PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27462820-3	2016	We test the hypothesis that GIRK2 is necessary for the GABAB R agonist-induced infantile spasms phenotype in Ts.	gabab	55-60	potassium inwardly-rectifying channel, subfamily J, member 6	Mus musculus	28-33	
27462820-4	2016	METHODS: We assessed the result of either genetic or pharmacological knockdown of the GIRK2 channel in Ts brain upon the GABAB R agonist-induced infantile spasms phenotype in the Ts mouse model of DS.	gabab	121-126	potassium inwardly-rectifying channel, subfamily J, member 6	Mus musculus	86-91	
27462820-6	2016	RESULTS: The reduction of the copy number of Kcnj6 in Ts mice rescued the GABAB R agonist-induced infantile spasms phenotype.	gabab	74-79	potassium inwardly-rectifying channel, subfamily J, member 6	Mus musculus	45-50	
27462820-7	2016	There was an increase in GABAB R-mediated GIRK2 currents in GIRK2-trisomic Ts mouse hippocampal neurons, which were normalized in the GIRK2-disomic Ts mice.	gabab	25-30	potassium inwardly-rectifying channel, subfamily J, member 6	Mus musculus	42-47	
27462820-7	2016	There was an increase in GABAB R-mediated GIRK2 currents in GIRK2-trisomic Ts mouse hippocampal neurons, which were normalized in the GIRK2-disomic Ts mice.	gabab	25-30	potassium inwardly-rectifying channel, subfamily J, member 6	Mus musculus	60-65	
27462820-8	2016	Similarly, pharmacological knockdown of the GIRK2 channel in Ts brain using the GIRK antagonist tertiapin-Q also rescued the GABAB R agonist-induced infantile spasms phenotype in Ts mutants.	gabab	125-130	potassium inwardly-rectifying channel, subfamily J, member 6	Mus musculus	44-49	
27462820-9	2016	INTERPRETATION: The GABAB R-coupled GIRK2 channel is necessary for the GABAB R agonist-induced infantile spasms phenotype in the Ts mouse and may represent a novel therapeutic target for the treatment of infantile spasms in DS.	gabab	20-25	potassium inwardly-rectifying channel, subfamily J, member 6	Mus musculus	36-41	
26808347-5	2016	Accordingly, FsE triggers GABAB1 and GIRK2 internalization, leading to rapid and persistent weakening of GABAB-activated GIRK-mediated (GABAB-GIRK) currents.	gabab	105-110	potassium inwardly-rectifying channel, subfamily J, member 6	Mus musculus	37-42