PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2892826-1 1988 Mutations in the GLN3 gene prevented a normal increase in the NAD-glutamate dehydrogenase and glutamine synthetase levels in glutamate-grown Saccharomyces cerevisiae cells, whereas mutations in the URE2 gene resulted in high levels of these enzymes in glumate- and glutamine-grown cells. Glutamine 94-103 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 17-21 2892826-8 1988 We propose that the URE2-GLN3 system regulates enzyme synthesis, in response to glutamine and glutamate, to adjust the intracellular concentration of ammonia so as to maintain glutamine at the level required for optimal growth. Glutamine 80-89 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 25-29 2892826-8 1988 We propose that the URE2-GLN3 system regulates enzyme synthesis, in response to glutamine and glutamate, to adjust the intracellular concentration of ammonia so as to maintain glutamine at the level required for optimal growth. Glutamine 176-185 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 25-29 2892826-2 1988 A ure2 gln3 double mutant had low levels of glutamate dehydrogenase and glutamine synthetase in cells grown on glutamate and glutamine; thus, gln3 mutations were epistatic to the ure2 mutations. Glutamine 72-81 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 7-11 6152012-4 1984 Four polypeptides, in addition to the glutamine synthetase subunit are synthesized at elevated rates when GLN3+ cultures are shifted from glutamine to glutamate media as determined by pulse-labeling and one- and two-dimensional gel electrophoresis. Glutamine 38-47 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 106-110 6152012-8 1984 We suggest that there is a regulatory circuit that responds to glutamine availability through the GLN3 product. Glutamine 63-72 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 98-102 20974806-3 2011 Here, we demonstrate for the first time that binding of the nitrogen catabolite repression-responsive GATA transcription activators (Gln3 and Gat1) to the DAL5 promoter and DAL5 expression require Pph21/22-Tpd3-Cdc55/Rts1 in rapamycin-treated glutamine-grown cells. Glutamine 243-252 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 133-137 27293098-0 2016 A Glutamine/Asparagine-Rich Fragment of Gln3, but not the Full-Length Protein, Aggregates in Saccharomyces cerevisiae. Glutamine 2-11 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 40-44 26333687-7 2015 However, once within the nucleus, Gln3 can follow one of two courses depending on the glutamine levels themselves or a metabolite directly related to glutamine. Glutamine 86-95 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 34-38 26333687-7 2015 However, once within the nucleus, Gln3 can follow one of two courses depending on the glutamine levels themselves or a metabolite directly related to glutamine. Glutamine 150-159 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 34-38 26333687-8 2015 When glutamine levels are high, e.g., glutamine or ammonia as the sole nitrogen source or addition of glutamine analogues, Gln3 can exit from the nucleus without binding to DNA. Glutamine 5-14 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 123-127 26333687-8 2015 When glutamine levels are high, e.g., glutamine or ammonia as the sole nitrogen source or addition of glutamine analogues, Gln3 can exit from the nucleus without binding to DNA. Glutamine 38-47 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 123-127 26333687-8 2015 When glutamine levels are high, e.g., glutamine or ammonia as the sole nitrogen source or addition of glutamine analogues, Gln3 can exit from the nucleus without binding to DNA. Glutamine 38-47 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 123-127 26333687-9 2015 In contrast, when glutamine levels are lowered, e.g., adding additional nitrogen sources to glutamine-grown cells or providing repressive nonglutamine nitrogen sources, Gln3 export does not occur in the absence of DNA binding. Glutamine 18-27 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 169-173 26333687-9 2015 In contrast, when glutamine levels are lowered, e.g., adding additional nitrogen sources to glutamine-grown cells or providing repressive nonglutamine nitrogen sources, Gln3 export does not occur in the absence of DNA binding. Glutamine 92-101 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 169-173 23996237-7 2013 Moreover, the results indicated that the manner of urea metabolism regulation was different for two positive regulators involved in NCR; Gln3p can be retained in the cytoplasm by glutamine, while Gat1p can be retained by glutamine and glutamate. Glutamine 179-188 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 137-142 32801125-5 2020 Moreover, we found that glutamine levels were reduced by combined deletions of EGO1, GTR1, TOR1, and PIB2 with GLN3 These results suggested that high pressure leads to the intracellular accumulation of amino acids. Glutamine 24-33 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 111-115 32801125-6 2020 Subsequently, Pib2 loaded with glutamine stimulates the EGOC-TORC1 complex to inactivate Gln3, downregulating glutamine synthesis. Glutamine 31-40 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 89-93 18245087-2 2008 Gln3-Myc(13) and Gat1-Myc(13) are restricted to the cytoplasm of cells provided with good nitrogen sources, e.g. glutamine. Glutamine 113-122 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 0-4 19015262-2 2009 Gln3 is cytoplasmic in cells cultured with repressive nitrogen sources (Gln) and nuclear with derepressive ones (Pro) or after treating Gln-grown cells with the Tor inhibitor, rapamycin (Rap). Glutamine 72-75 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 0-4 17015442-8 2006 We found