PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15115391-2	2004	The ability of the new analogues to inhibit reduction of dihydrofolate to tetrahydrofolate by Pc, Tg, Ma, and rat DHFR was determined, and the selectivity index (SI) was calculated from the ratio IC(50)(rat DHFR)/IC(50)(Pc, Tg, or Ma DHFR).	dihydrofolate	57-70	dihydrofolate reductase	Rattus norvegicus	114-118	
9526565-3	1998	The products were tested as competitive inhibitors of the reduction of dihydrofolate by Pneumocystis carinii, Toxoplasma gondii, and rat liver DHFR.	dihydrofolate	71-84	dihydrofolate reductase	Rattus norvegicus	143-147	
10862611-6	2000	Again, methotrexate abolished the lysosomal uptake of the fusion protein, which was partially restored by washing of methotrexate from DHFR or by adding together methotrexate and dihydrofolate, the natural substrate of DHFR.	dihydrofolate	179-192	dihydrofolate reductase	Rattus norvegicus	219-223	
1613754-10	1992	Kinetic studies with rat liver DHFR show that MBP is an inhibitor that competes with NADPH as well as dihydrofolate.	dihydrofolate	102-115	dihydrofolate reductase	Rattus norvegicus	31-35	
2354716-6	1990	P. carinii DHFR could be easily distinguished from rat DHFR, which is similar in size, by the differences in Km for dihydrofolate (P. carinii, 17.6 +/- 3.9 microM; rat, 4.0 +/- 2.2 microM).	dihydrofolate	116-129	dihydrofolate reductase	Rattus norvegicus	11-15