PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21399655-13	2011	Dicoumarol 100 mumol/L, a JNK1/2 inhibitor, markedly suppressed the formation of apoptotic bodies and JNK activation induced by genipin 400 mumol/L.	Dicumarol	0-10	mitogen-activated protein kinase 8	Homo sapiens	26-32	
21399655-13	2011	Dicoumarol 100 mumol/L, a JNK1/2 inhibitor, markedly suppressed the formation of apoptotic bodies and JNK activation induced by genipin 400 mumol/L.	Dicumarol	0-10	mitogen-activated protein kinase 8	Homo sapiens	26-29	
20430442-9	2010	The VEGF-mediated decrease in amyloid beta is dependent on a functional Flt-1 receptor and is inhibited by dicoumarol, a multifunctional inhibitor of stress-activated protein kinase (SAPK)/JNK and NFkappaB pathways.	Dicumarol	107-117	mitogen-activated protein kinase 8	Homo sapiens	189-192	
16773182-7	2006	Inhibitors of mitogen-activated protein/extracellular signal regulated kinase (MEK), such as ERK inhibitor PD98059 and JNK inhibitors dicumarol and SP60015, but not p38 inhibitor SB203580, inhibited PMA-induced MUC5AC reporter activity.	Dicumarol	134-143	mitogen-activated protein kinase 8	Homo sapiens	119-122	
16518417-0	2006	Dicoumarol potentiates cisplatin-induced apoptosis mediated by c-Jun N-terminal kinase in p53 wild-type urogenital cancer cell lines.	Dicumarol	0-10	mitogen-activated protein kinase 8	Homo sapiens	63-86	
16518417-5	2006	In RT112 and LNCap, CDDP induced p53 and p21 expression, while pretreatment of dicoumarol suppressed induction of p53/p21 and resulted in sequential activation of c-Jun N-terminal kinase (JNK) in a time-dependent manner.	Dicumarol	79-89	mitogen-activated protein kinase 8	Homo sapiens	163-186	
16518417-5	2006	In RT112 and LNCap, CDDP induced p53 and p21 expression, while pretreatment of dicoumarol suppressed induction of p53/p21 and resulted in sequential activation of c-Jun N-terminal kinase (JNK) in a time-dependent manner.	Dicumarol	79-89	mitogen-activated protein kinase 8	Homo sapiens	188-191	
16518417-6	2006	Furthermore, inhibition of JNK, using SP600125, completely suppressed activity of caspases and poly-(ADP-ribose) polymerase cleavage, leading to suppression of enhancement of CDDP-mediated apoptosis by dicoumarol.	Dicumarol	202-212	mitogen-activated protein kinase 8	Homo sapiens	27-30	
16518417-7	2006	These results suggested that dicoumarol could enhance cytotoxicity of CDDP in urogenital cancer cells with wild-type p53 through the p53/p21/JNK pathways.	Dicumarol	29-39	mitogen-activated protein kinase 8	Homo sapiens	141-144	
15388230-5	2004	Inhibition of c-jun-NH2-terminal kinase (JNK) by using both dicoumarol and SP600125 totally inhibited the stimulatory effect of hypoosmolarity.	Dicumarol	60-70	mitogen-activated protein kinase 8	Homo sapiens	14-39	
15388230-5	2004	Inhibition of c-jun-NH2-terminal kinase (JNK) by using both dicoumarol and SP600125 totally inhibited the stimulatory effect of hypoosmolarity.	Dicumarol	60-70	mitogen-activated protein kinase 8	Homo sapiens	41-44	
14701702-7	2004	Furthermore, treatment of arsenic trioxide-sensitive APL cells with the JNK inhibitor, dicumarol, significantly increased growth and survival in response to As(2)O(3) but did not protect cells from doxorubicin.	Dicumarol	87-96	mitogen-activated protein kinase 8	Homo sapiens	72-75	
11856743-8	2002	Pretreatment of K562 cells with the JNK inhibitor, dicoumarol, abolished PBOX-6-induced phosphorylation of c-Jun and ATF-2 and inhibited the induced apoptosis, suggesting that JNK activation is an essential component of the apoptotic pathway induced by PBOX-6.	Dicumarol	51-61	mitogen-activated protein kinase 8	Homo sapiens	36-39	
11856743-8	2002	Pretreatment of K562 cells with the JNK inhibitor, dicoumarol, abolished PBOX-6-induced phosphorylation of c-Jun and ATF-2 and inhibited the induced apoptosis, suggesting that JNK activation is an essential component of the apoptotic pathway induced by PBOX-6.	Dicumarol	51-61	mitogen-activated protein kinase 8	Homo sapiens	176-179	
24466103-5	2014	ATO dose-dependently induced c-Jun NH2-terminal kinase (JNK) activation, and JNK specific inhibitor dicumarol obviously reduced ATO-induced DeltaPsim depolarization in platelets.	Dicumarol	100-109	mitogen-activated protein kinase 8	Homo sapiens	77-80