PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12396098-4 2002 The activity of NAT (N-acetylation of substrate) was measured and determined by high-performance liquid chromatography (HPLC) assaying for the amounts of acetylated 2-aminofluorene (AF) and nonacetylated AF. 2-aminofluorene 165-180 bromodomain containing 2 Homo sapiens 16-19 12396098-4 2002 The activity of NAT (N-acetylation of substrate) was measured and determined by high-performance liquid chromatography (HPLC) assaying for the amounts of acetylated 2-aminofluorene (AF) and nonacetylated AF. 2-aminofluorene 165-180 bromodomain containing 2 Homo sapiens 21-47 11955676-2 2002 The activity of NAT was measured by HPLC assaying for the amounts of N-acetyl-2-aminofluorene (2-AAF) and remaining 2-aminofluorene (2-AF). 2-aminofluorene 78-93 bromodomain containing 2 Homo sapiens 16-19 11808848-4 2001 Using 2-aminofluorene (2-AF) and p-aminobenzoic acid (PABA) as substrates, NAT activity of all samples was determined by high pressure liquid chromatography. 2-aminofluorene 6-21 bromodomain containing 2 Homo sapiens 75-78 12230020-2 2002 The NAT activity was measured by high performance liquid chromatography assaying for amounts of N-acetyl-2-aminofluorene (2-AAF) and remaining 2-aminofluorene (2-AF). 2-aminofluorene 105-120 bromodomain containing 2 Homo sapiens 4-7 12230020-2 2002 The NAT activity was measured by high performance liquid chromatography assaying for amounts of N-acetyl-2-aminofluorene (2-AAF) and remaining 2-aminofluorene (2-AF). 2-aminofluorene 160-164 bromodomain containing 2 Homo sapiens 4-7 11807928-2 2002 The activity of NAT was measured by high-performance liquid chromatography, assaying for the amounts of N-acetyl-2-aminofluorene and N-acetyl-p-aminobenzoic acid and remaining 2-aminofluorene and p-aminobenzoic acid. 2-aminofluorene 113-128 bromodomain containing 2 Homo sapiens 16-19 9449220-1 1997 This study was designed to assess the effect of vitamin C on arylamine N-acetyltransferase (NAT) activity in Klebsiella pneumoniae by using HPLC to measure the acetylation of 2-aminofluorene (2-AF) with and without vitamin C. 2-aminofluorene 175-190 bromodomain containing 2 Homo sapiens 92-95 11764764-1 2001 N-acetyltransferase (NAT) activity was determined in 40 human benign prostatic hyperplasia tissues using 2-aminofluorene (AF) and p-aminobenzoic acid (PABA) as substrates. 2-aminofluorene 105-120 bromodomain containing 2 Homo sapiens 0-19 11764764-1 2001 N-acetyltransferase (NAT) activity was determined in 40 human benign prostatic hyperplasia tissues using 2-aminofluorene (AF) and p-aminobenzoic acid (PABA) as substrates. 2-aminofluorene 105-120 bromodomain containing 2 Homo sapiens 21-24 11396144-2 2001 BHA or BHT were added to the cytosols or to the medium of human colon tumor cells: The NAT activity was measured by high performance liquid chromatography, assaying the amounts of acetylated 2-aminoflluorene (AAF), p aminobenzoic acid (N-Ac-PABA), nonacetylated 2 aminofluorene (AF) and p-aminobenzoic acid (PABA). 2-aminofluorene 262-277 bromodomain containing 2 Homo sapiens 87-90 11321474-2 2001 By using high performance liquid chromatography, NAT activity on acetylation of 2-aminofluorene (AF) and p-aminobenzoic acid (PABA) were examined. 2-aminofluorene 80-95 bromodomain containing 2 Homo sapiens 49-52 11527074-2 2001 By using high performance liquid chromatography, NAT activity for acetylation of 2-aminofluorene (AF) was determined. 2-aminofluorene 81-96 bromodomain containing 2 Homo sapiens 49-52 11011961-3 2000 The activity of NAT was measured using high-performance liquid chromatography (HPLC), by assaying for the amounts of acetylated 2-aminofluorene (AF) and p-aminobenzoic acid (PABA) and the remaining amounts of AF and PABA. 2-aminofluorene 128-143 bromodomain containing 2 Homo sapiens 16-19 10885506-2 2000 Using high performance liquid chromatography, the NAT activity for acetylation of arylamine substrates (2-aminofluorene and p-aminobenzoic acid) was determined. 