PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32219872-6	2021	Keap1 Cys151 mutation significantly reduced Keap1 S-sulfhydration and abolished the hepatoprotective effects of H2 S both in vivo and in vitro.	Hydrogen Sulfide	112-116	kelch-like ECH-associated protein 1	Mus musculus	0-5	
32219872-0	2021	Hydrogen sulfide alleviates liver injury via S-sulfhydrated-Keap1/Nrf2/LRP1 pathway.	Hydrogen Sulfide	0-16	kelch-like ECH-associated protein 1	Mus musculus	60-65	
32219872-9	2021	Moreover, H2 S increased the binding of Nrf2 to the promoter region of LDL-related protein 1 (Lrp1) and consequently upregulated LRP1 expression, but these effects were disrupted by Keap1 Cys151 mutation.	Hydrogen Sulfide	10-14	kelch-like ECH-associated protein 1	Mus musculus	182-187	
28842592-0	2017	Neglected role of hydrogen sulfide in sulfur mustard poisoning: Keap1 S-sulfhydration and subsequent Nrf2 pathway activation.	Hydrogen Sulfide	18-34	kelch-like ECH-associated protein 1	Mus musculus	64-69	
31349040-12	2019	Taken together, our results showed that attenuation of oxidative stress by CySSPe is associated with its ability to produce H2S or RSSH, which persulfidates Keap1 and activates Nrf2 signaling.	Hydrogen Sulfide	124-127	kelch-like ECH-associated protein 1	Mus musculus	157-162	
28842592-10	2017	Furthermore, we also found that H2S S-sulfhydrated Keap1, which induced Nrf2 dissociation from Keap1, and enhanced Nrf2 nuclear translocation.	Hydrogen Sulfide	32-35	kelch-like ECH-associated protein 1	Mus musculus	51-56	
28842592-10	2017	Furthermore, we also found that H2S S-sulfhydrated Keap1, which induced Nrf2 dissociation from Keap1, and enhanced Nrf2 nuclear translocation.	Hydrogen Sulfide	32-35	kelch-like ECH-associated protein 1	Mus musculus	95-100	
28796243-10	2017	Moreover, exogenous H2S increased Keap-1 expression by suppressing its ubiquitylation, which might have an important role in ubiquitin aggregate clearance via autophagy.	Hydrogen Sulfide	20-23	kelch-like ECH-associated protein 1	Mus musculus	34-40	
23176571-0	2013	Hydrogen sulfide protects against cellular senescence via S-sulfhydration of Keap1 and activation of Nrf2.	Hydrogen Sulfide	0-16	kelch-like ECH-associated protein 1	Mus musculus	77-82	
27335232-0	2016	Hydrogen Sulfide Induces Keap1 S-sulfhydration and Suppresses Diabetes-Accelerated Atherosclerosis via Nrf2 Activation.	Hydrogen Sulfide	0-16	kelch-like ECH-associated protein 1	Mus musculus	25-30	
27335232-6	2016	H2S increased S-sulfhydration of Keap1, induced Nrf2 dissociation from Keap1, enhanced Nrf2 nuclear translocation, and inhibited O2 (-) generation, which were abrogated after Keap1 mutated at Cys151, but not Cys273, in endothelial cells.	Hydrogen Sulfide	0-3	kelch-like ECH-associated protein 1	Mus musculus	33-38	
27335232-6	2016	H2S increased S-sulfhydration of Keap1, induced Nrf2 dissociation from Keap1, enhanced Nrf2 nuclear translocation, and inhibited O2 (-) generation, which were abrogated after Keap1 mutated at Cys151, but not Cys273, in endothelial cells.	Hydrogen Sulfide	0-3	kelch-like ECH-associated protein 1	Mus musculus	71-76	
27335232-6	2016	H2S increased S-sulfhydration of Keap1, induced Nrf2 dissociation from Keap1, enhanced Nrf2 nuclear translocation, and inhibited O2 (-) generation, which were abrogated after Keap1 mutated at Cys151, but not Cys273, in endothelial cells.	Hydrogen Sulfide	0-3	kelch-like ECH-associated protein 1	Mus musculus	71-76	
27335232-7	2016	Collectively, H2S attenuates diabetes-accelerated atherosclerosis, which may be related to inhibition of oxidative stress via Keap1 sulfhydrylation at Cys151 to activate Nrf2 signaling.	Hydrogen Sulfide	14-17	kelch-like ECH-associated protein 1	Mus musculus	126-131	
23176571-11	2013	CONCLUSION: H2S protects against cellular aging via S-sulfhydration of Keap1 and Nrf2 activation in association with oxidative stress.	Hydrogen Sulfide	12-15	kelch-like ECH-associated protein 1	Mus musculus	71-76