018 Transferrin (TrF) is a very important human body glycoprotein and a clinical biomarker which controls the body"s iron ion channels and iron ion balance. Iron 135-139 transferrin Homo sapiens 0-11 29982934-1 2018 Transferrin (TrF) is a very important human body glycoprotein and a clinical biomarker which controls the body"s iron ion channels and iron ion balance. Iron 135-139 transferrin Homo sapiens 13-16 30123964-10 2018 Moreover, heterologous fluorescently-labeled mammalian iron-bound transferrin is actively taken up, providing direct evidence for active iron uptake by basal endocytosis. Iron 55-59 transferrin Homo sapiens 66-77 29322429-0 2018 Comment on "Serum Hepcidin and Soluble Transferrin Receptor in the Assessment of Iron Metabolism in Children on a Vegetarian Diet". Iron 81-85 transferrin Homo sapiens 39-50 30002097-1 2018 BACKGROUND: Transferrin is synthetized in the liver and is the most important iron-transport carrier in the human body. Iron 78-82 transferrin Homo sapiens 12-23 30123964-10 2018 Moreover, heterologous fluorescently-labeled mammalian iron-bound transferrin is actively taken up, providing direct evidence for active iron uptake by basal endocytosis. Iron 137-141 transferrin Homo sapiens 66-77 29860209-1 2018 Understanding the effect of glycation on the function of transferrin, the systemic iron transporter, is fundamental to fully grasp the mechanisms leading to the loss of iron homeostasis observed in diabetes mellitus (DM). Iron 83-87 transferrin Homo sapiens 57-68 29665075-1 2018 BACKGROUND: Transferrin is the major plasma transport protein for iron. Iron 66-70 transferrin Homo sapiens 12-23 29889872-4 2018 We report that, compared to the natural iron delivery proteins, transferrin and H-ferritin, the pharmaceutical iron formulations neither cross the blood-brain barrier model nor significantly load the endothelial cells with iron. Iron 111-115 transferrin Homo sapiens 64-75 30371224-12 2018 Conclusions The authors recommend avoiding a low hemoglobin level and maintaining serum ferritin between 300 and 800 ng/mL and transferrin saturation between 30% and 50%, which were associated with lower risks of all-cause mortality among patients undergoing hemodialysis receiving the restricted erythropoiesis-stimulating agent doses but prompt intravenous iron supplementation in Taiwan. Iron 359-363 transferrin Homo sapiens 127-138 29702192-6 2018 Mechanistically, PAB improved intracellular iron by upregulation of transferrin receptor. Iron 44-48 transferrin Homo sapiens 68-79 29966105-3 2018 Excess iron in the form of non-transferrin-bound iron (NTBI) causes injury and is readily uptaken by cardiomyocytes, pancreatic islet cells, and hepatocytes. Iron 7-11 transferrin Homo sapiens 31-42 29966105-3 2018 Excess iron in the form of non-transferrin-bound iron (NTBI) causes injury and is readily uptaken by cardiomyocytes, pancreatic islet cells, and hepatocytes. Iron 49-53 transferrin Homo sapiens 31-42 29877528-6 2018 This value, close to that of transferrin with iron, evidenced the high affinity of the protein for thorium. Iron 46-50 transferrin Homo sapiens 29-40 29395830-3 2018 Labile plasma iron (LPI, the redox-active component of non-transferrin bound iron) has been studied as an indicator of systemic iron overload and of chelation efficacy, and may particularly reflect recent iron equilibrium. Iron 14-18 transferrin Homo sapiens 59-70 30146840-9 2018 In iron overload thalassemia groups, expression levels of erythropoietin and ferritin were increased, but hepcidin and transferrin were significantly reduced. Iron 3-7 transferrin Homo sapiens 119-130 29452568-7 2018 Validation by quantitative real-time PCR revealed that only the expression of transferrin receptor, which is involved in iron transport; and tribbles pseudokinase 3, which is involved in insulin signaling, were unequivocally regulated by primary cilia sensing of fluid flow. Iron 121-125 transferrin Homo sapiens 78-89 29703633-7 2018 RESULTS: Iron supplementation significantly increased hemoglobin, mean corpuscular volume, ferritin, and transferrin saturation rate, and decreased erythropoiesis-stimulating agent dose and erythropoiesis-stimulating agent resistance index value. Iron 9-13 transferrin Homo sapiens 105-116 29808889-1 2018 Blood contains a poorly characterized pool of labile iron called non-transferrin-bound iron (NTBI). Iron 53-57 transferrin Homo sapiens 69-80 29808889-1 2018 Blood contains a poorly characterized pool of labile iron called non-transferrin-bound iron (NTBI). Iron 87-91 transferrin Homo sapiens 69-80 29808889-14 2018 Column-adsorbing-iron coordinated apo-transferrin whereas the more tightly coordinated iron species did not. Iron 17-21 transferrin Homo sapiens 38-49 29889872-4 2018 We report that, compared to the natural iron delivery proteins, transferrin and H-ferritin, the pharmaceutical iron formulations neither cross the blood-brain barrier model nor significantly load the endothelial cells with iron. Iron 111-115 transferrin Homo sapiens 64-75 29874829-5 2018 It was expected that iron supplementation with FeDex improved the iron status with higher levels of serum iron, ferritin, transferrin, and iron loading in the liver by regulating the interaction of hepcidin and ferroportin (FPN). Iron 21-25 transferrin Homo sapiens 122-133 30034931-4 2018 In systemic iron metabolism that is regulated by hepcidin-ferroportin axis, plasma iron is bound with transferrin (TF) which has two high-affinity binding sites for ferric iron. Iron 12-16 transferrin Homo sapiens 102-113 29767396-1 2018 A number of important Gram-negative pathogens that reside exclusively in the upper respiratory or genitourinary tract of their mammalian host rely on surface receptors that specifically bind host transferrin and lactoferrin as a source of iron for growth. Iron 239-243 transferrin Homo sapiens 196-207 29767396-2 2018 The transferrin receptors have been targeted for vaccine development due to their critical role in acquiring iron during invasive infection and for survival on the mucosal surface. Iron 109-113 transferrin Homo sapiens 4-15 29937171-10 2018 In comparing patients with an event (death or recurrence) and no event in the intravenous iron group, a distinct trend was found for decreased transferrin in the event group (median 2.53 g/L vs 2.83 g/L, p = 0.052). Iron 90-94 transferrin Homo sapiens 143-154 29771984-1 2018 Production of the iron regulatory peptide hepcidin is tightly controlled by a network of proteins in hepatocytes that sense levels of iron in the circulation (as diferric-transferrin) and in tissues (in ferritin). Iron 18-22 transferrin Homo sapiens 171-182 29771984-1 2018 Production of the iron regulatory peptide hepcidin is tightly controlled by a network of proteins in hepatocytes that sense levels of iron in the circulation (as diferric-transferrin) and in tissues (in ferritin). Iron 134-138 transferrin Homo sapiens 171-182 29351867-5 2018 Furthermore, non-target proteins including the iron-free apo-Trf were discriminated by pronounced size and shape specificity. Iron 47-51 transferrin Homo sapiens 61-64 30034931-4 2018 In systemic iron metabolism that is regulated by hepcidin-ferroportin axis, plasma iron is bound with transferrin (TF) which has two high-affinity binding sites for ferric iron. Iron 12-16 transferrin Homo sapiens 115-117 29636978-5 2018 Results: When analyses were restricted to mothers without iron supplementation during late pregnancy, negative associations were found between the maternal transferrin saturation score and childhood forced expiratory volume in 1 s and forced vital capacity (difference in age, height and gender-adjusted SD units per SD increase in genotypic score: -0.05 (-0.09, -0.01) p=0.03, and -0.04 (-0.08, 0.00) p=0.04, respectively). Iron 58-62 transferrin Homo sapiens 156-167 30034931-4 2018 In systemic iron metabolism that is regulated by hepcidin-ferroportin axis, plasma iron is bound with transferrin (TF) which has two high-affinity binding sites for ferric iron. Iron 83-87 transferrin Homo sapiens 102-113 30034931-4 2018 In systemic iron metabolism that is regulated by hepcidin-ferroportin axis, plasma iron is bound with transferrin (TF) which has two high-affinity binding sites for ferric iron. Iron 83-87 transferrin Homo sapiens 115-117 30034931-6 2018 During the iron intake process in generic cells, transferrin receptors (TFRs) act as the most important receptor mediated controls. Iron 11-15 transferrin Homo sapiens 49-60 30034931-7 2018 TFR1 and TFR2 are two subtypes of TFRs those bind with iron-transferrin complex to facilitate iron into cells. Iron 55-59 transferrin Homo sapiens 60-71 30034931-7 2018 TFR1 and TFR2 are two subtypes of TFRs those bind with iron-transferrin complex to facilitate iron into cells. Iron 94-98 transferrin Homo sapiens 60-71 29466707-1 2018 BACKGROUND: Transferrin and its receptors play an important role during the uptake and transcytosis of iron through blood-brain barrier (BBB) endothelial cells (ECs) to maintain iron homeostasis in BBB endothelium and brain. Iron 103-107 transferrin Homo sapiens 12-23 29466707-1 2018 BACKGROUND: Transferrin and its receptors play an important role during the uptake and transcytosis of iron through blood-brain barrier (BBB) endothelial cells (ECs) to maintain iron homeostasis in BBB endothelium and brain. Iron 178-182 transferrin Homo sapiens 12-23 29466707-4 2018 METHODS: Ordinary differential equations are formulated based on the first order reaction kinetics to model the iron transport considering their interactions with transferrin and transferrin receptors. Iron 112-116 transferrin Homo sapiens 163-174 29466707-4 2018 METHODS: Ordinary differential equations are formulated based on the first order reaction kinetics to model the iron transport considering their interactions with transferrin and transferrin receptors. Iron 112-116 transferrin Homo sapiens 179-190 29466707-7 2018 Model results also suggest that the BBB ECs can regulate the extent of the two possible iron transport pathways (free and transferrin-bound iron) by controlling the receptor expression, internalization of holo-transferrin-receptor complexes and acidification of holo-transferrin inside the cell endosomes. Iron 88-92 transferrin Homo sapiens 122-133 29466707-7 2018 Model results also suggest that the BBB ECs can regulate the extent of the two possible iron transport pathways (free and transferrin-bound iron) by controlling the receptor expression, internalization of holo-transferrin-receptor complexes and acidification of holo-transferrin inside the cell endosomes. Iron 88-92 transferrin Homo sapiens 210-221 29466707-7 2018 Model results also suggest that the BBB ECs can regulate the extent of the two possible iron transport pathways (free and transferrin-bound iron) by controlling the receptor expression, internalization of holo-transferrin-receptor complexes and acidification of holo-transferrin inside the cell endosomes. Iron 88-92 transferrin Homo sapiens 210-221 29466707-7 2018 Model results also suggest that the BBB ECs can regulate the extent of the two possible iron transport pathways (free and transferrin-bound iron) by controlling the receptor expression, internalization of holo-transferrin-receptor complexes and acidification of holo-transferrin inside the cell endosomes. Iron 140-144 transferrin Homo sapiens 122-133 29466707-9 2018 The model can also predict the transferrin and iron transport behavior in iron-enriched and iron-depleted cells, which has not been addressed in previous work. Iron 74-78 transferrin Homo sapiens 31-42 29466707-9 2018 The model can also predict the transferrin and iron transport behavior in iron-enriched and iron-depleted cells, which has not been addressed in previous work. Iron 74-78 transferrin Homo sapiens 31-42 29484788-7 2018 Four days of iron depletion resulted in an 84% decrease in ferritin (P < 0.0001) and significantly increased gene expression of transferrin receptor 1 and divalent metal transporter 1 (both P < 0.001). Iron 13-17 transferrin Homo sapiens 131-142 29484788-11 2018 Supplementation of transferrin-bound iron recovered functional and morphological abnormalities within 3 days. Iron 37-41 transferrin Homo sapiens 19-30 29659573-7 2018 Current whole-body models lack the mechanistic details of iron transport related to RBC maturation, transferrin (Tf and TfR) dynamics and assume passive iron efflux from macrophages. Iron 58-62 transferrin Homo sapiens 100-111 29458730-2 2018 Risk factors for cardiosiderosis are discussed with particular reference to the balance of transfusional iron loading rate and transferrin-iron utilization rate as marked by plasma levels of soluble transferrin receptors. Iron 139-143 transferrin Homo sapiens 127-138 29458730-3 2018 Low transfusion regimens increase residual erythropoiesis allowing for apotransferrin-dependent clearance of non-transferrin-bound iron species otherwise destined for myocardium. Iron 131-135 transferrin Homo sapiens 74-85 29518107-4 2018 In details, four genes of iron homeostasis (Hemochromatosis (HFE: C282Y, H63D), Ferroportin (FPN1: -8CG), Hepcidin (HAMP: -582AG), Transferrin (TF: P570S)), and the three major alleles of APOE (APOE2, APOE3, APOE4) were analyzed to explore causative interactions and synergies. Iron 26-30 transferrin Homo sapiens 131-142 29388418-5 2018 TfR2 is predicted to bind the iron carrier transferrin (Tf) when the iron saturation of Tf is high. Iron 30-34 transferrin Homo sapiens 43-54 29388418-5 2018 TfR2 is predicted to bind the iron carrier transferrin (Tf) when the iron saturation of Tf is high. Iron 30-34 transferrin Homo sapiens 0-2 29388418-5 2018 TfR2 is predicted to bind the iron carrier transferrin (Tf) when the iron saturation of Tf is high. Iron 30-34 transferrin Homo sapiens 56-58 29388418-5 2018 TfR2 is predicted to bind the iron carrier transferrin (Tf) when the iron saturation of Tf is high. Iron 69-73 transferrin Homo sapiens 43-54 29388418-5 2018 TfR2 is predicted to bind the iron carrier transferrin (Tf) when the iron saturation of Tf is high. Iron 69-73 transferrin Homo sapiens 0-2 29388418-5 2018 TfR2 is predicted to bind the iron carrier transferrin (Tf) when the iron saturation of Tf is high. Iron 69-73 transferrin Homo sapiens 56-58 28762519-2 2018 Decreased transferrin and transferrin receptor levels were observed in seminal plasma from idiopathic azoospermia (IA) patients, suggesting disturbed iron metabolism in IA testes. Iron 150-154 transferrin Homo sapiens 10-21 29544561-0 2018 Measurement of interaction behavior of six biologically important noble metal ions with the iron(III) binding protein, apo-transferrin, using mobility-shift affinity electrophoresis. Iron 92-96 transferrin Homo sapiens 123-134 29544561-2 2018 At saturation level 70% of transferrin remains free from iron (apo-transferrin), suggesting a broader scope of binding capabilities with non-iron (III) metal ions. Iron 57-61 transferrin Homo sapiens 27-38 29544561-2 2018 At saturation level 70% of transferrin remains free from iron (apo-transferrin), suggesting a broader scope of binding capabilities with non-iron (III) metal ions. Iron 141-145 transferrin Homo sapiens 27-38 28762519-2 2018 Decreased transferrin and transferrin receptor levels were observed in seminal plasma from idiopathic azoospermia (IA) patients, suggesting disturbed iron metabolism in IA testes. Iron 150-154 transferrin Homo sapiens 26-37 29399922-0 2018 LDL dinitrosyl iron complex: A new transferrin-independent route for iron delivery in hepatocytes. Iron 15-19 transferrin Homo sapiens 35-46 29395073-0 2018 Impaired Transferrin Receptor Palmitoylation and Recycling in Neurodegeneration with Brain Iron Accumulation. Iron 91-95 transferrin Homo sapiens 9-20 32254488-0 2018 Iron-mimic peptide converts transferrin from foe to friend for orally targeting insulin delivery. Iron 0-4 transferrin Homo sapiens 28-39 29481068-4 2018 Here, we describe the switchable display of the iron-transporting protein, transferrin (Tf), at the surface of thermoresponsive polymer-coated gold nanoparticles and show that internalization of the coated nanoparticles into target cells changes across temperature ranges over which transferrin is expected to be sterically "hidden" by an extended polymer chain and then "revealed" by polymer chain collapse. Iron 48-52 transferrin Homo sapiens 75-86 29481068-4 2018 Here, we describe the switchable display of the iron-transporting protein, transferrin (Tf), at the surface of thermoresponsive polymer-coated gold nanoparticles and show that internalization of the coated nanoparticles into target cells changes across temperature ranges over which transferrin is expected to be sterically "hidden" by an extended polymer chain and then "revealed" by polymer chain collapse. Iron 48-52 transferrin Homo sapiens 88-90 29481068-4 2018 Here, we describe the switchable display of the iron-transporting protein, transferrin (Tf), at the surface of thermoresponsive polymer-coated gold nanoparticles and show that internalization of the coated nanoparticles into target cells changes across temperature ranges over which transferrin is expected to be sterically "hidden" by an extended polymer chain and then "revealed" by polymer chain collapse. Iron 48-52 transferrin Homo sapiens 283-294 29407589-1 2018 OBJECTIVES: Transferrin saturation (TSAT) 20% or less is considered to represent functional iron deficiency in the context of malignant disease, phenomenon mediated through inflammatory changes of iron homeostasis. Iron 92-96 transferrin Homo sapiens 12-23 29250797-8 2018 High increase in Hb level after iron infusion was associated with initial higher transferrin and lower ferritin levels (high vs. poor responders: median transferrin 2.9 g/L vs. 2.7 g/L, median ferritin 12 microg/L vs. 27 microg/L). Iron 32-36 transferrin Homo sapiens 81-92 29250797-8 2018 High increase in Hb level after iron infusion was associated with initial higher transferrin and lower ferritin levels (high vs. poor responders: median transferrin 2.9 g/L vs. 2.7 g/L, median ferritin 12 microg/L vs. 27 microg/L). Iron 32-36 transferrin Homo sapiens 153-164 29250797-10 2018 IV iron therapy is most effective in patients presenting with more severe anemia, and with higher transferrin and lower ferritin levels, markers for an absolute iron deficiency (ID), compared to functional ID. Iron 3-7 transferrin Homo sapiens 98-109 29512626-3 2018 METHODS: In this study, the prevalence of iron (serum ferritin <100 microg/L or ferritin 100-299 microg/L with transferrin saturation <20%), vitamin B12 (<200 pg/mL), and folate deficiency (<4.0 ng/mL) was evaluated in 101 patients with non-valvular AF with preserved left ventricular ejection fraction and no signs of HF, and the results were compared with 35 age- and gender-matched controls. Iron 42-46 transferrin Homo sapiens 114-125 20301523-6 1993 MANAGEMENT: Treatment of manifestations: Removal of excess iron by routine phlebotomy to maintain serum ferritin concentration at 50 ng/mL or lower and transferrin-iron saturation below 50%; lifelong hormone replacement therapy for hypogonadism; gonadotropins for fertility/pregnancy; nonsteroidal anti-inflammatory drugs (NSAIDs) and joint replacement for arthropathy; diuretics; routine treatment for cardiac failure and diabetes mellitus. Iron 164-168 transferrin Homo sapiens 152-163 29167213-8 2018 RESULTS: Higher heme iron intake (per 1 SD) was associated with higher ferritin levels (beta = 0.113 [95% CI 0.082; 0.144]), but not with transferrin (-0.019 [-0.043; 0.006]) or transferrin saturation (0.016 [-0.006; 0.037]). Iron 21-25 transferrin Homo sapiens 178-189 29399922-0 2018 LDL dinitrosyl iron complex: A new transferrin-independent route for iron delivery in hepatocytes. Iron 69-73 transferrin Homo sapiens 35-46 29122992-5 2018 Increases of hepcidin and non-transferrin bound iron levels were visible early in follow-up of all transfusion-dependent patient groups. Iron 48-52 transferrin Homo sapiens 30-41 29070546-4 2017 Key players in mammalian iron trafficking include several types of cells important to iron acquisition, homeostasis, and hematopoiesis (enterocytes, hepatocytes, macrophages, hematopoietic cells, and in the case of pregnancy, placental syncytiotrophoblast cells) and several forms of chaperone proteins, including, for nonheme iron, the transport protein transferrin and the intracellular iron-storage protein ferritin, and for heme iron, the chaperone proteins haptoglobin and hemopexin. Iron 25-29 transferrin Homo sapiens 355-366 28885776-7 2018 Interactions of the carrier ampholytes with the iron of transferrin may prevent iron saturation and thus provide more complicated isoform patterns. Iron 48-52 transferrin Homo sapiens 56-67 28885776-7 2018 Interactions of the carrier ampholytes with the iron of transferrin may prevent iron saturation and thus provide more complicated isoform patterns. Iron 80-84 transferrin Homo sapiens 56-67 29054412-4 2017 In this study, we demonstrate that both iron-poor transferrin (apo-Tf) and the iron chelator, deferoxamine, stimulate release of iron from iron-loaded endothelial cells in an in vitro BBB model. Iron 40-44 transferrin Homo sapiens 50-61 29313518-1 2017 To overcome limitations in iron acquisition, enterococci have evolved a number of mechanisms to scavenge iron from the host iron-binding proteins - transferrin (TR) and lactoferrin (LF). Iron 27-31 transferrin Homo sapiens 148-159 29313518-1 2017 To overcome limitations in iron acquisition, enterococci have evolved a number of mechanisms to scavenge iron from the host iron-binding proteins - transferrin (TR) and lactoferrin (LF). Iron 105-109 transferrin Homo sapiens 148-159 29313518-1 2017 To overcome limitations in iron acquisition, enterococci have evolved a number of mechanisms to scavenge iron from the host iron-binding proteins - transferrin (TR) and lactoferrin (LF). Iron 105-109 transferrin Homo sapiens 161-163 29313518-1 2017 To overcome limitations in iron acquisition, enterococci have evolved a number of mechanisms to scavenge iron from the host iron-binding proteins - transferrin (TR) and lactoferrin (LF). Iron 105-109 transferrin Homo sapiens 148-159 29313518-1 2017 To overcome limitations in iron acquisition, enterococci have evolved a number of mechanisms to scavenge iron from the host iron-binding proteins - transferrin (TR) and lactoferrin (LF). Iron 105-109 transferrin Homo sapiens 161-163 29313518-6 2017 Reduction of iron bound to TR and LF was assayed with ferrozine. Iron 13-17 transferrin Homo sapiens 27-29 29313518-9 2017 The study revealed that enterococci use several ways to acquire iron from TR and LF, such as iron chelating siderophores, iron reduction - facilitated iron release, protein degradation - promoted iron release, and receptor mediated capture of the iron-host protein complexes. Iron 64-68 transferrin Homo sapiens 74-76 29313518-9 2017 The study revealed that enterococci use several ways to acquire iron from TR and LF, such as iron chelating siderophores, iron reduction - facilitated iron release, protein degradation - promoted iron release, and receptor mediated capture of the iron-host protein complexes. Iron 93-97 transferrin Homo sapiens 74-76 29313518-9 2017 The study revealed that enterococci use several ways to acquire iron from TR and LF, such as iron chelating siderophores, iron reduction - facilitated iron release, protein degradation - promoted iron release, and receptor mediated capture of the iron-host protein complexes. Iron 93-97 transferrin Homo sapiens 74-76 29313518-9 2017 The study revealed that enterococci use several ways to acquire iron from TR and LF, such as iron chelating siderophores, iron reduction - facilitated iron release, protein degradation - promoted iron release, and receptor mediated capture of the iron-host protein complexes. Iron 93-97 transferrin Homo sapiens 74-76 29313518-9 2017 The study revealed that enterococci use several ways to acquire iron from TR and LF, such as iron chelating siderophores, iron reduction - facilitated iron release, protein degradation - promoted iron release, and receptor mediated capture of the iron-host protein complexes. Iron 93-97 transferrin Homo sapiens 74-76 29313518-9 2017 The study revealed that enterococci use several ways to acquire iron from TR and LF, such as iron chelating siderophores, iron reduction - facilitated iron release, protein degradation - promoted iron release, and receptor mediated capture of the iron-host protein complexes. Iron 93-97 transferrin Homo sapiens 74-76 28342014-0 2017 Serum Hepcidin and Soluble Transferrin Receptor in the Assessment of Iron Metabolism in Children on a Vegetarian Diet. Iron 69-73 transferrin Homo sapiens 27-38 29101207-5 2017 This leads to progressive and preferential iron trapping in tissue macrophages, reduced iron release to serum transferrin (i.e. inappropriately low transferrin saturation) and a tendency towards anemia at menarche or after intense bloodletting. Iron 88-92 transferrin Homo sapiens 110-121 29292794-6 2017 Moreover, knockdown of p53 resulted in higher non-transferrin-bound iron uptake, which was mediated by increased ZIP14 levels. Iron 68-72 transferrin Homo sapiens 50-61 29070551-4 2017 Newly absorbed iron binds to plasma transferrin and is distributed around the body to sites of utilization with the erythroid marrow having particularly high iron requirements. Iron 15-19 transferrin Homo sapiens 36-47 29070551-5 2017 Iron-loaded transferrin binds to transferrin receptor 1 on the surface of most body cells, and after endocytosis of the complex, iron enters the cytoplasm via DMT1 in the endosomal membrane. Iron 0-4 transferrin Homo sapiens 12-23 29070551-5 2017 Iron-loaded transferrin binds to transferrin receptor 1 on the surface of most body cells, and after endocytosis of the complex, iron enters the cytoplasm via DMT1 in the endosomal membrane. Iron 0-4 transferrin Homo sapiens 33-44 29070551-5 2017 Iron-loaded transferrin binds to transferrin receptor 1 on the surface of most body cells, and after endocytosis of the complex, iron enters the cytoplasm via DMT1 in the endosomal membrane. Iron 129-133 transferrin Homo sapiens 12-23 29070551-5 2017 Iron-loaded transferrin binds to transferrin receptor 1 on the surface of most body cells, and after endocytosis of the complex, iron enters the cytoplasm via DMT1 in the endosomal membrane. Iron 129-133 transferrin Homo sapiens 33-44 29126480-2 2017 The developed MCFA system based on simple photometric detection of iron with chromogenic agent (ferrozine) enables a speciation of transferrin (determination of free and Fe-bound protein) in human serum. Iron 67-71 transferrin Homo sapiens 131-142 29126480-2 2017 The developed MCFA system based on simple photometric detection of iron