PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16144700-1 2006 Acyl-coenzyme A:cholesterol acyltransferase (ACAT) esterifies free cholesterol and stores cholesteryl esters in lipid droplets. Cholesterol Esters 90-108 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 45-49 20133765-2 2010 Acyl-CoA:cholesterol acyltransferases (ACAT1 and ACAT2) are two enzymes that convert free cholesterol to cholesteryl esters. Cholesterol Esters 105-123 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 39-44 23123480-1 2012 In order to isolate a cholesterol-lowering compound from Alpinia katsumadai, an inhibitor for acyl-CoA : cholesterol acyltransferase (ACAT), an enzyme responsible for the cholesterol ester formation in liver, was purified, its chemical structure was determined, and in vivo and in vitro inhibition activities were performed. Cholesterol Esters 171-188 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 134-138 22427949-2 2012 However, certain manipulations of the cholesteryl ester cycle, such as the inhibition of ACAT1, an ER-resident enzyme that re-esterifies cholesterol, are not well tolerated. Cholesterol Esters 38-55 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 89-94 19866465-6 2010 RESULTS: Herein, using a prostate cancer xenograft mouse model it is demonstrated by Western blot analysis that proteins responsible for cholesterol regulation (LDL-r, SR-B1, HMG-CoA reductase, ACAT1,2, ABCA1) are altered during disease progression to increase influx and synthesis of cholesterol as well as free cholesterol formation from cholesteryl ester stores. Cholesterol Esters 340-357 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 194-199 19652367-4 2009 Thus, these data strongly suggest that rubimaillin inhibits macrophage ACAT activity in order to decrease cholesteryl ester (CE) synthesis, leading to a reduction in the number of lipid droplets. Cholesterol Esters 106-123 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 71-75 18618086-2 2009 Inhibition of acyl-coenzyme A: cholesterol acyltransferase (ACAT), which generates intracellular cholesteryl esters from free cholesterol and fatty acids, reduces the biogenesis of the Abeta from the amyloid precursor protein (APP). Cholesterol Esters 97-115 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 60-64 18502767-6 2008 Conversely, coexpression of MTP and apoB in AC29 cells stably transfected with ACAT1 and ACAT2 increases cholesteryl ester synthesis. Cholesterol Esters 105-122 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 79-84 15499044-1 2005 OBJECTIVE: Acyl-coenzyme A: cholesterol acyltransferase (ACAT) converts intracellular free cholesterol (FC) into cholesteryl esters (CE) for storage in lipid droplets. Cholesterol Esters 113-131 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 57-61 15831806-5 2005 ACAT1 functions in converting cellular cholesterol into cholesteryl ester in response to cholesterol abundance inside the cells. Cholesterol Esters 56-73 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 0-5 12518025-8 2003 Thus, ACBP was the most potent intracellular fatty acyl CoA binding protein in differentially modulating the activity of microsomal ACAT to form cholesteryl esters independent of cholesterol binding/transfer ability. Cholesterol Esters 145-163 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 132-136 14617738-1 2004 Acyl CoA:cholesterol acyltransferase 1 (ACAT1) and ACAT2 are enzymes responsible for the formation of cholesteryl esters in tissues. Cholesterol Esters 102-120 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 0-38 14617738-1 2004 Acyl CoA:cholesterol acyltransferase 1 (ACAT1) and ACAT2 are enzymes responsible for the formation of cholesteryl esters in tissues. Cholesterol Esters 102-120 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 40-45 14704742-9 2003 In the macrophage, ACAT-1 is responsible for esterifying free cholesterol with fatty acids to form cholesterol esters. Cholesterol Esters 99-117 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 19-25 11264983-1 2001 Two enzymes are responsible for cholesterol ester formation in tissues, acyl coenzyme A:cholesterol acyltransferase types 1 and 2 (ACAT1 and ACAT2). Cholesterol Esters 32-49 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 131-136 12200416-6 2002 Because ACAT is the main enzyme responsible for cholesterol ester synthesis and HSL contributes significantly to neutral cholesterol ester hydrolase activity, this suggests that glucose primes the J774.2 cells so that in the presence of high insulin or leptin they will store cholesterol esters. Cholesterol Esters 48-65 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 8-12 11264983-9 2001 Taken