PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20840867-0	2011	ERK1 and ERK2 kinases activate hydroxyurea-induced S-phase checkpoint in MCF7 cells by mediating ATR activation.	Hydroxyurea	31-42	mitogen-activated protein kinase 1	Homo sapiens	9-13	
20840867-1	2011	Modulation of MEK has been demonstrated to affect hydroxyurea (HU) induced-DNA damage response (DDR), implying the involvement of ERK1 and ERK2 in the process.	Hydroxyurea	50-61	mitogen-activated protein kinase 1	Homo sapiens	139-143	
16186792-2	2006	We report here that hydroxyurea (HU) activates Erk via MEK1, a process that is sensitized by a constitutively active MEK1 (MEK1Q56P) and attenuated by a dominant-negative MEK1 (MEK1K97M).	Hydroxyurea	20-31	mitogen-activated protein kinase 1	Homo sapiens	47-50	
11571231-4	2001	Using a panel of anti-extracellular signal-related kinase (ERK), c-Jun NH2-terminal kinase (JNK), and p38 phosphospecific antibodies, we demonstrated that phosphorylation of ERK and JNK is decreased after the treatment of cells with hydroxyurea, whereas phosphorylation of p38 is increased.	Hydroxyurea	233-244	mitogen-activated protein kinase 1	Homo sapiens	174-177	
11571231-5	2001	Moreover, inhibition of ERK activity by PD98059 induced erythroid differentiation, and it acted synergistically with hydroxyurea on hemoglobin synthesis, whereas inhibition of p38 activity by SB203580 inhibited induction of hemoglobin production by hydroxyurea.	Hydroxyurea	117-128	mitogen-activated protein kinase 1	Homo sapiens	24-27	
11571231-5	2001	Moreover, inhibition of ERK activity by PD98059 induced erythroid differentiation, and it acted synergistically with hydroxyurea on hemoglobin synthesis, whereas inhibition of p38 activity by SB203580 inhibited induction of hemoglobin production by hydroxyurea.	Hydroxyurea	249-260	mitogen-activated protein kinase 1	Homo sapiens	24-27	
20840867-4	2011	While HU potently induced CDC2 Y15 (tyrosine 15) phosphorylation, an event causing CDC2 inactivation, inhibition of ERK kinases using U0126 (a MEK inhibitor), MEK1K97M (a dominant negative MEK1), and knockdown of either ERK1 or ERK2 significantly attenuated HU-induced CDC2 Y15 phosphorylation.	Hydroxyurea	6-8	mitogen-activated protein kinase 1	Homo sapiens	116-119	
20840867-4	2011	While HU potently induced CDC2 Y15 (tyrosine 15) phosphorylation, an event causing CDC2 inactivation, inhibition of ERK kinases using U0126 (a MEK inhibitor), MEK1K97M (a dominant negative MEK1), and knockdown of either ERK1 or ERK2 significantly attenuated HU-induced CDC2 Y15 phosphorylation.	Hydroxyurea	6-8	mitogen-activated protein kinase 1	Homo sapiens	228-232