PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14750795-5 2004 The oxadiazinones were subsequently applied in the titanium-mediated asymmetric aldol addition reaction by treatment with titanium tetrachloride, triethylamine, and a variety of aldehydes at 0 degrees C. The aldol adducts 10a-i and 11a,b were found to have diastereoselectivities ranging from 8:1 to >99:1 favoring the formation of the non-Evans syn configuration. oxadiazinones 4-17 synemin Homo sapiens 349-352