that Sit4 actively brought about Gln3-Myc(13) dephosphorylation in both good (glutamine or ammonia) and poor (proline) nitrogen sources. Glutamine 87-96 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 42-46 17439949-2 2007 Gln3 is cytoplasmic in cells provided with repressive nitrogen sources such as glutamine and is nuclear in cells growing with a derepressive nitrogen source such as proline or those treated with rapamycin or methionine sulfoximine (Msx). Glutamine 79-88 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 0-4 16864574-2 2006 In cells using ammonium or glutamine, the GATA transcription factor Gln3 is sequestered in the cytoplasm by Ure2 whereas it enters the nucleus after a shift to a nonpreferred nitrogen source like proline or upon addition of rapamycin, the TOR complex inhibitor. Glutamine 27-36 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 68-72 14970238-3 2004 When cells are transferred from a good to a poor nitrogen source (glutamine to proline) or treated with rapamycin, an inhibitor of the protein kinases Tor1/2, Gln3 (NCR-sensitive transcription activator) moves from the cytoplasm into the nucleus. Glutamine 66-75 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 159-163 16864577-9 2006 Other good nitrogen sources, e.g. glutamine, serine, or asparagine, restricted Gln3-Myc(13) to the cytoplasm of both wild type and npr1Delta cells. Glutamine 34-43 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 79-83 16275904-2 2005 The interpretation of recently published observations provides evidence for the view that Ure2p is the sensor for a drop in the intracellular concentration of glutamine, a signal that results in the polyubiquitination of the vesicle responsible for retaining the Gln3p-Ure2p complex in the cytoplasm. Glutamine 159-168 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 263-268 16275904-3 2005 As a consequence of the drop in glutamine concentration, Gln3p is able to enter the nucleus and to activate the transcription of nitrogen-regulated genes. Glutamine 32-41 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 57-62 12140287-1 2002 Regulated intracellular localization of Gln3, the transcriptional activator responsible for nitrogen catabolite repression (NCR)-sensitive transcription, permits Saccharomyces cerevisiae to utilize good nitrogen sources (e.g. glutamine and ammonia) in preference to poor ones (e.g. proline). Glutamine 226-235 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 40-44 11356843-2 2001 When cells are cultured with a good nitrogen source (glutamine, ammonia), Gln3p and Gat1p are restricted to the cytoplasm, whereas with a poor nitrogen source (proline), they localize to the nucleus, bind to the GATA sequences of NCR-sensitive gene promoters, and activate transcription. Glutamine 53-62 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 74-79 7568152-4 1995 The results further indicate that Gln3p is inactivated by an increase in the intracellular concentration of glutamine and that Nil1p is inactivated by an increase in intracellular glutamate. Glutamine 108-117 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 34-39 1682800-1 1991 The GLN3 gene of Saccharomyces cerevisiae is required for the activation of transcription of a number of genes in response to the replacement of glutamine by glutamate as source of nitrogen. Glutamine 145-154 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 4-8 12140287-6 2002 Here we show that nuclear localization of Gln3 during carbon starvation derives from its indirect effects on nitrogen metabolism, i.e. Gln3 does not move into the nucleus of carbon-starved cells if glutamine rather than ammonia is provided as the nitrogen source. Glutamine 198-207 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 42-46 11997479-0 2002 The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine. Glutamine 118-127 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 44-48 11997479-6 2002 MSX-induced glutamine starvation caused nuclear localization and activation of the TOR-inhibited transcription factors GLN3, RTG1, and RTG3, all of which mediate glutamine synthesis. Glutamine 12-21 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 119-123 11997479-6 2002 MSX-induced glutamine starvation caused nuclear localization and activation of the TOR-inhibited transcription factors GLN3, RTG1, and RTG3, all of which mediate glutamine synthesis. Glutamine 162-171 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 119-123 9171427-2 1997 The expression of many nitrogen-regulated genes of Saccharomyces cerevisiae requires activation by GATA factor Gln3p or Nil1p and is prevented by the presence of glutamine in the growth medium. Glutamine 162-171 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 111-116 9065690-3 1997 We show that Gln3p activates CAR1 expression through the GATAA sequences in the absence of an optimal nitrogen source, such as ammonia, glutamine or asparagine. Glutamine 136-145 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 13-18 8755910-1 1996 We used cells carrying plasmids causing the overproduction of Gln3p, Ure2p, or both of these proteins to elucidate the ability of Ure2p to prevent the activation of gene expression by Gln3p in cells growing in a glutamine-containing medium. Glutamine 212-221 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 184-189 7798155-1 1995 The cellular level and activity of the general amino acid permease, the product of the GAP1 gene of Saccharomyces cerevisiae, are regulated at the level of transcription by two systems, the products of URE2/GLN3 and NIL1 in response to the nitrogen sources of the growth medium and inactivation in response to the presence of glutamine or glutamate. Glutamine 326-335 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 207-211