PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31792371-1 2020 The aim of the study was to validate the impact of the single-nucleotide polymorphism rs2413739 (T > C) in the PACSIN2 gene on thiopurines pharmacological parameters and clinical response in an Italian cohort of pediatric patients with acute lymphoblastic leukemia (ALL) and inflammatory bowel disease (IBD). thiopurines 127-138 protein kinase C and casein kinase substrate in neurons 2 Homo sapiens 111-118 31792371-7 2020 Further evidence on PBMC and pediatric patients with IBD supports an association between PACSIN2 variants, TPMT activity, and thiopurines effects, even if more studies are needed since some of these effects may be tissue specific. thiopurines 126-137 protein kinase C and casein kinase substrate in neurons 2 Homo sapiens 89-96