together, the data suggest that cholesterol ester formation by ACAT1 supports separate functions compared with cholesterol esterification by ACAT2. Cholesterol Esters 38-55 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 69-74 25522268-2 2014 Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) promotes foam cell formation by promoting intracellular cholesteryl ester synthesis. Cholesterol Esters 110-127 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 47-52 2393386-6 1990 When ACAT activity was determined after incubation of J774 cell with Ox- or Ac-LDL, Ox-LDL were 12 times less effective than Ac-LDL in stimulating cholesteryl ester formation. Cholesterol Esters 147-164 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 5-9 3624250-1 1987 Cholesteryl ester (CE) accumulation in arterial wall macrophages (foam cells), mediated by the intracellular enzyme acyl coenzyme A:cholesterol acyl transferase (ACAT), is a prominent feature of atherosclerotic lesions. Cholesterol Esters 0-17 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 162-166 20482-12 1977 These changes in ACAT activity may be partly responsible for the differences in cholesteryl ester contents of Ehrlich cells grown in mice fed the coconut and sunflower oil diets. Cholesterol Esters 80-97 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 17-21 30282838-1 2019 AIM: Acyl-CoA cholesterol acyltransferase 1 (ACAT1) esterifies free cholesterol to cholesteryl esters (CE), which are subsequently hydrolyzed by neutral cholesterol ester hydrolase 1 (NCEH1). Cholesterol Esters 83-101 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 5-43 30282838-1 2019 AIM: Acyl-CoA cholesterol acyltransferase 1 (ACAT1) esterifies free cholesterol to cholesteryl esters (CE), which are subsequently hydrolyzed by neutral cholesterol ester hydrolase 1 (NCEH1). Cholesterol Esters 83-101 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 45-50 30354239-1 2018 Objective- ACAT1 (Acyl-CoA cholesterol acyltransferase 1) esterifies cellular free cholesterol, thereby converting macrophages to cholesteryl ester-laden foam cells in atherosclerotic lesions and cutaneous xanthoma. Cholesterol Esters 130-147 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 11-16 30354239-1 2018 Objective- ACAT1 (Acyl-CoA cholesterol acyltransferase 1) esterifies cellular free cholesterol, thereby converting macrophages to cholesteryl ester-laden foam cells in atherosclerotic lesions and cutaneous xanthoma. Cholesterol Esters 130-147 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 18-56 29533741-2 2018 Acyl-CoA:cholesterol acyltransferase 1 (ACAT1) converts cellular cholesterol to cholesteryl esters and is expressed in many cell types. Cholesterol Esters 80-98 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 0-38 29533741-2 2018 Acyl-CoA:cholesterol acyltransferase 1 (ACAT1) converts cellular cholesterol to cholesteryl esters and is expressed in many cell types. Cholesterol Esters 80-98 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 40-45 26801614-1 2016 Acyl-CoA:cholesterol acyltransferase 1 (Acat1) converts cellular cholesterol to cholesteryl esters and is considered a drug target for treating atherosclerosis. Cholesterol Esters 80-98 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 0-38 26801614-1 2016 Acyl-CoA:cholesterol acyltransferase 1 (Acat1) converts cellular cholesterol to cholesteryl esters and is considered a drug target for treating atherosclerosis. Cholesterol Esters 80-98 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 40-45 26801614-6 2016 Analyses of atherosclerotic lesions showed that Acat1(-M/-M) reduced macrophage numbers and diminished the cholesterol and cholesteryl ester load without causing detectable apoptotic cell death. Cholesterol Esters 123-140 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 48-53 11160132-2 2001 The inhibition of macrophage acyl coenzyme A:cholesterol acyltransferase (ACAT), which catalyzes the formation of cholesterol esters, has been proposed as a strategy to reduce foam cell formation and to treat atherosclerosis. Cholesterol Esters 114-132 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 74-78 11100106-0 2000 Cholesterol esters and atherosclerosis-a game of ACAT and mouse. Cholesterol Esters 0-18 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 49-53 9684737-11 1998 Inhibition of ACAT led to a 62% and 90% reduction in the %EC in oxLDL and acLDL treated mouse macrophages, respectively. Cholesterol Esters 58-60 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 14-18 9559268-1 1998 Acyl coenzyme A:cholesterol acyltransferase (ACAT) (EC 2.3.1.26) is an enzyme, located in the endoplasmic reticulum of many types of cells, that catalyzes