with chromogenic agent (ferrozine) enables a speciation of transferrin (determination of free and Fe-bound protein) in human serum. Iron 170-172 transferrin Homo sapiens 131-142 28836730-5 2017 Two larger-scale trials confirming these results (FAIR-HF and CONFIRM-HF) have led to guideline recommendations that IV iron therapy should be considered in patients with CHF with reduced ejection fraction and iron deficiency (serum ferritin <100 mug/L, or ferritin between 100 and 299 mug/L with transferrin saturation <20%) to provide symptomatic relief and improve exercise capacity and quality of life. Iron 120-124 transferrin Homo sapiens 300-311 29079528-2 2017 Serotransferrin (Trf) and ceruloplasmin (Cp) are two key proteins involved in iron metabolism and anti-oxidant defense. Iron 78-82 transferrin Homo sapiens 0-15 29158016-3 2017 For most HC forms (types 1, 2, 3 and 4B HC) iron overload is related to cellular hepcidin deprivation which causes an increase of plasma iron concentration and the appearance of plasma non-transferrin bound iron. Iron 44-48 transferrin Homo sapiens 189-200 28971232-2 2017 Transferrin (Tf) is the major iron-transporting protein in the human body and, for this reason, has been extensively studied in biomedicine. Iron 30-34 transferrin Homo sapiens 0-11 28755795-8 2017 Hereby, transferrin protects the host against the reactive oxygen species that can be formed as a consequence of free iron. Iron 118-122 transferrin Homo sapiens 8-19 28670831-0 2017 Varying iron release from transferrin and lactoferrin proteins. Iron 8-12 transferrin Homo sapiens 26-37 28670831-4 2017 The experiment described here deals with different iron release mechanisms of two protagonists in iron metabolism: serum transferrin (Tf) and lactoferrin (Lf). Iron 51-55 transferrin Homo sapiens 121-132 28670831-4 2017 The experiment described here deals with different iron release mechanisms of two protagonists in iron metabolism: serum transferrin (Tf) and lactoferrin (Lf). Iron 51-55 transferrin Homo sapiens 134-136 28670831-4 2017 The experiment described here deals with different iron release mechanisms of two protagonists in iron metabolism: serum transferrin (Tf) and lactoferrin (Lf). Iron 98-102 transferrin Homo sapiens 121-132 28670831-5 2017 Despite having very similar structures and iron-binding sites, Tf releases practically all its iron at pH 5.5 while Lf requires a significantly lower pH of 3. Iron 43-47 transferrin Homo sapiens 63-65 28670831-5 2017 Despite having very similar structures and iron-binding sites, Tf releases practically all its iron at pH 5.5 while Lf requires a significantly lower pH of 3. Iron 95-99 transferrin Homo sapiens 63-65 28670831-6 2017 This difference in behavior is directly related to their respective biological functions as Tf blood-borne iron into the cell, while Lf competes with pathogens to sequester iron in biological fluids at more acidic pHs. Iron 107-111 transferrin Homo sapiens 92-94 28670831-7 2017 During this experiment, the students will carry out iron loading and unloading on both human Lf and Tf and monitor the iron release at different pHs using UV-Vis spectroscopy. Iron 52-56 transferrin Homo sapiens 100-102 28670831-8 2017 With this simple approach, the students will discover the different patterns of iron release of Tf and Lf and how this variance in behavior relates to their biological functions. Iron 80-84 transferrin Homo sapiens 96-98 28755795-0 2017 Therapeutic use of transferrin to modulate anemia and conditions of iron toxicity. Iron 68-72 transferrin Homo sapiens 19-30 28755795-1 2017 As the main iron transporter, transferrin delivers iron to target tissues like the bone marrow for erythropoiesis. Iron 12-16 transferrin Homo sapiens 30-41 28755795-2 2017 Also, by binding free iron, transferrin prevents formation of reactive oxygen species. Iron 22-26 transferrin Homo sapiens 28-39 28755795-5 2017 First, transferrin can correct anemia by modulating the amount of iron that is available for erythropoiesis. Iron 66-70 transferrin Homo sapiens 7-18 28755795-7 2017 Second, under conditions of iron overload, transferrin reduces oxidative stress by binding free iron in the circulation and in tissues. Iron 28-32 transferrin Homo sapiens 43-54 28755795-7 2017 Second, under conditions of iron overload, transferrin reduces oxidative stress by binding free iron in the circulation and in tissues. Iron 96-100 transferrin Homo sapiens 43-54 28755795-11 2017 This review summarizes the preclinical and clinical data on the efficacy of exogenous transferrin administration to modulate certain forms of anemia and to prevent the toxic effects of free iron. Iron 190-194 transferrin Homo sapiens 86-97 28671021-0 2017 Upregulation of transferrin receptor-1 induces cholangiocarcinoma progression via induction of labile iron pool. Iron 102-106 transferrin Homo sapiens 16-27 29073555-0 2017 Effects of synergistic and non-synergistic anions on the iron binding site from serum transferrin: A molecular dynamic simulation analysis. Iron 57-61 transferrin Homo sapiens 86-97 28815927-0 2017 Metallofullerenol Inhibits Cellular Iron Uptake by Inducing Transferrin Tetramerization. Iron 36-40 transferrin Homo sapiens 60-71 28815927-5 2017 The larger change of SAXS shapes between Tf+C60 (OH)22 and Tf+FeCl3 implies that C60 (OH)22 is bound to Tf, blocking the iron-binding site. Iron 121-125 transferrin Homo sapiens 41-43 28815927-5 2017 The larger change of SAXS shapes between Tf+C60 (OH)22 and Tf+FeCl3 implies that C60 (OH)22 is bound to Tf, blocking the iron-binding site. Iron 121-125 transferrin Homo sapiens 59-61 28815927-5 2017 The larger change of SAXS shapes between Tf+C60 (OH)22 and Tf+FeCl3 implies that C60 (OH)22 is bound to Tf, blocking the iron-binding site. Iron 121-125 transferrin Homo sapiens 59-61 28815927-6 2017 The larger deviation of the SAXS shape from a possible crystal structure of Tf tetramer implies that Gd@C82 (OH)22 is bound to the Tf tetramer, thus disturbing iron transport. Iron 160-164 transferrin Homo sapiens 76-78 28815927-6 2017 The larger deviation of the SAXS shape from a possible crystal structure of Tf tetramer implies that Gd@C82 (OH)22 is bound to the Tf tetramer, thus disturbing iron transport. Iron 160-164 transferrin Homo sapiens 131-133 28671201-1 2017 The transferrin receptor (TfR1), which mediates cellular iron uptake through clathrin-dependent endocytosis of iron-loaded transferrin, plays a key role in iron homeostasis. Iron 57-61 transferrin Homo sapiens 4-15 28671201-1 2017 The transferrin receptor (TfR1), which mediates cellular iron uptake through clathrin-dependent endocytosis of iron-loaded transferrin, plays a key role in iron homeostasis. Iron 111-115 transferrin Homo sapiens 4-15 28671201-1 2017 The transferrin receptor (TfR1), which mediates cellular iron uptake through clathrin-dependent endocytosis of iron-loaded transferrin, plays a key role in iron homeostasis. Iron 111-115 transferrin Homo sapiens 4-15 29404495-6 2017 We found that hepatic NNMT expression is inversely correlated with serum ferritin levels and serum transferrin saturation in patients who are obese, suggesting that body iron stores regulate human liver NNMT expression. Iron 170-174 transferrin Homo sapiens 99-110 28609757-1 2017 Human Transferrin (hTf) is a metal-binding protein found in blood plasma and is well known for its role in iron delivery. Iron 107-111 transferrin Homo sapiens 6-17 28790810-6 2017 In the total population, Pearson correlation coefficients between 1) serum ferritin and iron concentrations and transferrin saturation and 2) FVC and FEV1 were significantly positive; whereas those between 1) serum ferritin concentrations and transferrin saturation and 2) FEV1/FVC were significantly negative. Iron 88-92 transferrin Homo sapiens 112-123 28644630-1 2017 The recent X-ray structure of titanium(IV)-bound human serum transferrin (STf) exhibiting citrate as a synergistic anion reveals a difference in Ti(IV) coordination versus iron(III), the metal endogenously delivered by the protein to cells. Iron 172-176 transferrin Homo sapiens 61-72 28644630-2 2017 This finding enriches our bioinspired drug design strategy for Ti(IV)-based anticancer therapeutics, which applies a family of Fe(III) chelators termed chemical transferrin mimetic (cTfm) ligands to inhibit Fe bioavailability in cancer cells. Iron 127-129 transferrin Homo sapiens 161-172 28216263-2 2017 Absolute ID/IDA, i.e. the decrease of total body iron, is easily diagnosed based on decreased levels of serum ferritin and transferrin saturation. Iron 49-53 transferrin Homo sapiens 123-134 29073555-2 2017 A synergistic anion as carbonate is an anion that is required for iron binding by transferrin while non-synergistic anions do not act as the synergistic anions to promote iron binding, but affect the iron binding and release. Iron 66-70 transferrin Homo sapiens 82-93 29073555-4 2017 In the present work, molecular dynamic simulation techniques were employed in order to gain access into a molecular level understanding of the iron binding site of the human serum transferrin during the synergistic and non-synergistic anion binding. Iron 143-147 transferrin Homo sapiens 180-191 29073555-7 2017 Meanwhile,the simulation of the open (Apo), partially closed (Carbonate) and fully closed (Carbonate-Fe) forms of the transferrin structure allows a direct comparison between the iron binding site of these three states.On the basis of results, synergistic anions form high affinity binding site, while non-synergistic anions act like Apo state of the transferrin structure and change the proper conformation of the binding site. Iron 101-103 transferrin Homo sapiens 118-129 29073555-7 2017 Meanwhile,the simulation of the open (Apo), partially closed (Carbonate) and fully closed (Carbonate-Fe) forms of the transferrin structure allows a direct comparison between the iron binding site of these three states.On the basis of results, synergistic anions form high affinity binding site, while non-synergistic anions act like Apo state of the transferrin structure and change the proper conformation of the binding site. Iron 179-183 transferrin Homo sapiens 118-129 28849262-10 2017 Differences in the integrated intensity of the EPR signal from transferrin translate directly into the amount of bound iron. Iron 119-123 transferrin Homo sapiens 63-74 28642302-2 2017 Plasma non-transferrin-bound iron and its redox-active component, labile plasma iron, are key sources of iron loading in cardiosiderosis. Iron 29-33 transferrin Homo sapiens 11-22 28642302-2 2017 Plasma non-transferrin-bound iron and its redox-active component, labile plasma iron, are key sources of iron loading in cardiosiderosis. Iron 80-84 transferrin Homo sapiens 11-22 28642302-2 2017 Plasma non-transferrin-bound iron and its redox-active component, labile plasma iron, are key sources of iron loading in cardiosiderosis. Iron 80-84 transferrin Homo sapiens 11-22 28642302-12 2017 In conclusion, high transferrin iron utilization, relative to the transfusion-iron load rate, decreases the risk of cardiosiderosis. Iron 32-36 transferrin Homo sapiens 20-31 28837344-0 2017 Role of Macromolecular Crowding on Stability and Iron Release Kinetics of Serum Transferrin. Iron 49-53 transferrin Homo sapiens 80-91 28967645-7 2017 In cells with CSC characteristics an increased expression of transferrin and its receptor, ferritin, fentorin and hepcidin was revealed indicating activation of the endogenous iron metabolism. Iron 176-180 transferrin Homo sapiens 61-72 28970716-7 2017 Markedly elevated transferrin saturation can simulate iron overload syndrome, but a liver biopsy can guide physicians to navigate the diagnosis. Iron 54-58 transferrin Homo sapiens 18-29 28712636-11 2017 Iron-sequestering proteins including transferrin and lactoferrin/lactotransferrin were found in many samples. Iron 0-4 transferrin Homo sapiens 37-48 28930842-4 2017 PATIENT CONCERNS: We report the case of a 48-year-old Chinese Han woman who presented with abnormal liver function, diabetes mellitus, hyperferritinemia, and high transferrin saturation, with severe iron overload in parenchymal cells, Kupffer cells, and periportal fibrosis on liver biopsy. Iron 199-203 transferrin Homo sapiens 163-174 28827805-8 2017 In contrast, the expression of transferrin, which is responsible for the transport of iron into cells, is increased following treatment with lapatinib alone or in combination with siramesine. Iron 86-90 transferrin Homo sapiens 31-42 28585071-3 2017 We hypothesize that non-transferrin-bound iron (NBTI) is possibly a better marker to predict the effect of IO on the outcome than serum ferritin (SF), which however is not specific for IO. Iron 42-46 transferrin Homo sapiens 24-35 28671021-12 2017 The expressions of iron regulatory proteins in human cholangiocarcinoma tissues and normal liver from cadaveric donors revealed that transferrin receptor-1 expression was increased in the cancer cells of cholangiocarcinoma tissues when compared with the adjacent normal bile ducts and was significantly correlated with cholangiocarcinoma metastasis. Iron 19-23 transferrin Homo sapiens 133-144 28671021-14 2017 Additionally, the suppression of transferrin receptor-1 expression significantly decreased intracellular labile iron pool, cholangiocarcinoma migration, and cell proliferation when compared with control media and control small