PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11281555-2	2001	Buprenorphine is N-dealkylated to norbuprenorphine by CYP3A.	Buprenorphine	0-13	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	54-59	
17084876-4	2006	Thus, our aim was to study the consequences of CYP3A induction on buprenorphine-associated effects on resting ventilation in rats.	Buprenorphine	66-79	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	47-52	
17084876-10	2006	Our results suggest a limited role of drug-mediated CYP3A induction in the occurrence of buprenorphine-attributed respiratory depression in addicts.	Buprenorphine	89-102	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	52-57	
11281555-5	2001	Both buprenorphine and norbuprenorphine (200 microM) underwent CYP3A-mediated covalent binding to rat liver microsomal proteins and both caused moderate glutathione depletion and increased cell calcium in isolated rat hepatocytes, but only buprenorphine also depleted cell adenosine triphosphate (ATP) and caused necrotic cell death.	Buprenorphine	5-18	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	63-68	
11281555-5	2001	Both buprenorphine and norbuprenorphine (200 microM) underwent CYP3A-mediated covalent binding to rat liver microsomal proteins and both caused moderate glutathione depletion and increased cell calcium in isolated rat hepatocytes, but only buprenorphine also depleted cell adenosine triphosphate (ATP) and caused necrotic cell death.	Buprenorphine	26-39	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	63-68	
10755464-0	2000	Effect of buprenorphine on CYP3A activity in rat and human liver microsomes.	Buprenorphine	10-23	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	27-32