PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16394532-3	2006	We examined the effects of the selective M(1) muscarinic receptor antagonist pirenzepine on the elevation of Dai-kenchu-to-induced plasma neuropeptide (gastrin, motilin, somatostatin, VIP, CGRP, substance P)-IS levels in human volunteers and the area under the plasma neuropeptide concentration-time curve from 0 to 240 min (AUC(0-->240 min)), which were calculated from the plasma neuropeptide concentration-time curves from each volunteers.	Pirenzepine	77-88	gastrin	Homo sapiens	152-159	
16394532-5	2006	Combined treatment with Dai-kenchu-to and pirenzepine increased plasma somatostatin-IS levels and decreased plasma gastrin-IS levels and had no effects on plasma CGRP- and substance P-IS levels and AUC(0-->240 min) compared with administration of Dai-kenchu-to alone.	Pirenzepine	42-53	gastrin	Homo sapiens	115-122	
3818148-5	1986	Mean integrated gastrin responses after pirenzepine and ranitidine alone as well as pirenzepine plus ranitidine were not significantly different from placebo.	Pirenzepine	40-51	gastrin	Homo sapiens	16-23	
7951847-0	1994	Serum gastrin levels following administration of omeprazole alone or in combination with pirenzepine.	Pirenzepine	89-100	gastrin	Homo sapiens	6-13	
8680534-2	1996	Pirenzepine has been reported to inhibit gastrin secretion.	Pirenzepine	0-11	gastrin	Homo sapiens	41-48	
8680534-7	1996	Additional treatment with pirenzepine suppressed serum gastrin level to 0.6-fold the omeprazole-treatment level.	Pirenzepine	26-37	gastrin	Homo sapiens	55-62	
7933468-5	1994	Pirenzepine premedication reduced serum gastrin level.	Pirenzepine	0-11	gastrin	Homo sapiens	40-47	
3840755-1	1985	The aim of this study was to compare the effects of atropine with those of placebo and pirenzepine on food-induced gastrin release, and gastric and acid secretion.	Pirenzepine	87-98	gastrin	Homo sapiens	115-122	
6689097-0	1983	[Serum gastrin levels before and after short-term treatment of duodenal ulcer with cimetidine and pirenzepin].	Pirenzepine	98-108	gastrin	Homo sapiens	7-14	
6150592-1	1984	The effect of pirenzepine--a selective antimuscarinic compound--on plasma catecholamine, serum gastrin and somatostatin concentrations was studied in duodenal ulcer patients.	Pirenzepine	14-25	gastrin	Homo sapiens	95-102	
6895273-0	1981	[Acid secretion and serum gastrin during acute and chronic treatment with pirenzepine in duodenal ulcer (author"s transl)].	Pirenzepine	74-85	gastrin	Homo sapiens	26-33	
6896230-0	1982	[Acid and gastrin secretion before and after treatment with pirenzepine in patients with duodenal ulcer].	Pirenzepine	60-71	gastrin	Homo sapiens	10-17	
6753111-4	1982	Using highly selective antimuscarinic agent, pirenzepine, the evidence is presented that gastrin release during vagal activation or gastric distention is exerted by cholinergic transmission without involvement of cholinergic inhibitory pathway suggested previously.	Pirenzepine	45-56	gastrin	Homo sapiens	89-96	
6113682-7	1980	The postprandial gastrin response was prolonged slightly, but insignificantly, by pirenzepine.	Pirenzepine	82-93	gastrin	Homo sapiens	17-24	
6941379-3	1980	Serum gastrin response to sham-feeding was negative and it was enhanced by atropine but suppressed by pirenzepine.	Pirenzepine	102-113	gastrin	Homo sapiens	6-13	
6895560-0	1981	Inhibition of gastrin secretion by pirenzepine (LS 519) in treatment of gastric ulcer.	Pirenzepine	35-46	gastrin	Homo sapiens	14-21	
6895560-1	1981	The effects of pirenzepine on the serum gastrin levels in the basal state and in response to a liquid test meal were investigated in nine patients with gastric ulcer.	Pirenzepine	15-26	gastrin	Homo sapiens	40-47	
34059932-8	2021	In cases with hypergastrinemia (gastrin >= 200 pg/ml) induced by vonoprazan 10 mg alone, concomitant treatment with pirenzepine significantly reduced serum gastrin levels from 370 to 180 pg/ml (P = 0.028).	Pirenzepine	116-127	gastrin	Homo sapiens	19-26	
34059932-8	2021	In cases with hypergastrinemia (gastrin >= 200 pg/ml) induced by vonoprazan 10 mg alone, concomitant treatment with pirenzepine significantly reduced serum gastrin levels from 370 to 180 pg/ml (P = 0.028).	Pirenzepine	116-127	gastrin	Homo sapiens	32-39