PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21613233-0 2011 Inhibition of renal NQO1 activity by dicoumarol suppresses nitroreduction of aristolochic acid I and attenuates its nephrotoxicity. Dicumarol 37-47 NAD(P)H dehydrogenase, quinone 1 Mus musculus 20-24 21613233-5 2011 Inhibition of NQO1 activity by dicoumarol pretreatment significantly decreased renal aristolactam I (ALI) levels, a major reductive metabolite of AAI, whereas it increased renal AAI and its major oxidative metabolite 8-hydroxy-aristolochic acid I (AAIa) levels in male C57BL/6 mice. Dicumarol 31-41 NAD(P)H dehydrogenase, quinone 1 Mus musculus 14-18 21296895-7 2011 DQ reduction in NQO1(+/+) lungs was inhibited by 90 +- 4% with dicumarol; there was no inhibition in NQO1(-/-) lungs. Dicumarol 63-72 NAD(P)H dehydrogenase, quinone 1 Mus musculus 16-20 8763837-7 1996 The DT-diaphorase inhibitor, dicoumarol, inhibited the effect of D3T on the antitumour activity of the bioreductive agents, supporting the proposal that the enhanced anticancer activity was due to the elevated enzyme level. Dicumarol 29-39 NAD(P)H dehydrogenase, quinone 1 Mus musculus 4-17 18810995-5 2008 In addition, the cytotoxicity of nitroaromatics is also partly prevented by an inhibitor of NQO1, dicumarol. Dicumarol 98-107 NAD(P)H dehydrogenase, quinone 1 Mus musculus 92-96 15467770-4 2004 The mice were then treated with saline, 2.0, 3.5 or 2.0 mg kg(-1) MMC and dicoumarol, an NQO1 inhibitor. Dicumarol 74-84 NAD(P)H dehydrogenase, quinone 1 Mus musculus 89-93 10755406-2 2000 Among the various enzymes, dicoumarol inhibitable cytosolic NAD(P)H:quinone oxidoreductase1 (NQO1) was shown to catalyse bioreductive activation of MMC leading to cross-linking of the DNA and cytotoxicity. Dicumarol 27-37 NAD(P)H dehydrogenase, quinone 1 Mus musculus 60-91 10755406-2 2000 Among the various enzymes, dicoumarol inhibitable cytosolic NAD(P)H:quinone oxidoreductase1 (NQO1) was shown to catalyse bioreductive activation of MMC leading to cross-linking of the DNA and cytotoxicity. Dicumarol 27-37 NAD(P)H dehydrogenase, quinone 1 Mus musculus 93-97 10755406-12 2000 This activity, like NQO1, was inhibited by dicoumarol and immunologically related to NQO1. Dicumarol 43-53 NAD(P)H dehydrogenase, quinone 1 Mus musculus 20-24 10755406-12 2000 This activity, like NQO1, was inhibited by dicoumarol and immunologically related to NQO1. Dicumarol 43-53 NAD(P)H dehydrogenase, quinone 1 Mus musculus 85-89 16682409-5 2006 The treatment of wild-type cells with dicoumarol, a known inhibitor of NQO1, also abolished TNF-induced NF-kappaB activation. Dicumarol 38-48 NAD(P)H dehydrogenase, quinone 1 Mus musculus 71-75 12188909-11 2002 Death of NQO1 expressing cells is prevented by the NQO1 inhibitor dicoumarol, and cells with low NQO1 are resistant. Dicumarol 66-76 NAD(P)H dehydrogenase, quinone 1 Mus musculus 9-13 12188909-11 2002 Death of NQO1 expressing cells is prevented by the NQO1 inhibitor dicoumarol, and cells with low NQO1 are resistant. Dicumarol 66-76 NAD(P)H dehydrogenase, quinone 1 Mus musculus 51-55 12188909-11 2002 Death of NQO1 expressing cells is prevented by the NQO1 inhibitor dicoumarol, and cells with low NQO1 are resistant. Dicumarol 66-76 NAD(P)H dehydrogenase, quinone 1 Mus musculus 51-55 1382426-1 1992 Dicumarol, often used as a specific inhibitor of DT diaphorase (NAD(P)H:(quinone-acceptor) oxidoreductase; EC 1.6.99.2), was found to potently inhibit GSH transferases (EC 2.5.1.18). Dicumarol 0-9 NAD(P)H dehydrogenase, quinone 1 Mus musculus 49-62 7677784-2 1995 However, these conclusions have mainly been drawn from the experiments using the DT-diaphorase inhibitor, dicoumarol. Dicumarol 106-116 NAD(P)H dehydrogenase, quinone 1 Mus musculus 81-94 7690996-6 1993 At concentrations of dicumarol that completely block NMO1 and GSTA1 activities, the 14CoS/14CoS cells show more than twice as much resistance to menadione toxicity than the ch/ch cells. Dicumarol 21-30 NAD(P)H dehydrogenase, quinone 1 Mus musculus 53-57 1280990-5 1992 Dicoumarol, an inhibitor of DT-diaphorase, was shown to cause only small reductions in misonidazole binding to oesophageal epithelium and smooth muscle in vitro and