PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31251971-0	2019	2,3"4,4",5-Pentachlorobiphenyl induces hepatocellular carcinoma cell proliferation through pyruvate kinase M2-dependent glycolysis.	2,3',4,4',5-pentachlorobiphenyl	0-30	pyruvate kinase M1/2	Homo sapiens	91-109	
31251971-4	2019	Moreover, PCB118 exposure increased the expression level of pyruvate kinase M2 (PKM2) and its nuclear translocation, whereas treatment with PKM2 shRNA suppressed the induction of cell proliferation and glycolysis by PCB118.	2,3',4,4',5-pentachlorobiphenyl	10-16	pyruvate kinase M1/2	Homo sapiens	60-78	
31251971-4	2019	Moreover, PCB118 exposure increased the expression level of pyruvate kinase M2 (PKM2) and its nuclear translocation, whereas treatment with PKM2 shRNA suppressed the induction of cell proliferation and glycolysis by PCB118.	2,3',4,4',5-pentachlorobiphenyl	10-16	pyruvate kinase M1/2	Homo sapiens	80-84	
31251971-4	2019	Moreover, PCB118 exposure increased the expression level of pyruvate kinase M2 (PKM2) and its nuclear translocation, whereas treatment with PKM2 shRNA suppressed the induction of cell proliferation and glycolysis by PCB118.	2,3',4,4',5-pentachlorobiphenyl	216-222	pyruvate kinase M1/2	Homo sapiens	140-144	
31251971-6	2019	Treatment with the antioxidants N-acetyl-L-cysteine (NAC) and superoxide dismutase (SOD) prevented PCB118-induced effects on PKM2, cell proliferation and glycolysis.	2,3',4,4',5-pentachlorobiphenyl	99-105	pyruvate kinase M1/2	Homo sapiens	125-129	
31251971-8	2019	Consistently, treatment with AhR shRNA suppressed PCB118-induced effects on PKM2, cell proliferation and glycolysis.	2,3',4,4',5-pentachlorobiphenyl	50-56	pyruvate kinase M1/2	Homo sapiens	76-80	
31251971-9	2019	Overall, these results indicated that PCB118 promotes HCC cell proliferation via PKM2-dependent upregulation of glycolysis, which is mediated by AhR/NADPH oxidase-induced ROS production.	2,3',4,4',5-pentachlorobiphenyl	38-44	pyruvate kinase M1/2	Homo sapiens	81-85	
30821169-5	2019	Moreover, we found that the expression and nuclear distribution of PKM2 protein was significantly increased in PCB126, PCB118, or PCB153-treated HeLa cells.	2,3',4,4',5-pentachlorobiphenyl	119-125	pyruvate kinase M1/2	Homo sapiens	67-71	
30821169-9	2019	Taken together, these results indicated that PCB126, PCB118, or PCB153 exposure promotes cervical cancer HeLa cell survival by PKM2-dependent upregulation of glycolysis, which is mediated by NADPH oxidase-induced ROS production.	2,3',4,4',5-pentachlorobiphenyl	53-59	pyruvate kinase M1/2	Homo sapiens	127-131