PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28398541-0 2017 Pregnancy Augments VEGF-Stimulated In Vitro Angiogenesis and Vasodilator (NO and H2S) Production in Human Uterine Artery Endothelial Cells. Hydrogen Sulfide 81-84 vascular endothelial growth factor A Homo sapiens 19-23 34657441-1 2021 Pregnancy and VEGF (vascular endothelial growth factor) stimulate uterine artery endothelial cell (UAEC) hydrogen sulfide production via selectively upregulating CBS (cystathionine beta-synthase) but not CSE (cystathionine gamma-lyase) expression. Hydrogen Sulfide 105-121 vascular endothelial growth factor A Homo sapiens 14-18 34657441-1 2021 Pregnancy and VEGF (vascular endothelial growth factor) stimulate uterine artery endothelial cell (UAEC) hydrogen sulfide production via selectively upregulating CBS (cystathionine beta-synthase) but not CSE (cystathionine gamma-lyase) expression. Hydrogen Sulfide 105-121 vascular endothelial growth factor A Homo sapiens 20-54 34657441-2 2021 This study was conducted to determine the mechanisms by which VEGF utilizes to stimulate pregnancy-dependent upregulation of CBS and hydrogen sulfide production in human UAEC. Hydrogen Sulfide 133-149 vascular endothelial growth factor A Homo sapiens 62-66 34657441-7 2021 Treatment with Sp1 and YY1 siRNAs completely blocked Sp1/YY1-mediated pregnancy-dependent CBS protein upregulation and hydrogen sulfide production by VEGF in human UAEC. Hydrogen Sulfide 119-135 vascular endothelial growth factor A Homo sapiens 150-154 34657441-9 2021 Thus, pregnancy augments EC Sp1 and YY1 expression and promotes the recruitment of Sp1/YY1 to their DNA-binding sequences in proximal human CBS promoter to upregulate CBS transcription, underlying a novel mechanism to mediate VEGF-stimulated pregnancy-dependent endothelial hydrogen sulfide production in the human uterine artery. Hydrogen Sulfide 274-290 vascular endothelial growth factor A Homo sapiens 226-230 30927279-0 2019 Exogenous hydrogen sulphide supplement accelerates skin wound healing via oxidative stress inhibition and vascular endothelial growth factor enhancement. Hydrogen Sulfide 10-27 vascular endothelial growth factor A Homo sapiens 106-140 29288927-10 2018 These findings indicate that H2S and NO cooperatively attenuates left ventricular remodeling and dysfunction during the development of heart failure through VEGF/cGMP pathway and ZYZ-803 provide expanding insight into strategies for treatment of heart failure. Hydrogen Sulfide 29-32 vascular endothelial growth factor A Homo sapiens 157-161 28398541-7 2017 VEGF stimulated CBS protein expression, accounting for VEGF-stimulated H2S production in hUAECs. Hydrogen Sulfide 71-74 vascular endothelial growth factor A Homo sapiens 0-4 28398541-7 2017 VEGF stimulated CBS protein expression, accounting for VEGF-stimulated H2S production in hUAECs. Hydrogen Sulfide 71-74 vascular endothelial growth factor A Homo sapiens 55-59 24742186-5 2014 Moreover, this N-Cdot-TiO2 nanowire photoanode has been demonstrated for direct growth and interfacing of H9c2 cardiac myoblasts, with the capability of interrogating H2S cellular generation pathways by vascular endothelial growth factor stimulation as well as inhibition. Hydrogen Sulfide 167-170 vascular endothelial growth factor A Homo sapiens 203-237 24743641-13 2014 CONCLUSION: These results indicated that anti-vascular endothelial growth factor may downregulate the H2S level in the vitreous body, and H2S may play a role in the development of DR. Hydrogen sulfide may be a novel target for the therapy of DR. Hydrogen Sulfide 102-105 vascular endothelial growth factor A Homo sapiens 46-80 24743641-13 2014 CONCLUSION: These results indicated that anti-vascular endothelial growth factor may downregulate the H2S level in the vitreous body, and H2S may play a role in the development of DR. Hydrogen sulfide may be a novel target for the therapy of DR. Hydrogen Sulfide 184-200 vascular endothelial growth factor A Homo sapiens 46-80 25113159-0 2014 Hydrogen sulphide triggers