PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11571231-4 2001 Using a panel of anti-extracellular signal-related kinase (ERK), c-Jun NH2-terminal kinase (JNK), and p38 phosphospecific antibodies, we demonstrated that phosphorylation of ERK and JNK is decreased after the treatment of cells with hydroxyurea, whereas phosphorylation of p38 is increased. Hydroxyurea 233-244 mitogen-activated protein kinase 1 Homo sapiens 174-177 11571231-5 2001 Moreover, inhibition of ERK activity by PD98059 induced erythroid differentiation, and it acted synergistically with hydroxyurea on hemoglobin synthesis, whereas inhibition of p38 activity by SB203580 inhibited induction of hemoglobin production by hydroxyurea. Hydroxyurea 117-128 mitogen-activated protein kinase 1 Homo sapiens 24-27 11571231-5 2001 Moreover, inhibition of ERK activity by PD98059 induced erythroid differentiation, and it acted synergistically with hydroxyurea on hemoglobin synthesis, whereas inhibition of p38 activity by SB203580 inhibited induction of hemoglobin production by hydroxyurea. Hydroxyurea 249-260 mitogen-activated protein kinase 1 Homo sapiens 24-27 20840867-0 2011 ERK1 and ERK2 kinases activate hydroxyurea-induced S-phase checkpoint in MCF7 cells by mediating ATR activation. Hydroxyurea 31-42 mitogen-activated protein kinase 1 Homo sapiens 9-13 20840867-1 2011 Modulation of MEK has been demonstrated to affect hydroxyurea (HU) induced-DNA damage response (DDR), implying the involvement of ERK1 and ERK2 in the process. Hydroxyurea 50-61 mitogen-activated protein kinase 1 Homo sapiens 139-143 20840867-4 2011 While HU potently induced CDC2 Y15 (tyrosine 15) phosphorylation, an event causing CDC2 inactivation, inhibition of ERK kinases using U0126 (a MEK inhibitor), MEK1K97M (a dominant negative MEK1), and knockdown of either ERK1 or ERK2 significantly attenuated HU-induced CDC2 Y15 phosphorylation. Hydroxyurea 6-8 mitogen-activated protein kinase 1 Homo sapiens 116-119 20840867-4 2011 While HU potently induced CDC2 Y15 (tyrosine 15) phosphorylation, an event causing CDC2 inactivation, inhibition of ERK kinases using U0126 (a MEK inhibitor), MEK1K97M (a dominant negative MEK1), and knockdown of either ERK1 or ERK2 significantly attenuated HU-induced CDC2 Y15 phosphorylation. Hydroxyurea 6-8 mitogen-activated protein kinase 1 Homo sapiens 228-232 16186792-2 2006 We report here that hydroxyurea (HU) activates Erk via MEK1, a process that is sensitized by a constitutively active MEK1 (MEK1Q56P) and attenuated by a dominant-negative MEK1 (MEK1K97M). Hydroxyurea 20-31 mitogen-activated protein kinase 1 Homo sapiens 47-50