PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34513672-0	2021	Valproic Acid Regulates HR and Cell Cycle Through MUS81-pRPA2 Pathway in Response to Hydroxyurea.	Hydroxyurea	85-96	MUS81 structure-specific endonuclease subunit	Homo sapiens	50-55	
34513672-5	2021	It was further found that VPA and HU combination treatment also resulted in the decrease of endonuclease MUS81.	Hydroxyurea	34-36	MUS81 structure-specific endonuclease subunit	Homo sapiens	105-110	
34513672-6	2021	After MUS81 elimination, not only the level of pRPA2 was abolished in response to HU treatment, but also VPA-caused HU sensitization was significantly down-regulated through pRPA2-mediated checkpoint kinases phosphorylation and HR repair pathways.	Hydroxyurea	82-84	MUS81 structure-specific endonuclease subunit	Homo sapiens	6-11	
34513672-8	2021	Overall, our findings demonstrated that VPA influences HR repair and cell cycle through down-regulating MUS81-pRPA2 pathway in response to HU treatment.	Hydroxyurea	139-141	MUS81 structure-specific endonuclease subunit	Homo sapiens	104-109