interfering RNA. Iron 112-116 transferrin Homo sapiens 33-44 28671021-15 2017 In Conclusion, high expression of transferrin receptor-1 resulting in iron uptake contributes to increase in the labile iron pool which plays roles in cholangiocarcinoma progression with aggressive clinical outcomes. Iron 70-74 transferrin Homo sapiens 34-45 28671021-15 2017 In Conclusion, high expression of transferrin receptor-1 resulting in iron uptake contributes to increase in the labile iron pool which plays roles in cholangiocarcinoma progression with aggressive clinical outcomes. Iron 120-124 transferrin Homo sapiens 34-45 29296759-3 2017 Canonical erythroid iron trafficking occurs via the first transferrin receptor (TfR1)-mediated endocytosis of diferric-transferrin into recycling endosomes, where ferric iron is released, reduced, and exported to the cytosol via DMT1. Iron 20-24 transferrin Homo sapiens 58-69 28557453-5 2017 Both partners of the fusion protein retained their functionality; the hydrophobin moiety enabled migration to a surfactant phase in an aqueous two-phase system, and the transferrin moiety was able to reversibly bind iron. Iron 216-220 transferrin Homo sapiens 169-180 28342427-1 2017 Transferrin (Tf) is an important protein responsible for circulating and transporting iron into cytoplasm. Iron 86-90 transferrin Homo sapiens 0-11 28342427-1 2017 Transferrin (Tf) is an important protein responsible for circulating and transporting iron into cytoplasm. Iron 86-90 transferrin Homo sapiens 13-15 28137239-3 2017 Further, lactoferrin, a milk protein belonging to the transferrin family is now an established multi-functional iron-binding protein. Iron 112-116 transferrin Homo sapiens 54-65 28568509-3 2017 Furthermore, iron-deficient patients in chronic heart failure with a serum ferritin of <100 mug/l or <300 mug/l with reduced transferrin saturation of <20%, who were given intravenous iron showed improved clinical outcomes. Iron 13-17 transferrin Homo sapiens 131-142 28276700-1 2017 Transferrin is one of the sources of iron that is most readily available to colonizing and invading pathogens. Iron 37-41 transferrin Homo sapiens 0-11 28414228-2 2017 Ferrous ion supplied by the ferroportin exporter is converted by Cp to ferric ion that is accepted by plasma metallo-chaperone transferrin. Iron 71-81 transferrin Homo sapiens 127-138 28328144-3 2017 Dialysis clinical practice guidelines recommend tailoring Fe therapy based on transferrin saturation and serum ferritin levels. Iron 58-60 transferrin Homo sapiens 78-89 28371325-1 2017 Capillary electrophoresis analysis of transferrin in human serum is used to assess genetic variants after desialylation with neuraminidase and iron saturation to reduce the complexity of the transferrin pattern and thus facilitate the recognition of transferrin polymorphisms. Iron 143-147 transferrin Homo sapiens 38-49 28371325-3 2017 With the carrier ampholytes used, peaks for iron saturated and iron depleted transferrin are monitored which indicates complexation of iron ions by carrier ampholytes. Iron 63-67 transferrin Homo sapiens 77-88 28371325-3 2017 With the carrier ampholytes used, peaks for iron saturated and iron depleted transferrin are monitored which indicates complexation of iron ions by carrier ampholytes. Iron 63-67 transferrin Homo sapiens 77-88 28342790-7 2017 Recent evidence supports the existence of transferrin-independent iron transport mechanisms in the tumor microenvironment, which points to local iron transport proteins such as lipocalin-2 and/or low molecular weight iron-trafficking substances such as siderophores. Iron 66-70 transferrin Homo sapiens 42-53 28342790-7 2017 Recent evidence supports the existence of transferrin-independent iron transport mechanisms in the tumor microenvironment, which points to local iron transport proteins such as lipocalin-2 and/or low molecular weight iron-trafficking substances such as siderophores. Iron 113-117 transferrin Homo sapiens 42-53 28342790-7 2017 Recent evidence supports the existence of transferrin-independent iron transport mechanisms in the tumor microenvironment, which points to local iron transport proteins such as lipocalin-2 and/or low molecular weight iron-trafficking substances such as siderophores. Iron 113-117 transferrin Homo sapiens 42-53 28350442-2 2017 We designed specific conjugates of the iron-binding and transport protein, transferrin (Tf), to combine the advantages of this serum-stable protein as a targeting agent for cancer cells with self-assembling polymers to act as carriers of cytotoxic drugs. Iron 39-43 transferrin Homo sapiens 75-86 28350442-2 2017 We designed specific conjugates of the iron-binding and transport protein, transferrin (Tf), to combine the advantages of this serum-stable protein as a targeting agent for cancer cells with self-assembling polymers to act as carriers of cytotoxic drugs. Iron 39-43 transferrin Homo sapiens 88-90 27659401-12 2017 The increase in uric acid associated with hyperferritinemia, could be a response to the visceral toxicity of excess non-transferrin bound iron linked to oxidative stress via the antioxidant properties of uric acid. Iron 138-142 transferrin Homo sapiens 120-131 28347462-6 2017 The influence of Mn on Fe homeostasis may be mediated through its influence on Fe absorption, circulating transporters like transferrin, and regulatory proteins. Iron 23-25 transferrin Homo sapiens 124-135 28347462-10 2017 Numerous data also demonstrate the possibility of competition between Fe and chromium (Cr) for transferrin binding. Iron 70-72 transferrin Homo sapiens 95-106 28318177-0 2017 Can soluble transferrin receptor be used in diagnosing iron deficiency anemia and assessing iron response in infants with moderate acute malnutrition? Iron 55-59 transferrin Homo sapiens 12-23 28341433-1 2017 Herein we report on a drastic release of metal ions from the Fe-bound transferrin, and Fe- or Mn-bound lactoferrin, observed upon the increase in the separation voltage during CE-based analysis. Iron 61-63 transferrin Homo sapiens 70-81 28318177-1 2017 OBJECTIVE: To evaluate the efficacy of soluble transferrin receptor (sTfR) in diagnosing iron deficiency anemia (IDA) and evaluating iron response in infants with moderate acute malnutrition (MAM). Iron 89-93 transferrin Homo sapiens 47-58 28233916-9 2017 We also found a generalized decrease in the amount of the iron-binding proteins transferrin and ceruloplasmin, and decreased number of neurons and glial cells that contained ceruloplasmin. Iron 58-62 transferrin Homo sapiens 80-91 28281897-9 2017 Pharmacological targeting of iron metabolism (iron chelation, transferrin receptor blocking) altered the cytokine release profile. Iron 29-33 transferrin Homo sapiens 62-73 28189691-4 2017 Therefore, we developed human IgG monoclonal antibodies to human TFR1 using a phage display method (ICOS method) to block the incorporation of the transferrin (TF)-iron complex into ATLL cells for inhibiting cell growth. Iron 164-168 transferrin Homo sapiens 147-158 28189691-4 2017 Therefore, we developed human IgG monoclonal antibodies to human TFR1 using a phage display method (ICOS method) to block the incorporation of the transferrin (TF)-iron complex into ATLL cells for inhibiting cell growth. Iron 164-168 transferrin Homo sapiens 65-67 28327200-2 2017 Neutralizing hepcidin with a monoclonal antibody (mAb) may prevent ferroportin internalization, restore iron efflux from cells, and allow transferrin-mediated iron transport to the bone marrow. Iron 159-163 transferrin Homo sapiens 138-149 28439220-2 2017 The reference values for transferrin saturation have been previously reported to be lower in children compared to adults, caused by a combination of low serum iron and high serum transferrin levels in children, warranting specific reference intervals. Iron 159-163 transferrin Homo sapiens 25-36 28065783-3 2017 By using diphtheria toxin (DT) as a model toxin, we found that mutating the Tf protein to change its iron release rate improves cellular association and efficacy of the drug. Iron 101-105 transferrin Homo sapiens 76-78 28229980-9 2017 Oral iron supplementation brought more obvious improvements of iron status indicators including absolute increases in serum iron (11.08 +- 2.19 mumol/L vs. 4.43 +- 0.47 mumol/L), transferrin saturation (11.26 +- 1.65% vs. 1.01 +- 0.23%), and hemoglobin (31.47 +- 1.19 g/L vs. 21.00 +- 2.69 g/L) in the acupuncture group than control group (all P < 0.05). Iron 5-9 transferrin Homo sapiens 179-190 28257476-12 2017 Non-transferrin-bound iron was high in the thalassemia and MDS groups but low in the SCA group (P<0.001). Iron 22-26 transferrin Homo sapiens 4-15 28128726-3 2017 Intravenous iron was given at each site"s discretion if ferritin <= 1,000 ng/mL and transferrin saturation <= 30%. Iron 12-16 transferrin Homo sapiens 87-98 28128726-5 2017 Multivariable generalized estimating equations related elevated ESA and intravenous iron doses to trailing 90-day averages of ferritin and transferrin saturation with covariate adjustment. Iron 84-88 transferrin Homo sapiens 139-150 28128726-8 2017 Adjusted odds ratios for higher intravenous iron dose were lower in the highest (0.23 [0.16 - 0.35], p < 0.001) and middle transferrin saturation tertile (0.42 [0.31 - 0.57], p < 0.001) vs. lowest. Iron 44-48 transferrin Homo sapiens 126-137 28128726-11 2017 Transferrin saturation may be a better marker than serum ferritin to judge optimal iron stores in dialysis patients. Iron 83-87 transferrin Homo sapiens 0-11 28075490-1 2017 BACKGROUND: Studies evaluating the relationship between soluble transferrin receptor (sTfR), a biomarker inversely related to body iron stores, and risk of type 2 diabetes mellitus (T2DM) are scarce and inconclusive. Iron 131-135 transferrin Homo sapiens 64-75 28257033-2 2017 This protein of the transferrin family has broad antimicrobial properties by depriving pathogens from iron, or disrupting their plasma membranes through its highly cationic charge. Iron 102-106 transferrin Homo sapiens 20-31 28110161-0 2017 Citrate and albumin facilitate transferrin iron loading in the presence of phosphate. Iron 43-47 transferrin Homo sapiens 31-42 28174761-5 2017 From their Raman spectra apo-and holo-forms of iron-binding proteins, transferrin and ferritin, could be readily distinguished and variations in spectral features as a result of structural changes could also be determined. Iron 47-51 transferrin Homo sapiens 70-81 28031261-8 2017 Our results demonstrate that ceruloplasmin decreases the bioavailability of iron in urine by a transferrin-dependent mechanism. Iron 76-80 transferrin Homo sapiens 95-106 28230785-2 2017 ROS-derived hydroperoxides, as an indicator of ROS production, have been measured by using the diacron reactive oxygen metabolites (d-ROMs) test, which requires iron-containing transferrin in the reaction mixture. Iron 161-165 transferrin Homo sapiens 177-188 28110161-2 2017 Serum transferrin binds iron in a non-exchangeable form and delivers iron to cells. Iron 24-28 transferrin Homo sapiens 6-17 28110161-2 2017 Serum transferrin binds iron in a non-exchangeable form and delivers iron to cells. Iron 69-73 transferrin Homo sapiens 6-17 28110161-4 2017 This work evaluates possible pathways leading to LPI and examines potential mediators of apo transferrin iron loading to prevent LPI. Iron 105-109 transferrin Homo sapiens 93-104 28110161-5 2017 Previously phosphate was shown to inhibit iron loading into apo transferrin by competitively binding free Fe3+. Iron 42-46 transferrin Homo sapiens 64-75 28110161-7 2017 In this study we evaluate iron loading into transferrin under physiologically relevant phosphate conditions to evaluate the roles of citrate and albumin in mediating iron delivery into apo transferrin. Iron 26-30 transferrin Homo sapiens 44-55 28110161-7 2017 In this study we evaluate iron loading into transferrin under physiologically relevant phosphate conditions to evaluate the roles of citrate and albumin in mediating iron delivery into apo transferrin. Iron 166-170 transferrin Homo sapiens 189-200 28110161-14 2017 Our results suggest a physiologically important role for albumin and citrate for apo transferrin iron loading. Iron 97-101 transferrin Homo sapiens 85-96 27718450-2 2017 Human serum transferrin is the most abundant serum protein responsible for the transport of iron ions and many endogenous and exogenous ligands. Iron 92-96 transferrin Homo sapiens 12-23 28261264-2 2017 BPAN is a movement disorder with Non Transferrin Bound Iron (NTBI) accumulation in the basal ganglia as common hallmark between NBIA classes (Hayflick et al., 2013). Iron 55-59 transferrin Homo sapiens 37-48 27986638-2 2017 The well-studied transferrins are mammalian serum transferrin, which is involved in iron transport, and mammalian lactoferrin, which functions as an immune protein. Iron 84-88 transferrin Homo sapiens 17-28 27986638-9 2017 Unlike iron-saturated lactoferrin, iron-saturated transferrin had no detectable antibacterial activity. Iron 35-39 transferrin Homo sapiens 50-61 27986638-10 2017 In contrast, 1 muM iron-free transferrin inhibited bacterial growth, and this inhibition was blocked by supplementing the culture medium with 1 muM iron. Iron 19-23 transferrin Homo sapiens 29-40 27986638-10 2017 In contrast, 1 muM iron-free transferrin inhibited bacterial growth, and this inhibition was blocked by supplementing