to EMT6 tumours, liver, oesophageal and tracheal epithelium, parotid gland and smooth muscle in vivo. Dicumarol 0-10 NAD(P)H dehydrogenase, quinone 1 Mus musculus 28-41 1382426-7 1992 Whereas several other non-substrate ligands were more potent inhibitors of 1-chloro-2,4-dinitrobenzene conjugation, dicumarol effectively inhibited GSH transferase and GSH peroxidase II activities in the range of dicumarol concentrations frequently used for detection of DT diaphorase action. Dicumarol 116-125 NAD(P)H dehydrogenase, quinone 1 Mus musculus 271-284 1382426-8 1992 These results indicate that physiological consequences resulting from the use of supramicromolar concentrations of dicumarol should not be interpreted in terms of DT diaphorase inhibition alone. Dicumarol 115-124 NAD(P)H dehydrogenase, quinone 1 Mus musculus 163-176 1692249-9 1990 Dicoumarol, an inhibitor of DT-diaphorase, increased the cytotoxic activity of both benzoquinone mustard and benzoquinone dimustard in L5178Y/HBM10 cells. Dicumarol 0-10 NAD(P)H dehydrogenase, quinone 1 Mus musculus 28-41 1373799-4 1992 In L5178Y/HBM10 cells, dicoumarol, an inhibitor of DT-diaphorase, decreased cell kill and DNA cross-linking by mitomycin C in air but had no significant effect on these activities under hypoxia. Dicumarol 23-33 NAD(P)H dehydrogenase, quinone 1 Mus musculus 51-64 1371987-3 1992 Inhibition of DT-diaphorase by dicoumarol markedly inhibited the cytotoxic activity of trenimon to the resistant L5178Y/HBM10 cells. Dicumarol 31-41 NAD(P)H dehydrogenase, quinone 1 Mus musculus 14-27 2471583-4 1989 Dicoumarol, an inhibitor of DT-diaphorase, significantly inhibited crosslinking and cytotoxicity by mitomycin C in the quinone resistant cells. Dicumarol 0-10 NAD(P)H dehydrogenase, quinone 1 Mus musculus 28-41 2455523-5 1988 When control and induced cells were also exposed to dicoumarol, a specific and potent inhibitor of DT-diaphorase, the cytotoxicity of the quinones in both control and induced cells was enhanced markedly. Dicumarol 52-62 NAD(P)H dehydrogenase, quinone 1 Mus musculus 99-112 3934922-10 1985 The DT-diaphorase inhibitor dicoumarol was employed to show that this enzyme is not involved in the activation of mitomycin C to a cytotoxic agent. Dicumarol 28-38 NAD(P)H dehydrogenase, quinone 1 Mus musculus 4-17 2419579-6 1985 Moreover, we have found that the cytotoxic effects of DBNQ on human tumor and murine bone marrow stem cells can be prevented or lessened by pretreatment of the cells with dicoumarol, a potent inhibitor of DT-diaphorase. Dicumarol 171-181 NAD(P)H dehydrogenase, quinone 1 Mus musculus 205-218 6437671-7 1984 Exposure of cell sonicates to dicumarol inhibited DT-diaphorase activity, while the rate of formation of reactive metabolites of MC was enhanced. Dicumarol 30-39 NAD(P)H dehydrogenase, quinone 1 Mus musculus 50-63 32987030-7 2021 RESULTS: Dicoumarol, an inhibitor of NAD(P)H:quinone oxidoreductase (NQO1), significantly reduced HBx expression. Dicumarol 9-19 NAD(P)H dehydrogenase, quinone 1 Mus musculus 69-73 26612783-11 2016 We also assessed whether DC inhibits cell proliferation and viability through NQO1 [NAD(P)H Quinone Oxidoreductase 1], an intracellular inhibitor of reactive oxygen species (ROS). Dicumarol 25-27 NAD(P)H dehydrogenase, quinone 1 Mus musculus 78-82 26612783-11 2016 We also assessed whether DC inhibits cell proliferation and viability through NQO1 [NAD(P)H Quinone Oxidoreductase 1], an intracellular inhibitor of reactive oxygen species (ROS). Dicumarol 25-27 NAD(P)H dehydrogenase, quinone 1 Mus musculus 84-116 33460769-10 2021 Intriguingly, we found that the AMPK inhibitor, compound C, mimicked the effects of dicoumarol, suggesting the presence of a crosstalk between NQO1 and AMPK. Dicumarol 84-94 NAD(P)H dehydrogenase, quinone 1 Mus musculus 143-147 33228195-6 2020 The cytotoxicity of compounds in murine hepatoma MH22a cells was decreased by antioxidants and the inhibitor of NQO1, dicoumarol. Dicumarol 118-128 NAD(P)H dehydrogenase, quinone 1 Mus musculus 112-116 24598128-4 2014 Inhibition of renal NQO1 activity by dicoumarol has been shown in mice. Dicumarol 37-47 NAD(P)H dehydrogenase, quinone 1 Mus musculus 20-24