PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2849677-0 1988 Pseudo-noncompetitive antagonism of muscarinic receptor-mediated cyclic GMP formation and phosphoinositide hydrolysis by pirenzepine. Pirenzepine 121-132 5'-nucleotidase, cytosolic II Mus musculus 72-75 2849677-1 1988 Pirenzepine selectively antagonized muscarinic receptor-mediated cyclic GMP formation in a noncompetitive fashion in mouse neuroblastoma cells (clone N1E-115). Pirenzepine 0-11 5'-nucleotidase, cytosolic II Mus musculus 72-75 2849677-8 1988 Therefore, the noncompetitive antagonism by pirenzepine detected in cyclic GMP measurements might be only apparent and might be attributed, at least in part, to a lack of an equilibrium state under the specific conditions of these assays. Pirenzepine 44-55 5'-nucleotidase, cytosolic II Mus musculus 75-78 2982089-4 1985 Pirenzepine inhibited the [3H]cyclic GMP response to carbachol with a KD value of approximately 6 nM, whereas it inhibited the ability of carbachol to reduce prostaglandin E1-mediated elevations in [3H]cyclic AMP levels with a KD value of 93 nM, thus differentiating between two classes of receptors involved in these responses. Pirenzepine 0-11 5'-nucleotidase, cytosolic II Mus musculus 37-40