PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7761624-6	1995	It is well established that amino acids (particularly aromatics like Phe and Trp) and peptides stimulate gastrin release in mammals.	Tryptophan	77-80	gastrin	Homo sapiens	105-112	
6161125-4	1981	To test this hypothesis, we have synthesized an oligodeoxynucleotide (oligo II) complementary to the region of gastrin mRNA coding for Trp-Met-Asp-Phe and have compared its effectiveness as a hybridization probe and as a primer for the synthesis of gastrin-specific cDNA with another oligonucleotide (oligo I) complementary to the region of gastrin mRNA coding for Trp-Met-Glu-Glu.	Tryptophan	135-138	gastrin	Homo sapiens	111-118	
3953532-5	1986	Only phenylalanine and tryptophan produced significant stimulation of serum gastrin levels with peak increases above basal occurring 30 min after administration (p less than 0.05).	Tryptophan	23-33	gastrin	Homo sapiens	76-83	
3953532-6	1986	It is concluded that: aspartic acid, leucine and glycine produced no significant changes in LES pressure or serum gastrin level; tryptophan and phenylalanine significantly increased serum gastrin concentration; tryptophan significantly decreased LES pressure whereas phenylalanine had no effect; the mechanism of inhibition of LES pressure by tryptophan is not defined and may be mediated by neural or hormonal pathways possibly involving a duodenal receptor.	Tryptophan	129-139	gastrin	Homo sapiens	188-195	
6806140-4	1982	We conclude that a major part of the acid-stimulating action of mixed amino acid solution can be explained by the aromatic amino acids, phenylalanine and tryptophan, which are also the most potent stimulants of gastrin and pancreatic polypeptide release.	Tryptophan	154-164	gastrin	Homo sapiens	211-218	
1523164-5	1992	Changing the peptide bond between Trp and Leu residues to a -omega(CH2-NH)- bond resulted in a compound which also bound to gastrin receptors (Kd approximately 10 nM) but presented agonist activity on acid secretion in the rat.	Tryptophan	34-37	gastrin	Homo sapiens	124-131	
1773057-4	1991	We found that pairs of arginine residues flanking gastrin 34, the typical processing site sequence of all other preprogastrins and many peptide hormones, were arginines in the bovine preprogastrin, but the first basic amino acid pair had changed to Arg-Trp (57-58 residues) instead of Arg-Arg in the feline preprogastrin.	Tryptophan	253-256	gastrin	Homo sapiens	50-57	
6806140-2	1982	Phenylalanine and tryptophan were significantly more potent stimulants of gastric acid secretion and of pancreatic polypeptide and gastrin release than any of the other amino acids tested.	Tryptophan	18-28	gastrin	Homo sapiens	131-138	
22855967-0	2004	(111)In/(68)Ga-Labeled DOTA conjugated cyclo[gamma-d-Glu-Ala-Tyr-d-Lys]-Trp-Nle-Asp-Phe-NH2 (cyclo-MG2), a minigastrin analog The three subtypes of the cholecystokinin (CCK) receptors (CCKR) belong to the G-protein coupled receptor family and are classified (CCK1R, CCK2R and CCK2i4svR) on the basis of their affinities for the CCK and the gastrin peptides, differential distribution in the tissues and molecular structure (1).	Tryptophan	72-75	gastrin	Homo sapiens	111-118	
738695-3	1978	It was found to be absolutely identical with a "modified tryptophan" which was isolated after the total synthesis of a gastrin analogue; Nin-tert-butyl-tryptophan peptides are formed as the main products of a tert-butylation reaction, the mechanism of which is not very clear yet.	Tryptophan	57-67	gastrin	Homo sapiens	119-126	