the culture medium with 1 muM iron. Iron 148-152 transferrin Homo sapiens 29-40 27986638-11 2017 Our results suggest that M. sexta transferrin does not have bactericidal activity, but that it does have a bacteriostatic function that depends on its iron sequestering ability. Iron 151-155 transferrin Homo sapiens 34-45 27986638-12 2017 This study supports the hypothesis that insect transferrin participates in an iron withholding strategy to protect insects from infectious bacteria. Iron 78-82 transferrin Homo sapiens 47-58 27957820-1 2017 Serum ferritin level and transferrin saturation (TSAT) are widely used to evaluate iron status in patients with chronic kidney disease, and are also important variables for performing statistical analyses. Iron 83-87 transferrin Homo sapiens 25-36 27473364-10 2017 CONCLUSION: Among the investigated indicators of iron metabolism, serum transferrin concentration was the best indicator of organ failure and an independent predictor of short-term mortality at 30 days. Iron 49-53 transferrin Homo sapiens 72-83 29474757-2 2017 Iron supplementation leads to a rise of transferrin saturation and ferritin concentration, resulting in an increased hemoglobin level and decrease of anemia symptoms. Iron 0-4 transferrin Homo sapiens 40-51 28112296-4 2017 In the absence of bicarbonate the affinity of transferrin for plutonium at pH 6 is about 104 times stronger than that of iron at pH 6.7 . Iron 121-125 transferrin Homo sapiens 46-57 28203319-5 2017 Iron supplementation at rest increased iron concentration and transferrin saturation (p < 0.01). Iron 0-4 transferrin Homo sapiens 62-73 29226154-6 2017 In UC, transferrin correlates negatively with CRP, erythrocyte sedimentation rate (ESR), leukocytes, platelets, interleukin-6, interleukin-10, and TNF-alpha and positively with albumins, cholesterol, hemoglobin, hematocrit, erythrocytes, iron, and paraoxonase-1. Iron 238-242 transferrin Homo sapiens 7-18 28240188-7 2017 Moreover, Fe levels were negatively associated with Hp and positively with PON1, total iron binding capacity and Tf, while ferritin and sTfR were positively associated with MDA levels. Iron 10-12 transferrin Homo sapiens 113-115 29223935-4 2017 Serum ferritin and transferrin saturation were determined; criteria for Fe overload was serum ferritin > 300 ng/ml and transferrin saturation = 50%. Iron 72-74 transferrin Homo sapiens 122-133 27576370-7 2017 Serum ferritin and non-transferrin-bound iron also decreased significantly. Iron 41-45 transferrin Homo sapiens 23-34 27696454-1 2017 BACKGROUND: Transfusion of a single unit of stored red blood cells (RBCs) has been hypothesized to induce supra-physiological levels of non-transferrin bound iron (NTBI), which may enhance inflammation and act as a nutrient for bacteria. Iron 158-162 transferrin Homo sapiens 140-151 28042856-7 2016 Selective dietary supplementation with phenolics exhibiting pro-oxidant activity may increase the possibility of systemic oxidative stress in patients treated with medications containing chelating properties or those with high plasma concentrations of H2O2 and non-transferrin bound iron. Iron 283-287 transferrin Homo sapiens 265-276 27871472-9 2016 DISCUSSION: In the placenta of NH, increases in expressions of TFR1, transferrin, and ferritin of which those of TFR1 were especially marked, reflect increased iron influx from the mother to fetus. Iron 160-164 transferrin Homo sapiens 69-80 27627839-1 2016 In erythroid cells, more than 90% of transferrin-derived iron enters mitochondria where ferrochelatase inserts Fe2+ into protoporphyrin IX. Iron 57-61 transferrin Homo sapiens 37-48 27627839-4 2016 In contrast, this study supports the hypothesis that the highly efficient transport of iron toward ferrochelatase in erythroid cells requires a direct interaction between transferrin-endosomes and mitochondria (the "kiss-and-run" hypothesis). Iron 87-91 transferrin Homo sapiens 171-182 27627839-11 2016 Altogether, our results suggest that a molecular mechanism exists to coordinate the iron status of endosomal transferrin with its trafficking. Iron 84-88 transferrin Homo sapiens 109-120 28105341-7 2016 The excessive Fe levels in the bloodstream induced changes in serum ferritin and transferrin levels. Iron 14-16 transferrin Homo sapiens 81-92 28043306-9 2016 Transferrin saturation was determined by dividing serum iron by TIBC and multiplying by 100. Iron 56-60 transferrin Homo sapiens 0-11 27838686-5 2017 The comparison between pre- and post-chelation demonstrated significantly lower iron load: median serum ferritin (551.4 vs. 486.2 ng/ml, p = 0.047), median TIBC (211.5 vs. 233.5 microg/dl, p = 0.009) and median non-transferrin binding iron (5.5 vs. 1.4 microM, p = 0.005). Iron 80-84 transferrin Homo sapiens 215-226 27681840-1 2016 Divalent metal transporter-1 (DMT1) mediates dietary iron uptake across the intestinal mucosa and facilitates peripheral delivery of iron released by transferrin in the endosome. Iron 53-57 transferrin Homo sapiens 150-161 27681840-1 2016 Divalent metal transporter-1 (DMT1) mediates dietary iron uptake across the intestinal mucosa and facilitates peripheral delivery of iron released by transferrin in the endosome. Iron 133-137 transferrin Homo sapiens 150-161 27534995-3 2016 Catalytic iron, also known as labile iron, is a transitional pool of non-transferrin-bound iron that is readily available to participate in redox cycling. Iron 10-14 transferrin Homo sapiens 73-84 27581396-2 2016 Herein, we report that covalent anchoring of human transferrin to carbon-coated iron magnetic nanoparticles functionalized with carboxylic groups (Fe@C-COOH Nps) in the presence of magnetic field results in its conformational integrity and electroactivity. Iron 147-149 transferrin Homo sapiens 51-62 27581396-3 2016 We have found that, the direct contact of human transferrin with Fe@C-COOH Nps does not lead to release of iron and in consequence to the irreversible conformational changes of the protein. Iron 65-67 transferrin Homo sapiens 48-59 27581396-3 2016 We have found that, the direct contact of human transferrin with Fe@C-COOH Nps does not lead to release of iron and in consequence to the irreversible conformational changes of the protein. Iron 107-111 transferrin Homo sapiens 48-59 27581396-7 2016 We showed that it is possible to attach, without changing pH, more than one single layer of transferrin to the Fe@C-COOH Nps. Iron 111-113 transferrin Homo sapiens 92-103 27534995-3 2016 Catalytic iron, also known as labile iron, is a transitional pool of non-transferrin-bound iron that is readily available to participate in redox cycling. Iron 37-41 transferrin Homo sapiens 73-84 27534995-3 2016 Catalytic iron, also known as labile iron, is a transitional pool of non-transferrin-bound iron that is readily available to participate in redox cycling. Iron 37-41 transferrin Homo sapiens 73-84 27620552-7 2016 Iron transferrin saturation and serum ferritin levels were lower in the CKD patients. Iron 0-4 transferrin Homo sapiens 5-16 27589831-8 2016 FAC is a cell-permeable form of iron, which can passively enter into cells bypassing the transferrin receptor mediated uptake of transferrin-bound iron. Iron 32-36 transferrin Homo sapiens 89-100 27344508-0 2016 Clinical and methodological factors affecting non-transferrin-bound iron values using a novel fluorescent bead assay. Iron 68-72 transferrin Homo sapiens 50-61 27344508-1 2016 Nontransferrin-bound iron (NTBI) is a heterogeneously speciated plasma iron, typically detectable when transferrin saturation (TfSat) exceeds 75%. Iron 21-25 transferrin Homo sapiens 3-14 27344508-1 2016 Nontransferrin-bound iron (NTBI) is a heterogeneously speciated plasma iron, typically detectable when transferrin saturation (TfSat) exceeds 75%. Iron 71-75 transferrin Homo sapiens 3-14 27589831-8 2016 FAC is a cell-permeable form of iron, which can passively enter into cells bypassing the transferrin receptor mediated uptake of transferrin-bound iron. Iron 32-36 transferrin Homo sapiens 129-140 27589831-8 2016 FAC is a cell-permeable form of iron, which can passively enter into cells bypassing the transferrin receptor mediated uptake of transferrin-bound iron. Iron 147-151 transferrin Homo sapiens 89-100 27589831-8 2016 FAC is a cell-permeable form of iron, which can passively enter into cells bypassing the transferrin receptor mediated uptake of transferrin-bound iron. Iron 147-151 transferrin Homo sapiens 129-140 27692637-4 2016 IMPLICATIONS: This agent may be administered to patients with stage 5 chronic kidney disease receiving hemodialysis as a new iron supplementation option to maintain hemoglobin, transferrin saturation, and ferritin concentrations. Iron 125-129 transferrin Homo sapiens 177-188 27664951-1 2016 OBJECTIVES: Transferrin is a glycosylated protein responsible for transporting iron, an essential metal responsible for proper fetal development. Iron 79-83 transferrin Homo sapiens 12-23 27581396-0 2016 Conformational control of human transferrin covalently anchored to carbon-coated iron nanoparticles in presence of a magnetic field. Iron 81-85 transferrin Homo sapiens 32-43 27581396-2 2016 Herein, we report that covalent anchoring of human transferrin to carbon-coated iron magnetic nanoparticles functionalized with carboxylic groups (Fe@C-COOH Nps) in the presence of magnetic field results in its conformational integrity and electroactivity. Iron 80-84 transferrin Homo sapiens 51-62 27682263-8 2016 A new therapeutic concept with conservative iron chelation rescues iron-overloaded neurons by scavenging labile iron and, by delivering this chelated metal to endogenous apo-transferrin, allows iron redistribution to avoid systemic loss of iron. Iron 44-48 transferrin Homo sapiens 174-185 26998752-4 2016 RESULTS: Dysmetabolic iron overload syndrome patients had higher peak transferrin saturation and area under the-curve of transferrin saturation than subjects with normal iron status, but lower values than haemochromatosis patients (P < 0.05 for all). Iron 22-26 transferrin Homo sapiens 70-81 26998752-4 2016 RESULTS: Dysmetabolic iron overload syndrome patients had higher peak transferrin saturation and area under the-curve of transferrin saturation than subjects with normal iron status, but lower values than haemochromatosis patients (P < 0.05 for all). Iron 22-26 transferrin Homo sapiens 121-132 27353397-0 2016 The genes that encode the gonococcal transferrin binding proteins, TbpB and TbpA, are differentially regulated by MisR under iron-replete and iron-depleted conditions. Iron 125-129 transferrin Homo sapiens 37-48 27353397-0 2016 The genes that encode the gonococcal transferrin binding proteins, TbpB and TbpA, are differentially regulated by MisR under iron-replete and iron-depleted conditions. Iron 142-146 transferrin Homo sapiens 37-48 27353397-1 2016 Neisseria gonorrhoeae produces two transferrin binding proteins, TbpA and TbpB, which together enable efficient iron transport from human transferrin. Iron 112-116 transferrin Homo sapiens 35-46 27353397-1 2016 Neisseria gonorrhoeae produces two transferrin binding proteins, TbpA and TbpB, which together enable efficient iron transport from human transferrin. Iron 112-116 transferrin Homo sapiens 138-149 27353397-4 2016 The misR mutant was capable of transferrin-iron uptake at only 50% of wild-type levels, consistent with decreased tbp expression. Iron 43-47 transferrin Homo sapiens 31-42 27646275-0 2016 Endosome-mitochondria interactions are modulated by iron release from transferrin. Iron 52-56 transferrin Homo sapiens 70-81 27646275-1 2016 Transient "kiss and run" interactions between endosomes containing iron-bound transferrin (Tf) and mitochondria have been shown to facilitate direct iron transfer in erythroid cells. Iron 67-71 transferrin Homo sapiens 78-89 27646275-1 2016 Transient "kiss and run" interactions between endosomes containing iron-bound transferrin (Tf) and mitochondria have been shown to facilitate direct iron transfer in erythroid cells. Iron 67-71 transferrin Homo sapiens 91-93 27646275-1 2016 Transient "kiss and run" interactions between endosomes containing iron-bound transferrin (Tf) and mitochondria have been shown to facilitate direct iron transfer in erythroid cells. Iron 149-153 transferrin Homo sapiens 78-89 27646275-1 2016 Transient "kiss and run" interactions between endosomes containing iron-bound transferrin (Tf) and mitochondria have been shown to facilitate direct iron transfer in erythroid cells. Iron 149-153 transferrin Homo sapiens 91-93 27646275-4 2016 Quenching of iron sensor RDA-labeled mitochondria confirmed functional iron transfer by an interacting Tf-endosome. Iron 13-17 transferrin Homo sapiens 103-105 27646275-4 2016 Quenching of iron sensor RDA-labeled mitochondria confirmed functional iron transfer by an interacting Tf-endosome. Iron 71-75 transferrin Homo sapiens 103-105 27646275-6 2016 To further assess the functional role of iron in the ability of Tf-endosomes to interact with mitochondria, we blocked endosomal iron release by using a Tf K206E/K534A mutant. Iron 41-45 transferrin Homo sapiens 64-66 27646275-7 2016 Blocking intraendosomal iron release led to significantly increased motility of Tf-endosomes and increased duration of endosome-mitochondria interactions. Iron 24-28 transferrin Homo sapiens 80-82 27646275-8 2016 Thus, intraendosomal iron regulates the kinetics of the interactions