PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2167003-3 1990 Low levels of A23187, when combined with OAG (a direct activator of PKC), stimulated mIL-1 expression in the absence of sIL-1 release. Calcimycin 14-20 interleukin 1 complex Mus musculus 85-90 3079793-6 1986 In the case of the IL 1-dependent line LBRM33-1A5.47, there was a strong response when both A23187 and PMA were used simultaneously. Calcimycin 92-98 interleukin 1 complex Mus musculus 19-23 2848778-4 1988 An assay for the measurement of interleukin-1 (IL-1), based on its ability to induce interleukin-2 (IL-2) production by the EL-4 mouse thymoma line in the presence of the calcium ionophore A23187, was examined. Calcimycin 189-195 interleukin 1 complex Mus musculus 32-51 3116092-5 1987 A23187 induced IL-1 production by C3H/He macrophages, but it did not induce IL-1 production by C3H/HeJ macrophages and neither did LPS. Calcimycin 0-6 interleukin 1 complex Mus musculus 15-19 3116092-9 1987 A calmodulin antagonist W-7 effectively inhibited A23187-induced IL-1 production by C3H/He macrophages. Calcimycin 50-56 interleukin 1 complex Mus musculus 65-69 3079793-12 1986 We suggest that the activating signals provided by A23187 and PMA are at least part of the sequence of events that lead to production of IL 2 in either IL 1-dependent or IL 1-independent T cell lines. Calcimycin 51-57 interleukin 1 complex Mus musculus 152-156 3079793-12 1986 We suggest that the activating signals provided by A23187 and PMA are at least part of the sequence of events that lead to production of IL 2 in either IL 1-dependent or IL 1-independent T cell lines. Calcimycin 51-57 interleukin 1 complex Mus musculus 170-174 3934287-1 1985 A simple and reliable biological assay for interleukin-1 (IL-1) was developed, based on the production of interleukin-2 (IL-2) from the EL-4 murine T-cell lymphoma cell line, in the presence of 2-5 X 10(-7) M calcium ionophore A23187. Calcimycin 227-233 interleukin 1 complex Mus musculus 43-62 6432347-3 1984 The optimal effective concentration of A23187 was found to be 2.5 X 10(-7) M, and the costimulating effect of IL-1 was dose-dependent. Calcimycin 39-45 interleukin 1 complex Mus musculus 110-114 7879702-3 1994 Human recombinant tumour necrosis factor-alpha (TNF-alpha) and the calcium ionophores A23187 and ionomycin induced a concentration-dependent increase of cell-associated IL-1 but failed to cause release of IL-1 at concentrations producing maximal stimulation of cell-associated IL-1. Calcimycin 86-92 interleukin 1 complex Mus musculus 169-173 1792067-2 1991 The incubation of mouse hepatic sinusoidal endothelial cells with lipopolysaccharide (LPS) or calcium-ionophore (CaI) A23187 resulted in a concentration-dependent production of IL1 and PAF. Calcimycin 118-124 interleukin 1 complex Mus musculus 177-180 1792067-3 1991 However, Lipo-PGE1 dose-dependently decreased the LPS- or CaI A23187-induced production of IL1 and PAF. Calcimycin 62-68 interleukin 1 complex Mus musculus 91-94