PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29791013-0	2018	Frontline Science: Buprenorphine decreases CCL2-mediated migration of CD14+ CD16+ monocytes.	Buprenorphine	19-32	C-C motif chemokine ligand 2	Homo sapiens	43-47	
29791013-9	2018	The effects of buprenorphine on CCL2-mediated CD14+ CD16+ monocytes transmigration across the BBB, a critical mechanism that promotes neuroinflammation and HAND, have not been characterized.	Buprenorphine	15-28	C-C motif chemokine ligand 2	Homo sapiens	32-36	
29791013-10	2018	We showed for the first time that buprenorphine decreases several steps of CCL2-mediated human mature monocyte transmigration.	Buprenorphine	34-47	C-C motif chemokine ligand 2	Homo sapiens	75-79	
30079432-10	2018	Participants having higher levels of plasma MCP-1 reported higher SOWS, most notably after the buprenorphine taper ended.	Buprenorphine	95-108	C-C motif chemokine ligand 2	Homo sapiens	44-49	
25716997-0	2015	Buprenorphine decreases the CCL2-mediated chemotactic response of monocytes.	Buprenorphine	0-13	C-C motif chemokine ligand 2	Homo sapiens	28-32	
25716997-7	2015	Buprenorphine decreases the formation of membrane projections in response to CCL2.	Buprenorphine	0-13	C-C motif chemokine ligand 2	Homo sapiens	77-81	
25716997-8	2015	It also decreases CCL2-induced chemotaxis and mediates a delay in reinsertion of the CCL2 receptor, CCR2, into the cell membrane after CCL2-mediated receptor internalization, suggesting a mechanism of action of buprenorphine.	Buprenorphine	211-224	C-C motif chemokine ligand 2	Homo sapiens	18-22	
25716997-8	2015	It also decreases CCL2-induced chemotaxis and mediates a delay in reinsertion of the CCL2 receptor, CCR2, into the cell membrane after CCL2-mediated receptor internalization, suggesting a mechanism of action of buprenorphine.	Buprenorphine	211-224	C-C motif chemokine ligand 2	Homo sapiens	85-89	
25716997-8	2015	It also decreases CCL2-induced chemotaxis and mediates a delay in reinsertion of the CCL2 receptor, CCR2, into the cell membrane after CCL2-mediated receptor internalization, suggesting a mechanism of action of buprenorphine.	Buprenorphine	211-224	C-C motif chemokine ligand 2	Homo sapiens	85-89	
25716997-10	2015	We show that buprenorphine decreases these phosphorylations in CCL2-treated monocytes.	Buprenorphine	13-26	C-C motif chemokine ligand 2	Homo sapiens	63-67	
25716997-11	2015	Using DAMGO, CTAP, and Nor-BNI, we demonstrate that the effect of buprenorphine on CCL2 signaling is opioid receptor mediated.	Buprenorphine	66-79	C-C motif chemokine ligand 2	Homo sapiens	83-87	
25716997-12	2015	To identify additional potential mechanisms by which buprenorphine inhibits CCL2-induced monocyte migration, we performed proteomic analyses to characterize additional proteins in monocytes whose phosphorylation after CCL2 treatment was inhibited by buprenorphine.	Buprenorphine	53-66	C-C motif chemokine ligand 2	Homo sapiens	76-80	
25716997-12	2015	To identify additional potential mechanisms by which buprenorphine inhibits CCL2-induced monocyte migration, we performed proteomic analyses to characterize additional proteins in monocytes whose phosphorylation after CCL2 treatment was inhibited by buprenorphine.	Buprenorphine	53-66	C-C motif chemokine ligand 2	Homo sapiens	218-222	
25716997-12	2015	To identify additional potential mechanisms by which buprenorphine inhibits CCL2-induced monocyte migration, we performed proteomic analyses to characterize additional proteins in monocytes whose phosphorylation after CCL2 treatment was inhibited by buprenorphine.	Buprenorphine	250-263	C-C motif chemokine ligand 2	Homo sapiens	76-80	
25716997-12	2015	To identify additional potential mechanisms by which buprenorphine inhibits CCL2-induced monocyte migration, we performed proteomic analyses to characterize additional proteins in monocytes whose phosphorylation after CCL2 treatment was inhibited by buprenorphine.	Buprenorphine	250-263	C-C motif chemokine ligand 2	Homo sapiens	218-222	
25716997-14	2015	We propose that buprenorphine limits CCL2-mediated monocyte transmigration into the CNS, thereby reducing neuroinflammation characteristic of HAND.	Buprenorphine	16-29	C-C motif chemokine ligand 2	Homo sapiens	37-41