between Tf-containing endosomes and mitochondria in epithelial cells. Iron 21-25 transferrin Homo sapiens 77-79 27374715-8 2016 The analysis of serum iron status according to feeding methods during the first six months revealed higher iron, ferritin, and transferrin saturation levels in children exclusively or mainly fed formula than in children exclusively or mainly fed breast milk. Iron 22-26 transferrin Homo sapiens 127-138 27448041-2 2016 Transferrin, is an essential metal-binding protein responsible for iron transport and proper foetal development. Iron 67-71 transferrin Homo sapiens 0-11 27448041-7 2016 Transferrin isoforms showed positive correlation with lowered iron stores in the blood of non-smoking women. Iron 62-66 transferrin Homo sapiens 0-11 27465531-5 2016 Transferrin-mediated iron uptake by regenerating myofibers occurs independently of systemic iron homeostasis. Iron 21-25 transferrin Homo sapiens 0-11 27356954-4 2016 One of biological sources of iron ions are iron-rich proteins, such as transferrin or ferritin. Iron 29-33 transferrin Homo sapiens 71-82 27356954-4 2016 One of biological sources of iron ions are iron-rich proteins, such as transferrin or ferritin. Iron 43-47 transferrin Homo sapiens 71-82 27170339-2 2016 Vitamin C acts as an enzyme cofactor and enhances mobilization of the ferrous form of iron to transferrin thus increasing its bioavailability. Iron 86-90 transferrin Homo sapiens 94-105 27226592-1 2016 Clathrin-mediated endocytosis of transferrin (Tf) and its cognate receptor (TfR1) is a central pathway supporting the uptake of trophic iron. Iron 136-140 transferrin Homo sapiens 33-44 27503259-13 2016 CONCLUSION: Beyond our current view of iron metabolism in insects, with ferritin and transferrin as its key players, this study provides a comprehensive catalogue of genes with possible roles in the acquisition; transport and storage of iron hence iron homeostasis in the tsetse fly. Iron 237-241 transferrin Homo sapiens 85-96 27503259-13 2016 CONCLUSION: Beyond our current view of iron metabolism in insects, with ferritin and transferrin as its key players, this study provides a comprehensive catalogue of genes with possible roles in the acquisition; transport and storage of iron hence iron homeostasis in the tsetse fly. Iron 237-241 transferrin Homo sapiens 85-96 27226592-1 2016 Clathrin-mediated endocytosis of transferrin (Tf) and its cognate receptor (TfR1) is a central pathway supporting the uptake of trophic iron. Iron 136-140 transferrin Homo sapiens 46-48 27418684-8 2016 Following administration of intravenous iron, values for ferritin concentration, transferrin saturation, and hepcidin concentration rose significantly (P < 0.001, P < 0.005, and P < 0.001, respectively), and values for transferrin concentration fell significantly (P < 0.001). Iron 40-44 transferrin Homo sapiens 81-92 27418684-8 2016 Following administration of intravenous iron, values for ferritin concentration, transferrin saturation, and hepcidin concentration rose significantly (P < 0.001, P < 0.005, and P < 0.001, respectively), and values for transferrin concentration fell significantly (P < 0.001). Iron 40-44 transferrin Homo sapiens 228-239 27441659-7 2016 We found that the expression of transferrin, which is responsible for the transport of iron into cells, is increased following treatment with lapatinib alone or in combination with siramesine. Iron 87-91 transferrin Homo sapiens 32-43 26549031-5 2016 The hydroxyl radical, which is produced in a Fenton reaction catalyzed by an iron ion, serves as a potent DNA-DSB-inducing molecule, raising the potential of an iron ion transporter of transferrin in the formation of DNA-DSBs. Iron 77-81 transferrin Homo sapiens 185-196 26549031-5 2016 The hydroxyl radical, which is produced in a Fenton reaction catalyzed by an iron ion, serves as a potent DNA-DSB-inducing molecule, raising the potential of an iron ion transporter of transferrin in the formation of DNA-DSBs. Iron 161-165 transferrin Homo sapiens 185-196 26558919-6 2016 Percentage of transferrin saturation was calculated using serum iron and total iron binding capacity values. Iron 64-68 transferrin Homo sapiens 14-25 27307498-1 2016 The transferrin receptor is the primary means of iron importation for most mammalian cells and understanding its regulatory mechanisms is relevant to hematologic, oncologic, and other disorders in which iron homeostasis is perturbed. Iron 49-53 transferrin Homo sapiens 4-15 27307498-1 2016 The transferrin receptor is the primary means of iron importation for most mammalian cells and understanding its regulatory mechanisms is relevant to hematologic, oncologic, and other disorders in which iron homeostasis is perturbed. Iron 203-207 transferrin Homo sapiens 4-15 26558919-6 2016 Percentage of transferrin saturation was calculated using serum iron and total iron binding capacity values. Iron 79-83 transferrin Homo sapiens 14-25 27261274-3 2016 Early kinetic studies provided valuable data on the initial uptake of maternal transferrin, an iron-binding protein, by the placenta. Iron 95-99 transferrin Homo sapiens 79-90 27498743-1 2016 Erythropoiesis requires large amounts of iron for hemoglobin synthesis, which is mainly provided by macrophages and the intestines in a transferrin (Tf)-bound form. Iron 41-45 transferrin Homo sapiens 136-147 26934143-8 2016 Hepcidin values correlated with ferritin levels, and serum iron correlated strongly with transferrin saturation. Iron 59-63 transferrin Homo sapiens 89-100 26999720-6 2016 Elevated iron levels were defined by high serum ferritin (SF>110 mug/L in women and>200 mug/L in men) and/or transferrin saturation (TS)>45%. Iron 9-13 transferrin Homo sapiens 115-126 26850692-7 2016 Iron enters BM-MSCs through both transferrin-dependent and transferrin-independent mechanisms, inducing the accumulation of cyclins E and A, the decrease of p27(Kip1), and the activation of MAPK pathway. Iron 0-4 transferrin Homo sapiens 33-44 26850692-7 2016 Iron enters BM-MSCs through both transferrin-dependent and transferrin-independent mechanisms, inducing the accumulation of cyclins E and A, the decrease of p27(Kip1), and the activation of MAPK pathway. Iron 0-4 transferrin Homo sapiens 59-70 26934143-13 2016 CONCLUSIONS: Our findings demonstrate that parameters of iron metabolism, particularly transferrin saturation, that reflect serum iron availability, are strong outcome predictors in ICU patients. Iron 57-61 transferrin Homo sapiens 87-98 26934143-13 2016 CONCLUSIONS: Our findings demonstrate that parameters of iron metabolism, particularly transferrin saturation, that reflect serum iron availability, are strong outcome predictors in ICU patients. Iron 130-134 transferrin Homo sapiens 87-98 27091216-10 2016 Oxidative stress as a result of IV iron infusions and iron overload, by releasing labile non-transferrin-bound iron, might represent a "second hit" on the vascular bed. Iron 35-39 transferrin Homo sapiens 93-104 27249004-2 2016 Total body iron, calculated from serum ferritin and soluble transferrin receptor concentrations, and hemoglobin allow for monitoring of the iron and anemia status of children in the United States. Iron 11-15 transferrin Homo sapiens 60-71 27070073-1 2016 Human serum transferrin (sTf) is a protein that mediates the transport of iron from blood to cells. Iron 74-78 transferrin Homo sapiens 12-23 27091216-10 2016 Oxidative stress as a result of IV iron infusions and iron overload, by releasing labile non-transferrin-bound iron, might represent a "second hit" on the vascular bed. Iron 54-58 transferrin Homo sapiens 93-104 27091216-10 2016 Oxidative stress as a result of IV iron infusions and iron overload, by releasing labile non-transferrin-bound iron, might represent a "second hit" on the vascular bed. Iron 54-58 transferrin Homo sapiens 93-104 27161430-2 2016 To supply adequate iron the carrier transferrin is required together with transferrin receptor endosomal cycle and normal mitochondrial iron utilization. Iron 19-23 transferrin Homo sapiens 36-47 27161430-2 2016 To supply adequate iron the carrier transferrin is required together with transferrin receptor endosomal cycle and normal mitochondrial iron utilization. Iron 136-140 transferrin Homo sapiens 36-47 27161430-12 2016 Erythroblasts sense circulating iron through the second transferrin receptor (TFR2) that, in animal models, modulates the sensitivity of the erythroid cells to EPO. Iron 32-36 transferrin Homo sapiens 56-67 27305829-1 2016 Due to their abundant ubiquitous presence, rapid uptake and increased requirement in neoplastic tissue, the delivery of the iron carrier macromolecules transferrin (Tf) and lactoferrin (Lf) into mammalian cells is the subject of intense interest for delivery of drugs and other target molecules into cells. Iron 124-128 transferrin Homo sapiens 152-163 27305829-1 2016 Due to their abundant ubiquitous presence, rapid uptake and increased requirement in neoplastic tissue, the delivery of the iron carrier macromolecules transferrin (Tf) and lactoferrin (Lf) into mammalian cells is the subject of intense interest for delivery of drugs and other target molecules into cells. Iron 124-128 transferrin Homo sapiens 165-167 26759251-4 2016 A fitting model using a linear combination of the XANES of Tf and deliquescent Fe(III) sulfate allowed to explain the near edge structure recorded for HT-29 cells indicating that cellular overload with inorganic Fe results in a non-ferritin-like fast Fe storage. Iron 212-214 transferrin Homo sapiens 59-61 27629729-4 2016 OBJECTIVES: The aim of the study was to evaluate the usefulness of determining the reticulocyte hemoglobin content and serum concentration of soluble transferrin receptor in the detection of anemia caused by iron deficiency in comparison with the classic markers of iron circulation in serum in chronic dialysis patients with ESRD. Iron 208-212 transferrin Homo sapiens 150-161 27629729-10 2016 Moreover, the concentration of soluble transferrin receptor confirmed its high diagnostic value in the detection of iron deficiency-based anemia in patients undergoing dialysis for chronic renal failure at the end-stage compared to conventional iron turnover ratios in the serum. Iron 116-120 transferrin Homo sapiens 39-50 26835887-8 2016 Iron deficiency was calculated using ferritin and soluble transferrin receptor in the body iron formula. Iron 91-95 transferrin Homo sapiens 58-69 26759251-8 2016 These Fe/S ratios were dramatically lower for HCA-7 treated with organic Fe(III) treatments suggesting dissimilarities from the Tf-like Fe uptake. Iron 73-75 transferrin Homo sapiens 128-130 26250435-10 2016 Serum-ferritin and transferrin saturation concentrations were also significantly increased with IV iron. Iron 99-103 transferrin Homo sapiens 19-30 26861925-10 2016 CONCLUSIONS: The pattern of association of TSAT and transferrin with T2D suggests that the underlying relationship between iron stores and T2D is more complex than the simple link suggested by the association of ferritin with T2D. Iron 123-127 transferrin Homo sapiens 52-63 27277369-6 2016 Percentage of transferrin saturation (TS) calculated from serum iron and TIBC. Iron 64-68 transferrin Homo sapiens 14-25 26759376-4 2016 These inhibitors partially prevented intracellular iron provision by attenuating intracellular transport of transferrin or autophagic degradation of ferritin. Iron 51-55 transferrin Homo sapiens 108-119 26715163-6 2016 Iron depletion caused a significant reduction in serum ferritin, transferrin saturation, and MSNA (from 64.8 +- 13.3 to 39.2 +- 9.2 bs/100 hb, P < 0.01) and a significant improvement in baroreflex-MSNA modulation. Iron 0-4 transferrin Homo sapiens 65-76 26679080-7 2016 Coating NT50 with hemoglobin or transferrin significantly aggravated cytotoxicity to RPMC, with an increase in cellular catalytic ferrous iron and DNA damage also observed. Iron 138-142 transferrin Homo sapiens 32-43 26616335-4 2016 Moreover, by bypassing physiologic safeguards, indiscriminate use of IV iron overwhelms transferrin, imposing stress on the reticuloendothelial system that can have long-term adverse consequences. Iron 72-76 transferrin Homo sapiens 88-99 26999450-2 2016 Recent improvements in our knowledge of iron metabolism have been focused on elevated non-transferrin-bound iron and labile plasma iron levels in the peritransplantation period as potential contributors to tissue toxicity and subsequent adverse transplant outcome. Iron 40-44 transferrin Homo sapiens 90-101 26999450-2 2016 Recent improvements in our knowledge of iron metabolism have been focused on elevated non-transferrin-bound iron and labile plasma iron levels in the peritransplantation period as potential contributors to tissue toxicity and subsequent adverse transplant outcome. Iron 108-112 transferrin Homo sapiens 90-101 26999450-2 2016 Recent improvements in our knowledge of iron metabolism have been focused on elevated non-transferrin-bound iron and labile plasma iron levels in the peritransplantation period as potential contributors to tissue toxicity and subsequent adverse transplant outcome. Iron 108-112 transferrin Homo sapiens 90-101 27186942-5 2016 Epidemiological data from the general population draw clear associations between increased transferrin saturation (and, by inference, labile iron) and early death, diabetes, and malignant transformation. Iron 141-145 transferrin