PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31963392-2	2020	Herein, we unveiled that p53 activation by (S)-tryptophanol-derived oxazoloisoindolinone (SLMP53-1) mediated the reprograming of glucose metabolism in cancer cells and xenograft human tumor tissue, interfering with angiogenesis and migration.	tryptophanol	43-59	tumor protein p53	Homo sapiens	25-28	
32737944-0	2021	Potency and selectivity optimization of tryptophanol-derived oxazoloisoindolinones: novel p53 activators in human colorectal cancer.	tryptophanol	40-52	tumor protein p53	Homo sapiens	90-93	
25814188-3	2015	Herein, we report the identification of a dual inhibitor of the p53 interaction with MDM2 and MDMX, the (S)-tryptophanol derivative OXAZ-1, from the screening of a small library of enantiopure tryptophanol-derived oxazolopiperidone lactams, using a yeast-based assay.	tryptophanol	104-120	tumor protein p53	Homo sapiens	64-67	
31536751-3	2020	Recently, we have reported the (S)-tryptophanol-derived oxazoloisoindolinone SLMP53-1 as a new reactivator of wt and mutp53 R280K with in vitro and in vivo p53-dependent antitumor activity.	tryptophanol	31-47	tumor protein p53	Homo sapiens	120-123	
26735173-2	2016	Herein, we report the identification of the enantiopure tryptophanol-derived oxazoloisoindolinone SLMP53-1 as a novel reactivator of wild-type (wt) and mut p53, using a yeast-based screening strategy.	tryptophanol	56-68	tumor protein p53	Homo sapiens	156-159	
26735173-8	2016	Collectively, besides the potential use of SLMP53-1 as anticancer drug, the tryptophanol-derived oxazoloisoindolinone scaffold represents a promissing starting point for the development of effective p53-reactivating drugs.	tryptophanol	76-88	tumor protein p53	Homo sapiens	199-202	
28296148-4	2017	Here, we describe the synthesis of the new tryptophanol-derived oxazoloisoindolinone DIMP53-1 and identify its activity as a dual inhibitor of the p53-MDM2/X interactions using a yeast-based assay.	tryptophanol	43-55	tumor protein p53	Homo sapiens	147-150	
27035541-5	2016	These events were p53-independent in the case of RAP, but were accompanied by an increase in p53 levels in the case of TRP.	tryptophanol	119-122	tumor protein p53	Homo sapiens	93-96	
25814188-3	2015	Herein, we report the identification of a dual inhibitor of the p53 interaction with MDM2 and MDMX, the (S)-tryptophanol derivative OXAZ-1, from the screening of a small library of enantiopure tryptophanol-derived oxazolopiperidone lactams, using a yeast-based assay.	tryptophanol	108-120	tumor protein p53	Homo sapiens	64-67	
33801507-2	2021	Previously, we demonstrated the ability of tryptophanol-derived polycyclic compounds to activate the tumor suppressor protein p53, a relevant therapeutic target in cancer.	tryptophanol	43-55	tumor protein p53	Homo sapiens	126-129