PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34513672-0 2021 Valproic Acid Regulates HR and Cell Cycle Through MUS81-pRPA2 Pathway in Response to Hydroxyurea. Hydroxyurea 85-96 MUS81 structure-specific endonuclease subunit Homo sapiens 50-55 34513672-5 2021 It was further found that VPA and HU combination treatment also resulted in the decrease of endonuclease MUS81. Hydroxyurea 34-36 MUS81 structure-specific endonuclease subunit Homo sapiens 105-110 34513672-6 2021 After MUS81 elimination, not only the level of pRPA2 was abolished in response to HU treatment, but also VPA-caused HU sensitization was significantly down-regulated through pRPA2-mediated checkpoint kinases phosphorylation and HR repair pathways. Hydroxyurea 82-84 MUS81 structure-specific endonuclease subunit Homo sapiens 6-11 34513672-8 2021 Overall, our findings demonstrated that VPA influences HR repair and cell cycle through down-regulating MUS81-pRPA2 pathway in response to HU treatment. Hydroxyurea 139-141 MUS81 structure-specific endonuclease subunit Homo sapiens 104-109