PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29434187-4 2018 Herein we demonstrate that TNBC cells are markedly sensitized to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis upon glutamine deprivation. Glutamine 152-161 TNF superfamily member 10 Homo sapiens 122-127 29434187-0 2018 Glutamine metabolism regulates FLIP expression and sensitivity to TRAIL in triple-negative breast cancer cells. Glutamine 0-9 TNF superfamily member 10 Homo sapiens 66-71 29434187-4 2018 Herein we demonstrate that TNBC cells are markedly sensitized to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis upon glutamine deprivation. Glutamine 152-161 TNF superfamily member 10 Homo sapiens 65-120 14519785-5 2003 This study examined whether Gln protects against apoptosis induced by the cytokine tumor necrosis factor-alpha-related apoptosis-inducing ligand (TRAIL) in the human colon carcinoma cell line, HT-29. Glutamine 28-31 TNF superfamily member 10 Homo sapiens 146-151 28202415-3 2017 Therefore, we examined whether treatment with TNF-related apoptosis-inducing ligand (TRAIL) sensitizes MDA-MB-231 cells to apoptosis under Gln deprivation condition (TRAIL/Gln deprivation). Glutamine 139-142 TNF superfamily member 10 Homo sapiens 46-83 28202415-3 2017 Therefore, we examined whether treatment with TNF-related apoptosis-inducing ligand (TRAIL) sensitizes MDA-MB-231 cells to apoptosis under Gln deprivation condition (TRAIL/Gln deprivation). Glutamine 139-142 TNF superfamily member 10 Homo sapiens 85-90 28202415-3 2017 Therefore, we examined whether treatment with TNF-related apoptosis-inducing ligand (TRAIL) sensitizes MDA-MB-231 cells to apoptosis under Gln deprivation condition (TRAIL/Gln deprivation). Glutamine 172-175 TNF superfamily member 10 Homo sapiens 46-83 28202415-5 2017 TRAIL/Gln deprivation, however, significantly increased growth inhibition and morphological shrinkage of MDA-MB-231 cells compared to those induced by treatment with either Gln deprivation or TRAIL alone. Glutamine 6-9 TNF superfamily member 10 Homo sapiens 192-197 28202415-5 2017 TRAIL/Gln deprivation, however, significantly increased growth inhibition and morphological shrinkage of MDA-MB-231 cells compared to those induced by treatment with either Gln deprivation or TRAIL alone. Glutamine 173-176 TNF superfamily member 10 Homo sapiens 0-5 28202415-6 2017 Moreover, TRAIL/Gln deprivation upregulated the apoptotic sub-G1 phase accompanied with a remarkable decrease of pro-caspase-3, pro-caspase-9, and anti-apoptotic xIAP, and Bcl-2. Glutamine 16-19 TNF superfamily member 10 Homo sapiens 10-15 28202415-7 2017 Increased cleavage of PARP and pro-apoptotic Bid protein expression suggests that TRAIL/Gln deprivation triggers mitochondrion-mediated apoptosis in MDA-MB-231 cells. Glutamine 88-91 TNF superfamily member 10 Homo sapiens 82-87 28202415-8 2017 Additionally, TRAIL/Gln deprivation upregulated the expression of endoplasmic reticulum (ER) stress markers such as ATF4 and phosphorylated eIF2alpha, thereby enhancing the C/EBP homologous protein (CHOP) protein level. Glutamine 20-23 TNF superfamily member 10 Homo sapiens 14-19 28202415-10 2017 Accordingly, TRAIL/Gln deprivation enhanced the expression of death receptor 5 (DR5) and transient knockdown of DR5 completely restored TRAIL/Gln deprivation-mediated apoptosis. Glutamine 142-145 TNF superfamily member 10 Homo sapiens 13-18 28202415-10 2017 Accordingly, TRAIL/Gln deprivation enhanced the expression of death receptor 5 (DR5) and transient knockdown of DR5 completely restored TRAIL/Gln deprivation-mediated apoptosis. Glutamine 142-145 TNF superfamily member 10 Homo sapiens 136-141 28202415-11 2017 Taken together, our results suggest that Gln deprivation conditions can be used for the development of new therapies for TRAIL-resistant cancers. Glutamine 41-44 TNF superfamily member 10 Homo sapiens 121-126 20599741-0 2010 Targeting glutamine metabolism sensitizes melanoma cells to TRAIL-induced death. Glutamine 10-19 TNF superfamily member 10 Homo sapiens 60-65 20599741-11 2010 These results indicate some lines are addicted to glutamine, and treatment with AOA or glutamine depletion sensitizes melanoma to TRAIL-mediated killing, while sparing normal cells. Glutamine 87-96 TNF superfamily member 10 Homo sapiens 130-135 15878985-4 2005 The current research examines mechanism(s) for Gln-induced antiapoptotic effects in HT-29 cells treated with TNF-alpha-related apoptosis-inducing ligand (TRAIL). Glutamine 47-50 TNF superfamily member 10 Homo sapiens 109-152 15878985-4 2005 The current research examines mechanism(s) for Gln-induced antiapoptotic effects in HT-29 cells treated with TNF-alpha-related apoptosis-inducing ligand (TRAIL). Glutamine 47-50 TNF superfamily member 10 Homo sapiens 154-159 15878985-13 2005 In conclusion, Gln prevents TRAIL-induced apoptosis in HT-29 cells through a mechanism involving the pyrimidine pathway. Glutamine 15-18 TNF superfamily member 10 Homo sapiens 28-33 14519785-7 2003 TRAIL-induced apoptosis was completely prevented by Gln, but not inhibited by other amino acids, including the GSH constituents, glutamate, cysteine and glycine. Glutamine 52-55 TNF superfamily member 10 Homo sapiens 0-5