Homo sapiens 91-102 26679080-8 2016 Knockdown of transferrin receptor with ferristatin II decreased not only NT50 uptake but also cellular catalytic ferrous iron. Iron 121-125 transferrin Homo sapiens 13-24 26679080-9 2016 Our results suggest that adsorption of hemoglobin and transferrin on the surface of NT50 play a role in causing mesothelial iron overload, contributing to oxidative damage and possibly subsequent carcinogenesis in mesothelial cells. Iron 124-128 transferrin Homo sapiens 54-65 27236130-6 2016 The efficacy of intravenous iron in improving hemoglobin, ferritin, and transferrin saturation is well established, and superior to oral iron, but the long-term safety of this route of administration has not been established and there are theoretical concerns that patients may be exposed to increased oxidative stress and exacerbation of infections. Iron 28-32 transferrin Homo sapiens 72-83 26852655-2 2016 Total iron binding capacity was strongly associated (p=10(-14)) with variants in and near the TF gene (transferrin), the serum iron transporting protein, and with variants in HFE (p=4x10(-7)), which encodes the human hemochromatosis gene. Iron 6-10 transferrin Homo sapiens 103-114 27236131-7 2016 All IV iron products are taken up into the reticuloendothelial system where the shell is metabolized and the iron is stored within tissue ferritin or exported to circulating transferrin. Iron 7-11 transferrin Homo sapiens 174-185 27236131-7 2016 All IV iron products are taken up into the reticuloendothelial system where the shell is metabolized and the iron is stored within tissue ferritin or exported to circulating transferrin. Iron 109-113 transferrin Homo sapiens 174-185 27236135-2 2016 Intestinal absorption of iron from FC results in increases in serum iron, ferritin, and transferrin saturation, effects that occur over 12 to 24 weeks and subsequently appear to plateau. Iron 25-29 transferrin Homo sapiens 88-99 26606902-0 2016 Luminescence turn-on/off sensing of biological iron by carbon dots in transferrin. Iron 47-51 transferrin Homo sapiens 70-81 26955866-1 2016 Transferrin (Tf) is an essential transport protein circulating iron in the blood and delivering it to tissues. Iron 63-67 transferrin Homo sapiens 0-11 26955866-1 2016 Transferrin (Tf) is an essential transport protein circulating iron in the blood and delivering it to tissues. Iron 63-67 transferrin Homo sapiens 13-15 26606902-10 2016 Furthermore, the results from UV-Vis and far-UV CD measurements revealed a significant conformational change of Tf at pH 3.5 relative to pH 7.4, which triggers the subsequent release of bound iron from Tf. Iron 192-196 transferrin Homo sapiens 112-114 26606902-10 2016 Furthermore, the results from UV-Vis and far-UV CD measurements revealed a significant conformational change of Tf at pH 3.5 relative to pH 7.4, which triggers the subsequent release of bound iron from Tf. Iron 192-196 transferrin Homo sapiens 202-204 26606902-12 2016 Our present results show that these chemically synthesized water-dispersed CDs have the ability to selectively sense the bound iron from released iron of Tf without any conformational perturbation and hence they can be used as potential biological iron sensors as well as luminescent markers for the detection of iron deficiency/overload in biological macromolecules. Iron 127-131 transferrin Homo sapiens 154-156 26606902-12 2016 Our present results show that these chemically synthesized water-dispersed CDs have the ability to selectively sense the bound iron from released iron of Tf without any conformational perturbation and hence they can be used as potential biological iron sensors as well as luminescent markers for the detection of iron deficiency/overload in biological macromolecules. Iron 146-150 transferrin Homo sapiens 154-156 26606902-12 2016 Our present results show that these chemically synthesized water-dispersed CDs have the ability to selectively sense the bound iron from released iron of Tf without any conformational perturbation and hence they can be used as potential biological iron sensors as well as luminescent markers for the detection of iron deficiency/overload in biological macromolecules. Iron 146-150 transferrin Homo sapiens 154-156 26606902-2 2016 In mammalian cells, serum transferrin (Tf) is responsible for iron transport and its iron overload/deficiency causes various diseases. Iron 62-66 transferrin Homo sapiens 26-37 26606902-2 2016 In mammalian cells, serum transferrin (Tf) is responsible for iron transport and its iron overload/deficiency causes various diseases. Iron 62-66 transferrin Homo sapiens 39-41 26606902-2 2016 In mammalian cells, serum transferrin (Tf) is responsible for iron transport and its iron overload/deficiency causes various diseases. Iron 85-89 transferrin Homo sapiens 26-37 26606902-2 2016 In mammalian cells, serum transferrin (Tf) is responsible for iron transport and its iron overload/deficiency causes various diseases. Iron 85-89 transferrin Homo sapiens 39-41 27346617-0 2016 Transferrin Saturation: A Body Iron Biomarker. Iron 31-35 transferrin Homo sapiens 0-11 26866805-1 2016 BACKGROUND: Spontaneous reports from patients able to report vascular sequelae in real time, and recognition that serum non transferrin bound iron may reach or exceed 10mumol/L in the blood stream after iron tablets or infusions, led us to hypothesize that conventional iron treatments may provoke acute vascular injury. Iron 142-146 transferrin Homo sapiens 124-135 26866805-1 2016 BACKGROUND: Spontaneous reports from patients able to report vascular sequelae in real time, and recognition that serum non transferrin bound iron may reach or exceed 10mumol/L in the blood stream after iron tablets or infusions, led us to hypothesize that conventional iron treatments may provoke acute vascular injury. Iron 203-207 transferrin Homo sapiens 124-135 26866805-1 2016 BACKGROUND: Spontaneous reports from patients able to report vascular sequelae in real time, and recognition that serum non transferrin bound iron may reach or exceed 10mumol/L in the blood stream after iron tablets or infusions, led us to hypothesize that conventional iron treatments may provoke acute vascular injury. Iron 203-207 transferrin Homo sapiens 124-135 23606586-2 2016 Based upon the high levels of iron-saturated transferrin in plasma serum, it was hypothesized that terminal differentiation in serum-free media may be highly dependent on the concentration of iron. Iron 30-34 transferrin Homo sapiens 45-56 23606586-2 2016 Based upon the high levels of iron-saturated transferrin in plasma serum, it was hypothesized that terminal differentiation in serum-free media may be highly dependent on the concentration of iron. Iron 192-196 transferrin Homo sapiens 45-56 23606586-3 2016 Here adult human CD34(+) cells were cultured in a serum-free medium containing dosed levels of iron-saturated transferrin (holo-Tf, 0.1-1.0 mg/ml). Iron 95-99 transferrin Homo sapiens 110-121 26666535-2 2016 Iron influx to the developing erythroblast is controlled by the expression of the transferrin receptor, while iron efflux is regulated by ferroportin (FPN), the sole iron-exporting protein. Iron 0-4 transferrin Homo sapiens 82-93 26596411-2 2016 Physiologically, the liver synthesizes transferrin, in charge of blood iron transport; ceruloplasmin, acting through its ferroxidase activity; and hepcidin, the master regulator of systemic iron. Iron 71-75 transferrin Homo sapiens 39-50 27346617-3 2016 Among these is plasma transferrin, which is central to iron metabolism not only through iron transport between body tissues in a soluble nontoxic form but also through its protective scavenger role in sequestering free toxic iron. Iron 55-59 transferrin Homo sapiens 22-33 27346617-3 2016 Among these is plasma transferrin, which is central to iron metabolism not only through iron transport between body tissues in a soluble nontoxic form but also through its protective scavenger role in sequestering free toxic iron. Iron 88-92 transferrin Homo sapiens 22-33 27346617-3 2016 Among these is plasma transferrin, which is central to iron metabolism not only through iron transport between body tissues in a soluble nontoxic form but also through its protective scavenger role in sequestering free toxic iron. Iron 88-92 transferrin Homo sapiens 22-33 27346617-4 2016 The transferrin saturation (TSAT), an index that takes into account both plasma iron and its main transport protein, is considered an important biochemical marker of body iron status. Iron 80-84 transferrin Homo sapiens 4-15 27346617-4 2016 The transferrin saturation (TSAT), an index that takes into account both plasma iron and its main transport protein, is considered an important biochemical marker of body iron status. Iron 171-175 transferrin Homo sapiens 4-15 29421281-1 2016 Iron is essential for cell growth and is imported into cells in part through the action of transferrin (Tf), a protein that binds its receptor (TfR1 or CD71) on the surface of a cell, and then releases iron into endosomes. Iron 0-4 transferrin Homo sapiens 91-102 26408108-5 2016 No single test is diagnostic of ID unless the serum ferritin is low or the percent transferrin saturation is low with an elevated total iron binding capacity. Iron 136-140 transferrin Homo sapiens 83-94 26342303-5 2016 According to the new guidelines, when transferrin saturation is lower than 30% and ferritin lower than 500 ng/mL, a trial with iron should be started, to avoid therapy with ESAs or at least to reduce the doses needed to treat the anemia. Iron 127-131 transferrin Homo sapiens 38-49 27170390-8 2016 Considering the fact that an increased saturation of transferrin and high iron in plasma are the hallmark of all hemochromatosis forms, an alternative view would be that toxic iron in the circulation is involved in the pathogenesis of hemochromatosis. Iron 176-180 transferrin Homo sapiens 53-64 27170390-9 2016 Recent studies have shown an increased concentration of redox-active iron in plasma in patients with increased transferrin saturation. Iron 69-73 transferrin Homo sapiens 111-122 27861481-5 2016 Lactoferrin is a protein member of the transferrin family of iron-binding proteins, present inside polymorphonuclear granular structure, and has been reported to affect growth and development of infectious agents, including fungal organisms. Iron 61-65 transferrin Homo sapiens 39-50 26385212-0 2016 Second international round robin for the quantification of serum non-transferrin-bound iron and labile plasma iron in patients with iron-overload disorders. Iron 87-91 transferrin Homo sapiens 69-80 26385212-1 2016 Non-transferrin-bound iron and its labile (redox active) plasma iron component are thought to be potentially toxic forms of iron originally identified in the serum of patients with iron overload. Iron 22-26 transferrin Homo sapiens 4-15 26385212-6 2016 Absolute levels differed considerably between assays and were lower for labile plasma iron than for non-transferrin-bound iron. Iron 122-126 transferrin Homo sapiens 104-115 26385212-9 2016 Assays correlated and correlations were highest within the group of non-transferrin-bound iron assays and within that of labile plasma iron assays. Iron 90-94 transferrin Homo sapiens 72-83 26385212-10 2016 Increased transferrin saturation, but not ferritin, was a good indicator of the presence of forms of circulating non-transferrin-bound iron. Iron 135-139 transferrin Homo sapiens 10-21 26385212-10 2016 Increased transferrin saturation, but not ferritin, was a good indicator of the presence of forms of circulating non-transferrin-bound iron. Iron 135-139 transferrin Homo sapiens 117-128 29421281-1 2016 Iron is essential for cell growth and is imported into cells in part through the action of transferrin (Tf), a protein that binds its receptor (TfR1 or CD71) on the surface of a cell, and then releases iron into endosomes. Iron 0-4 transferrin Homo sapiens 104-106 29421281-1 2016 Iron is essential for cell growth and is imported into cells in part through the action of transferrin (Tf), a protein that binds its receptor (TfR1 or CD71) on the surface of a cell, and then releases iron into endosomes. Iron 202-206 transferrin Homo sapiens 91-102 29421281-1 2016 Iron is essential for cell growth and is imported into cells in part through the action of transferrin (Tf), a protein that binds its receptor (TfR1 or CD71) on the surface of a cell, and then releases iron into endosomes. Iron 202-206 transferrin Homo sapiens 104-106 26725908-2 2016 Excess iron in the blood, in the absence of increased erythropoietic needs, can saturate the buffering capacity of serum transferrin and result in non-transferrin-bound highly reactive forms of iron that can cause damage, as well as promote fibrogenesis and carcinogenesis in the parenchymatous organs. Iron 7-11 transferrin Homo sapiens 121-132 26725908-2 2016 Excess iron in the blood, in the absence of increased erythropoietic needs, can saturate the buffering capacity of serum transferrin and result in non-transferrin-bound highly reactive forms of iron that can cause damage, as well as promote fibrogenesis and carcinogenesis in the parenchymatous organs. Iron 7-11 transferrin Homo sapiens 151-162 26725908-2 2016 Excess iron in the blood, in the absence of increased erythropoietic needs, can saturate the buffering capacity of serum transferrin and result in