2-aminofluorene 104-119 bromodomain containing 2 Homo sapiens 50-53 10885506-3 2000 The cytosolic NAT activity in human liver tumour cells was 2.74+/-0.26 and 1.68+/-0.20 nmol/min/mg of protein for 2-aminofluorene and p-aminobenzoic acid, respectively. 2-aminofluorene 114-129 bromodomain containing 2 Homo sapiens 14-17 10418949-2 1999 The NAT activity was measured by HPLC assaying for the amounts of N-acetyl-2-aminofluorene (AAF) and N-acetyl-p-aminobenzoic acid (N-Ac-PABA) and remaining 2-aminofluorene (AF) and p-aminobenzoic acid (PABA). 2-aminofluorene 75-90 bromodomain containing 2 Homo sapiens 4-7 10418950-1 1999 Paeonol was used to determine any effects on the N-acetyltransferase (NAT) activity in human colon tumour cells as measured by HPLC exhibited for the amounts of N-acetyl-2-aminofluorene (AAF) and N-acetyl-p-aminobenzoic acid (N-Ac-PABA) and remaining 2-aminofluorene (AF) and p-aminobenzoic acid (PABA). 2-aminofluorene 170-185 bromodomain containing 2 Homo sapiens 70-73 9858928-2 1998 Using high performance liquid chromatography, NAT activity on the acetylation of 2-aminofluorene and p-aminobenzoic acid was examined. 2-aminofluorene 81-96 bromodomain containing 2 Homo sapiens 46-49 11828994-3 2001 The NAT activity (N-acetylation of 2-aminofluorene) was measured by high performance liquid chromatography assaying for the amount of acetylated 2-aminofluorene and the remaining 2-aminofluorene (AF). 2-aminofluorene 35-50 bromodomain containing 2 Homo sapiens 4-7 11828994-3 2001 The NAT activity (N-acetylation of 2-aminofluorene) was measured by high performance liquid chromatography assaying for the amount of acetylated 2-aminofluorene and the remaining 2-aminofluorene (AF). 2-aminofluorene 145-160 bromodomain containing 2 Homo sapiens 4-7 11828994-3 2001 The NAT activity (N-acetylation of 2-aminofluorene) was measured by high performance liquid chromatography assaying for the amount of acetylated 2-aminofluorene and the remaining 2-aminofluorene (AF). 2-aminofluorene 145-160 bromodomain containing 2 Homo sapiens 4-7 12889515-6 2001 But the results also showed that NAT activity and 2-Aminofluorene-DNA adduct formation in HL-60 cells were inhibited and decreased by tamoxifen in a dose-dependent manner when the doses of tamoxifen up to 100 micro M. We also examined the standard steady-state kinetic analysis, and the data showed that tamoxifen may be an uncompetitive inhibitor to NAT activity in cytosols based on the decrease apparent values of Km and Vmax. 2-aminofluorene 50-65 bromodomain containing 2 Homo sapiens 351-354 11038234-4 2000 The NAT activity in cytosol and intact PC-3 cells were measured by HPLC assaying exhibited for the amounts of N-acetyl-2-aminofluorene and N-acetyl-p-aminobenzoic acid, 2-aminofluorene and p-aminobenzoic acid. 2-aminofluorene 119-134 bromodomain containing 2 Homo sapiens 4-7 10547619-2 1999 The activity of NAT was measured by high-performance liquid chromatography, assaying for the amounts of N-acetyl-2-aminofluorene and N-acetyl-p-aminobenzoic acid and remaining 2-aminofluorene and p-aminobenzoic acid. 2-aminofluorene 113-128 bromodomain containing 2 Homo sapiens 16-19 10234471-2 1999 The NAT activity was measured by high performance liquid chromatography assaying for the amounts of N-acetyl-2-aminofluorene (2-AAF) and N-acetyl-p-aminobenzoic acid (N-Ac-PABA) and remaining 2-aminofluorene (2-AF) and p-aminobenzoic acid (PABA). 2-aminofluorene 109-124 bromodomain containing 2 Homo sapiens 4-7 10226534-2 1999 The bacterial NAT activities were determined by HPLC measuring the acetylation of 2-aminofluorene (2-AF). 