PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21060845-5 2010 Here we report that an S. cerevisiae strain expressing the mre11-H59A allele, mutant at a conserved active site histidine, is sensitive to hydroxyurea and also to ionizing radiation, which induces DSBs, but not to CPT or ETP. Hydroxyurea 139-150 MRX complex nuclease subunit Saccharomyces cerevisiae S288C 59-64