PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19825182-3	2009	DOHH activity is inhibited by two clinically used drugs, the topical fungicide ciclopirox and the systemic medicinal iron chelator deferiprone.	Iron	117-121	deoxyhypusine hydroxylase	Homo sapiens	0-4	
23943044-7	2013	This pre-selective step of parasitic eradication will be used further for a test of the Malaria Box with a potential in iron chelating capacity to inhibit deoxyhypusine hydroxylase (DOHH) from P. falciparum and vivax.	Iron	120-124	deoxyhypusine hydroxylase	Homo sapiens	155-180	
19706422-2	2009	Recombinant human deoxyhypusine hydroxylase (hDOHH) has been reported to have oxygen- and iron-dependent activity, an estimated iron/holoprotein stoichiometry of 2, and a visible band at 630 nm responsible for the blue color of the as-isolated protein.	Iron	90-94	deoxyhypusine hydroxylase	Homo sapiens	18-43	
19706422-2	2009	Recombinant human deoxyhypusine hydroxylase (hDOHH) has been reported to have oxygen- and iron-dependent activity, an estimated iron/holoprotein stoichiometry of 2, and a visible band at 630 nm responsible for the blue color of the as-isolated protein.	Iron	90-94	deoxyhypusine hydroxylase	Homo sapiens	45-50	
16533814-5	2006	The purified human recombinant DOHH was a mixture of active holoenzyme containing 2 mol of iron/mol of DOHH and inactive metal-free apoenzyme.	Iron	91-95	deoxyhypusine hydroxylase	Homo sapiens	31-35	
16533814-7	2006	The DOHH apoenzyme exhibited markedly reduced levels of iron and activity.	Iron	56-60	deoxyhypusine hydroxylase	Homo sapiens	4-8	
16533814-13	2006	Furthermore, the iron to DOHH stoichiometry and dependence of iron binding on each of the four conserved His-Glu motifs suggest a binuclear iron mediated reaction mechanism, distinct from that of other Fe(II)-dependent protein hydroxylases, such as prolyl 4-hydroxylase or lysyl hydroxylases.	Iron	17-21	deoxyhypusine hydroxylase	Homo sapiens	25-29	
16371467-10	2006	However, metal coordination sites composed of four strictly conserved histidine-glutamate sequences were identified, suggesting that DOHH enzymes have convergently evolved an iron-dependent hydroxylation mechanism.	Iron	175-179	deoxyhypusine hydroxylase	Homo sapiens	133-137	
24843120-3	2014	Here, we show that PCBP1 and PCBP2 also deliver iron to deoxyhypusine hydroxylase (DOHH), the dinuclear iron enzyme required for hypusine modification of the translation factor eukaryotic initiation factor 5A.	Iron	48-52	deoxyhypusine hydroxylase	Homo sapiens	56-81	
24843120-3	2014	Here, we show that PCBP1 and PCBP2 also deliver iron to deoxyhypusine hydroxylase (DOHH), the dinuclear iron enzyme required for hypusine modification of the translation factor eukaryotic initiation factor 5A.	Iron	48-52	deoxyhypusine hydroxylase	Homo sapiens	83-87	
24843120-3	2014	Here, we show that PCBP1 and PCBP2 also deliver iron to deoxyhypusine hydroxylase (DOHH), the dinuclear iron enzyme required for hypusine modification of the translation factor eukaryotic initiation factor 5A.	Iron	104-108	deoxyhypusine hydroxylase	Homo sapiens	56-81	
24843120-3	2014	Here, we show that PCBP1 and PCBP2 also deliver iron to deoxyhypusine hydroxylase (DOHH), the dinuclear iron enzyme required for hypusine modification of the translation factor eukaryotic initiation factor 5A.	Iron	104-108	deoxyhypusine hydroxylase	Homo sapiens	83-87	
24843120-6	2014	PCBP1 bound to DOHH in iron-treated cells but not in control or iron-deficient cells.	Iron	23-27	deoxyhypusine hydroxylase	Homo sapiens	15-19	
23943044-7	2013	This pre-selective step of parasitic eradication will be used further for a test of the Malaria Box with a potential in iron chelating capacity to inhibit deoxyhypusine hydroxylase (DOHH) from P. falciparum and vivax.	Iron	120-124	deoxyhypusine hydroxylase	Homo sapiens	182-186	
23943044-8	2013	DOHH, a metalloprotein which consists of ferrous iron and catalyzes the second step of the posttranslational modification at a specific lysine in eukaryotic initiation factor 5A (EIF-5A) to hypusine.	Iron	49-53	deoxyhypusine hydroxylase	Homo sapiens	0-4