PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29678622-10 2018 TRIM8 stabilizes the turnover of XIAP during genotoxic stress and forms complex with XIAP and caspase-3 to inhibit its activation in presence of etoposide. Etoposide 145-154 X-linked inhibitor of apoptosis Homo sapiens 85-89 31855962-0 2019 Isobaric tags for relative and absolute quantitation-based quantitative proteomic analysis of X-linked inhibitor of apoptosis and H2AX in etoposide-induced renal cell carcinoma apoptosis. Etoposide 138-147 X-linked inhibitor of apoptosis Homo sapiens 94-125 31855962-3 2019 This study investigated the regulatory mechanism of XIAP in etoposide-induced apoptosis in two Caki-1 cell lines with high or low XIAP expression. Etoposide 60-69 X-linked inhibitor of apoptosis Homo sapiens 52-56 15031723-2 2004 The aim of this study was to investigate if downregulation of bcl-2 or xIAP by RNA interference (RNAi) would sensitize MCF-7 cells to etoposide and doxorubicin. Etoposide 134-143 X-linked inhibitor of apoptosis Homo sapiens 71-75 23435429-2 2014 In this study, we demonstrate that following treatment with the DNA-damaging agents, etoposide or camptothecin, BRCA1 is required for the activation of nuclear factor-kappaB (NF-kappaB), and that BRCA1 and NF-kappaB cooperate to regulate the expression of the NF-kappaB antiapoptotic targets BCL2 and XIAP. Etoposide 85-94 X-linked inhibitor of apoptosis Homo sapiens 301-305 21102524-5 2011 Importantly, protection from the apoptosis-inducing agent etoposide by overexpression of HuR requires the presence of XIAP, suggesting that HuR-mediated cytoprotection is partially executed through enhanced XIAP translation. Etoposide 58-67 X-linked inhibitor of apoptosis Homo sapiens 118-122 21102524-5 2011 Importantly, protection from the apoptosis-inducing agent etoposide by overexpression of HuR requires the presence of XIAP, suggesting that HuR-mediated cytoprotection is partially executed through enhanced XIAP translation. Etoposide 58-67 X-linked inhibitor of apoptosis Homo sapiens 207-211 19223549-7 2009 This XIAP-dependent event occurs in response to camptotechin or etoposide/VP16; however, XIAP is dispensable for activation of NF-kappaB by doxorubicin, which engages a MEK-ERK pathway to activate IKK. Etoposide 64-73 X-linked inhibitor of apoptosis Homo sapiens 5-9 19223549-7 2009 This XIAP-dependent event occurs in response to camptotechin or etoposide/VP16; however, XIAP is dispensable for activation of NF-kappaB by doxorubicin, which engages a MEK-ERK pathway to activate IKK. Etoposide 74-78 X-linked inhibitor of apoptosis Homo sapiens 5-9 18927073-6 2008 Furthermore, we found that etoposide-induced apoptosis and mitochondrial events were inhibited in cells stably overexpressing either full-length X-linked inhibitor of apoptosis protein (XIAP) or the BIR1/BIR2 domains of XIAP. Etoposide 27-36 X-linked inhibitor of apoptosis Homo sapiens 145-184 18927073-6 2008 Furthermore, we found that etoposide-induced apoptosis and mitochondrial events were inhibited in cells stably overexpressing either full-length X-linked inhibitor of apoptosis protein (XIAP) or the BIR1/BIR2 domains of XIAP. Etoposide 27-36 X-linked inhibitor of apoptosis Homo sapiens 186-190 18927073-6 2008 Furthermore, we found that etoposide-induced apoptosis and mitochondrial events were inhibited in cells stably overexpressing either full-length X-linked inhibitor of apoptosis protein (XIAP) or the BIR1/BIR2 domains of XIAP. Etoposide 27-36 X-linked inhibitor of apoptosis Homo sapiens 220-224 17611394-5 2007 Treatment with XIAP siRNA in combination with Paclitaxel, Cisplatin, Fluorouracil and Etoposide enhanced chemosensitivity. Etoposide 86-95 X-linked inhibitor of apoptosis Homo sapiens 15-19 29403558-5 2018 A number of differentially expressed proteins were detected between the original Caki-1 cell line and the XIAP-knockdown Caki-1 cell line; 87 at 0 h (prior to etoposide treatment), 178 at 0.5 h and 169 at 3 h, while no differentially expressed proteins were detected (ratio >1.5 or <0.5; P<0.05) at 12 h after etoposide treatment. Etoposide 159-168 X-linked inhibitor of apoptosis Homo sapiens 106-110 29403558-5 2018 A number of differentially expressed proteins were detected between the original Caki-1 cell line and the XIAP-knockdown Caki-1 cell line; 87 at 0 h (prior to etoposide treatment), 178 at 0.5 h and 169 at 3 h, while no differentially expressed proteins were detected (ratio >1.5 or <0.5; P<0.05) at 12 h after etoposide treatment. Etoposide 319-328 X-linked inhibitor of apoptosis Homo sapiens 106-110 25161875-10 2014 SG1 not only sensitizes the XIAP-overexpressing leukemia cell line Molt3/XIAP to etoposide treatment but also different neuroblastoma cell lines endogenously expressing high XIAP levels. Etoposide 81-90 X-linked inhibitor of apoptosis Homo sapiens 28-32 22760199-6 2012 RESULTS: XIAP KD cells were more sensitive to etoposide, Rsv, vincristine and doxorubicin compared to wild-type (WT) cells. Etoposide 46-55 X-linked inhibitor of apoptosis Homo sapiens 9-13 21707856-10 2011 Importantly, the phosphorylation of XIAP at the site by PKC significantly increased cell survival up to approximately 2.5 times under the condition of apoptosis induced by 25 microg/ml etoposide. Etoposide 185-194 X-linked inhibitor of apoptosis Homo sapiens 36-40 16572900-2 2006 This was carried out by studying the effects of downregulation of XIAP expression on cellular viability, cellular apoptosis and on the response to two chemotherapeutical drugs, etoposide and doxorubicin. Etoposide 177-186 X-linked inhibitor of apoptosis Homo sapiens 66-70 15031723-6 2004 Therefore, downregulation of bcl-2 or xIAP by RNAi enhances the effects of etoposide and doxorubicin. Etoposide 75-84 X-linked inhibitor of apoptosis Homo sapiens 38-42 10797013-2 2000 The c-IAP1 and XIAP inhibitors of apoptosis were selectively lost in glucocorticoid- or etoposide-treated thymocytes in a proteasome-dependent manner before death. Etoposide 88-97 X-linked inhibitor of apoptosis Homo sapiens 15-19 14560006-6 2003 Exogenous expression of XIAP is sufficient to inhibit caspase 9 activation, Smac release, and cell death induced by etoposide. Etoposide 116-125 X-linked inhibitor of apoptosis Homo sapiens 24-28