PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12464252-0	2003	The enantiomer of progesterone (ent-progesterone) is a competitive inhibitor of human cytochromes P450c17 and P450c21.	ent-progesterone	32-48	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	98-105	
12464252-7	2003	We conclude that CYP17 accommodates the stereochemically unnatural ent-progesterone better than CYP21.	ent-progesterone	67-83	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	17-22	
12464252-3	2003	To probe the active site topologies of these related enzymes, we synthesized the enantiomer of progesterone and determined if ent-progesterone is a substrate or inhibitor of CYP17 and CYP21.	ent-progesterone	126-142	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	174-179	
12464252-4	2003	Neither enzyme metabolizes ent-progesterone; however, ent-progesterone is a potent competitive inhibitor of CYP17 (K(I)=0.2 microM).	ent-progesterone	27-43	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	108-113	
12464252-4	2003	Neither enzyme metabolizes ent-progesterone; however, ent-progesterone is a potent competitive inhibitor of CYP17 (K(I)=0.2 microM).	ent-progesterone	54-70	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	108-113