PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8233617-1 1993 Thrombospondin related anonymous protein (TRAP) of Plasmodium falciparum is characterized by the presence of an amino acid motif based on the sequence Trp-Ser-Pro-Cys-Ser-Val-Thr-Cys-Gly (WSPCSVTCG) that is found in a growing family of proteins. Tryptophan 151-154 TRAP Homo sapiens 42-46 17154157-6 2007 This portion of TRAP targets the PfAldo active site, with its n-1 Trp residue, which is essential for this interaction, buried within the PfAldo catalytic pocket. Tryptophan 66-69 TRAP Homo sapiens 16-20 24550461-4 2014 Upon activation by tryptophan, the outer circumference of the TRAP ring binds specifically to a series of tandem sequences present in the 5" UTR of RNA transcripts encoding several tryptophan metabolism genes, leading to their silencing. Tryptophan 19-29 TRAP Homo sapiens 62-66 24550461-4 2014 Upon activation by tryptophan, the outer circumference of the TRAP ring binds specifically to a series of tandem sequences present in the 5" UTR of RNA transcripts encoding several tryptophan metabolism genes, leading to their silencing. Tryptophan 181-191 TRAP Homo sapiens 62-66 24550461-5 2014 AT, whose expression is up-regulated upon tryptophan depletion to concentrations not exceeding a ratio of one AT trimer per TRAP 11-mer, restores tryptophan production by binding activated TRAP and preventing RNA binding. Tryptophan 42-52 TRAP Homo sapiens 189-193 24550461-5 2014 AT, whose expression is up-regulated upon tryptophan depletion to concentrations not exceeding a ratio of one AT trimer per TRAP 11-mer, restores tryptophan production by binding activated TRAP and preventing RNA binding. Tryptophan 146-156 TRAP Homo sapiens 124-128 24550461-5 2014 AT, whose expression is up-regulated upon tryptophan depletion to concentrations not exceeding a ratio of one AT trimer per TRAP 11-mer, restores tryptophan production by binding activated TRAP and preventing RNA binding. Tryptophan 146-156 TRAP Homo sapiens 189-193 24550461-6 2014 How the smaller AT inhibitor prevents RNA binding at such low stoichiometries has remained a puzzle, in part because of the large RNA-binding surface on the tryptophan-activated TRAP ring and its high affinity for RNA. Tryptophan 157-167 TRAP Homo sapiens 178-182 22115774-1 2012 The trp RNA-binding attenuation protein (TRAP) is a paradigmatic allosteric protein that regulates the tryptophan biosynthetic genes associated with the trp operon in bacilli. Tryptophan 103-113 TRAP Homo sapiens 4-39 22115774-1 2012 The trp RNA-binding attenuation protein (TRAP) is a paradigmatic allosteric protein that regulates the tryptophan biosynthetic genes associated with the trp operon in bacilli. Tryptophan 103-113 TRAP Homo sapiens 41-45 22115774-2 2012 The ring-shaped 11-mer TRAP is activated for recognition of a specific trp-mRNA target by binding up to 11 tryptophan molecules. Tryptophan 107-117 TRAP Homo sapiens 23-27 22115774-3 2012 To characterize the mechanisms of tryptophan-induced TRAP activation, we have performed methyl relaxation dispersion (MRD) nuclear magnetic resonance (NMR) experiments that probe the time-dependent structure of TRAP in the microsecond-to-millisecond "chemical exchange" time window. Tryptophan 34-44 TRAP Homo sapiens 53-57 22115774-3 2012 To characterize the mechanisms of tryptophan-induced TRAP activation, we have performed methyl relaxation dispersion (MRD) nuclear magnetic resonance (NMR) experiments that probe the time-dependent structure of TRAP in the microsecond-to-millisecond "chemical exchange" time window. Tryptophan 34-44 TRAP Homo sapiens 211-215 18334255-1 2008 The trp RNA-binding attenuation protein (TRAP) regulates expression of the tryptophan biosynthetic (trp) genes in