non-transferrin-bound highly reactive forms of iron that can cause damage, as well as promote fibrogenesis and carcinogenesis in the parenchymatous organs. Iron 194-198 transferrin Homo sapiens 151-162 26987842-3 2016 Iron status was determined by a combination of several indicators: ferritin, transferrin, blood count, total iron binding capacity, transferrin saturation, and C-reactive protein. Iron 0-4 transferrin Homo sapiens 77-88 26987842-3 2016 Iron status was determined by a combination of several indicators: ferritin, transferrin, blood count, total iron binding capacity, transferrin saturation, and C-reactive protein. Iron 0-4 transferrin Homo sapiens 132-143 26362814-7 2015 Our results support the model that the medial habenula responds to disease activity by upregulating transferrin receptor to facilitate the movement of iron into the brain from the third ventricle, raising the possibility that a similar mechanism accounts for iron accumulation in deep gray matter structures in patients with multiple sclerosis. Iron 151-155 transferrin Homo sapiens 100-111 27180706-8 2016 Iron incorporation into hemoglobin and scavenging by transferrin may buffer iron toxicity more effectively in White than in Black individuals. Iron 0-4 transferrin Homo sapiens 53-64 27180706-8 2016 Iron incorporation into hemoglobin and scavenging by transferrin may buffer iron toxicity more effectively in White than in Black individuals. Iron 76-80 transferrin Homo sapiens 53-64 26915864-3 2016 Functional iron deficiency (defined as ferritin greater than 200 ng/mL with TSAT (Transferrin saturation) less than 20%) is characterized by the presence of adequate iron stores as defined by conventional criteria, but with insufficient iron mobilization to adequately support. Iron 11-15 transferrin Homo sapiens 82-93 25964094-3 2015 Non-transferrin-bound iron (NTBI) is a form of free-plasma iron that is a good indicator of iron overload. Iron 22-26 transferrin Homo sapiens 4-15 25964094-3 2015 Non-transferrin-bound iron (NTBI) is a form of free-plasma iron that is a good indicator of iron overload. Iron 59-63 transferrin Homo sapiens 4-15 25964094-3 2015 Non-transferrin-bound iron (NTBI) is a form of free-plasma iron that is a good indicator of iron overload. Iron 59-63 transferrin Homo sapiens 4-15 26700986-6 2015 RESULTS: Ferritin and transferrin-bound iron levels were significantly higher in women with PCOS than normoweight controls. Iron 40-44 transferrin Homo sapiens 22-33 26175145-2 2015 FPC donates iron directly to transferrin, bypassing the reticuloendothelial system and avoiding iron sequestration. Iron 12-16 transferrin Homo sapiens 29-40 26556366-1 2015 Ovotransferrin or conalbumin belong to the transferrin protein family and is endowed with both iron-transfer and protective activities. Iron 95-99 transferrin Homo sapiens 3-14 26635045-3 2015 In case of inflammation, the interpretation of usual biomarkers of iron deficiency (serum ferritin, transferrin saturation, serum iron) may be difficult. Iron 67-71 transferrin Homo sapiens 100-111 26183122-7 2015 In these patients, transfusion-associated hemolysis was accompanied by increases in circulating non-transferrin-bound iron and free hemoglobin and by an acute phase response, as assessed by an increase in median C-reactive protein levels of 21.2 mg/L (P < 0.05). Iron 118-122 transferrin Homo sapiens 100-111 26261881-0 2015 Transferrin-mediated iron sequestration as a novel therapy for bacterial and fungal infections. Iron 21-25 transferrin Homo sapiens 0-11 26261881-5 2015 Iron sequestration in mammals is predominantly mediated by the transferrin family of iron-binding proteins. Iron 0-4 transferrin Homo sapiens 63-74 26261881-5 2015 Iron sequestration in mammals is predominantly mediated by the transferrin family of iron-binding proteins. Iron 85-89 transferrin Homo sapiens 63-74 26261881-6 2015 In this review, we explore the possibility of administering supraphysiological levels of exogenous transferrin as an iron sequestering therapy for infections, which could overcome some of the problems associated with small molecule chelation. Iron 117-121 transferrin Homo sapiens 99-110 26208277-2 2015 The HmbR protein and heterodimeric HpuAB complex bind to haemoglobin whilst TbpBA and LbpBA bind iron-loaded transferrin and lactoferrin complexes, respectively. Iron 97-101 transferrin Homo sapiens 109-120 26315622-6 2015 After multivariate adjustment, a positive association was found between transferrin and incident METS in men: odds ratio (OR) and 95% confidence interval for the fourth relative to the first quartile 1.55 (1.04-2.31), p for trend = 0.03, while no association was found for iron OR = 0.81 (0.53-1.24), p for trend = 0.33 and ferritin OR = 1.30 (0.88-1.92), p for trend = 0.018. Iron 273-277 transferrin Homo sapiens 72-83 26315622-7 2015 In women, a negative association was found between iron and incident METS: OR for the fourth relative to the first quartile 0.51 (0.33-0.80), p for trend<0.03; the association between transferrin and incident METS was borderline significant: OR = 1.45 (0.97-2.17), p for trend = 0.07 and no association was found for ferritin: OR = 1.11 (0.76-1.63), p for trend = 0.58. Iron 51-55 transferrin Homo sapiens 187-198 26235415-6 2015 Thus, iron inaccessibility induces lower coefficient of transferrin saturation, which can lead to a non-regenerative normocytic or microcytic anaemia. Iron 6-10 transferrin Homo sapiens 56-67 26104728-0 2015 Non-transferrin-bound iron is associated with biomarkers of oxidative stress, inflammation and endothelial dysfunction in type 2 diabetes. Iron 22-26 transferrin Homo sapiens 4-15 26104728-1 2015 AIMS: To investigate the association between circulating non-transferrin-bound iron [NTBI], and markers of oxidative stress, endothelial function and inflammation in subjects with type 2 diabetes and non-diabetic subjects with varying degrees of obesity. Iron 79-83 transferrin Homo sapiens 61-72 26399527-1 2015 Lactoferrin is an iron-binding glycoprotein with a molecular weight of about 80 kDa that belongs to the transferrin family. Iron 18-22 transferrin Homo sapiens 104-115 26327704-6 2015 Generalized estimating equations developed from 313 observations obtained from these 148 patients suggested that average transferrin saturation percentage and iron concentration were both significantly higher in the group that received iron once weekly than in the group that received iron by the conventional accelerated regimen (p = 0.014 and 0.008, respectively). Iron 236-240 transferrin Homo sapiens 121-132 26327704-6 2015 Generalized estimating equations developed from 313 observations obtained from these 148 patients suggested that average transferrin saturation percentage and iron concentration were both significantly higher in the group that received iron once weekly than in the group that received iron by the conventional accelerated regimen (p = 0.014 and 0.008, respectively). Iron 236-240 transferrin Homo sapiens 121-132 26199472-13 2015 Iron status evaluation done in 44 patients after a follow up period of 15.1 +- 11.5 weeks showed increases in Hb of 1.6 +- 2.2 g/dl (P = 0.001), transferrin saturation of 9.1 +- 16.9% (P = 0.001), and ferritin of 406 +- 449 ng/ml (P = 0.001). Iron 0-4 transferrin Homo sapiens 145-156 26241638-2 2015 Non-Transferrin Bound Iron (NTBI) induces cardiac toxicity through the production of reactive oxygen species and lipid peroxidation. Iron 22-26 transferrin Homo sapiens 4-15 26099594-12 2015 TF severed as the carrier to delivery irons, and could directly stimulate cardiomyocytes hypertrophy. Iron 38-43 transferrin Homo sapiens 0-2 26664465-7 2015 CONCLUSION: Cerium is competitive element in the mechanism of iron absorption and can interfere and inhibit the growth of adenocarcinoma cancer cells; also, the use of Cerium and transferrin simultaneously may cause a greater inhibitory effect. Iron 62-66 transferrin Homo sapiens 179-190 25981872-2 2015 HFE competes with transferrin-bound iron for the TR and thus reduces uptake of iron into cells. Iron 36-40 transferrin Homo sapiens 18-29 25981872-2 2015 HFE competes with transferrin-bound iron for the TR and thus reduces uptake of iron into cells. Iron 79-83 transferrin Homo sapiens 18-29 26208277-8 2015 These results suggest that transferrin is the major source of iron for N. meningitidis during replication in healthy human blood. Iron 62-66 transferrin Homo sapiens 27-38 26089776-2 2015 Accordingly, neuronal iron supply is tightly controlled: it depends not only on transferrin-bound iron but also on non-transferrin-bound iron (NTBI), which represents a relevant quote of the iron physiologically present in the cerebrospinal fluid (CSF). Iron 98-102 transferrin Homo sapiens 80-91 26106291-3 2015 DMT1 locates to cellular membranes and endosomal membranes, where it is a key player in non-transferrin bound iron uptake and transferrin-bound iron uptake, respectively. Iron 144-148 transferrin Homo sapiens 126-137 26106291-9 2015 This supports existing evidence that iron uptake at the BBB occurs by means of transferrin-receptor mediated endocytosis followed by detachment of iron from transferrin inside the acidic compartment of the endosome and DMT1-mediated pumping iron into the cytosol. Iron 37-41 transferrin Homo sapiens 79-90 26106291-9 2015 This supports existing evidence that iron uptake at the BBB occurs by means of transferrin-receptor mediated endocytosis followed by detachment of iron from transferrin inside the acidic compartment of the endosome and DMT1-mediated pumping iron into the cytosol. Iron 37-41 transferrin Homo sapiens 157-168 26106291-9 2015 This supports existing evidence that iron uptake at the BBB occurs by means of transferrin-receptor mediated endocytosis followed by detachment of iron from transferrin inside the acidic compartment of the endosome and DMT1-mediated pumping iron into the cytosol. Iron 147-151 transferrin Homo sapiens 157-168 26106291-9 2015 This supports existing evidence that iron uptake at the BBB occurs by means of transferrin-receptor mediated endocytosis followed by detachment of iron from transferrin inside the acidic compartment of the endosome and DMT1-mediated pumping iron into the cytosol. Iron 147-151 transferrin Homo sapiens 157-168 26106291-11 2015 The virtual absent expression of transferrin receptors and DMT1 in glial cells, i.e., astrocytes, microglia and oligodendrocytes, suggest that the steady state uptake of iron in glia is much lower than in neurons and/or other mechanisms for iron uptake in these cell types prevail. Iron 170-174 transferrin Homo sapiens 33-44 26089776-2 2015 Accordingly, neuronal iron supply is tightly controlled: it depends not only on transferrin-bound iron but also on non-transferrin-bound iron (NTBI), which represents a relevant quote of the iron physiologically present in the cerebrospinal fluid (CSF). Iron 22-26 transferrin Homo sapiens 80-91 26089776-2 2015 Accordingly, neuronal iron supply is tightly controlled: it depends not only on transferrin-bound iron but also on non-transferrin-bound iron (NTBI), which represents a relevant quote of the iron physiologically present in the cerebrospinal fluid (CSF). Iron 22-26 transferrin Homo sapiens 119-130 26089776-2 2015 Accordingly, neuronal iron supply is tightly controlled: it depends not only on transferrin-bound iron but also on non-transferrin-bound iron (NTBI), which represents a relevant quote of the iron physiologically present in the cerebrospinal fluid (CSF). Iron 98-102 transferrin Homo sapiens 80-91 26089776-2 2015 Accordingly, neuronal iron supply is tightly controlled: it depends not only on transferrin-bound iron but also on non-transferrin-bound iron (NTBI), which represents a relevant quote of the iron physiologically present in the cerebrospinal fluid (CSF). Iron 98-102 transferrin Homo sapiens 80-91 25386711-5 2015 RESULTS: Serum ferritin, serum iron, and transferrin saturation were significantly improved in the iron group after intervention and compared with those in placebo (P < 0.05). Iron 99-103 transferrin Homo sapiens 41-52 26262699-17 2015 IV iron supplementation in iron-deficient patients (n = 9) increased hemoglobin (13.5 g/l +- 0.7), compared with the pre-op (12.8 g/l +- 1.2; p: 0.05), as well as transferrin saturation and ferritin. Iron 3-7 transferrin Homo sapiens 163-174 25946517-3 2015 The present study aimed to examine the association between maternal Fe status during the first trimester of pregnancy, as assessed by serum ferritin, transferrin receptor and their ratio, with size at birth and preterm birth. Iron 68-70 transferrin Homo sapiens 150-161 25779881-0 2015 Monoclonal anti-transferrin antibody: a paradigm for better understanding of iron metabolism. Iron 77-81 transferrin Homo sapiens 16-27 25698609-9 2015 The percentage of hypochromic red blood cells (r=0.52) and soluble transferrin receptor (r=0.59) value were significantly correlated to the Hb increase in patients receiving iron. Iron 174-178 transferrin Homo sapiens 67-78 25000850-14 2015 Induction of transferrin by H2O2, and consequently, decreased iron absorption, suggests a novel mechanism for iron deficiency in NASH patients. Iron 62-66 transferrin Homo sapiens 13-24 25792380-0 2015 Detailed molecular dynamics simulations of human transferrin provide insights into iron release dynamics at serum and endosomal pH. Iron 83-87 transferrin Homo sapiens 49-60