2-aminofluorene 82-97 bromodomain containing 2 Homo sapiens 14-17 9608747-2 1998 Using high performance liquid chromatography (HPLC) to analyze NAT activity in bacteria, the authors found that Pseudomonas aeruginosa exhibited high NAT activity with 2-aminofluorene (2-AF) as substrate. 2-aminofluorene 168-183 bromodomain containing 2 Homo sapiens 63-66 9608747-2 1998 Using high performance liquid chromatography (HPLC) to analyze NAT activity in bacteria, the authors found that Pseudomonas aeruginosa exhibited high NAT activity with 2-aminofluorene (2-AF) as substrate. 2-aminofluorene 168-183 bromodomain containing 2 Homo sapiens 150-153 8035095-6 1994 In the current study we characterized the activity of human placental NAT and deacetylase toward the carcinogenic arylamine, 2-aminofluorene (AF) and its acetylated metabolite, 2-acetylaminofluorene (AAF). 2-aminofluorene 125-140 bromodomain containing 2 Homo sapiens 70-73 2568902-8 1989 Comparison of homozygous rapid and slow acetylator bladder cytosol showed that the apparent Vmax for 2-aminofluorene NAT activity was significantly higher in rapid than slow acetylators (6-fold in cytosol, 50-fold in the polymorphic NAT isozyme). 2-aminofluorene 101-116 bromodomain containing 2 Homo sapiens 117-120 8182542-4 1994 Arylamine N-acetyltransferase (NAT) catalyzes the acetyl CoA-dependent N-acetylation of primary arylamine and hydrazine substrates such as sulfamethazine, isoniazid, p-aminobenzoic acid as well as arylamine carcinogens such as 2-aminofluorene and benzidine. 2-aminofluorene 227-242 bromodomain containing 2 Homo sapiens 31-34 2568902-8 1989 Comparison of homozygous rapid and slow acetylator bladder cytosol showed that the apparent Vmax for 2-aminofluorene NAT activity was significantly higher in rapid than slow acetylators (6-fold in cytosol, 50-fold in the polymorphic NAT isozyme). 2-aminofluorene 101-116 bromodomain containing 2 Homo sapiens 233-236 16309210-0 2005 Berberine decreased N-acetylation of 2-aminofluorene through inhibition of N-acetyltransferase gene expression in human leukemia HL-60 cells. 2-aminofluorene 37-52 bromodomain containing 2 Homo sapiens 75-94 21526848-6 2011 In addition, our data showed that exposure to CB NPs altered the acetylation of 2-aminofluorene in intact lung Clara cells by impairing the endogenous NAT-dependent pathway. 2-aminofluorene 80-95 bromodomain containing 2 Homo sapiens 151-154 18189370-3 2008 NAT in the film catalyzed the conversion of the arylamine 2-aminofluorene (2-AF) to 2-acetylaminofluorene (2-AAF) by acetyl coenzyme A (AcCoA) dependent N-acetylation, as verified by liquid chromatography. 2-aminofluorene 75-79 bromodomain containing 2 Homo sapiens 0-3 15833378-4 2005 NAT activity was measured by the amounts of N-acetylation of 2-aminofluorene (AF) and non-acetylation of AF by high performance liquid chromatography on cells treated with or without DADS. 2-aminofluorene 61-76 bromodomain containing 2 Homo sapiens 0-3 15796204-0 2005 N-acetyltransferase is involved in baicalein-induced N-acetylation of 2-aminofluorene and DNA-2-aminofluorene adduct formation in human leukemia HL-60 cells. 2-aminofluorene 70-85 bromodomain containing 2 Homo sapiens 0-19 15796204-0 2005 N-acetyltransferase is involved in baicalein-induced N-acetylation of 2-aminofluorene and DNA-2-aminofluorene adduct formation in human leukemia HL-60 cells. 2-aminofluorene 94-109 bromodomain containing 2 Homo sapiens 0-19 15274316-0 2004 N-acetyltransferase activity is involved in paclitaxel-induced N-acetylation of 2-aminofluorene in human bladder cancer cells (T24). 2-aminofluorene 80-95 bromodomain containing 2 Homo sapiens 0-19 15274316-1 2004 Arylamine N-acetyltransferase (NAT) plays an important role in the metabolism of 2-aminofluorene (AF) and some types of arylamine drugs and carcinogens. 