response to changes in intracellular levels of free l-tryptophan in many Gram-positive bacteria. Tryptophan 75-85 TRAP Homo sapiens 4-39 18334255-1 2008 The trp RNA-binding attenuation protein (TRAP) regulates expression of the tryptophan biosynthetic (trp) genes in response to changes in intracellular levels of free l-tryptophan in many Gram-positive bacteria. Tryptophan 75-85 TRAP Homo sapiens 41-45 18334255-1 2008 The trp RNA-binding attenuation protein (TRAP) regulates expression of the tryptophan biosynthetic (trp) genes in response to changes in intracellular levels of free l-tryptophan in many Gram-positive bacteria. Tryptophan 4-7 TRAP Homo sapiens 41-45 18334255-1 2008 The trp RNA-binding attenuation protein (TRAP) regulates expression of the tryptophan biosynthetic (trp) genes in response to changes in intracellular levels of free l-tryptophan in many Gram-positive bacteria. Tryptophan 166-178 TRAP Homo sapiens 4-39 18334255-1 2008 The trp RNA-binding attenuation protein (TRAP) regulates expression of the tryptophan biosynthetic (trp) genes in response to changes in intracellular levels of free l-tryptophan in many Gram-positive bacteria. Tryptophan 166-178 TRAP Homo sapiens 41-45 18334255-2 2008 When activated by binding tryptophan, TRAP binds to the mRNAs of several genes involved in tryptophan metabolism, and down-regulates transcription or translation of these genes. Tryptophan 26-36 TRAP Homo sapiens 38-42 18334255-2 2008 When activated by binding tryptophan, TRAP binds to the mRNAs of several genes involved in tryptophan metabolism, and down-regulates transcription or translation of these genes. Tryptophan 91-101 TRAP Homo sapiens 38-42 18334255-3 2008 Anti-TRAP (AT) is an antagonist of TRAP that binds to tryptophan-activated TRAP and prevents it from binding to its RNA targets, and thereby up-regulates trp gene expression. Tryptophan 54-64 TRAP Homo sapiens 5-9 18334255-3 2008 Anti-TRAP (AT) is an antagonist of TRAP that binds to tryptophan-activated TRAP and prevents it from binding to its RNA targets, and thereby up-regulates trp gene expression. Tryptophan 54-64 TRAP Homo sapiens 35-39 18334255-3 2008 Anti-TRAP (AT) is an antagonist of TRAP that binds to tryptophan-activated TRAP and prevents it from binding to its RNA targets, and thereby up-regulates trp gene expression. Tryptophan 54-64 TRAP Homo sapiens 35-39 21870865-6 2011 The study clearly shows the determining influence of symmetry and topology on the elastic properties and also offers a detailed view on the Trp affinity of TRAP. Tryptophan 140-143 TRAP Homo sapiens 156-160 19164760-2 2009 The protein TRAP (trp RNA-binding attenuation protein) predominantly forms a ring-shaped 11-mer, which binds cognate RNA in the presence of tryptophan to suppress expression of the trp operon. Tryptophan 140-150 TRAP Homo sapiens 12-16 19164760-2 2009 The protein TRAP (trp RNA-binding attenuation protein) predominantly forms a ring-shaped 11-mer, which binds cognate RNA in the presence of tryptophan to suppress expression of the trp operon. Tryptophan 140-150 TRAP Homo sapiens 18-53 17154157-7 2007 Docking of a TRAP peptide bearing a Trp to Ala mutation rendered the lower energy configurations either bound weakly outside the active site or not bound to PfAldo at all. Tryptophan 36-39 TRAP Homo sapiens 13-17 15050822-1 2004 The trp RNA-binding attenuation protein (TRAP) regulates expression of the tryptophan biosynthetic genes in several Bacilli by binding to the leader region of the nascent trp mRNA, inhibiting continued transcription. Tryptophan 75-85 TRAP Homo sapiens 4-39 16784236-0 2006 Thermodynamics of tryptophan-mediated activation of the trp RNA-binding attenuation protein. Tryptophan 18-28 TRAP Homo sapiens 56-91 16784236-1 