PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25236722-2	2014	Maintenance of these neurotransmitter pools is strictly dependent on the de novo synthesis of glutamine in astrocytes which requires both the anaplerotic enzyme pyruvate carboxylase and glutamine synthetase.	Glutamine	94-103	pyruvate carboxylase	Homo sapiens	161-181	
26070193-7	2015	siRNA-mediated knockdown of PC expression in MDA-MB-231 and MDA-MB-435 cells resulted in a 50% reduction of cell proliferation, migration and in vitro invasion ability, under both glutamine-dependent and glutamine-depleted conditions.	Glutamine	180-189	pyruvate carboxylase	Homo sapiens	28-30	
26070193-7	2015	siRNA-mediated knockdown of PC expression in MDA-MB-231 and MDA-MB-435 cells resulted in a 50% reduction of cell proliferation, migration and in vitro invasion ability, under both glutamine-dependent and glutamine-depleted conditions.	Glutamine	204-213	pyruvate carboxylase	Homo sapiens	28-30	
7805589-7	1993	Altogether, these observations led to the conclusion that glutamine precursors and citrate are either produced in different types of astrocytes or in different tricarboxylic acid cycles, situated in functionally different mitochondria in the same cell, and that in all likelihood pyruvate carboxylase is expressed differently in these mitochondria.	Glutamine	58-67	pyruvate carboxylase	Homo sapiens	280-300	
33931119-3	2021	In breast cancer, PC activity is linked to pulmonary metastasis, potentially by providing the ability to utilize glucose, fatty acids, and glutamine metabolism as needed under varying conditions as cells metastasize.	Glutamine	139-148	pyruvate carboxylase	Homo sapiens	18-20	
33931119-4	2021	PC enzymatic activity appears to be of particular importance in cancer cells that are unable to utilize glutamine for anaplerosis.	Glutamine	104-113	pyruvate carboxylase	Homo sapiens	0-2	
25607840-2	2015	The major anaplerotic sources are pyruvate and glutamine, which require the activity of pyruvate carboxylase (PC) and glutaminase 1 (GLS1), respectively.	Glutamine	47-56	pyruvate carboxylase	Homo sapiens	88-108	
25607840-2	2015	The major anaplerotic sources are pyruvate and glutamine, which require the activity of pyruvate carboxylase (PC) and glutaminase 1 (GLS1), respectively.	Glutamine	47-56	pyruvate carboxylase	Homo sapiens	110-112	
21555572-0	2011	Pyruvate carboxylase is required for glutamine-independent growth of tumor cells.	Glutamine	37-46	pyruvate carboxylase	Homo sapiens	0-20	
23748856-8	2013	RESULTS: The most significant metabolite difference (P<0.0056) was [2-C]glutamine"s higher final/control ratio for the hypothermia group (1.75+-0.12) compared with ratios for the delayed (1.12+-0.12) and normothermia group (0.94+-0.06), implying a higher pyruvate carboxylase/pyruvate dehydrogenase ratio for glutamine formation.	Glutamine	75-84	pyruvate carboxylase	Homo sapiens	258-278	
21555572-7	2011	Profiling metabolic fluxes in GLS-suppressed cells revealed induction of a compensatory anaplerotic mechanism catalyzed by pyruvate carboxylase (PC), allowing the cells to use glucose-derived pyruvate rather than glutamine for anaplerosis.	Glutamine	213-222	pyruvate carboxylase	Homo sapiens	123-143	
21555572-7	2011	Profiling metabolic fluxes in GLS-suppressed cells revealed induction of a compensatory anaplerotic mechanism catalyzed by pyruvate carboxylase (PC), allowing the cells to use glucose-derived pyruvate rather than glutamine for anaplerosis.	Glutamine	213-222	pyruvate carboxylase	Homo sapiens	145-147	
21555572-8	2011	Although PC was dispensable when glutamine was available, forcing cells to adapt to low-glutamine conditions rendered them absolutely dependent on PC for growth.	Glutamine	88-97	pyruvate carboxylase	Homo sapiens	147-149	
21555572-10	2011	Cells with high PC activity were resistant to GLS silencing and did not require glutamine for survival or growth, but displayed suppressed growth when PC was silenced.	Glutamine	80-89	pyruvate carboxylase	Homo sapiens	16-18	
21555572-11	2011	Thus, PC-mediated, glucose-dependent anaplerosis allows cells to achieve glutamine independence.	Glutamine	73-82	pyruvate carboxylase	Homo sapiens	6-8	
21555572-12	2011	Induction of PC during chronic suppression of glutamine metabolism may prove to be a mechanism of resistance to therapies targeting glutaminolysis.	Glutamine	46-55	pyruvate carboxylase	Homo sapiens	13-15	
12573011-0	2003	Improving glucose and glutamine metabolism of human HEK 293 and Trichoplusia ni insect cells engineered to express a cytosolic pyruvate carboxylase enzyme.	Glutamine	22-31	pyruvate carboxylase	Homo sapiens	127-147	
18697738-8	2008	In addition, in BCH plus glutamine-stimulated PC knockdown cells, pyruvate plus lactate was increased, whereas citrate was severely decreased, and malate and aspartate were slightly decreased.	Glutamine	25-34	pyruvate carboxylase	Homo sapiens	46-48