VEGF-induced intracellular Ca2+ signals in human endothelial cells but not in their immature progenitors. Hydrogen Sulfide 0-17 vascular endothelial growth factor A Homo sapiens 27-31 25113159-1 2014 Hydrogen sulphide (H2S) is a newly discovered gasotransmitter that regulates multiple steps in VEGF-induced angiogenesis. Hydrogen Sulfide 0-17 vascular endothelial growth factor A Homo sapiens 95-99 25113159-1 2014 Hydrogen sulphide (H2S) is a newly discovered gasotransmitter that regulates multiple steps in VEGF-induced angiogenesis. Hydrogen Sulfide 19-22 vascular endothelial growth factor A Homo sapiens 95-99 25113159-3 2014 Albeit VEGFR-2 might serve as H2S receptor, the mechanistic relationship between VEGF- and H2S-induced Ca(2+) signals in endothelial cells is unclear. Hydrogen Sulfide 30-33 vascular endothelial growth factor A Homo sapiens 7-11 25113159-8 2014 However, VEGF-induced Ca(2+) signals were suppressed by dl-propargylglycine (PAG), which blocks the H2S-producing enzyme, cystathionine gamma-lyase. Hydrogen Sulfide 100-103 vascular endothelial growth factor A Homo sapiens 9-13 25113159-11 2014 Therefore, H2S-evoked elevation in [Ca(2+)]i is essential to trigger the pro-angiogenic Ca(2+) response to VEGF in mature endothelial cells, but not in their immature progenitors. Hydrogen Sulfide 11-14 vascular endothelial growth factor A Homo sapiens 107-111 27569706-4 2016 Importantly, H2S up-regulates expression of the key angiogenic factor vascular endothelial growth factor (VEGF) and contributes to the angiogenic signaling in response to VEGF. Hydrogen Sulfide 13-16 vascular endothelial growth factor A Homo sapiens 106-110 27569706-4 2016 Importantly, H2S up-regulates expression of the key angiogenic factor vascular endothelial growth factor (VEGF) and contributes to the angiogenic signaling in response to VEGF. Hydrogen Sulfide 13-16 vascular endothelial growth factor A Homo sapiens 171-175 26992682-0 2016 MiR 20a,-20b and -200c are involved in hydrogen sulfide stimulation of VEGF production in human placental trophoblasts. Hydrogen Sulfide 39-55 vascular endothelial growth factor A Homo sapiens 71-75 26992682-2 2016 We sought to investigate the role of hydrogen sulfide (H2S) in regulating production of vascular endothelial growth factor (VEGF) proteins, the key factors of angiogenesis and vasculogenesis, in placenta. Hydrogen Sulfide 37-53 vascular endothelial growth factor A Homo sapiens 88-122 26992682-2 2016 We sought to investigate the role of hydrogen sulfide (H2S) in regulating production of vascular endothelial growth factor (VEGF) proteins, the key factors of angiogenesis and vasculogenesis, in placenta. Hydrogen Sulfide 37-53 vascular endothelial growth factor A Homo sapiens 124-128 26992682-2 2016 We sought to investigate the role of hydrogen sulfide (H2S) in regulating production of vascular endothelial growth factor (VEGF) proteins, the key factors of angiogenesis and vasculogenesis, in placenta. Hydrogen Sulfide 55-58 vascular endothelial growth factor A Homo sapiens 88-122 26992682-2 2016 We sought to investigate the role of hydrogen sulfide (H2S) in regulating production of vascular endothelial growth factor (VEGF) proteins, the key factors of angiogenesis and vasculogenesis, in placenta. Hydrogen Sulfide 55-58 vascular endothelial growth factor A Homo sapiens 124-128 26992682-9 2016 H2S prolonged the half-life of VEGF mRNA and decreased the expression of miR-200c,-20a and -20b in placental cells. Hydrogen Sulfide 0-3 vascular endothelial growth factor A Homo sapiens 31-35 26992682-12 2016 CONCLUSION: H2S produced via CSE and CBS plays a critical role in VEGF production in human placenta. Hydrogen Sulfide 12-15 vascular endothelial growth factor A Homo sapiens 66-70 26405298-6 2016 Reinstating H2S but not GSH in CBS-silenced ECs restored Sp1 levels and its binding to the VEGFR-2 promoter and VEGFR-2, NRP-1 expression, VEGF-dependent proliferation, and migration phenotypes. Hydrogen Sulfide 12-15 vascular endothelial growth factor A Homo sapiens 91-95 25587904-5 