PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34552110-5 2021 Specifically, Tyr and Asn have higher occurrence rates on the Receptor Binding Domain (RBD) and in the overall sequence of spike proteins of Betacoronavirus, whereas His and Arg have lower occurrence rates. Asparagine 22-25 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 123-128 34783057-7 2022 Surprisingly, we discovered that this mutation reduces the immunogenicity of the spike protein; also, displacement of Asn with Tyr reduces protein compactness and significantly increases the stability of the spike protein and its affinity to ACE2. Asparagine 118-121 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 81-86 34783057-7 2022 Surprisingly, we discovered that this mutation reduces the immunogenicity of the spike protein; also, displacement of Asn with Tyr reduces protein compactness and significantly increases the stability of the spike protein and its affinity to ACE2. Asparagine 118-121 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 208-213 32753553-2 2020 By using deep mutagenesis, mutations in ACE2 that increase S binding are found across the interaction surface, in the asparagine 90-glycosylation motif and at buried sites. Asparagine 118-128 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 59-60 34499924-4 2021 Here we studied asparagine deamidation of the spike protein, a spontaneous event that leads to the appearance of aspartic and isoaspartic residues, which affect both the protein backbone and its charge. Asparagine 16-26 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 46-51 34490059-7 2021 According to this model, their replacement (perhaps with asparagine) would remove the pH-dependent destabilisation of locked spike trimer conformations, and increase their recovery at neutral pH. Asparagine 57-67 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 125-130