PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21786666-3	2011	Mutation mec1-212, similar to deletion alleles of this gene, causes sensitivity to hydroxyurea, disturbs the check-point function, and suppresses UV-induced mutagenesis.	Hydroxyurea	83-94	protein kinase MEC1	Saccharomyces cerevisiae S288C	9-13	
23045388-5	2012	In fact, delaying either the G(1)/S transition or spindle elongation in mec1 and rad53 mutants allows their survival both after exposure to hydroxyurea and under unperturbed conditions.	Hydroxyurea	140-151	protein kinase MEC1	Saccharomyces cerevisiae S288C	72-76	
19805819-7	2009	In contrast, cells with the mec1-1 sml1-1 mutations suffer from severely impaired replication resumption upon removal of hydroxyurea.	Hydroxyurea	121-132	protein kinase MEC1	Saccharomyces cerevisiae S288C	28-34	
21172804-5	2011	Contrary to the expectation that each factor would contribute to fragile site expression in an independent manner, we show that rrm3Delta and high concentrations of HU suppressed RSZ expression in mec1-4ts cells.	Hydroxyurea	165-167	protein kinase MEC1	Saccharomyces cerevisiae S288C	197-201	
10747050-4	2000	Deleting PTC2 specifically suppresses the hydroxyurea hypersensitivity of mec1 mutants and the lethality of mec1Delta.	Hydroxyurea	42-53	protein kinase MEC1	Saccharomyces cerevisiae S288C	74-78	
11497275-3	2001	RESULTS: Hydroxyurea (20 mM) decreased proliferation rates only in mec1 mutant and deletion strains.	Hydroxyurea	9-20	protein kinase MEC1	Saccharomyces cerevisiae S288C	67-71	
10733584-7	2000	Hydroxyurea inhibits late-origin firing in S. cerevisiae, and the checkpoint genes, RAD53 and MEC1, are involved in this inhibition.	Hydroxyurea	0-11	protein kinase MEC1	Saccharomyces cerevisiae S288C	94-98	
11000264-4	2000	We now demonstrate that Rfa1p is phosphorylated in response to various forms of genotoxic stress, including radiation and hydroxyurea exposure, and further show that phosphorylation of Rfa1p is dependent on the central checkpoint regulator Mec1p.	Hydroxyurea	122-133	protein kinase MEC1	Saccharomyces cerevisiae S288C	240-245	
11000264-5	2000	Analysis of the requirement for other checkpoint genes indicates that different mechanisms mediate radiation- and hydroxyurea-induced Rfa1p phosphorylation despite the common requirement for functional Mec1p.	Hydroxyurea	114-125	protein kinase MEC1	Saccharomyces cerevisiae S288C	202-207	
34569643-2	2021	Here, we identify a hydroxyurea-induced phosphorylation site on Mec1, Mec1-S1991, that contributes to the eviction of RNAPII and RNAPIII during replication stress.	Hydroxyurea	20-31	protein kinase MEC1	Saccharomyces cerevisiae S288C	64-68	
34569643-2	2021	Here, we identify a hydroxyurea-induced phosphorylation site on Mec1, Mec1-S1991, that contributes to the eviction of RNAPII and RNAPIII during replication stress.	Hydroxyurea	20-31	protein kinase MEC1	Saccharomyces cerevisiae S288C	70-74	
25609572-1	2015	We have previously demonstrated that in Saccharomyces cerevisiae replication, checkpoint inactivation via a mec1 mutation leads to chromosome breakage at replication forks initiated from virtually all origins after transient exposure to hydroxyurea (HU), an inhibitor of ribonucleotide reductase.	Hydroxyurea	237-248	protein kinase MEC1	Saccharomyces cerevisiae S288C	108-112	
9927443-8	1999	We propose that the essential function for MEC1 may be the same as its checkpoint function during hydroxyurea treatment, namely, to slow S phase when nucleotides are limiting.	Hydroxyurea	98-109	protein kinase MEC1	Saccharomyces cerevisiae S288C	43-47