2015 Vascular endothelial growth factor is the key downstream mediator that is involved in H2S induced angiogenesis. Hydrogen Sulfide 86-89 vascular endothelial growth factor A Homo sapiens 0-34 25587904-6 2015 By having both direct effects on its receptor and increasing the bioavailability of vascular endothelial growth factor, H2S is proangiogenic. Hydrogen Sulfide 120-123 vascular endothelial growth factor A Homo sapiens 84-118 20823573-10 2010 In addition, H2S promoted VEGF and HIF-1alpha mRNA levels. Hydrogen Sulfide 13-16 vascular endothelial growth factor A Homo sapiens 26-30 20148917-14 2010 Based on the studies reviewed in the present article, we assume that, at physiologically relevant doses/concentrations, H(2)S/HS(-) promote angiogenesis at least partly via the VEGF signalling pathway. Hydrogen Sulfide 120-125 vascular endothelial growth factor A Homo sapiens 177-181 23199280-3 2013 H2S promoted angiogenesis in Matrigel plug assay in mice and this effect was attenuated by a VEGF receptor inhibitor. Hydrogen Sulfide 0-3 vascular endothelial growth factor A Homo sapiens 93-97 23589874-6 2013 In particular, Sulfidefluor-7 acetoxymethyl ester allows for direct, real-time visualization of endogenous H2S produced in live human umbilical vein endothelial cells upon stimulation with vascular endothelial growth factor (VEGF). Hydrogen Sulfide 107-110 vascular endothelial growth factor A Homo sapiens 189-223 23589874-6 2013 In particular, Sulfidefluor-7 acetoxymethyl ester allows for direct, real-time visualization of endogenous H2S produced in live human umbilical vein endothelial cells upon stimulation with vascular endothelial growth factor (VEGF). Hydrogen Sulfide 107-110 vascular endothelial growth factor A Homo sapiens 225-229 23589874-7 2013 Moreover, we show that H2S production is dependent on NADPH oxidase-derived hydrogen peroxide (H2O2), which attenuates VEGF receptor 2 phosphorylation and establishes a link for H2S/H2O2 crosstalk. Hydrogen Sulfide 23-26 vascular endothelial growth factor A Homo sapiens 119-123 22842066-0 2012 Hydrogen sulfide modulates the release of nitric oxide and VEGF in human keratinocytes. Hydrogen Sulfide 0-16 vascular endothelial growth factor A Homo sapiens 59-63 22842066-2 2012 The present study aimed to: (i) characterize the in vitro effects of H(2)S on human keratinocyte"s proliferation and death; (ii) investigate the ability of H(2)S to modulate VEGF and NO production; (iii) examine the intracellular signaling pathways involved in VEGF and NO modulatory effect. Hydrogen Sulfide 156-161 vascular endothelial growth factor A Homo sapiens 174-178 22842066-2 2012 The present study aimed to: (i) characterize the in vitro effects of H(2)S on human keratinocyte"s proliferation and death; (ii) investigate the ability of H(2)S to modulate VEGF and NO production; (iii) examine the intracellular signaling pathways involved in VEGF and NO modulatory effect. Hydrogen Sulfide 156-161 vascular endothelial growth factor A Homo sapiens 261-265 23675260-4 2012 It seems that a potent interaction of hydrogen sulfide with vascular endothelial growth factor (VEGF) becomes important in angiogenesis, in the process of wound healing, but also in tumor angiogenesis. Hydrogen Sulfide 38-54 vascular endothelial growth factor A Homo sapiens 60-94 23675260-4 2012 It seems that a potent interaction of hydrogen sulfide with vascular endothelial growth factor (VEGF) becomes important in angiogenesis, in the process of wound healing, but also in tumor angiogenesis. Hydrogen Sulfide 38-54 vascular endothelial growth factor A Homo sapiens 96-100 20823573-11 2010 H2S also significantly upregulated HIF-1alpha and VEGF protein levels and increased HIF-1alpha binding activity under hypoxic condition. Hydrogen Sulfide 0-3 vascular endothelial growth factor A Homo sapiens 50-54 20823573-12 2010 Our findings suggest that HIF-1/VEGF is involved in H2S promotes proliferation and migration of ECs. Hydrogen Sulfide 52-55 vascular endothelial growth factor A Homo sapiens 32-36