PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19346993-11	2009	CONCLUSIONS: Suppression of mevalonate pathway activities, be it by modulators of HMG CoA reductase (statins, tocotrienols, and farnesol), farnesyl transferase (farnesyl transferase inhibitors), and/or mevalonate pyrophosphate decarboxylase (phenylacetate) activity, may have a potential in pancreatic cancer chemotherapy.	Mevalonic Acid	28-38	mevalonate diphosphate decarboxylase	Homo sapiens	202-240	
31854421-1	2020	Mevalonate diphosphate decarboxylase (MDD) catalyses a crucial step of the mevalonate pathway via Mg2+-ATP-dependent phosphorylation and decarboxylation reactions to ultimately produce isopentenyl diphosphate, the precursor of isoprenoids, which is essential to bacterial functions and provides ideal building blocks for the biosynthesis of isopentenols.	Mevalonic Acid	75-85	mevalonate diphosphate decarboxylase	Homo sapiens	0-36	
32477466-5	2020	Relative to A-I KO, day 7 B16F10L melanoma tumor homografts from A-I Tg+/- exhibited reduced expression of mevalonate-5-pyrophosphate decarboxylase (Mvd), a key enzyme targeted in cancer therapy, along with a number of key genes in the sterol synthesis arm of the mevalonate pathway.	Mevalonic Acid	107-117	mevalonate diphosphate decarboxylase	Homo sapiens	149-152	
31854421-1	2020	Mevalonate diphosphate decarboxylase (MDD) catalyses a crucial step of the mevalonate pathway via Mg2+-ATP-dependent phosphorylation and decarboxylation reactions to ultimately produce isopentenyl diphosphate, the precursor of isoprenoids, which is essential to bacterial functions and provides ideal building blocks for the biosynthesis of isopentenols.	Mevalonic Acid	75-85	mevalonate diphosphate decarboxylase	Homo sapiens	38-41	
31854421-2	2020	However, the metal ion(s) in MDD has not been unambiguously resolved, which limits the understanding of the catalytic mechanism and the exploitation of enzymes for the development of antibacterial therapies or the mevalonate metabolic pathway for the biosynthesis of biofuels.	Mevalonic Acid	214-224	mevalonate diphosphate decarboxylase	Homo sapiens	29-32	
31854421-5	2020	The results here would shed light on the active conformation of MDD-related enzymes and their catalytic mechanisms and therefore be useful for developing novel antimicrobial therapies or reconstructing mevalonate metabolic pathways for the biosynthesis of biofuels.	Mevalonic Acid	202-212	mevalonate diphosphate decarboxylase	Homo sapiens	64-67	
29722423-3	2018	We performed Sanger sequencing of exons and flanking intron-exon boundaries of mevalonate pathway genes (MVD, MVK, PMVK and FDPS) and of SLC17A9.	Mevalonic Acid	79-89	mevalonate diphosphate decarboxylase	Homo sapiens	105-108	
28777842-3	2017	PCR and direct sequencing were carried out for five patients from a family, 4 sporadic cases, and 120 healthy controls to identify potential mutations of four genes (MVK, MVD, PMVK, FDPS) involved in the mevalonate pathway as well as SLC17A9, SSH1, and SART3 genes.	Mevalonic Acid	204-214	mevalonate diphosphate decarboxylase	Homo sapiens	171-174