88048-2	1979	The nucleotide sequence of the oligonucleotide, d(C-T-C-C-T-C-C-A-T-C-C-A), was deduced from the unique amino acid sequence Trp-Met-Glu-Glu of gastrin.	Tryptophan	124-127	gastrin	Homo sapiens	143-150	
21362032-8	2011	Plasma gastrin level also rose significantly during treatment with omeprazole plus melatonin or Trp, but it was also significantly increased in patients treated with omeprazole plus placebo.	Tryptophan	96-99	gastrin	Homo sapiens	7-14	
22204799-8	2011	Plasma gastrin and leptin levels showed a significant rise over initial values in patients treated with omeprazole and placebo, MT or TRP while plasma ghrelin levels were not significantly affected by these treatments.	Tryptophan	134-137	gastrin	Homo sapiens	7-14	
11000005-1	2000	The two hormones cholecystokinin and gastrin share the same C-terminal sequence of amino acids, namely Gly(29)-Trp(30)-Met(31)-Asp(32)-Phe(33)-NH(2).	Tryptophan	111-114	gastrin	Homo sapiens	37-44	
20443220-9	2010	Plasma gastrin levels were raised in subjects given melatonin or tryptophan plus ASA, but not in those with ASA alone.	Tryptophan	65-75	gastrin	Homo sapiens	7-14	
20443220-10	2010	We conclude that melatonin and its precursor tryptophan given orally significantly reduce gastric lesions induced by ASA possibly due to (a) direct gastroprotective action of exogenous melatonin or that generated from tryptophan and (b) gastrin released from the gastric mucosa by melatonin or tryptophan.	Tryptophan	45-55	gastrin	Homo sapiens	237-244	
19552764-5	2009	Moreover, plasma gastrin, ghrelin, leptin and insulin levels under fasting and postprandial conditions were significantly higher in LC subjects than in healthy controls and they further rose significantly after oral application of melatonin or Trp.	Tryptophan	244-247	gastrin	Homo sapiens	17-24	
17950490-3	2007	The C-terminal conformation of [Nle(15)] gastrin-17 contained a short alpha-helix spanning the Ala(11)-Trp(14) sequence and an inverse gamma-turn centered on Nle(15) while that of [Tyr(9)-SO(3)] cholecystokinin-15 contained a short 3(10) helix spanning its Met(10) to Met(13) sequence and an inverse gamma-turn centered on Asp(14).	Tryptophan	103-106	gastrin	Homo sapiens	41-48	
17698249-4	2007	The conformation of [Nle(15)] gastrin-17 consisted of two short helices between Leu(5)-Glu(9) and Ala(11)-Trp(14), with the one helix terminating in a type I beta-turn spanning Gly(13)-Asp(16).	Tryptophan	106-109	gastrin	Homo sapiens	30-37	
10541353-7	1999	For this purpose, a variety of CCK/gastrin-related peptides, all having in common the COOH-terminal CCK-receptor binding tetrapeptide sequence Trp-Met-Asp-PheNH2 or derivatives thereof, were studied.	Tryptophan	143-146	gastrin	Homo sapiens	35-42	
9578981-1	1998	The neuroendocrine peptides cholecystokinin (CCK) and gastrin, originally identified in mammals, are characterized by a common amidated C-terminal tetrapeptide sequence, Trp-Met-Asp-Phe.NH2, which also constitutes the minimal structure necessary for biological activity of both.	Tryptophan	170-173	gastrin	Homo sapiens	54-61	
9392446-6	1997	L-tryptophan, which significantly elevated the plasma melatonin by about 3-5-fold, also reduced the stress and I/R-induced lesions and blood levels of free radicals, while increasing the GBF, DNA synthesis, and plasma gastrin levels.	Tryptophan	0-12	gastrin	Homo sapiens	218-225	
10751901-11	1999	The gastric phase (hydrochloric acid and pepsinogen secretions) is activated by gastrin, histamine and acetilcholine which respond to both dietary-amino acids (tryptophan and phenylalanine) and mechanic distention of stomach.	Tryptophan	160-170	gastrin	Homo sapiens	80-87