PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7669073-5 1995 The apparent Km values (at 100 microM acetyl CoA as co-substrate) of the different NAT2 variants for sulphamethazine, dapsone, p-anisidine, 2-aminofluorene, procainamide and isoniazid were determined. 2-aminofluorene 140-155 N-acetyltransferase 2 Homo sapiens 83-87 28523442-2 2017 NAT2 also catalyzes the N-acetylation of aromatic amine carcinogens such as 2-aminofluorene and the O- and N,O-acetylation of aromatic amine and heterocyclic amine metabolites. 2-aminofluorene 76-91 N-acetyltransferase 2 Homo sapiens 0-4 17936995-1 2007 The product of gene NAT2 (N-acetyltransferase 2) is involved in the biotransformation system and participates in detoxication of some arylamine derivatives (in particular 2-aminofluorene, 4-aminobiphenyl and 4-naphthylamine) which are strongly mutagenic and carcinogenic. 2-aminofluorene 171-186 N-acetyltransferase 2 Homo sapiens 20-24 17936995-1 2007 The product of gene NAT2 (N-acetyltransferase 2) is involved in the biotransformation system and participates in detoxication of some arylamine derivatives (in particular 2-aminofluorene, 4-aminobiphenyl and 4-naphthylamine) which are strongly mutagenic and carcinogenic. 2-aminofluorene 171-186 N-acetyltransferase 2 Homo sapiens 26-47 12618593-5 2003 A gene dose-response (NAT2*15/*15>NAT2*15/*16A>NAT2*16A/*16A) relationship was observed in liver and prostate cytosol towards the N-acetylation of p-aminobenzoic acid, 2-aminofluorene, beta-napthylamine, 4-aminobiphenyl, and 3,2"-dimethyl-4-aminobiphenyl. 2-aminofluorene 174-189 N-acetyltransferase 2 Homo sapiens 22-26 12618593-5 2003 A gene dose-response (NAT2*15/*15>NAT2*15/*16A>NAT2*16A/*16A) relationship was observed in liver and prostate cytosol towards the N-acetylation of p-aminobenzoic acid, 2-aminofluorene, beta-napthylamine, 4-aminobiphenyl, and 3,2"-dimethyl-4-aminobiphenyl. 2-aminofluorene 174-189 N-acetyltransferase 2 Homo sapiens 37-41 12618593-5 2003 A gene dose-response (NAT2*15/*15>NAT2*15/*16A>NAT2*16A/*16A) relationship was observed in liver and prostate cytosol towards the N-acetylation of p-aminobenzoic acid, 2-aminofluorene, beta-napthylamine, 4-aminobiphenyl, and 3,2"-dimethyl-4-aminobiphenyl. 2-aminofluorene 174-189 N-acetyltransferase 2 Homo sapiens 37-41 12618593-7 2003 NAT1 and NAT2 in liver and prostate catalysed -acetylation of the arylamines above and O-acetylation of N-hydroxy derivatives of 2-aminofluorene, 4-aminobiphenyl and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. 2-aminofluorene 129-144 N-acetyltransferase 2 Homo sapiens 9-13 12222688-7 2002 The enzymatic activities for N-acetylation of two arylamine carcinogens (2-aminofluorene, 4-aminobiphenyl), and a sulfonamide drug (sulfamethazine) were over 100-fold lower for NAT2 19 compared to reference NAT2 4. 2-aminofluorene 73-88 N-acetyltransferase 2 Homo sapiens 177-181 12222688-7 2002 The enzymatic activities for N-acetylation of two arylamine carcinogens (2-aminofluorene, 4-aminobiphenyl), and a sulfonamide drug (sulfamethazine) were over 100-fold lower for NAT2 19 compared to reference NAT2 4. 2-aminofluorene 73-88 N-acetyltransferase 2 Homo sapiens 207-211 11337936-5 2001 Reductions in catalytic activity for the N-acetylation of a sulfonamide drug (sulfamethazine) and an aromatic amine carcinogen (2-aminofluorene) were observed for NAT2 variants possessing G191A (R64Q), T341C (I114T), A434C (E145P), G590A (R197Q), A845C (K282T) or G857A (G286T). 2-aminofluorene 128-143 N-acetyltransferase 2 Homo sapiens 163-167 9459121-4 1998 Forty-eight hours after irradiation of UVB (200 J/m2), the activity was not increased (114 +/- 8.3%, n = 3), while increase in N-acetylating capacity for 2-aminofluorene (substrate for NAT1 and NAT2) amounted to 201 +/- 16% (n = 3). 2-aminofluorene 154-169 N-acetyltransferase 2 Homo sapiens 194-198 8425184-16 1993 In rapid acetylator hamster colon, NAT2/NAT1 activity ratios were 18 and 13 for the N-acetylation of 2-aminofluorene and 4-aminobiphenyl and 28 for the O-acetylation of N-hydroxy-2-aminofluorene. 2-aminofluorene 101-116 N-acetyltransferase 2 Homo sapiens 35-39 1996083-10 1991 Interestingly, the carcinogen 2-aminofluorene was very efficiently metabolized by both NAT1 and NAT2. 2-aminofluorene 30-45 N-acetyltransferase 2 Homo sapiens 96-100