PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12471139-6	2002	Depletion of tryptophan led to stabilization of IL-6 and IL-8 mRNA and increased IL-6 and IL-8 responses, whereas supplementing tryptophan largely restored these changes.	Tryptophan	13-23	C-X-C motif chemokine ligand 8	Homo sapiens	57-61	
33960079-3	2021	Among them, GCP-1 (Cycle-(Trp-Glu-His-Thr)) inhibited proliferation and induced human cervical cancer (HeLa) cells apoptosis and blocked the HeLa cells in G0/G1 phase significantly.	Tryptophan	26-29	C-X-C motif chemokine ligand 8	Homo sapiens	12-17	
19428234-10	2010	Moreover, tryptophan reduced the expression of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin (IL)-6, interferon (IFN)-gamma, IL-12p40, IL-1beta and IL-17, as well as IL-8 and intracellular adhesion molecule-1, and resulted in increased expression of apoptosis initiators caspase-8 and Bax.	Tryptophan	10-20	C-X-C motif chemokine ligand 8	Homo sapiens	192-196	
17883254-3	2007	The inhibition of H 2O 2-induced IL-8 secretion from Caco-2 cells was observed by pretreatment with Cys, Val, Ile, Leu, Trp, His, Lys, and Ala.	Tryptophan	120-123	C-X-C motif chemokine ligand 8	Homo sapiens	33-37	
26551350-5	2015	l-Trp treatment (5 mM) reduced TNF-alpha-induced IL-8 secretion from HT-29 or Caco-2 cells to about 50 or 40%, respectively.	Tryptophan	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	49-53	
24024768-9	2013	Only TRP significantly decreased serum levels of apolipoprotein B (apoB; -6%), interleukin-8 (IL-8; -11%) and monocyte chemotactic protein-1 (MCP-1; -19%).	Tryptophan	5-8	C-X-C motif chemokine ligand 8	Homo sapiens	79-92	
24024768-9	2013	Only TRP significantly decreased serum levels of apolipoprotein B (apoB; -6%), interleukin-8 (IL-8; -11%) and monocyte chemotactic protein-1 (MCP-1; -19%).	Tryptophan	5-8	C-X-C motif chemokine ligand 8	Homo sapiens	94-98	
22891766-5	2012	In this novel mechanism, TWIST1-mediated IL8 transcription is induced through the TWIST1 carboxy-terminal WR (Trp-Arg) domain instead of the classic DNA binding bHLH domain.	Tryptophan	110-113	C-X-C motif chemokine ligand 8	Homo sapiens	41-44	
12471139-6	2002	Depletion of tryptophan led to stabilization of IL-6 and IL-8 mRNA and increased IL-6 and IL-8 responses, whereas supplementing tryptophan largely restored these changes.	Tryptophan	13-23	C-X-C motif chemokine ligand 8	Homo sapiens	90-94	
9629951-7	1998	There were significant and inverse relationships between the availability of plasma tryptophan and serum IL-1RA, IL-6 and IL-8.	Tryptophan	84-94	C-X-C motif chemokine ligand 8	Homo sapiens	122-126	
9657419-3	1998	There were significant correlations between the availability of tryptophan to the brain and serum IL-6, IL-8 and IL-1RA (all negative) and CC16 (positive).	Tryptophan	64-74	C-X-C motif chemokine ligand 8	Homo sapiens	104-108