PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26519956-0 2016 2,3",4,4",5-Pentachlorobiphenyl Induces Inflammatory Responses in the Thyroid Through JNK and Aryl Hydrocarbon Receptor-Mediated Pathway. 2,3',4,4',5-pentachlorobiphenyl 0-31 mitogen-activated protein kinase 8 Rattus norvegicus 86-89 26519956-6 2016 In vivo and in vitro studies also suggested that the c-Jun N-terminal kinase (JNK) pathway was activated on PCB118 exposure, and the experiments using siRNA for JNK partially blocked PCB118-induced upregulation of IL-6 and ICAM-1 and downregulation of NIS. 2,3',4,4',5-pentachlorobiphenyl 108-114 mitogen-activated protein kinase 8 Rattus norvegicus 53-76 26519956-6 2016 In vivo and in vitro studies also suggested that the c-Jun N-terminal kinase (JNK) pathway was activated on PCB118 exposure, and the experiments using siRNA for JNK partially blocked PCB118-induced upregulation of IL-6 and ICAM-1 and downregulation of NIS. 2,3',4,4',5-pentachlorobiphenyl 108-114 mitogen-activated protein kinase 8 Rattus norvegicus 78-81 26519956-6 2016 In vivo and in vitro studies also suggested that the c-Jun N-terminal kinase (JNK) pathway was activated on PCB118 exposure, and the experiments using siRNA for JNK partially blocked PCB118-induced upregulation of IL-6 and ICAM-1 and downregulation of NIS. 2,3',4,4',5-pentachlorobiphenyl 108-114 mitogen-activated protein kinase 8 Rattus norvegicus 161-164 26519956-6 2016 In vivo and in vitro studies also suggested that the c-Jun N-terminal kinase (JNK) pathway was activated on PCB118 exposure, and the experiments using siRNA for JNK partially blocked PCB118-induced upregulation of IL-6 and ICAM-1 and downregulation of NIS. 2,3',4,4',5-pentachlorobiphenyl 183-189 mitogen-activated protein kinase 8 Rattus norvegicus 53-76 26519956-6 2016 In vivo and in vitro studies also suggested that the c-Jun N-terminal kinase (JNK) pathway was activated on PCB118 exposure, and the experiments using siRNA for JNK partially blocked PCB118-induced upregulation of IL-6 and ICAM-1 and downregulation of NIS. 2,3',4,4',5-pentachlorobiphenyl 183-189 mitogen-activated protein kinase 8 Rattus norvegicus 78-81 26519956-6 2016 In vivo and in vitro studies also suggested that the c-Jun N-terminal kinase (JNK) pathway was activated on PCB118 exposure, and the experiments using siRNA for JNK partially blocked PCB118-induced upregulation of IL-6 and ICAM-1 and downregulation of NIS. 2,3',4,4',5-pentachlorobiphenyl 183-189 mitogen-activated protein kinase 8 Rattus norvegicus 161-164 26519956-7 2016 Altogether, PCB118 stimulates production of IL-6, TNF-alpha, and ICAM-1 in the thyroid through AhR and JNK activations and subsequently interferes with NIS expression, resulting in the disruption of thyroid structure and function. 2,3',4,4',5-pentachlorobiphenyl 12-18 mitogen-activated protein kinase 8 Rattus norvegicus 103-106