cholesterol ester formation from cholesterol and fatty acyl CoA substrates. Cholesterol Esters 155-172 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 45-49 35507892-3 2022 ACAT1 is an enzyme that converts cholesterol to cholesteryl esters for storage. Cholesterol Esters 48-66 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 0-5 3949765-4 1986 Treatment of J774 cells with LDL in the presence of ACAT inhibitor 58-035 (Sandoz) prevented both cholesteryl ester and total cholesterol accumulation. Cholesterol Esters 98-115 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 52-56 31495784-1 2019 Cholesterol esters are a key ingredient of foamy cells in atherosclerotic lesions; their formation is catalyzed by two enzymes: acyl-CoA:cholesterol acyltransferases (ACATs; also called sterol O-acyltransferases, or SOATs) ACAT1 and ACAT2. Cholesterol Esters 0-18 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 223-228 27678191-0 2017 miR-467b regulates the cholesterol ester formation via targeting ACAT1 gene in RAW 264.7 macrophages. Cholesterol Esters 23-40 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 65-70 26017812-0 2015 Oxidized-low density lipoprotein accumulates cholesterol esters via the PKCalpha-adipophilin-ACAT1 pathway in RAW264.7 cells. Cholesterol Esters 45-63 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 93-98 26017812-4 2015 The results revealed that ox-LDL increased the activation of protein kinase C alpha (PKCalpha), expression of adipophilin and acyl-coenzymeA: cholesterol acyltransferse 1 (ACAT1) and increased accumulation of intracellular cholesterol esters. Cholesterol Esters 223-241 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 172-177 26017812-7 2015 Taken together, these results demonstrated that ox-LDL induces the accumulation of cholesterol esters, which is mediated by the PKCalpha-adipophilin-ACAT1 pathway. Cholesterol Esters 83-101 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 149-154 26669800-3 2015 ACAT1 converts free cholesterol to cholesteryl esters, and plays important roles in cellular cholesterol homeostasis. Cholesterol Esters 35-53 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 0-5 25264044-3 2014 These macrophages show significant cholesterol ester formation even when free cholesterol egress from late endosomes is impaired, which indicates that free cholesterol is esterified at ACAT1-LE. Cholesterol Esters 35-52 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 185-190 25339759-1 2014 Acyl-CoA:cholesterol acyltransferase 1 (ACAT1) is a resident endoplasmic reticulum enzyme that prevents the buildup of cholesterol in membranes by converting it to cholesterol esters. Cholesterol Esters 164-182 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 0-38 25339759-1 2014 Acyl-CoA:cholesterol acyltransferase 1 (ACAT1) is a resident endoplasmic reticulum enzyme that prevents the buildup of cholesterol in membranes by converting it to cholesterol esters. Cholesterol Esters 164-182 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 40-45 24657401-1 2014 BACKGROUND & AIMS: Acyl-coenzyme A: cholesterol acyltransferase (ACAT) catalyzes the conversion of free cholesterol (FC) to cholesterol ester, which prevents excess accumulation of FC. Cholesterol Esters 128-145 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 69-73 23774792-1 2013 Both genetic inactivation and pharmacological inhibition of the cholesteryl ester synthetic enzyme acyl-CoA:cholesterol acyltransferase 1 (ACAT1) have shown benefit in mouse models of Alzheimer"s disease (AD). Cholesterol Esters 64-81 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 99-137 23774792-1 2013 Both genetic inactivation and pharmacological inhibition of the cholesteryl ester synthetic enzyme acyl-CoA:cholesterol acyltransferase 1 (ACAT1) have shown benefit in mouse models of Alzheimer"s disease (AD). Cholesterol Esters 64-81 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 139-144 23601809-6 2013 A sharp increase in cholesterol ester levels, particularly in the aged APOE epsilon4 diet-enriched group, might be suggestive of abnormal acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT) activity and/or levels. Cholesterol Esters 20-37 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 185-189 23395977-3 2013 However, the stimulation extent was reduced when incubating the cells with cholesterol plus the ACAT (acyl-CoA:cholesterol acyltransferase) inhibitor Sandoz58035 or SiRNA-ACAT1 [which blocks the esterification of free cholesterol (FC) to cholesteryl ester (CE)], indicating the osteogenic potency of cholesterol was mostly due to CE levels. Cholesterol Esters 238-255 acetyl-Coenzyme A acetyltransferase 1 Mus musculus 171-176