2006 The trp RNA-binding attenuation protein (TRAP) functions in many bacilli to control the expression of the tryptophan biosynthesis genes. Tryptophan 106-116 TRAP Homo sapiens 4-39 16784236-1 2006 The trp RNA-binding attenuation protein (TRAP) functions in many bacilli to control the expression of the tryptophan biosynthesis genes. Tryptophan 106-116 TRAP Homo sapiens 41-45 16784236-2 2006 Transcription of the trp operon is controlled by TRAP through an attenuation mechanism, in which competition between two alternative secondary-structural elements in the 5" leader sequence of the nascent mRNA is influenced by tryptophan-dependent binding of TRAP to the RNA. Tryptophan 226-236 TRAP Homo sapiens 49-53 16784236-2 2006 Transcription of the trp operon is controlled by TRAP through an attenuation mechanism, in which competition between two alternative secondary-structural elements in the 5" leader sequence of the nascent mRNA is influenced by tryptophan-dependent binding of TRAP to the RNA. Tryptophan 226-236 TRAP Homo sapiens 258-262 16784236-3 2006 Previously, NMR studies of the undecamer (11-mer) suggested that tryptophan-dependent control of RNA binding by TRAP is accomplished through ligand-induced changes in protein dynamics. Tryptophan 65-75 TRAP Homo sapiens 112-116 16784236-6 2006 Analysis of this excess heat capacity change using parameters derived from protein folding studies corresponds to the ordering of 17-24 residues per monomer of TRAP upon tryptophan binding. Tryptophan 170-180 TRAP Homo sapiens 160-164 15050822-1 2004 The trp RNA-binding attenuation protein (TRAP) regulates expression of the tryptophan biosynthetic genes in several Bacilli by binding to the leader region of the nascent trp mRNA, inhibiting continued transcription. Tryptophan 75-85 TRAP Homo sapiens 41-45 15050822-2 2004 The 11 subunit TRAP molecule is active in complex with tryptophan, and binds consequently an RNA target segment consisting of 11 (G/U)AG triplets, each separated by two or three non-conserved "spacer" nucleotides. Tryptophan 55-65 TRAP Homo sapiens 15-19 14595113-4 2003 Here, we confirm these unexpected findings in Plasmodium sporozoites and identify conserved features of the TRAP family cytoplasmic tail required to bind aldolase: a subterminal tryptophan residue and two noncontiguous stretches of negatively charged amino acids. Tryptophan 178-188 TRAP Homo sapiens 108-112 12855807-6 2003 Tandem sensing of uncharged tRNATrp therefore regulates synthesis of AT, which in turn regulates TRAP"s ability to inhibit trp operon expression. Tryptophan 123-126 TRAP Homo sapiens 97-101 11914485-1 2002 The trp RNA-binding attenuation protein (TRAP) regulates expression of the tryptophan biosynthetic genes in bacilli by binding to the leader region of the nascent trp operon mRNA. Tryptophan 75-85 TRAP Homo sapiens 4-39 11914485-1 2002 The trp RNA-binding attenuation protein (TRAP) regulates expression of the tryptophan biosynthetic genes in bacilli by binding to the leader region of the nascent trp operon mRNA. Tryptophan 75-85 TRAP Homo sapiens 41-45 11914485-2 2002 When activated by binding tryptophan, the 11-subunit circular TRAP molecule binds to a target sequence consisting of 11 (G/U)AG repeats, separated by two or three variable "spacer" nucleotides. Tryptophan 26-36 TRAP Homo sapiens 62-66 10499579-1 1999 The trp RNA-binding attenuation protein (TRAP) regulates expression of the tryptophan biosynthetic genes of several bacilli by binding single-stranded RNA. Tryptophan 75-85 TRAP Homo sapiens 4-39 10499579-1 1999 The trp RNA-binding attenuation protein (TRAP) regulates expression of the tryptophan biosynthetic genes of several bacilli by binding single-stranded RNA. Tryptophan 75-85 TRAP Homo sapiens 41-45