PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31400201-0 2020 Role of Asparagine Endopeptidase in Mediating Wild-Type p53 Inactivation of Glioblastoma. Asparagine 8-18 tumor protein p53 Homo sapiens 56-59 32273511-0 2020 p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival. Asparagine 34-44 tumor protein p53 Homo sapiens 0-3 32273511-3 2020 Here, we report that p53 suppresses asparagine synthesis through the transcriptional downregulation of ASNS expression and disrupts asparagine-aspartate homeostasis, leading to lymphoma and colon tumour growth inhibition in vivo and in vitro. Asparagine 36-46 tumor protein p53 Homo sapiens 21-24 32273511-3 2020 Here, we report that p53 suppresses asparagine synthesis through the transcriptional downregulation of ASNS expression and disrupts asparagine-aspartate homeostasis, leading to lymphoma and colon tumour growth inhibition in vivo and in vitro. Asparagine 132-142 tumor protein p53 Homo sapiens 21-24 32273511-4 2020 Moreover, the removal of asparagine from culture medium or the inhibition of ASNS impairs cell proliferation and induces p53/p21-dependent senescence and cell cycle arrest. Asparagine 25-35 tumor protein p53 Homo sapiens 121-124 32273511-5 2020 Mechanistically, asparagine and aspartate regulate AMPK-mediated p53 activation by physically binding to LKB1 and oppositely modulating LKB1 activity. Asparagine 17-27 tumor protein p53 Homo sapiens 65-68 32273511-6 2020 Thus, we found that p53 regulates asparagine metabolism and dictates cell survival by generating an auto-amplification loop via asparagine-aspartate-mediated LKB1-AMPK signalling. Asparagine 34-44 tumor protein p53 Homo sapiens 20-23 32273511-6 2020 Thus, we found that p53 regulates asparagine metabolism and dictates cell survival by generating an auto-amplification loop via asparagine-aspartate-mediated LKB1-AMPK signalling. Asparagine 128-138 tumor protein p53 Homo sapiens 20-23 19766654-6 2009 In fact, substitution of this Asn to Ala of CHC diminished its ability to interact with p53, leading to reduced activity to transactivate p53. Asparagine 30-33 tumor protein p53 Homo sapiens 138-141 19766654-6 2009 In fact, substitution of this Asn to Ala of CHC diminished its ability to interact with p53, leading to reduced activity to transactivate p53. Asparagine 30-33 tumor protein p53 Homo sapiens 88-91 25061640-0 2014 Reply to Liu: Amino acid 104 asparagine/glutamic acid of p53 is an adaptively selected site for extreme environments in mammals of the Tibet plateau. Asparagine 29-39 tumor protein p53 Homo sapiens 57-60 7923176-11 1994 p53 allelic amino acid variation with sequences coding for aspartic acid or asparagine was present in codon 61 in the variable region of exon 4 in both HCCs and nonneoplastic tissues of ground squirrels. Asparagine 76-86 tumor protein p53 Homo sapiens 0-3 12844488-6 2003 Patients with the XPD codon 312 Asn allele were less likely to have p53 mutations (13.8%) than XPD 312 Asp/Asp (27.3%) [odds ratio (OR) 0.43, 95% confidence interval (CI) 0.20-0.89, P = 0.023]. Asparagine 32-35 tumor protein p53 Homo sapiens 68-71