PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29695239-0 2018 Bortezomib prevents cytarabine resistance in MCL, which is characterized by down-regulation of dCK and up-regulation of SPIB resulting in high NF-kappaB activity. Cytarabine 20-30 Spi-B transcription factor Homo sapiens 120-124 29695239-12 2018 CONCLUSION: We show that cytarabine resistance potentially can be avoided or at least delayed through co-treatment with bortezomib, and that down-regulation of dCK and up-regulation of SPIB and NF-kappaB are the main molecular events driving cytarabine resistance development. Cytarabine 242-252 Spi-B transcription factor Homo sapiens 185-189