PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7879702-3	1994	Human recombinant tumour necrosis factor-alpha (TNF-alpha) and the calcium ionophores A23187 and ionomycin induced a concentration-dependent increase of cell-associated IL-1 but failed to cause release of IL-1 at concentrations producing maximal stimulation of cell-associated IL-1.	Calcimycin	86-92	interleukin 1 complex	Mus musculus	169-173	
3079793-6	1986	In the case of the IL 1-dependent line LBRM33-1A5.47, there was a strong response when both A23187 and PMA were used simultaneously.	Calcimycin	92-98	interleukin 1 complex	Mus musculus	19-23	
2167003-3	1990	Low levels of A23187, when combined with OAG (a direct activator of PKC), stimulated mIL-1 expression in the absence of sIL-1 release.	Calcimycin	14-20	interleukin 1 complex	Mus musculus	85-90	
1792067-2	1991	The incubation of mouse hepatic sinusoidal endothelial cells with lipopolysaccharide (LPS) or calcium-ionophore (CaI) A23187 resulted in a concentration-dependent production of IL1 and PAF.	Calcimycin	118-124	interleukin 1 complex	Mus musculus	177-180	
1792067-3	1991	However, Lipo-PGE1 dose-dependently decreased the LPS- or CaI A23187-induced production of IL1 and PAF.	Calcimycin	62-68	interleukin 1 complex	Mus musculus	91-94	
2848778-4	1988	An assay for the measurement of interleukin-1 (IL-1), based on its ability to induce interleukin-2 (IL-2) production by the EL-4 mouse thymoma line in the presence of the calcium ionophore A23187, was examined.	Calcimycin	189-195	interleukin 1 complex	Mus musculus	32-51	
3116092-5	1987	A23187 induced IL-1 production by C3H/He macrophages, but it did not induce IL-1 production by C3H/HeJ macrophages and neither did LPS.	Calcimycin	0-6	interleukin 1 complex	Mus musculus	15-19	
3116092-9	1987	A calmodulin antagonist W-7 effectively inhibited A23187-induced IL-1 production by C3H/He macrophages.	Calcimycin	50-56	interleukin 1 complex	Mus musculus	65-69	
3079793-12	1986	We suggest that the activating signals provided by A23187 and PMA are at least part of the sequence of events that lead to production of IL 2 in either IL 1-dependent or IL 1-independent T cell lines.	Calcimycin	51-57	interleukin 1 complex	Mus musculus	152-156	
3079793-12	1986	We suggest that the activating signals provided by A23187 and PMA are at least part of the sequence of events that lead to production of IL 2 in either IL 1-dependent or IL 1-independent T cell lines.	Calcimycin	51-57	interleukin 1 complex	Mus musculus	170-174	
6432347-3	1984	The optimal effective concentration of A23187 was found to be 2.5 X 10(-7) M, and the costimulating effect of IL-1 was dose-dependent.	Calcimycin	39-45	interleukin 1 complex	Mus musculus	110-114	
3934287-1	1985	A simple and reliable biological assay for interleukin-1 (IL-1) was developed, based on the production of interleukin-2 (IL-2) from the EL-4 murine T-cell lymphoma cell line, in the presence of 2-5 X 10(-7) M calcium ionophore A23187.	Calcimycin	227-233	interleukin 1 complex	Mus musculus	43-62