2-aminofluorene 81-96 bromodomain containing 2 Homo sapiens 10-29 15274316-1 2004 Arylamine N-acetyltransferase (NAT) plays an important role in the metabolism of 2-aminofluorene (AF) and some types of arylamine drugs and carcinogens. 2-aminofluorene 81-96 bromodomain containing 2 Homo sapiens 31-34 12929584-3 2003 The NAT activity was determined by high performance liquid chromatography assaying for the amounts of acetylated 2-aminofluorene (AAF) and p-aminobenzoic acid (N-Ac-PABA) and nonacetylated 2-aminofluorene (AF) and p-aminobenzoic acid (PABA). 2-aminofluorene 113-128 bromodomain containing 2 Homo sapiens 4-7 12929584-3 2003 The NAT activity was determined by high performance liquid chromatography assaying for the amounts of acetylated 2-aminofluorene (AAF) and p-aminobenzoic acid (N-Ac-PABA) and nonacetylated 2-aminofluorene (AF) and p-aminobenzoic acid (PABA). 2-aminofluorene 189-204 bromodomain containing 2 Homo sapiens 4-7 15340647-3 2004 NAT activities with p-aminobenzoic acid (PABA) and 2-aminofluorene (AF) as substrates were examined in the cytosol of K. pneumoniae. 2-aminofluorene 51-66 bromodomain containing 2 Homo sapiens 0-3 14667466-2 2004 In this study, DAS was selected for testing the inhibition of arylamine N-acetyltransferase (NAT) activity (N-acetylation of 2-aminofluorene) and gene expression (mRNA NAT) in human colon cancer cell lines (colo 205, colo 320 DM and colo 320 HSR). 2-aminofluorene 125-140 bromodomain containing 2 Homo sapiens 93-96 14667466-3 2004 The NAT activity was examined by high performance liquid chromatography and indicated that a 24 h DAS treatment decreases N-acetylation of 2-aminofluorene in three colon (colo 205, 320 DM and colo 320 HSR) cancer cell lines. 2-aminofluorene 139-154 bromodomain containing 2 Homo sapiens 4-7 15015580-3 2004 The activity of NAT was determined by high performance liquid chromatography (HPLC) assay for the amounts of acetylated 2-aminofluorene (AF) and p-aminobenzoic acid (PABA) and nonacetylated AF and PABA. 2-aminofluorene 120-135 bromodomain containing 2 Homo sapiens 16-19 17564303-1 2004 Evidence has shown that N-acetyltransferase (NAT) acetylated 2-aminofluorene (AF) to form N-acetyl-2-aminofluorene (AAF). 2-aminofluorene 61-76 bromodomain containing 2 Homo sapiens 24-43 17564303-1 2004 Evidence has shown that N-acetyltransferase (NAT) acetylated 2-aminofluorene (AF) to form N-acetyl-2-aminofluorene (AAF). 2-aminofluorene 61-76 bromodomain containing 2 Homo sapiens 45-48 17564303-5 2004 The activity of NAT was determined by high performance liquid chromatography (HPLC) assaying for the amounts of acetylated AF (AAF) or p-aminobenzoic acid (N-Ac-PABA) and nonacetylated AF or PABA. 2-aminofluorene 123-125 bromodomain containing 2 Homo sapiens 16-19 12929581-0 2003 N-acetyltransferase is involved in gypenosides-induced N-acetylation of 2-aminofluorene and DNA adduct formation in human cervix epidermoid carcinoma cells (Ca Ski). 2-aminofluorene 72-87 bromodomain containing 2 Homo sapiens 0-19 12929581-3 2003 The NAT activity was determined by high performance liquid chromatography, assaying for the amounts of acetylated 2-aminofluorene (AAF) and non-acetylated 2-aminofluorene (AF). 2-aminofluorene 114-129 bromodomain containing 2 Homo sapiens 4-7 12929581-3 2003 The NAT activity was determined by high performance liquid chromatography, assaying for the amounts of acetylated 2-aminofluorene (AAF) and non-acetylated 2-aminofluorene (AF). 2-aminofluorene 155-170 bromodomain containing 2 Homo sapiens 4-7 12680237-0 2003 Luteolin induces N-acetylation and DNA adduct of 2-aminofluorene accompanying N-acetyltransferase activity and gene expression in human bladder cancer T24 cell line. 2-aminofluorene 49-64 bromodomain containing 2 Homo sapiens 78-97