PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30339820-3	2019	Hydrogen sulfide (H2S), an endogenous signaling molecule, accelerates diabetic wound healing (DWH), and inhibits ROS production, ERK1/2 and p38 activation, while its level is decreased in diabetes.	Hydrogen Sulfide	0-16	mitogen-activated protein kinase 3	Mus musculus	129-135	
30339820-3	2019	Hydrogen sulfide (H2S), an endogenous signaling molecule, accelerates diabetic wound healing (DWH), and inhibits ROS production, ERK1/2 and p38 activation, while its level is decreased in diabetes.	Hydrogen Sulfide	18-21	mitogen-activated protein kinase 3	Mus musculus	129-135	
30339820-14	2019	The treatment with H2S not only attenuated ROS production but also abolished MAPK ERK1/2 and p38 activation.	Hydrogen Sulfide	19-22	mitogen-activated protein kinase 3	Mus musculus	82-88	
30339820-15	2019	Like the effects of H2S, inhibition of MAPK ERK1/2 or p38 could decrease NETs release.	Hydrogen Sulfide	20-23	mitogen-activated protein kinase 3	Mus musculus	44-50	
30339820-16	2019	These findings suggests that H2S attenuates NETosis and primes diabetic wound to heal through blockage of ROS-mediated MAPK ERK1/2 and p38 activation.	Hydrogen Sulfide	29-32	mitogen-activated protein kinase 3	Mus musculus	124-130	
28088675-5	2017	With real-time PCR and western blot assays, we found that H2S exposure contributed to a significant decrease in AQP5 expression both in murine lung tissue and the A549 cell line, and the ERK1/2 and p38 MAPK signaling pathways were demonstrated to be implicated in AQP5 regulation.	Hydrogen Sulfide	58-61	mitogen-activated protein kinase 3	Mus musculus	187-193	
29024947-8	2017	H2S donors activated endothelial nitric oxide synthase (NOS3), v-AKT murine thymoma viral oncogene homolog 1 (AKT1), and extracellular signal-activated kinase 1/2 (mitogen-activated protein kinase 3/1, MAPK3/1) in oFPAECs.	Hydrogen Sulfide	0-3	mitogen-activated protein kinase 3	Mus musculus	164-200	
29024947-8	2017	H2S donors activated endothelial nitric oxide synthase (NOS3), v-AKT murine thymoma viral oncogene homolog 1 (AKT1), and extracellular signal-activated kinase 1/2 (mitogen-activated protein kinase 3/1, MAPK3/1) in oFPAECs.	Hydrogen Sulfide	0-3	mitogen-activated protein kinase 3	Mus musculus	202-207	
28560384-0	2017	Hydrogen sulfide inhibits mitochondrial fission in neuroblastoma N2a cells through the Drp1/ERK1/2 signaling pathway.	Hydrogen Sulfide	0-16	mitogen-activated protein kinase 3	Mus musculus	92-98	
27518439-13	2016	CONCLUSIONS: Mice with CSE (an H2S synthesising enzyme) gene deletion are less susceptible to CLP-induced sepsis and associated inflammatory response through ERK1/2-NF-kappaB p65 pathway as evidenced by reduced inflammation, tissue damage, and LSECs defenestration and gaps formation.	Hydrogen Sulfide	31-34	mitogen-activated protein kinase 3	Mus musculus	158-164	
20583917-12	2010	PD98059 and SB203580, specific inhibitors of ERK1/2 and p38, suppressed the activation of these enzymes and osteoclast differentiation by H(2)S.	Hydrogen Sulfide	138-143	mitogen-activated protein kinase 3	Mus musculus	45-51	
21354302-10	2011	Cell viability and Western blotting analysis demonstrated that the protective effects of H2S were mediated by p38 and ERK1/2 MAPKs.	Hydrogen Sulfide	89-92	mitogen-activated protein kinase 3	Mus musculus	118-124	
21354302-11	2011	In conclusion, H2S protects osteoblastic cells against oxidative stress-induced cell injury and suppression of proliferation and differentiation via a MAPK (p38 and ERK1/2)-dependent mechanism.	Hydrogen Sulfide	15-18	mitogen-activated protein kinase 3	Mus musculus	165-171	
27035826-10	2016	H2S also decreased LPS-activated extracellular signal-regulated kinase (ERK) 1/2/ nuclear factor (NF)-kappaB signaling pathways in myometrium.	Hydrogen Sulfide	0-3	mitogen-activated protein kinase 3	Mus musculus	33-80	
23682813-8	2014	Pretreatment with NaHS or stimulation of endogenous H2S production also significantly suppressed opioid withdrawal-induced ERK1/2 activation in mice striatum or SH-SY5Y cells.	Hydrogen Sulfide	52-55	mitogen-activated protein kinase 3	Mus musculus	123-129	
20051385-8	2010	CSE KO mice showed much lower level of phosphorylated extracellular signal-regulated kinase (ERK1/2) in mesentery arteries compared with those of WT mice, and exogenous H2S induced more phosphorylation of ERK1/2 in SMCs-KO compared with that in SMCs-WT.	Hydrogen Sulfide	169-172	mitogen-activated protein kinase 3	Mus musculus	93-99	
20051385-8	2010	CSE KO mice showed much lower level of phosphorylated extracellular signal-regulated kinase (ERK1/2) in mesentery arteries compared with those of WT mice, and exogenous H2S induced more phosphorylation of ERK1/2 in SMCs-KO compared with that in SMCs-WT.	Hydrogen Sulfide	169-172	mitogen-activated protein kinase 3	Mus musculus	205-211	
20051385-12	2010	These cellular effects of H2S are mediated by phosphorylation of ERK1/2 and altered expression of cyclin D1 and p21(Cip/WAF-1).	Hydrogen Sulfide	26-29	mitogen-activated protein kinase 3	Mus musculus	65-71	
19258518-9	2009	We found that H(2)S-mediated activation of PI3K in caerulein-treated acinar cells correlated with the down-regulation of extracellular signal-regulated kinase 1/2 phosphorylation, whereas phosphorylation of p38 and c-Jun NH(2)-terminal kinase and mitogen-activated protein kinases was unchanged.	Hydrogen Sulfide	14-19	mitogen-activated protein kinase 3	Mus musculus	121-162