PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16677721-15	2006	This may reflect a role for IL-6 in the tryptophan and serotonin responses to IL-1 and LPS.	Tryptophan	40-50	interleukin 1 complex	Mus musculus	78-82	
9878816-7	1999	Pretreatment of mice with anti-IL-6 significantly attenuated the IL-1-induced increases of plasma ACTH and corticosterone at 2 h, but not at 4 h. The IL-1-induced increases of MHPG, tryptophan and 5-HIAA in hypothalamus and brain stem were not significantly altered.	Tryptophan	182-192	interleukin 1 complex	Mus musculus	65-69	
11268389-6	2000	The HPA-activating activity of IL-1 is associated with increases in the apparent release of brain noradrenaline (NA) and serotonin (5-HT), but not dopamine, as well as with increased brain tryptophan.	Tryptophan	189-199	interleukin 1 complex	Mus musculus	31-35	
9878816-7	1999	Pretreatment of mice with anti-IL-6 significantly attenuated the IL-1-induced increases of plasma ACTH and corticosterone at 2 h, but not at 4 h. The IL-1-induced increases of MHPG, tryptophan and 5-HIAA in hypothalamus and brain stem were not significantly altered.	Tryptophan	182-192	interleukin 1 complex	Mus musculus	150-154	
1614286-1	1992	Interleukin-1 (IL-1) has been shown to activate the hypothalamic-pituitary-adrenal (HPA) axis, and to elevate cerebral concentrations of tryptophan and the norepinephrine catabolite, 3-methoxy,4-hydroxyphenylethyleneglycol (MHPG).	Tryptophan	137-147	interleukin 1 complex	Mus musculus	0-13	
1614286-1	1992	Interleukin-1 (IL-1) has been shown to activate the hypothalamic-pituitary-adrenal (HPA) axis, and to elevate cerebral concentrations of tryptophan and the norepinephrine catabolite, 3-methoxy,4-hydroxyphenylethyleneglycol (MHPG).	Tryptophan	137-147	interleukin 1 complex	Mus musculus	15-19	
1473014-1	1992	Both interleukin-1 (IL-1) and endotoxin (lipopolysaccharide, LPS) are potent activators of the hypothalamo-pituitary-adrenal (HPA) axis, and they also increase cerebral norepinephrine metabolism and tryptophan.	Tryptophan	199-209	interleukin 1 complex	Mus musculus	20-24