PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17669387-1	2007	OBJECTIVES: In a preliminary study, NAD(P)H:quinone oxidoreductase 1 (NQO1) was found to be highly expressed in cultured human aortic smooth muscle cells (HASMC) and dicumarol, a NQO1 inhibitor and a coumarin-derived natural anticoagulant, suppressed tumor necrosis factor (TNF)-alpha-induced HASMC migration.	Dicumarol	166-175	tumor necrosis factor	Homo sapiens	251-284	
17669387-3	2007	METHODS AND RESULTS: Gelatin zymography, reporter gene, electrophoretic mobility shift and Western blotting assays showed that dicumarol, but not other coumarin-derived anticoagulants, inhibited TNF-alpha-induced HASMC migration and suppressed TNF-alpha-induced matrix metalloproteinase (MMP)-9 expression and secretion in a dose-dependent manner.	Dicumarol	127-136	tumor necrosis factor	Homo sapiens	195-204	
17669387-3	2007	METHODS AND RESULTS: Gelatin zymography, reporter gene, electrophoretic mobility shift and Western blotting assays showed that dicumarol, but not other coumarin-derived anticoagulants, inhibited TNF-alpha-induced HASMC migration and suppressed TNF-alpha-induced matrix metalloproteinase (MMP)-9 expression and secretion in a dose-dependent manner.	Dicumarol	127-136	tumor necrosis factor	Homo sapiens	244-253	
17669387-4	2007	In addition, down-regulation of NQO1 by transfection of its small interfering RNA similarly inhibited TNF-alpha-induced MMP-9 secretion, indicating that dicumarol-mediated inhibition of MMP-9 expression is due in large part to inhibition of NQO1.	Dicumarol	153-162	tumor necrosis factor	Homo sapiens	102-111	
10531305-6	1999	Dicoumarol prevented SAPK activation in vivo by chemical cell stressors and also prevented SAPK activation induced by expression of the tumor necrosis factor alpha (TNFalpha) receptor-associated protein TRAF2 but not by expression of truncated active MEKK1.	Dicumarol	0-10	tumor necrosis factor	Homo sapiens	165-173	
10531305-9	1999	Consistent with the proposed role of overlapping upstream signaling cascades in activation of NFkappaB, dicoumarol also blocked NFkappaB activation in primary macrophages stimulated with either lipopolysaccharide or TNFalpha.	Dicumarol	104-114	tumor necrosis factor	Homo sapiens	216-224	
10531305-10	1999	In addition, dicoumarol strongly potentiated TNFalpha-induced apoptosis in HeLa cells, probably by blocking the anti-apoptotic effect of NFkappaB.	Dicumarol	13-23	tumor necrosis factor	Homo sapiens	45-53	
17920036-7	2007	Both PD98095 and dicoumarol were capable of blocking TNFalpha production but had only a small effect on p21Waf1 expression.	Dicumarol	17-27	tumor necrosis factor	Homo sapiens	53-61