PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9773926-6	1998	In the group on the lansoprazole and pirenzepine combination, serum gastrin levels decreased, and gastrin and enterochromaffin-like cell numbers were significantly decreased, compared with the respective variables in the group on lansoprazole alone, while the number of somatostatin cells increased in the group on the combination.	Pirenzepine	37-48	gastrin	Rattus norvegicus	68-75	
11428583-4	2001	RESULTS: Pirenzepine treatment suppressed omeprazole-induced increases in serum gastrin levels and mRNA levels of H+-K+-ATPase and histidine decarboxylase.	Pirenzepine	9-20	gastrin	Rattus norvegicus	80-87	
9773926-6	1998	In the group on the lansoprazole and pirenzepine combination, serum gastrin levels decreased, and gastrin and enterochromaffin-like cell numbers were significantly decreased, compared with the respective variables in the group on lansoprazole alone, while the number of somatostatin cells increased in the group on the combination.	Pirenzepine	37-48	gastrin	Rattus norvegicus	98-105	
9773926-8	1998	It was thus demonstrated that pirenzepine corrects the abnormal gastric secretion kinetics resulting from treatment with lansoprazole alone, such as hypergastrinemia and gastrin and enterochromaffin-like cell hyperplasia.	Pirenzepine	30-41	gastrin	Rattus norvegicus	154-161	
8654146-0	1996	Effects of pirenzepine on omeprazole-induced gastrin gene expression in rat antral tissues.	Pirenzepine	11-22	gastrin	Rattus norvegicus	45-52	
8654146-1	1996	Pirenzepine has inhibitory effects on gastrin secretion both in vivo and in vitro.	Pirenzepine	0-11	gastrin	Rattus norvegicus	38-45	
8654146-6	1996	Combination treatment with omeprazole plus pirenzepine significantly decreased the gastrin mRNA level to half and significantly increased the somatostatin mRNA level up to 1.4-fold of the levels achieved with omeprazole treatment alone.	Pirenzepine	43-54	gastrin	Rattus norvegicus	83-90	
8654146-7	1996	These results suggest that the stimulatory effect of omeprazole on gastrin synthesis is partially blocked by pirenzepine via mediation of somatostatin synthesis in the antrum.	Pirenzepine	109-120	gastrin	Rattus norvegicus	67-74	
2857528-0	1985	Pirenzepine-sensitive muscarinic receptors regulate gastric somatostatin and gastrin.	Pirenzepine	0-11	gastrin	Rattus norvegicus	77-84	
2875917-4	1986	Inclusion of either atropine or pirenzepine in incubation medium prevented GABA-induced stimulation of gastrin release and inhibition of somatostatin release.	Pirenzepine	32-43	gastrin	Rattus norvegicus	103-110	
3619504-0	1986	[Effects of pirenzepine on blood gastrin in rats.	Pirenzepine	12-23	gastrin	Rattus norvegicus	33-40	
2857528-4	1985	Both atropine and pirenzepine reversed these effects in a dose-dependent fashion with D50 values of 1 X 10(-9) and 1 X 10(-7) M, respectively, against gastrin stimulation and 1 X 10(-8) and 1 X 10(-7) M, respectively, against SLI inhibition.	Pirenzepine	18-29	gastrin	Rattus norvegicus	151-158	
2857528-5	1985	Pirenzepine caused a progressive parallel rightward shift in the dose-response curves for SLI inhibition and gastrin stimulation by carbachol, suggesting competitive inhibition.	Pirenzepine	0-11	gastrin	Rattus norvegicus	109-116	
2857528-6	1985	The apparent inhibitory constant (ki) was calculated to be approximately 2 X 10(-9) M. These results indicate that gastrin and SLI release from the stomach is governed by high-affinity muscarinic receptors that are sensitive to pirenzepine.	Pirenzepine	228-239	gastrin	Rattus norvegicus	115-122