PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22485212-4	2011	H(2)S-induced cell apoptosis was accompanied by activation of caspase-3 and caspase-9.	Hydrogen Sulfide	0-5	caspase 3	Homo sapiens	62-71	
28738323-5	2017	RESULTS: H2S attenuated FFA-induced cell apoptosis, and reduced the expression of NLRP3, ASC, pro-caspase-1, caspase-1, IL- 1beta, IL-18 and caspase-3.	Hydrogen Sulfide	9-12	caspase 3	Homo sapiens	141-150	
26546573-10	2015	CONCLUSIONS: The protective effects of H2S are mediated by thiosulfate that is transported across cell membrane by NaS-2 and exerts antiapoptotic effects via persulfidation of caspase-3.	Hydrogen Sulfide	39-42	caspase 3	Homo sapiens	176-185	
25738635-10	2015	Treatment of PLC/PRF/5 hepatoma cells with 500 micromol/l NaHS (a donor of H2S) for 24 h markedly increased the expression levels of CSE, CBS, p-IkappaB and NF-kappaB activation, leading to COX-2 and MMP-2 overexpression, and decreased caspase-3 production, as well as increased cell viability and decreased number of apoptotic cells.	Hydrogen Sulfide	75-78	caspase 3	Homo sapiens	236-245	
23660955-10	2013	Moreover, H2S reduced the expression of the cleaved caspase-3, NOX4 and the leakage of cyt c from the mitochondria to the cytoplasm.	Hydrogen Sulfide	10-13	caspase 3	Homo sapiens	52-61	
23020085-7	2012	However, the activity of caspase-3 increased in the hypoxic bystander cells, and this could be regulated by both NaHS and the inhibitor of endogenous H(2)S.	Hydrogen Sulfide	150-155	caspase 3	Homo sapiens	25-34	
18373739-8	2008	H(2)S-induced apoptosis led to an increase in caspase 3 activity and this activity was attenuated when caspase 3 inhibitor were used.	Hydrogen Sulfide	0-5	caspase 3	Homo sapiens	46-55	
18373739-8	2008	H(2)S-induced apoptosis led to an increase in caspase 3 activity and this activity was attenuated when caspase 3 inhibitor were used.	Hydrogen Sulfide	0-5	caspase 3	Homo sapiens	103-112	
31443288-4	2019	Cell death induced by H2O2 treatment could be significantly attenuated by the pre-treatment of H2S, resulting in a decrease in the Bax/Bcl-2 ratio and the inhibition of caspase-3 activity in human lung epithelial cell line A549 cells.	Hydrogen Sulfide	95-98	caspase 3	Homo sapiens	169-178	
16597918-5	2006	Treatment with inhibitors of caspase-3, -8, and -9 significantly inhibited H(2)S-induced phosphatidylserine externalization as shown by reduced annexin V staining.	Hydrogen Sulfide	75-80	caspase 3	Homo sapiens	29-50	
16446703-0	2006	Hydrogen sulfide prevents apoptosis of human PMN via inhibition of p38 and caspase 3.	Hydrogen Sulfide	0-16	caspase 3	Homo sapiens	75-84	
15371330-0	2004	Hydrogen sulfide-induced apoptosis of human aorta smooth muscle cells via the activation of mitogen-activated protein kinases and caspase-3.	Hydrogen Sulfide	0-16	caspase 3	Homo sapiens	130-139	
15371330-7	2004	The activation of ERK by H2S in HASMCs was accompanied by increased caspase-3 activity.	Hydrogen Sulfide	25-28	caspase 3	Homo sapiens	68-77	
15371330-8	2004	Inhibition of caspase-3 by AC-DEVD-CHO attenuated the H2S-induced cell apoptosis.	Hydrogen Sulfide	54-57	caspase 3	Homo sapiens	14-23	
15371330-11	2004	Of the three investigated MAPKs, only ERK played an active role in mediating H2S-induced apoptosis of HASMCs by activating caspase-3.	Hydrogen Sulfide	77-80	caspase 3	Homo sapiens	123-132	
30456731-11	2019	Moreover, H2S could significantly decrease caspase-3 and GFAP-positive cells in the CA1 region of the hippocampus (P < 0.01) compared to the METH group.	Hydrogen Sulfide	10-13	caspase 3	Homo sapiens	43-52	
30129387-4	2018	The results indicate that NaHS (an H2S donor) administration in uranium-intoxicated kidney cells ameliorated uranium-induced reactive oxygen species generation, caspase-3-dependent apoptosis, and endoplasmic reticulum (ER) stress identified through several key markers including GRP78, C/EBP homologous protein (CHOP), and caspase-12.	Hydrogen Sulfide	35-38	caspase 3	Homo sapiens	161-170