PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33845232-0	2021	Discovery of chalcone analogues as novel NLRP3 inflammasome inhibitors with potent anti-inflammation activities.	Chalcone	13-21	NLR family pyrin domain containing 3	Homo sapiens	41-46	
33653970-0	2021	Interruption of Helicobacter pylori-Induced NLRP3 Inflammasome Activation by Chalcone Derivatives.	Chalcone	77-85	NLR family pyrin domain containing 3	Homo sapiens	44-49	
33653970-2	2021	To identify useful compounds against H. pylori-associated gastric disorders, the effect of chalcone derivatives to activate the nucleotide-binding oligomerization domain (NOD)-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome was examined in an H. pylori-infected human monocytic THP-1 cell line in this study.	Chalcone	91-99	NLR family pyrin domain containing 3	Homo sapiens	225-230	
33653970-3	2021	Among the five synthetic structurally-related chalcone derivatives examined, 2"-hydroxy-4",6"-dimethoxychalcone (8) and 2"-hydroxy-3,4,5- trimethoxychalcone (12) strongly blocked the NLRP3 inflammasome in H. pylori-infected THP-1 cells.	Chalcone	46-54	NLR family pyrin domain containing 3	Homo sapiens	183-188