PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19576950-1	2009	OBJECTIVE: We have previously shown that nitric oxide (NO) is involved in the hydroxyurea-induced increase of gamma-globin gene expression in cultured human erythroid progenitor cells and that hydroxyurea increases NO production in endothelial cells via endothelial NO synthase (NOS).	Hydroxyurea	78-89	nitric oxide synthase 2	Homo sapiens	266-277	
34070036-8	2021	NOS2A and MAP3K5 may predict the beta-thalassemia patient"s response to hydroxyurea, a HbF-inducing drug.	Hydroxyurea	72-83	nitric oxide synthase 2	Homo sapiens	0-5	
31039620-3	2019	Here, we aim to determine the effect of genomic variants located in genes, such as MAP3K5, ASS1, NOS2A, TOX, PDE7B, NOS1, FLT1 and ARG2, previously shown to modulate fetal hemoglobin (Hb F) levels in patients with beta type hemoglobinopathies and reflecting disease severity and response to HU therapy in an independent cohort of Greek patients with these diseases.	Hydroxyurea	291-293	nitric oxide synthase 2	Homo sapiens	97-102	
31039620-5	2019	Our study showed that genomic variants of the MAP3K5, NOS2A and ARG2 gene are associated with HU therapy efficacy in Hb S-beta-thal compound heterozygotes.	Hydroxyurea	94-96	nitric oxide synthase 2	Homo sapiens	54-59	
31039620-7	2019	Our findings provide evidence that MAP3K5, NOS2A, ARG2 and FLT1 genomic variants could be considered as genomic biomarkers to predict HU therapy efficacy in Hb S-beta-thal compound heterozygotes and also to describe disease severity in patients with beta type hemoglobinopathies.	Hydroxyurea	134-136	nitric oxide synthase 2	Homo sapiens	43-48	
16527893-3	2006	We show now that hydroxyurea increases endothelial-cell production of NO; this induction of NO in human umbilical vein endothelial cells (HUVECs) and human bone marrow endothelial cell line (TrHBMEC) is blocked by competitive inhibitors of NO synthase (NOS), such as NG-nitro-L-arginine-methyl ester (L-NAME) and NG-nitro-L-arginine.	Hydroxyurea	17-28	nitric oxide synthase 2	Homo sapiens	240-251